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DNA Viruses
parvo, papova, adeno, herpes, pox
Question | Answer |
---|---|
Parvovirus-linked condition in 2nd trimester fetuses | Hydrops fetalis (30% of carrier mothers pass it on. 10% of fetuses will stop fetal erythrpoiesis. |
what is fifth disease | Erythema infectiosum: Malar Rash in healthy children, immune mediated. |
Parvovirus effect on anemic patients | Transient Aplastic Crisis |
Conditions linked to Bocavirus | URI, LRI, gastroenteritis. |
Parvoviruses prevalence | B19: 15yo=50%, elderly=80%, Boca=63% |
VEP/RB mechanism | E2F-1 released from RB -> RB inactive ->DNA synthesis |
VEP/p53 mechanism | Lowers p53 -> inhib apoptosis + cycle stop (p21). |