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med micro ch3
commensals and pathogens pathogenesis
| Question | Answer |
|---|---|
| What relationship which dissimilar organisms exist with close union | Symbiosis |
| Relationship which both organisms get benefit from. | Mutualism |
| Relationship which is beneficial for the organism but has no effect on the host. | Commercialism |
| Relationship which the organism has a deleterious effect on the host | Parasitism |
| an organism always associated with disease. never be normal flora. | strict pathogen |
| an organism that does not cause disease in the normal setting, but can establish disease if introduced into other settings | opportunistic pathogen |
| examples of strict pathogen | Mycobacterium tuberculosis neisseria gonorrhoeal Francisella tularensis |
| factors determine pathogenic status.(factors make the opportunistic pathogen pathogenic) | the place the bacteria are status of host (immune status, sick, medication, surgery) |
| How bacteria get in our body? | trauma or hair follicles of skin. anatomical orifices |
| How bacteria evade body protective mechanism? | huge Lipopolysaccharide Agressins |
| List kinds of agressins | capsule surface proteins and carbohydrates enzymes toxins |
| what is agressins? | substances produced by bacteria that allow them to avoid or circumvent host defense mechanisms |
| The order to get disease | Exposure, infection, colonization, disease |
| what is this status? condition of being subject to some detrimental effect or harmful condition | exposure |
| what is this status? state produced by the establishment of infective agent in or on a suitable host | infection |
| what is this status? transient or permanent state of organism presence that does not affect normal body function | colonization |
| what is this status? interaction between organisms and host leading to a pathogenic process within the host | disease |
| What is called the protein that facilitate adhesion? | adhesins |
| List 4 that facilitate adhesion when bacteria is attempting colonization | adhesins lipoteichoic acid F protein Biolifms |
| When bacteria try to enter the cell of host, what mechanism they use? | Type III secretion device |
| What are bacterial products that directly harm tissue or trigger destructive biologic activities?(general term) | toxins |
| What are the protein which mostly gram-positive bacteria give off to alter a function or kill the cell? | exotoxins |
| Tell the function of each potion of bipartile toxins | B: binds to specific cell surface A: interacts with target and cause trouble |
| What is called for that bacterial cell wall components act as a signal of infection and activate the host's protective systems? | Endotoxins |
| Which toxins are specific for gram-negative? | Endotoxins |
| What cellular substance contribute for endotoxins? | lipopolisaccharide |
| What substances cause gram-positive bacterial endotoxin-like responses. | peptigoglycan, teichoic acid, lipoteichoic acid |
| What is called that protein toxin that binds T-cell and MHCII antigens. | Superantigens |
| What is caused by superantigens? | It binds T-cell and MHCII and stimulate the production of cytokines causing "cytokine storm" |
| What symptoms will appear by cytokine storm? | capillary leakage, tissue edema, organ failure, shock, death |
| What is called when human body immune system cause symptoms | Immunopathogenesis |
| How our immune system hurt our body? | Body reacts to bacteria by releasing CRP and MBLs that bind to bacterial surface and act as opsonins. But MBLs are also pyrogenic and produced WBCs can also hurt our body. |
| List the kind of immunopathogenesis | Cytokine storm granuloma formation autoimmune system |
| What is antisepsis? | disinfection of living tissue |
| Who is the father of antisepsis? | Semmelweis |
Created by:
hiroko lucky
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