nu600 last exam Word Scramble
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Question | Answer |
what is the most common cardiovascular disease in USA | HTN |
what values consist of HTN | BP of 140/90 or greater, 95% of cases, secondary at rest such as renal failure |
95% of all HT are what type of HTN | Primary |
what does primary HTN mean | renin angiotenson aldosterone system are implicated. |
what conditions and activation of what system is resulting the sodium excretion being implicated | low renal perfusion, decreased sodium delivery to distal nephrons and sympathetic stimulation. |
secondary HTN is as a result of what | renovascular disease, renal artery stenosis, hyper aldosternoism, pheochromocytoma, coarctation of aorta, |
which cause of secondary HTN can be fixed with surgery | coarctation or aorta, renal artery stenosis, pheochromocytoma |
sympatholytics do what | depress the SNS |
5 subtype of sympatholytics | central acting, adrenergic neuron blocker, alpha adrenergic atag, beta antag, mixed adrenergic antag |
describe impulse transmission from spinal cord to SNS | pre and post gangtionic, Pre-ganglionic neurons originate at thoraco lumbar of spine, short preganglionic with paravetebral ganglio (fast with ACh), long post ganglionic communicate with target organ. (norepi is neurotransmitter) |
pre ganglionic neurons originate where | thoraco lumbar T1-L2 |
length of pre ganlionic are what | short |
short pre ganglionic fiber and what other ganglion has ACh as neurotransmiter | paravetebral ganglion |
long post ganglionic’s neurotransmitter is what | norepi this process is slower than the ACh |
at pre ganglionic site there is a release of ACh which activate what receptor and where | nicotonic acetlycholine on the post ganglion neuron |
when the nicotinic receptor is stimulated there is release of what which does what | norepi, which activated adrenergic on peripheral tissue |
ACh activate what on the post ganglionic neuron | nicotinic acetylcholine |
centrally acting antihypertensive agents act how | prevent the brain from sending signal |
central acting antihypertensive ie alpha 2 agonist are | clonidine, methyldopa, dexmedetomidine aka Precedex, guanfacine, guanabenz |
sympatholytic dual action inhibits what | dopa decarboxylase which prevent Ldopa to Dopamine reducing methylation of norepi to epi |
central alpha adrenergic receptor create a false neurotransmitter called | methyl-norepinephrine and functions on the locus ceruleus to inhibit adrenergic outflow |
alpha 2 sympatholytic are used in what types of HTN | essential and gestational |
does methyldopa cross the placenta | yes and it appears to be safe in pregnancy |
methyldopa does what to SNS | decreases the SNS both centrally and peripherally |
side effects of methyldopa | sedation, head ache, dizziness, low HR and low BP low SVR, depression and anxiety and parkinsonism |
other side effects of methyldopa | positive coombs test, hemolytic anemia, bone marrow supression, increased LFTS and renal parameters. dry mouth, NV diarrhea no more for gestational |
clonidine aka catapres | prototypical central anti adrenergic, |
ratio of catapres alpha 2 to alpha 1 | 220:1 |
catapres aka clonidine uses | additiction, anxiety, regional block, chronic pain lowers MAC by 35% |
Dexmedetomidine aka | precedex |
precedex ratio of alpha 2 to alpha 1 | 1620:1 |
precedex and accumulation of narcotics | inhibition of enzymes can potentiate this |
adverse effect of precedex | hypotension, HTN, brady, NV, tachy, hypoxia, |
name other central acting alpha 2 | reserpine aka serpalin, metirosine aka demser |
reserpine aka | serpalin |
metirosine aka | demser |
adequate hydration is essential to avoid what intraoperatively | hypotension |
metyrosine may predispose patients to | arrhythmia with use of VA |
metrosine is useful for treatment of | pheochromocytoma and cateholamine depletion and depression |
phenoxybenzamine aka dibenzaline | alpha 1 and alpha 2 long acting |
dibenzaline metabolizes to an intermediate product that reacts with alpha receptors covalently which causes what | irreversible receptor blockade |
what does one use phenooxybezamine to treat | pheochromocytoma HTN, ischemic effects of pressors, and treat of BPH to imrove urine flow |
