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Antiarrhythmics

Drugs recognition: chap 14

QuestionAnswer
quinidine Sodium Channel Blockers clasee IA
lidocaine (Xylocaine) Sodium Channel Blockers class IB
flecainide (Tambacor) Sodium Channel Blockers IC
propafenone (Rythmol) Sodium Channel Blockers IC
esmolol (Brevibloc) Beta Blockers
metoprolol (Lopressor, Toprol XL) Beta Blockers
propranolol (Inderal) Beta Blockers
sotalol (Betapace) nonselective Beta Blockers Class III
amiodarone (Cordarone, Pacerone) Potassium Channel Blockers
dofetilide (Tikosyn) Potassium Channel Blockers restricted access in US
diltiazem (Cardizem, Diltia) Calcium channel Blockers class IV
verapamil (Verelan, Calan) Calcium Blockers Class IV
digoxin (Lanoxin) Miscellaneous
magnesium Miscellaneous
quinidine Diarrhea, syncope, thrombocytopenia, neuro symptoms
what dose class IA do? Decrease conduction velocity Prolong ventricular action
lidocaine indication sodium IB V-tach Ventricular arrhythmias
lidocaine side effects CNS (nervousness, tremor, paresthesia), cardiac arrest
flecaine indication supreventricular and ventricular arrhymias
flecaine side effects Reentrant v-tach, bronchospasm, hematologic abnormalities (leukopenia, thrombocytopenia) seizures
propafenone indication Ventricular arrhythmias
propafenone adverse effects ventricular arrhythmias, hematologic abnormalities (agranulocytosis, anemia, thrombocytopenia)
Atrial fib & flutter Control ventricular rate: BB, CCB, & digoxin AND anticoagulant Cardioversion & Class I or Class II drugs
magnesium sulfate drug-induced arrhythmias, preeclampsia, hypomagnesemia
diltiazem (Cardizem)** verapamil (Calan)** indication Acute SVT & atrial fib
verapamil, diltiazem adverse effects Exacerbate ventricular arrhythmias
sotalol indications atrial & ventricular arrhythmias
sotalol adverse effects arrhythmias, bronchospasm
dofetilide adverse effect life-threatening arrhythmias
dofetilide indication Atrial fib/flutter
dofetilide administration monitor EKG
amiodarone adverse effects Reversible cardiac effects Corneal micro-deposits Hypothyroidism Neuropathy Pulmonary fibrosis
amiodarone indications Suppress SV & ventricular arrhythmias, atrial fib & flutter, SV & ventricular tachycardia
metoprolol, propanolol indication SV & ventricular arrhythmias MI – protect heart against damage
esmolol indication Acute SV tachycardia & HTN IV
treatment of Torsades de pointes withdrawal of the causative agent, correction of any electrolyte abnormalities such as hypokalemia, IV administration of magnesium sulfate, cardiac over-drive pacing, IV administration of isoproterenol (B adrenoceptor agonist => shortening the QT interval
causes of Torsades de pointes polymorphic ventricular tachycardia, drug-induced (prolong the QT interval)
Created by: prinluu
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