MOA's and MOR's Word Scramble
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| Question | Answer |
| MOA of Metronidazole | Reactive metabolite damage of DNA and other macromolecules |
| MOA of Clindamycin | In hibits protein synthesis (50s ribosome) |
| MOA of TMP/SMX | Inhibits DNA synthesis by blocking the folate pathway |
| MOA of Aminoglycosides | Inhibits protein synthesis (30s ribosome) |
| MOR of Aminoglycosides | Enzyme inactivation (bacterial acetylase, adenylase, phosphorylase), altered target, dec. uptake |
| MOA of tetracyclines | Inhibit of protein synthesis at 30S ribosomal subunit |
| MOR of Tetracyclines | Decreased uptake |
| MOA of macrolides | Inhibits RNA-dependent protein synthesis 50s ribosomal subunits |
| MOR of Macrolides | Altered target, drug efflux |
| MOA of Penicillins | Inhibit cell wall formation |
| MOR of Penicillins | Enzyme inactivation (B-lactamase), alterred penicillin binding proteins (PBPs) |
| MOA of Cephalosporins | Inhibition of cell wall formation |
| MOR of Cephalosporins | Enzyme inactivation (B-lactamase), alterred penicillin binding proteins (PBPs)(strep pneumoniae) |
| MOR of carbapenems | Generally stable in presence of most B-lactamases (pseudomonas may have some resistance) |
| MOA of Monobactams | Binds to PBPs and inhibit cell wall formation |
| MOA of Vancomycin | Inhibits cell wall formation earlier than B-lactams |
| Vancomycin Resistance | VRE, VRSA |
| MOA of Fluroquinolones | Inhibits topoisomerases II and IV, DNA can't replicate |
| MOR of FLuroquinolones | Efflux pump, Gene mutations, permeability |
Created by:
becker15
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