phenoxybenzamine in contraindicated when | pts cant handle precipitous fall in BP, blunts respnse to phenyephrine, may cause epi reversal, then give norepi instead |
dibenzaline to treat pheochromocytoma pretreatment how long before surgery | |
side effects of dibenzaline | head ache, NV crosses BBB sedation |
what was the prototypical Alpha 1 blocker | Dibenzaline aka pheoxybenzamine |
selective postsynaptic alhpa 1 drug | phentolamine aka regitine |
regitine aka phentolamine causes what | vasodialation, decrease SVR and PA pressure, may cause reflex tachy and activates plasma renin |
phentolamine used in catecholamine infiltration dose | 5-10mg in 10ml of NS within 12 hours of extravasation |
phentolamine block what two receptors | alpha 1 and alpha 2 |
block in alpha 1 results in what | vasodilation by blocking alpha1 noepi release |
phentolamine may cause what | reflex tachycardia |
dose of phentolamine and uses | 1-5mg slow push, infiltration of pressor, mgmt of HTN from clonidine withdraw, ED |
Oraverse is what | its pretty much phentolamine used as a reversal by dentists |
prazosin aka minipres | selective alpha 1 inhibitor, arterial and venous dialation, encourges sodium and water. used with beta blocker and diuretic. |
adverse effect of minipres aka prazosin | hypotension, syncope, edema, marked hypotension with GA |
Terazosin aka hytrin causes what | nasal congestion so avoid nasal intubation |
doxazosin aka cardura compared to minipres | its 50% as potent as minipres, cardura may cause hypotension under anesthesia |
Beta blockers inhibit what | interaction of epi and norepi and sympathetic drugs, may be selective and non selective |
beta 1 antag decrease what | spontatneous rate of depolarization, slows AV conduction, increases refractory period of AV node |
B2 antag may cause what | life threatening bronchospasm |
when using Beta blocker, even B1 selective antag can cause what | depending on dose may also become a B2 antag |
non selective beta blockers blunt what | glycogenolysis may also block signs of hypoglycemia, nervousness, tremor and tachycardia |
contraindication of beta blocker | existing bradycardia, heart blocks, cardiogeneic shock, heart failure |
beta blocker and diabetic | may cause hypoglycemia, beta 1 agents are preferred in diabetics |
Inderal is the protypical what | nonselective beta blocker, competes with epi and norepi for beta sites |
classification of inderal | class 2 antiarrhythmic depress automaticity at SA node and AV conduction velocity. |
inderal can be used to treat what | HTN and HTN due to pheochomocytoma |
Inderal and pheochromocytoma | beta blocker should NOT be started until the alpha blocker has be started. without alpha blockers, can cause HTN crisis |
inderal dose | 2mg every 5 min duration less than 10 min max dose of 12mg a day. |
what patients are not good candidates for Inderal | pts with constrictive/reactive pulmonary disease |
inderal and neostigmine and VA | may cause HYPOtension |
abrupt stopage of inderal | severe HTN followd by MI |
Nadalol aka corgard | non selective beta blocker. |
timolol aka blocardren aka timoptic | non selective beta blocker used for aqueous humor increase outflow in glaucoma patients |
Metoprolol aka lopressor | beta 1 selective kinda, 1-5mg every 3 min max of 3 doses. lasts upto 4 hours. caution with neostigmine or amiodarone, large margin of safety |
Atenolol | selective Beta1 blocker Dose 5mg q5min x2 dose total dose of 10mg duration 24 hours. excreted by kidney and no hepatic metabolism. pee and pooped unchanged |
Intraoperative drug of choice for Beta1 blocker for cardiac patients due to ints long duration | Atenolol |
Esmolol | most Beta1 blocker, low beta2 effects. intraoperative HTN, SVT, Afib or flutter ventricle control |
esmolol reducsed release of what | renin, making it a titratble agent. |
dose of esmolol | 1mg blous, infusion 150-300mcg/kg.min |
how is esmolol metabolized | red blood cell esterase |
what patients are good candidates for esmolol | its non organ dependent metabolism hepatic and renal patients |
common situation where esmalol is used | intraoperative HTN SVT afib flutter |
esmolol supplied in 250mg/ml if you inject 10amps in 250cc give you a concentraion of | 2.5gm/250cc |
non selective adrenergic antagonist such as | labetalol |
labetalol aka | trandate |
