IOS 10 Exam 2 Word Scramble
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| Question | Answer |
| MOA of tetracycline | Bacteriostatic- Bind 30S ribsosomal subunit to aminoacyl transfer RNA to inhibit elongation |
| MOA of glycycline | Bind 30S subunit of ribosome and inhibit elongation |
| Resistance of tetracycline- | Considered constitutive, but can be plasmid mediated- penetration of porin, or efflux proteins |
| Resistance of glycylcylines | Ribosomal modification and active drug efflux |
| Gram + aerobe activity of Tetracycline | Intrinsic activity, strep, staph, MRSA, VRE (minocycline best against MRSA) |
| Gram -aerobe activity of tetracycline | Active but limited by PK |
| Anaerobic activity of tetracyclines | Active but limited by resistance |
| Atypical activity of tetracyclines | Good activity especially chlamydia |
| Other activity of tetracyclines | H.pylori, rickettsial (rocky mountain spotted, lyme dx) |
| Tetracycline ADME | Good oral bio,ALTERED BY FOOD, AL< MG, CA, Dairy, HUGE VD, all tissue less CNS penetration, no metabnolism, and up to 70 renal |
| Tetracycline SE | Deposition in teeth and bone, hepatotoxic (pregnant), GI discomfort, CNS, Superinfection with Candida, and resistant stap, Thrombophlebitis, phototoxcity with demeclocycline |
| Tetracycline DI | Drugs containing di and tri-valent cations(2-3 hours before or 2 after), warfarin, OC |
| Gram + activity of Glycycline | Highly active against MRSA, S epi, most strep, enterococci (and VRE) |
| Gram - aerobes activity of glycyclines | Excellent activity Enterobacteriae, citobacter, acinobacter, strenotrophomonas, poor pseudomonas activity |
| Anaerobes activity of glycyclines | Excellent-Bacteroides fragilis, Bacteroides group, Fusobaterum, Clostridium, Peptostreptococcus |
| Glycycycline ADME | Poor absorption, HUGE VD t 1/2 42 hrs, Elimination- 40% renal 60% fecal |
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