NURS 572 Pharm Ch 49 Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Question | Answer |
what are the classes of lipid lowering agents-5 | HMGCoA reductase inhibitors---nicotinic acid---bile acid-binding resins---fibric acid derivatives/fibrates----ezetimibe |
What class is BEST at lowering LDL | HMG-CoA reductase inhibitors do this best |
MOA HMG-CoA reductase inhibitors | they block the enzyme, so more LDL receptors can be made which then allow LDL to bind,removing LDL from bloodstream |
do HMG-CoA reductase inhibitors have additional pleitrophic effects that decrease risk of HA | Yes - primary action is to DECREASE LDL----also moderate increase of HDL, moderate decrease TG |
how long does it take for HMG-CoA's to become effective | dose dependent, peaks in 4-6 weeks |
tell me 3 cautions with the HMG-CoA's class | pregnancy category X---hepatotoxic---myopathy/rhabdomylosis |
Names of HMG-CoAreductase inhibitors - 7 | the 'statin family --- atorvastatin, fluvastatin, lovastatin, pravastatin, pitvastatin, simvastatin |
which to statins have greatest efficacy | atorvastatin, rosuvastatin |
which statin must be taken in lower dose to avoid myopathy | simvistatin |
Nicotinic acid/niacin MOA | decrease triglyceride carrier VLDL, of which LDL is a by-product |
Primary/secondary actions nicotinic/niacin | primary = decrease TGs--------------secondary = inc. HDL---dec. LDL |
ADRs nicotinic acid/niacin | compliance limiting flushing/itching ----hepatotxic |
MOA of bile-acid binding resins | bind bile acids in GI---liver makes more bile acids---bile acids made from cholesterol---liver INCREASES LDL RECEPTORS---lowers LDL |
Primary action of bile-acid binding resins | primary ---inc HDL------lower LDL same MOA as statins, which is why they are often used in combo |
downside of bile-acid containing resins | they actually inc TGs, but benefits outweigh |
major ADR of bile acid binding resins | constipation --- BUT NO LIVER TOXICITY |
name 3 bile acid binding resins | cholestyramine---colestipol---colesevelam |
which bile acid binding resin likely to be selected bwo best tolerated | colesevelam wins this prize |
fibric acid-fibrates - we don't know MOA, what is their major effect | primary = dec TGs as well as niacin/nicotinic------ secondary -----dec LDL---incl HDL |
ADRs of fibrates | hepatotoxic --- myopathy---GALLSTONES |
name 3 fibric acid/fibrates | gemfibrozil---fenofibrate---choline fenofibrate |
what stand alone drug acts as border patrol | ezetimibe---blocks chol from being absorbed at brush border |
what does ezetimibe do, though not particularly well, which is why it's 2nd/3rd add-on drug | mod inc HDL - - - not enough data to rank its dec LDL, dec TG |
ezetimibe class | stand alone- border patrol |
fenofibrate ----choline fenofibrate | fibric acid/fibrate |
gemfibrozil | fibric acid/fibrate |
cholestyramine | bile acid binding resin |
colestipol | bile acid binding resin |
cholestyramine | bile acid binding resin |
niacin | nicotinic acid |
any of the statins in this class | HMG-CoA reductase inhibitor |
Created by:
lorrelaws
Popular Nursing sets