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DNA Viruses

parvo, papova, adeno, herpes, pox

Parvovirus-linked condition in 2nd trimester fetuses Hydrops fetalis (30% of carrier mothers pass it on. 10% of fetuses will stop fetal erythrpoiesis.
what is fifth disease Erythema infectiosum: Malar Rash in healthy children, immune mediated.
Parvovirus effect on anemic patients Transient Aplastic Crisis
Conditions linked to Bocavirus URI, LRI, gastroenteritis.
Parvoviruses prevalence B19: 15yo=50%, elderly=80%, Boca=63%
VEP/RB mechanism E2F-1 released from RB -> RB inactive ->DNA synthesis
VEP/p53 mechanism Lowers p53 -> inhib apoptosis + cycle stop (p21).
Created by: harrysomerset