labetalol aka trandate is non selective what and selective what | non selective beta and selective alpha 1 antagonist |
ratio of alpha to beta blockade is | 1:7 strongly favoring beta. non titratable give slow and start low |
dose of trandate aka labetalol | 5-20mg over 2min total dose of 300mg infusion rate of 2mg/min ratio of 7:1 beta to alpha |
carvedilol aka coreg | non selective beta and selective alpha1, 3-5 times more potent than labetolol. PO only, preop hydration reduces hypotension and |
calcium channel blocking does what | slows voltage of sensitive Ca channels, L type or slow channels. controls entry into smooth muscle, cardiac muscle, and cardiac conduction. |
what stages does Ca go into the cell which the blockers act on | stage 2 where Ca is going in and K out, “plateau” of conduction curve |
what are the Ca blocker chemical structure groups | phenyl-alkylamines, dihydro-pyridines, benzo-thiazepines, diphenyl-piperazines, diaryl-amino-propylamine |
the different chemical structures of Ca blockers differ how | depending on the structure the differ in pharmacologic characteristics, interaction and toxicity |
nifedipine aka procardia aka aldalat chemical structure | dihydro-pyridine, no effect on cardiac conduction |
how does procardia work | decrease peripheral vascular resistance and increases cardiac output. dilate coronary more so than other agents. |
procardia is used for what other conditions | esophageal spasm, vascular headache, cardiomyopathy, asthma, primary pulm HTN |
nifedipine is no longer used as what | intranasal or sub lingual due to cardiac and neurological effect, dizziness, loss of consciousness, Heart block, MI sinus arrest |
nicardipine aka cardine a dihydro-pyridine, results and used in | decrease SVR, essential and chronic HTN, first dihydro-pyridine for IV use |
IV dose of nicardipine | 0.625-2.5mg this is half of what is normally used. hepatic-renal clearance , prolong QT segment prolongation |
nicardipine uses | perioprative HTN, pheochromocytoma, control of cerebral vasospasm, myocardial preservation during bypass, does not cause coronary steal, promotes myocardial oxygen supply and demand balance |
amlodipine aka norvasc another dihydro-pyridine works where | in periphery decreasing SVR and increasing cardiac output |
Clevidipine aka clevelox is a unique calcium channel blocker | treat intraoperative HTN |
Clevidipine is metabolized where | blood and tissue non specific esterase |
dose of clevidipine is | 0.3-3mcg/kg/min max of 16mcg/kg/min |
pts with what condition will have prolong recovery and where clearance is reduced | when a patient has pseudocholinesterase deficiency, ie Atypical chonlinestease |
verapamil aka calan what chemical structure | phenyl-alkamine |
verapamil aka calan a phenyl-alkamine slows Ca influx via slow channel into where | myocardial and arterial smooth muscle |
what does verapamil aka calan do | dialate coronary arteries, inhibits coronary artery spasm, and slows SA and AV node without altering intraventricular conduction. |
verapamil is used to treat | HTN, angina, SVT, arrhythmia and mirgraines |
dose of verapamil aka calan | 5-10mg bolus, repeast 15-30min PO has significant hepatic metabolism, less bioavailable |
Diltiazem aka cardizem is what chemical structure | benzo-thiazepine |
cardizem aka diltiazem is a slow Ca channel blocker similar to verapamil, useful in off pump CABG as is verapamil and esmolol. | |
what meds can be used in off pump CABG | verapamil, esmolol and cardizem |
cardizem slows conduction of what | SA and AV node does not affect intraventricular conduction. |
dose of cardizem | 0.25mg/kg followed by 15mg/hour infusion |
how does the renin angiotensin work | renin stored in nephron released under low renal perfusion or beta 1 stimulation, renin combines with angiotensinogen to make angiotensin 1, angio1 with ACE is converted to angio2 in lungs. |
angiotensin2 encourages vasoconstriction and release of what from where which causes increased blood pressure | aldosterone release from the zona glomerulosa |
release of aldosterone does what | encourage Na absorption in distal convoluted tubule and collecting duct. to absorb Na the nephron has to eliminate K+ or H+ |
