Step 2: Psych Word Scramble
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| Question | Answer |
| How long does normal bereavement last? | PERIODICALLY for 6 months. Does NOT impair ability to function. (2wks continuously after 2m is considered depression) |
| Neurotransmitter change in: Anxiety d/o? | increased NE, low 5HT, low GABA |
| Neurotransmitter change in: Depression? | low NE, low 5HT, low DA |
| Neurotransmitter change in: Mania? | high NE, high 5HT |
| Neurotransmitter change in: Alzheimer's? | low ACh |
| Neurotransmitter change in: Huntington's? | low ACh, low GABA |
| Neurotransmitter change in: Schizophrenia? | high DA |
| Neurotransmitter change in: Parkinsons? | low DA, high ACh |
| After how long can Major Depressive Disorder be diagnosed? | 2 weeks w/ functional impairment |
| What medical conditions can cause depression? list of 6. | hypothyroidism, hyperparathyroidism, Parkinsonism, ACA stroke, CNS neoplasm, Pancreatic Ca |
| What anti-HTN drug can cause depression? | methyl-DOPA |
| Haloperidol (1st gen antipsychotic) can cause ____________ | Depression |
| What antiviral can cause depression? | a-IFN |
| T/F glucocorticoids can cause depression. | True |
| What antineausea drugs can cause depression | metoclopramide, prochlorperazine |
| What's the difference between Major Depressive Disorder w/ Psychosis and Schizoaffective Disorder? | MDD w/Psychosis = Depression always present, psychosis comes and goes. Schizoaffective = Psychosis always present, depression comes and goes |
| What does SIG E CAPS stand for? | Sx of Major Dep d/o: Sleep disturbance, Interest loss, Guilt, Energy reduction, Concentration impaired, Appetite changes, Psychomotor change, Suicidal ideas |
| What are the Sx of atypical depression? | hyperphagia, hypersomnia, hypersensitivity to rejection, leaden paralysis |
| Which is better for treating atypical depression: MAOi or TCA? | MAOi |
| First line Rx for seasonal affective disorder? | light therapy + SSRIs/bupropion |
| Name 6 SSRIs | Fluvoxamine, fluoxetine, sertraline, paroxetine, citalopram, escitalopram |
| What drug group do these belong to: Imipramine, amytriptaline, desipramine, nortrypitaline, clomipramine, doxepine | TCAs |
| The 3 MAOi's are? | Fenalzine, Tranylcypromine, selegiline |
| Bupropion is what drug class? | NDRI |
| What drug class are venlafaxine, duloxetine, milnacipran, nefazodone | SDRI |
| What are teh 2 tetracyclics | mertazapine, trazadone |
| What drugs, combine with SSRIs, can cause serotonin syndrome? | other SSRIs, MAOi's, SNRIs, along with: St Johns Wort, tryptophan, illegal drugs (cocaine, amphetamines), L-DOPA |
| What eye signs are present in serotonin syndrome? | ocular clonus (slow horizontal movements |
| If a pt is suffering from serotonin syndrome, and is agitated in spite of benzos given, what's the next step? | Give anti-serotonin agent (ciproheptadine) |
| SSRI withdrawal syndrome consists of what symptoms? What 2 SSRI's are nototious for it? | dizzy, nausea, fatigue, chills, anxiety. Paroxetine, venlofaxine are the worst offenders. |
| How do you treat SSRI withdrawal syndrome? | fluoexitine (long acting SSRI) |
| Children who are to be put on TCAs should be screened for _________ abnormalities. | Cardiac (arrhythmias, syncope, etc) |
| Mild depression is called ________. What is the Rx? | Dysthymic disorder. Rx = psychotherapy (SSRIs if that doesn't work) |
| 3 s/e's of TCAs? | cardiotoxic, neurotoxic, anticholinergic symptoms |
| First line Rx for depression and anxiety? | SSRIs |
| SSRIs require ______wks to take effect. | 3-4 wks. |
| s/e of SSRIs include? | sex dysfxn, suicidal in adolescents, low platelets |
| What's first line Rx for depression w/ neurologic pain? | SNRIs |
| What do you give after ABCs in TCA overdose? | charcoal. gastric lavage if w/i 2hrs of ingestion. |
| How do you treat QRS prolongation of TCA overdose? | Sodium bicarb trial, then infusion if effective |
| Depression with fatigue and ADHD is treated with ______________. | Bupropion |
| Bupropion is avoided in patients with _____(2)_______ disorders, or taking ______(2)_________ | eating disorder, seizure disorder, coming off EtOH or MAOi |
| Psychotic depression is treated with _____________. | electro convulsive therapy |
| Depression with catatonic stupor is treated with ________________. | ECT |
| Why is electroconvulsive therapy given to patients with severe suicidal ideation? | Because drugs take 3-4w |
| What's the difference between manic and hypomanic episode? | manic = >1wk, interferes with normal fxning. hypomanic = 3d+, no impairment. (bipolar II is hypomanic) |
| What are the first line drugs for bipolar disorder? (3) | lithium, carbamezapine, valproate |
| Rapid cycling bipolar is treated with which 2 of the 3 typical Rx? | carbamezapine, valproate |
| What specific kidney problem can lithium cause? | Nephrogenic diabetes insipidus |
| True/False: you should add an antidepressant to mood stabilizers during depressive stage of bipolar d/o. | False: no added benefit of giving anti depressants. It's better to add another mood stabilizer or antipsychotic. ECT if very severe depression |
| Adjustment disorder has the same causes as major depressive disorder, except for ___________. | Bereavement. |
| Adjustment disorder begins _______months after stressor, and is usually releived within ____months of onset. | 3months, 6 months |
| How do you treat adjustment disorder? | psychotherapy |
| Cyclothymic disorder is a mild form of ______________. It must last _____. | Bipolar disorder. (rapid cycling of mild depression and hypomanic episodes for >2y) |
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jsad
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