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NAPLEX - HIV - 1
HIV Drug Side Effects
Question | Answer |
---|---|
Fusion Inhibitors | bacterial pneumonia, injection site reaction hypersensitivity |
CCR5 Antagonists | CNS-2, hepatotoxic, cough, muscle/joint pain |
Selzentry | dosing based on concomitant 3A4 inhibitors/inducers |
Non-Nucleoside Reverse Transcriptase Inhibitors/NNRTIs | CNS-2, GI-2, hepatitis, increased LFTs, rash/SJS |
Sustiva/efavirenz | hallucinations, dreams, hypertriglyceridemia |
Intelence/etravirine | peripheral neuropathy |
Viramune/nevirapine | hepatotoxicity (increased risk for MEN w/ CD4 > 400 & for WOMEN w/ CD4 > 250) |
Sustiva/efavirenz | take on empty stomach |
Nucleoside/-tide Reverse Transcriptase Inhibitors/NRTIs | CNS-2, GI-2, hepatic steatosis (fatty liver), hyperlipidemia Other: lipodystrophy, lactic acidosis |
Viread/tenofovir | nephrotoxic |
Videx/didanosine | retinal changes, pancreatitis, portal HTN, peripheral neuropathy |
Videx/didanosine | weight based dosing, take on empty stomach |
Retrovir/zidovudine | macrocytic anemia, neutropenia, hyperpigmentation (nails/mucosa) |
Zerit/stavudine | DM, neuromuscular weakness, peripheral neuropathy |
Emtriva/emtricitabine | hyperpigmentation |
Ziagen/abacavir | increased risk of MI, hypersensitivity reaction (more likely w/ HLA-B*5701 allele) |
Which NRTIs have anti-hep B activity? | TDF/tenofovir/Viread FTC/emtricitabine/Emtriva 3TC/lamivudine/Epivir |
Integrase Inhibitors | GI-2, transaminitis, may increase CK (myopathy, rhabdo) though uncommon |
Protease Inhibitors | CNS-2, CHD, stroke, hyperlipidemia, hyperTG GI-2, hepatitis Endo: DM Other: increased bleeding in hemophiliacs |
Reyataz/atazanavir | PR prolongation, increased indirect bilirubin, needs an acidic environment, take with food Derm: rash Other: kidney stones, fat maldistribution |
Prezista/darunavir | rash/SJS - SULFA MOIETY!!! |
Lexiva/fosamprenavvir | rash - SULFA MOIETY!!!; Other: paresthesias, fat maldistribution |
Crixivan/indinavir | increased bili, gallstones, alopecia, poor bioavailability (take on empty stomach, multiple daily dosing) BMS: hemolytic anemia Other: kidney stones, musculoskeletal pain |
Kaletra/lopinavir+ritonavir | pancreatitis |
Aptivus/tipranavir | BBW for intracranial hemorrhage SULFA MOIETY |