Alzheimers: Pharm Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Question | Answer |
What is the etiology of Alzheimer's Disease? | ACh is down (90% by the time symptoms occur) Neurofibrillary Tangles Neuritic Plaques |
what is an early symptom of Alzheimer's DIsease? | Impaired Judgement |
What is the action of Cholinesterase inhibitors? | These AD drugs inhibit the breakdown of ACh which leads to increased levels of ACh |
name 4 Cholinesterase inhibitors | Tacrine DOnepezil galantamine rivastigmine |
which of the cholinesterase inhibitors are very risky to the liver? | Tacrine |
What tests monitor liver function? | AST ALT Albumin Partial protein Total protein |
What are the adverse effects of Cholinesterase inhibitors? | n/v/d dyspepsia dizziness headache bronchoconstriction |
who should be cautioned when using cholinesterase inhibitors? | people with Asthma/COPD because an adverse effect can be bronchoconstriction |
what is dyspepsia? | metallic taste in mouth |
What type of drug is Tacrine? | Cholinesterase inhibitor |
what is the mechanism of action for Tacrine? | reversable inhibition of the enzyme that breaks down ACh |
what route is tacrine admninistered? | orally |
what is a downfall of tacrine? | it must be administered q6h which is difficult for people to comply to, especially patients suffering from Alzheimer's Disease |
What is Donepezil? | A Cholinesterase inhibitor |
what is the advantage of Donepezil? | it has a longer half life (doesn't have to be administered as often) No risk to liver |
what is the mechanism of action of donepezil? | same as tacrine reversable inhibition of the enzyme that breaks down ACh |
what is the major side effects of donepezil? | n/v/d |
What is memantine? | an NMDA receptor antagonist |
what is the mechanism of action of memantine? | prevents excess calcium influx. calcium in high amounts intracellularly can impair memory and learning |
metabolism and excretion of memantine: | not metabolized excreted in urine |
How does estrogen help in AD? | it doesn't |
what are the effects of NSAIDS on AD? | decreases incidence by 80% |
Fact: Gingko Bilopa helps AD | true |
Created by:
1398660434
Popular Pharmacology sets