when ACE inhibitors are used what happens | PVR is lowered without reflex tachycardia or changes in cardiac output. reduction of aldosterone reduce sodium reabsorption thus saving K. |
captopril aka capoten adverse effect | dizziness, fainting and cough |
Lisinopril aka zestril adverse effect | dizzy heache hypoten NV and cough |
enapril aka vasotec adverse effect | headache, fatigue, nervousness, chest pain cough |
ramapril aka altase adverse effect | dizziness headache angioedema, NV cough |
where are angiotensin2 receptors located | vascular and myocardial tissue, brain, kidney, adrenal cells where aldosterone is produced |
ACE 2 inhibitor use and GA | refractory hypotension have been reported. |
ACE 2 inhibitor has much less incidence of what | cough |
Cozaar aka Losartan blocks angiotensin II at what receptor and lowers what | at the T1 receptor and lowers aldosterone from adrenal cortex |
Cozaar aka losartan used to treat | chronic HTN |
consideration for ACE inhibitors and angiotensin II blockers and anesthesia | hypotension with GA, treat with IV fluid first, may require vasopressin agonist, 0.04mg ephedine releases norepi. my cause hyper K with K solutions, hypotensive compounded, Increasea effect of curare and NMB |
ACE II agents associated with what emergency | Angioedema |
arterial vasodialtors reduce BP by direct effect of vascular smooth muscle of arterial resistance with little effect on | capacitance vessels |
what is the prototypical arterial vasodialator | Hydralazine |
Hydralazine a very effective arterial dilator causes what | reflex tachycardia by stimulating the baroreceptor reflex |
reflex tachcardia does what to the heart | increase its myocardial oxygen demand |
hydralazine dose | 10-20mg q6h, in OR 2mg q15min observe for effect. supplied 20mg/ml dilute to 2mg/ml in 10ml syringe. |
Hydralazine is administered with caution particularly in | sitting position |
Fenoldopam aka corlopam | rapid vasodilator Dopa 1 receptor agonist. No dopa 2, alpha or beta or CNS effects. |
fenoldopam aka corlopam works how | decreases peripheral vascular tone while increasing renal blood flow and diuresis. |
fenoldopam aka corlopam dose | 0.025-2.3mcg/kg/min by continuous infusion NEVER Blous |
corlopam aka fenoldopam contains bisulfite ie can cause | severe allergic reaction |
what other agents contain bisulfites | additive in propofol and epinephrine |
other arterial vasodilators of note | minoxidil, diazoxide these have marked reflex tachycardia and increase cardiac output |
arterial and venous vasodilators name one | Nitroglycerin, first venous then arterial blood vessels, a nitric oxide compound. |
dose of nitro | paste is 1-2inches to chest wall, IV 20-4-mcg bolus to effect, infusion 0.5 to 10mcg/min titrate to effect duration is 5 min |
Sodium Nitroprusside aka nipride | potent arterial and venous smooth muscle dilating effects. decreases preload and after load while lowering BP |
nipride is used for what and dose | HTN emergencies, CHF or controlled hypotension for surgery. Dose 0.5 to 10mcg/kg/min. average dose is 3mcg/kg/min |
SNP aka nipride precautions | protect from sunlight, arterial monitoring is required when used, reflex tachycardia and rebound hypertension upon discontinuation, inhibits hypoxic pulmonary vasoconstriction, reduce renal flow |
SNP aka nipride hazzards | RBC convert to cyanogen which are metabolized in liver, excess of 4mcg/kg/min for over 3 hours may lead to cyanide toxicity. |
hemolysis and cyanide | hemolysis increases free cyanide, stimulate the release of nitric oxide generating hydroxyl radicals. |
cynaide toxicity due to SNP aka nipride | may alter mental status, seizures and coma. cardiovascular instability, hypertension due to tachyphylaxis, arrhythmia and ST segement changes. |
SNP aka nipride toxicity aka cyanide toxicity generally revealed with what physiological state | metabolic acidosis |
treatment of cynaide toxicity due to nipride | Na nitrate, it converts hemoglobin to methhemoglobin, which competes with cytochrome oxidase for cyanide radicals. |
treatment of cyanide after Na nitrate admin | sodium thiosulfate provides sulfur donor and prevent accumulation of cyanide radicals. |
vitamin B12 and cynide | B12 binds to cyanide, trans porting it to the kidneys to be excreted in urine |
