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Neg strd RNA viruses

paramyxoviridae exemples parainfluenza, mumps, measles, repiratory syncytial virus
paramyxoviridae transmission large droplets aerosol
paramyxoviridae important proteins RNA polymerase, HN/H/G (hemagglitinin-neuraminidase), Fusion protein, Matrix protein
Fusion protein role stimulate fusion of viral envelope and cell membrane=fusion of infected host cells (syncitia formation)
3 Parainfluenza viruses symptoms cold-like, bronchiolitis, croup (seal like barking)
Mumps clinical symptoms inflammation and enlargement of salivary glands (but systemic infection)
Measles incubation time 10-14 days
Measles symptoms fever, cough, conjunctivitis, sore throat, rash (diffuse and macular), Koplik's spots. Serious complicaitons: encephalitis and SSPE-subacute sclerosing panencephalitis)
Respiratory syncytial virus (RSV) symptoms bronchiolitis (75%) and pneumonia
Rhabdoviridae disease: rabies
Rabies symptoms acute, fatal viral inflammation of the brain, death by respiratory paralysis
post mortem diagnosis for rabies direct fluorescent antibody test (100%), negri bodies in cerebellum Purkinje cells (50%)
Filoviridae viruses Marburg and Ebola
Created by: harrysomerset