NURS 572 Park/Alz Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Question | Answer |
Parkinson's MOA | too little Dopa, too much ACh --> too much GABA |
dopaminergic agents to increase Dopa | levodopa - carbidopa |
what is carbidopa's role | suicide molecule to get levodopa from periphery thru BBB where it can be converted to Dopa |
what happens if we admin levodopa alone | peripheral decarboxylases degrade it so only 2% can get to brain (10% gets to brain if we combine with carbidopa) |
two classes of drugs that activate Dopa receptors | ergot derivatives, non-ergot derivatives |
bromocriptine | ergot derivative |
non-ergot derivatives are an alternate first line treatment, name these 3 drugs | pramipexole, ropinirole, apomorphine |
pramipexole | non-ergot dopa receptor activator |
ropinirole | non-ergot dopa receptor activator |
apomorphine | non-ergot dopa receptor activator |
noteworthy feature of 2 drug classes that prevent dopa degradation | COMT inhibitors (peripheral) and MAO-B inhibitors (brain) . . . must have levodopa, carbidopa administered for them to have their actions |
entacapone | COMT inhibitor in periphery |
selegiline | MAO-B inhibitor in brain |
rasagiline | MAO-B inhibitor in brain |
what drug class is first line for early-PD | drugs that promote Dopa release |
amantadine | promotes dopa release, first line if early dx |
what drug class blocks CNS ACh receptors (must cross BBB)so that ACh isn't utilized | anticholinergics |
name 2 anticholinergics that block ACh receptors in brain | trihexyphenidyl, benztropine |
what drug class is a 2nd line PD drug | anticholinergics |
trihexyphenidyl | PD anticholinergic |
beztropine | PD anticholinergic |
what must entacapone be administered with to have its effect | this COMT peripheral inhibitor must be admin with levodopa-carbidoba |
what must selegiline or rasagiline be administered with to have their effect? | these MAO-B inhibitors must be admin with levodopa-carbidopa |
MAO of Alzheimers | too little ACh, too much glutamate whose abnormal leakage binds NMDA receptor to allow excess Ca in cell --> excitatoxicity that impacts cells in hippocampus, etc. |
two classes of Alzheimer's drugs | CNS cholinesterase inhibitors (keep ACh), NMDA receptor antagonist |
name 4 CNS cholinesterase inhibitors | tacrine, donepezil, rivastigmine, galantamine |
tacrine | cholinesterase inhibitor - hepatotoxic |
donepezil | cholinesterase inhibitor - drug of choice |
rivastigmine | cholinesterase inhibitor - bad cholinergic SEs |
galantamine | cholinesterase inhibitor |
NMDA receptor antagonist | memantine |
Created by:
lorrelaws
Popular Nursing sets