cyanide tox treatment | stop infusion, admin 100% oxygen, treat metabolic acidosis, give 3% Na Nitrate, 4-6mg slow, give sodium thiosulfate 200mg per kg over 15min, consider B12 at 25mg per hour |
pages 294-99 Ouellette perioperative HTN mangement | |
autokoids do not circulate to site of action | |
autokoids are not excreted in glands | |
autos | self |
akos | remedy |
autocoids | array of biological active substances, specialized function to initiate the response to tissue injury. |
Name different autocoids | histamine, bradykinin, sertotonin 5-HT=5hydroxytyptamine, prostaglandin, |
seratonin is also known as | 5-HT or % hydroxytyptamine |
histamine is what | low molecular weight vasoactive amine autocoid |
histamine structure | B amino ethyl imidazole. |
where is histamine synthesized | in tissue by decarboxylation of histidine |
where is histamine stored and with what | composite with heparin and in mast cells |
why is histamine released | response to stimulation by mast cells, basophils and neurons |
metabolism of histamine | via methylation by histamine-N-methyl transferase and MAO |
histamine subtypes | 1, 2, 3, 4, Hic |
sources of histamine | mast cells, basophils, cardiac smooth muscle. Enterochromaffin |
what plays a central role in hypersensitivity allergic responses | histamine, H1 receptors |
H1 cardiac receptors when agonized does what | decrease AV nodal conduction |
H1 and coronary vessel | vasoconstriction, reduced atrial naturetic peptide |
H1 and bronchial | bronchospasm |
difference between H1 and H2 antagonist | H1 has antiemetic and H2 does not. acid blocking |
H2 stimulation causes | bronchial dilatory, gastric acid stimulation from parietal, dysrhythmia from cateholamine release GERD PEPTIC ULCER |
H2 vs H1 when it comes to vasodilatation | H2 is less of a vasodilator |
First-genertation H1 antagonist | not H1 specific, generate dopaminergic, serontenergic in cholinergic response |
H1 antagonist cause what side effect | somnolence, cognitive dysfunction, cross BBB |
overdose of H1 anatagonist | psychoses hallucination like schizophrenic breaks |
histamine release from stomach | ECL enterochormofain like |
H1 antag Promethazine aka | phnergan |
H1 antag Hydroxyzine aka | vistaril |
H1 antag Demenhydronate aka | dramamine |
H1 antag are effective antiemetics T or F | T |
H2 blockers like loratadine have no _____ effect. | no ANTIEMETIC |
H1 antag Diphenhydramine aka | benadryl |
benadryl can treat what | antiemetic, parkinson like symp, histamine mediated effects, adjunct of anesthesia, SLEEPY, |
anti-histamine for vertigo and motion sickness | cyclizine and Meclizine |
Vistaril AKA hydroxyzine can potentiate what and how to give or not to give | potentiate narcotic, DO NOT GIVE IV causes Twave abnormalities, dry mouth |
Second gen H1 antag | do not cross BBB, fewer undesirable side effect, can still cause cardio toxic effect. |
example of second gen H1 antag | calritin and cetrizine aka zyrtec |
name some second gen H2 antag | cimedtine, ranitdine, famatodine, |
second gen antag H2 are used as treatment of what | peptic ulcers and gerd |
how do second gen H2 antag work | block parietal cells from releasing HCL |
Bradykinin is an iimportant ____ and ____ | inflammartoy mediator and vasoactive peptide |
what is the most potent endogenous vasodilator after allergenic reaction and tissue damage | bradykinin |
bradykinin component is ____and from the ____system | kallikrein from kinin system |
precursor of bradykinin is | prekallikdrein |
changes in what and what or _____can stimulate the conversion of prekallikrein to bradykinin. | ph and temp or tissue damage |
bradykinin stimulates the release of neuropeptide_____ and ______ | substance P and neurokinin |
what is involved in the mediator of pain cascade | substance p and neurokinin ie bradykinin |
what is 10 times more of a potent vasodilator than histamine | bradykinin |
bradykinin may play a role in _____ _____ and _____ ____. | hereditary angioedema and carcinoid syndrome. |
Serotonin AKA | 5 hydroxytryptamine, or 5HT |
Serotonin found through out where in body | GI , CNS and platelets. |
5HT receptors belong to what regulatory receptors | G protein coupled transmembrane |
what neurotransmitter plays a important role in pain | 5HT |
what biogenic monoamine are responsible for states of mood feelings and motivation | dopamine, norepi, serotonin |
