Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards

Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

IOS 10 Exam 2

Tetracyclines & Glycyclines

MOA of tetracycline Bacteriostatic- Bind 30S ribsosomal subunit to aminoacyl transfer RNA to inhibit elongation
MOA of glycycline Bind 30S subunit of ribosome and inhibit elongation
Resistance of tetracycline- Considered constitutive, but can be plasmid mediated- penetration of porin, or efflux proteins
Resistance of glycylcylines Ribosomal modification and active drug efflux
Gram + aerobe activity of Tetracycline Intrinsic activity, strep, staph, MRSA, VRE (minocycline best against MRSA)
Gram -aerobe activity of tetracycline Active but limited by PK
Anaerobic activity of tetracyclines Active but limited by resistance
Atypical activity of tetracyclines Good activity especially chlamydia
Other activity of tetracyclines H.pylori, rickettsial (rocky mountain spotted, lyme dx)
Tetracycline ADME Good oral bio,ALTERED BY FOOD, AL< MG, CA, Dairy, HUGE VD, all tissue less CNS penetration, no metabnolism, and up to 70 renal
Tetracycline SE Deposition in teeth and bone, hepatotoxic (pregnant), GI discomfort, CNS, Superinfection with Candida, and resistant stap, Thrombophlebitis, phototoxcity with demeclocycline
Tetracycline DI Drugs containing di and tri-valent cations(2-3 hours before or 2 after), warfarin, OC
Gram + activity of Glycycline Highly active against MRSA, S epi, most strep, enterococci (and VRE)
Gram - aerobes activity of glycyclines Excellent activity Enterobacteriae, citobacter, acinobacter, strenotrophomonas, poor pseudomonas activity
Anaerobes activity of glycyclines Excellent-Bacteroides fragilis, Bacteroides group, Fusobaterum, Clostridium, Peptostreptococcus
Glycycycline ADME Poor absorption, HUGE VD t 1/2 42 hrs, Elimination- 40% renal 60% fecal
Created by: liza001