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hyperlipidemia
Drugs recognition: chap 15
| Question | Answer |
|---|---|
| rosuvastatin (Crestor) | HMG CoA Reductase Inhibitors “Statins” |
| atorvastatin (Lipitor) | HMG CoA Reductase Inhibitors “Statins” |
| simvastatin (Zocor) | HMG CoA Reductase Inhibitors “Statins” |
| pravastatin (Pravachol) | HMG CoA Reductase Inhibitors “Statins” |
| lovastatin (Mevacor) | HMG CoA Reductase Inhibitors “Statins” |
| fluvastatin (Lescol) | HMG CoA Reductase Inhibitors “Statins” |
| pitavastatin (Livalo) | HMG CoA Reductase Inhibitors “Statins” |
| cholestyramine (Questran) | Bile Acid Binding Resins |
| colestipol (Colestid) | Bile Acid Binding Resins |
| colesevelam (Welchol) | Bile Acid Binding Resins |
| ezetimibe (Zetia) | Cholesterol Absorption Inhibitor |
| ezetimibe/simvastatin (Vytorin) | Cholesterol Absorption Inhibitor |
| gemfibrozil (Lopid) | Fibric Acid Derivatives |
| fenofibrate (Tricor, Antara, Lipofen, Trilipix) | Fibric Acid Derivatives |
| niacin (Niaspan-rx, otc’s) | Other Drugs |
| omega-3-fatty acids (ethyl ester) (Lovaza) | Other Drugs |
| Statins indications | Hypercholesterolemia & mixed hyperlipidemia |
| statins adverse effects | GI (constipation, diarrhea, heartburn, abdominal cramps) Liver enzyme elevation & hepatitis Rhabdomyolysis |
| Bile Acid-binding Resins indications | Hypercholesterolemia, pruritis, & diarrhea |
| Bile acid-binding resins adverse effects | constipation, fecal impaction, and rash |
| niacin adverse effects | gastric irrigation, glucose intolerance, myalgia, rhabdomyolysis, myopathies, vasodilation, flusing, prutitus |
| Fibric acid derivatives adverse effects | allergic reactions, blood cell deficiencies, myalgia, rhabdomyolysis and other myopathies |
| rhabdomyolysis is | fatal form of skeletal muscle toxicity (myopathy) |
| etimibide (Zetia) ezetimibide/simvastatin indications | Hypercholesterolemia |
| cholesteron absorption inhibitors: etimibide (Zetia) ezetimibide/simvastatin adverse effects | Headache Myalgia |
| niacin indications | Mixed hyperlipidemia HDL deficiency |
| anticoagulant drugs indications | Patients who have had HIT Unstable angina Acute MI |
| anticoagulant drugs adverse effects | Vasodilation, pruritis (itching), & flushing Hepatitis GI Hyperglycemia |
| omega-3 fatty acids | lower triglyceride levels, improve LDL-c to HDL-C ratio |
| Fibric acid derivatives gemfibrozil (Lopid) fenofibrate (Tricor) indications | Hypertriglyceridemia Mixed hyperlipidemia |
| Fibric acid derivatives gemfibrozil (Lopid) fenofibrate (Tricor) contraindication | avoid with statins |
| Fibric acid derivatives moa | Decrease VLDL & LDL while raising HDL |
| drug to increase HLD | niacin |
| niacin contraindicated with | pt with diabetes |
| Bile Acid-binding Resins moa | Binds with bile acids to prevent recycling which makes the liver produce more from the cholesterol , reduce cholesterol LDL |