5HT1A is implicated in what disorders and or cerebral conditions | psychiatric and immunomodulation and ischemic conditions |
serotonin synthesis from | tryptophan |
Serotonin metabolism | via MAO by oxidative deamination |
non MAO metabolism of serotonin may lead to | hallucinogenic metabolites. |
where is 5HT action terminated | at the synaptic junction and in outer membrane of platelets |
5HT 1b/1d are effective class of____ therapeutics. and is contraindicated in coronary artery disease CAD | migraine therapeutics |
5HT2 function is unknown, it is attracted to _____ the site of CSF fluid generation | choroid plexus |
5HT4 given for_____ example of drug is____ causes cardiac problems | GERD, drug Cispride |
5HT3 has a strong relation with what receptor | nicotinic acytylcholine receptor |
5HT3 is found in high levels within the complex of what and where else | bainstem and parasympathetic terminals of the GI tract |
where does the initiation and coordination of vomiting reflex occur | the dorsal vagal complex |
site of action of nausea and vomiting initiation | nucleus tractus solitarius area postrema and dorsal motor nucleus of the vagus nerve. |
antagonism of 5HT3 contributes to | anti-emetic action |
polymorphism of 5HT3 gene suggest a role in what disorders | psychiatric disorders |
what are prostaglandins | naturally occurring endogenous substances |
what are prostaglandins derived from | arachidonic acid |
metabolite of arachidonic acid via what pathway are endogenous mediators of inflammation | cyclo-oxygenase pathway |
metabolites of arachidonic acid are considered what typr of receptors | 7 transmembrane domain receptors AKA G protein coupled. |
prostaglandin are similar to 5HT family in what regard | both are G protein coupled receptors. |
Prostaglandin play a role in what | SVR, airway resistance, platelet aggregation and increase uterine tone |
cell membrane phospholipid makes arachadonic acid which makes cox1 and cox2 which make prostanoids T or F | True |
cox 1 has what positive attribute | cyto protective cox 1 |
cox 1 because it is a cyto protective is produced how | continuously ie constitutive and its physiologic |
cox 2 is considered ____; shows up at presence of inflammation | inducible |
what is the primary site for prostaglandin synthesis | the lungs |
what can be exacerbated by circulating prostaglandins | asthma |
what may cause pulmonary HTN and bronchospasm by stimulation of thromboxane | protamine |
PONV is objective or subjective | subjective in how it feels, untill you puke then we can all see it and might join |
what percent of pts may feel PONV after surgeory | 30 to 70% |
deleterious effects of PONV | resources, time of discharge, co morbidities ie HTN, pain, aspiration etc... |
causes of N&V | infection, pregnancy, vestibular dysfunction, peritonitis, post radition etc.. |
why do we vomit | eliminate noxious or toxic substances, protective, reminded us what is safe to eat and what is not |
distention or stimulation of the what provides the strongest stimulus for N&V | distention or stimulation of the duodenum |
the emetic center is where | in the reticular formation of the medulla |
chemotherapy anesthetics and opoids act where to cause nausea and vomiting | chemoreceptor trigger zone, prostrema 4th ventricle |
vomiting centre is where | medulla |
name some sensory inputs that stimulate the emetic center | afferent impulses from pharynx, GI tract, mediastinum, cerebral cortex, sensory organs |
where is the CTZ | out side the BBB |
is the CTZ protected by BBB | NO |
name CTZ pro emetic agonists | serotonin, dopamine, histamine, ACh, neurokinin 1 aka substance P |
what kind of approach do we need to treat nausea and vomiting | multimodal |
name a widely distributed endogenous vasoactive autocoid | serotonin |
serotonin evokes complex changes within what throughout the body | vascular beds |
what acts as a key neurotransmitter in emesis and pain transmission | Serotonin |
where is serotonin released from | enterochromafin of the small intestine |
describe how the vomiting reflex in the medulla is initiated | serotonin stimulated the vagal afferent pathways through 5HT3 receptor which initiates the vomit reflex |
5-HT3 is what | serotonin receptor |
5-HT3 aka | 5 hydroxytryptamine type 3 |
