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MOA's and MOR's

Pharm III exam

QuestionAnswer
MOA of Metronidazole Reactive metabolite damage of DNA and other macromolecules
MOA of Clindamycin In hibits protein synthesis (50s ribosome)
MOA of TMP/SMX Inhibits DNA synthesis by blocking the folate pathway
MOA of Aminoglycosides Inhibits protein synthesis (30s ribosome)
MOR of Aminoglycosides Enzyme inactivation (bacterial acetylase, adenylase, phosphorylase), altered target, dec. uptake
MOA of tetracyclines Inhibit of protein synthesis at 30S ribosomal subunit
MOR of Tetracyclines Decreased uptake
MOA of macrolides Inhibits RNA-dependent protein synthesis 50s ribosomal subunits
MOR of Macrolides Altered target, drug efflux
MOA of Penicillins Inhibit cell wall formation
MOR of Penicillins Enzyme inactivation (B-lactamase), alterred penicillin binding proteins (PBPs)
MOA of Cephalosporins Inhibition of cell wall formation
MOR of Cephalosporins Enzyme inactivation (B-lactamase), alterred penicillin binding proteins (PBPs)(strep pneumoniae)
MOR of carbapenems Generally stable in presence of most B-lactamases (pseudomonas may have some resistance)
MOA of Monobactams Binds to PBPs and inhibit cell wall formation
MOA of Vancomycin Inhibits cell wall formation earlier than B-lactams
Vancomycin Resistance VRE, VRSA
MOA of Fluroquinolones Inhibits topoisomerases II and IV, DNA can't replicate
MOR of FLuroquinolones Efflux pump, Gene mutations, permeability
Created by: becker15
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