name some serotonin antagonists | zofran or ondansetron, granisetron, dolasetron, palonosteron |
adverse effects of serotonin antag | headache, dizziness, constipation or diarrhea |
why give serotonin antag | chemotherapy, post radiation, pregnancy, PONV |
Prototype of drug of SSRA | ondansetron |
ondansetron | 4 to 8mg IV may repeat 1 or not at all. onset 30min elimination 4 hours |
dolasetron aka anzemet metabolite that is responsible for its antiemetic effects | hydro-dolasatron |
hydrodolasetron T1/2 and strength when compared to dolasetron | 8hours and 100 times more potent than dolasetron. |
dose of dolasetrong aka anzemet | 12.5 mg IV, PO 50-100mg just like zofran |
granisetron aka kytril | more specific than ondansetron, chemo therapy, coverage for 24hrs, expensive, 1 mg before induction or 20-40mcg/kg |
polonasetron aka aloxi | newest, not a rescue antiemetic. 40 hours half life, dose 0.25mg IV prior to chemo |
any difference in efficacy or safety between the different serotonin receptor? and why use them then | no difference except the length of half life in body. |
corticosteroids have antiemetic properties | TRUE |
possible mechanism of corticosteroids | intracellular interaction that regulate expression. prolonged onset. not really known why it works. used in multimodal to enhance efficacy of 5HT3 antag |
phenothiazine aka compazine aka phenergan antipsychotic, used for chemo and radiation NV | |
phenothiazines, compazine, phenergan mechanism of action | inhibition of dopamine, muscarinic and H1 receptors, Side effect hypoten and extrapyramidal symptoms |
promethazine aka pheergan other uses | allergy to blood transfusion, anaphylaxis to H1 blocking action. NOT FOR sub q. venous irratent, burns |
butyrophenones aka droperdol | antipsychotics, inhibition of dopamine |
dose of dropperidol | 0.625 - 1.25mg one time dose, for chemo and radiation, PONV |
adverse effect of droperidol | long QT, black box warning, only used for pts with no response to other means |
dropperidol comes in 2.5mg/ml so how much is the one time dose if using the bigger range | 0.5ml or 1.25mg BUT should give small dose. 0.625 |
adverse effects of droperidol and OD and QT | 50mg in 24 hours pts die. Torsade de pointes, 12 lead needed prior, QT greater than 440ms for men and 450 in women NO GO. follow up ekg within 3 hours. |
Droperidol is in the class with which antipsychotic | haldol, D1 and D2 blocker |
cannabinoids aka WEED, AKA SKUNK, AKA Green monster, AKA CUSH, AKA | hahaha you still reading this....Mary J |
mechanism of action of week not known | TRUE |
First pass metabolism of weed | liver, biliary |
adverse effect of weed | euphoria, dysphoria, sedation hallucination. abrupt withdrawl symptoms, autonomic effects, orthostatic hypotension |
weed used for | chemo NV apetitie. |
cholindergic agents | no net propulsive activity. not useful for treating motility. increase contractions |
prokinetic agents | coordicnated GIT propulsive motility. act on motor neurons, increase ACh but not interfering with normal motility. |
ACh why is it not used for cholinergic agent | affects both nicotinic and muscarinic receptors. degraded fast by acetylcholineesterase |
what is a direct cholinergic receptor agonist that resists enzymatic hydrolysis | Bethanechol |
Indirect chilnergic agents | ACh inhibitors, eg neostigmine for paralytic ileus |
why does decreased motility of GIT happen | supperession of ACh release from myenteric motor neurons mediated by D2 dopanminergic receptors. |
mechanism of action of prokinetic agents | antagonize the inhibitory effect of dopamine on myenteric motor neurons, |
examples of prokinetics are | metocopramide and domperidone |
drugs in the benzamides family are | metoclopramide and trimethobenzamide |
mechanism of action of benzamides | dopamine receptor blocker |
side effect of dospamine receptor blockers | extrapyramidal, restessness, dystonia, parkinsonian |
metoclopramide | GIT propulsive motility, upper GI, increase esophageal sphincter tone, stiumlate enteral and small instestinal contractions. NOT significant on COLON |
metoclopramide mechanism of action on GIT | dopamine receptor antagonism, 5HT4 agonist, vagal and central %HT3 antagonist |
metoclopramide antiemetic action | antag dopamine receptor in CTZ |
metoclopramide aka | reglan |
reglan aka metoclopramide | NV with GI dysmotility, reflux not heal, gastroparesis improvement, diag procedures intestinal intubation or contrast radiography, post op ileus, hiccups. |
why reglan not used for bowel anastamosis | dont want to actively mobilize the bowel |
H1 antag and anticholinergics are used to prevent what | motion sicknes, vertigo, |
adverse effects of H1 antag and anticholinergics | sedation, dizziness, confusion, dry mouth, cycloplegia, and urine retention |
examples of H1 antag and anticholinergics | Diphenhydramine, dimenhydrinate aka dramamine |
Dimenhydranate aka | dramamine |
menier’s disease is aka@ vertigo like symptoms, aka hydrops aka endolymphatic hydrops | |
meclizine | aka antivert a antihistamine anticholinergic |
serotonin atagonist drugs@ ondansetron, dolasetron, granisetron good for PONV, DO NOT increase Ph or reduce aspiration pneumonitis | |
Anti histamine H4 blockers | good for inflam conditions involving mast and eosinophils, allergic conditions, asthma, Rheumatoid arthritis being studied. |
anti-cholinergics like scopolamine treats motion sickness cause by stimulation of what | vestibular apparatus |
the vestibular apparatus is rich in what recceptor sites | muscaarinic cholinergic type 1, M1 receptors |
can scopolamine cross BBB why? or why not? | yes, it is a tertiary amine like atropine |
Is scopolamine a rescue drug and some side effect | no can be given prophylaxix but not for acute vomiting, makes you sleepy and thirsty |
scopolamine non selevtive M1 antag dose and route | skin patch, 1mg over 72 hours, onset two hours |
scopolamine contraindication | close angel glaucoma, GI or urin obstruction, metabolic dysfunction |
neurokinin 1 atag include what drug@ aprepitant aka emend | |
aprepitant aka | emend |
emend aka apreitant blocks what, which is a regulartory peptine in GIT and CNS | substance P |
this is the only FDA approved neurokinin one antagonist | Emend aka aprepitant |
high risk patient should take emend how much and how long before induction | 40mg PO three hours prior to induction |
propofol and ponv | subtheraputic dose can be used |
ephedrine and NV from postural and hypotension | dose 5 to 10mg every 5 to 10min prn |
stimulation of what accu point decreased of PONV | stimulation of P6 accu point, loacted in palmaris longus and flexicarpi radialus or wrist |
strategies to prevent PONV | regional, TIVA, high FIO2, hydration, N2O avoidance, min opioids, Minimize Neostigmine |
other causes of PONV | pain, hypotension, hypoxemia, hypoglycemia, increased ICP, GI bleeding |
be alert to EKG changes after 5HT3 Blockers, or droperidol why | prolonged QT possible torsade de pointes |
deglutition aka | swallowing |
cough has a pressure of | 100torr |
cranial nerves associated with cough | 9 and 10. glassopharyngeal and vagus |
swallowing and breathing | parallel pathways, voluntary and involuntary mechanism are at play, |
pharyngeal reflex or _____blocks the respiratory pathway and forcefully expels foreign matter. | gagging |
define aspiration pneumonitis | inflow of highly acidic gastric content triggering severe inflammatory reaction |
with aspiration pneumonitis injury occurs to the | trachea, bronchioles, lung tissue, pulmonary capillary endothelium |
how long does it take for the inflamatroy reponse to kick in with aspiration pneumonitis | 6-12 hours or so |
reflux from the latin | refluere, which means to flow back |
aspirate is drive from latin | spire, means to breath upon, now mean inhilation of solid or liquid into airway. |
mendelson in 1946 spoke of aspiration of stomach contents into the lungs during | OB anesthesia. |
aspiration depends on two key parameters which makes it more deleterious | Ph less than 2.5 and volume greater than 25ml. |
what produces HCL acid | gastrin and the perital cell of stomach |
mendelson syndrome | Ph of less than 2.5 and volume more than 25ml |
process of deglutition | peristalic waves 3 to 4 a min, mixing gastric contents, and ideally 3% of gastric volume ie chyme enter the small bowel per min |
reasons why gastric volume emptying may be delayed | entrogastric inhibitory nervous reflex |
what can we give for Entrogastric Inhibitory Nervous Reflux | |
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