Female Word Scramble
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Question | Answer |
Breast mass | exclude malignancy |
Age 15 breast mass | Usually smooth, rubbery, round, mobile, nontender |
Age 25-50 breast mass | cysts, fibrocystic changes, cancer |
Cysts | Usually soft to firm, round, mobile, often tender (25-50) |
Fibrocystic changes | nodular and rope-like (25-50) |
Cancer | Irregular, firm, may be mobile or commonly, fixed to surrounding tissue (25-50) |
Pregnancy and lactation breast masses | lactating adenomas, cysts, mastitis and cancer |
Lactating adenomas in prego | Usually smooth, rubbery, round, mobile, nontender |
Mastitis in prego | Fever, tender, hard, area of fluctuation, erythema, and heat (± pus discharge) |
Greatest risk factor for breast CA | Two or more first degree relatives with breast cancer (diagnosed at an early age) |
Mammograms | Most effective mortality-reducing cancer screening method |
Clinical breast exam | its value is controversial (Sensitivity 40%, Specificity 88—99%)- use mammogram with it |
Chemoprevention | tamoxifen- at the age of 40 for 5 years- whenever ≥ 2 first degree relatives (mother, sister) have breast cancer- ↓ the risk by 30-50% |
Anatomy of breast | divided into 6 quadrants- upper outer quadrant has most malignancies- most glandular tissue- tail of spencer can have it too |
Male breast | has ducts instead of lobules |
Pay attention to the upper outer quadrant for lymphatic drainage | axillary and supraclavicular- also called pectoral |
Cyclic vs non-cyclic pain in breasts | Cyclic: r/t menstrual cycle; usually worse in the premenstrual and mid- cycle days, and improves toward the end and w/ oral contraceptive therapy, dopamine agonists or weak androgens. ↓Caffeine |
Non-cyclic pain in breasts | may indicate serious disease such as malignancy. |
Nipple discharge meds | steroids, Contraceptives, hormones, diuretics, phenothiazines, digitalis. |
Gynecomastia | from non-breast conditions- Hyperthyroidism, Testicular cancer, Klinefelter syndrome |
Meds that may cause gynecomastia | antiandrogens (finasteride) or gonadotropin-releasing hormone analogs, steroids, MJ, Cimetidine, PPIs (Omeprazole), Spironolactone, antiretroviral drugs (Efavirenz), chemotherapy agents (Bleomycin), CCB, Risperdal |
Family hx in breast CA | ask about 1st degree relatives, Known BRCA1 or BRCA2 mutation |
Caffeine and the breast | impact on breast tissue- (does not increase risk of breast CA, but can increase discomfort of fibrocystic breast lumps). |
Inspect of breasts | do BOTH breasts and compare: with patient seated and arms hanging loosely at the sides, veins in breast- both sides=IVC, one side is metastasis, Supernumerary breasts/ nipples |
A venous pattern that is prominent on one side over the other could be | a sign of a cancerous tumor of the breast, one side only=IVC |
Inspect nipple & areola for the 5 Ds | 1) Discharge 2) Depression- inversion, or retraction 3)Discoloration 4) Dermatologic changes- Pagets=eczema and is malignant 5) Deviation |
Palpation of the breast | Chest wall sweep, Bimanual digital palpation, Lymph nodes (Including axillary & infra-clavicular- Normally should NOT be palpable) |
Discharge of the nipple | unilateral or bilateral- single or multiple duct- unilateral is concerning |
Breast tissue in gynecomastia is often | TENDER, and in obesity (>2cm), psuedogyncoomastia, it is not |
Full breasts | (firm, dense, and slightly enlarged) may become engorged. |
Engorged breasts | feel hard and warm and are enlarged, shiny, and painful- not unusual in the 1st 24-48 Hrs after the breasts fill with milk; later development may signal the onset of mastitis. |
Benign breast masses | Size changes with the cycle: ↑early & ↓later in cycle-Tender, Mobile, Regular, well-delineated borders, Soft/cystic quality (Benign cyst is the MOST COMMON breast mass) |
Best diagnostic for Cyst | US |
Malignant masses | Rapid enlargement over a period of weeks to months, Lack of tenderness, Non-mobile, Irregular, poorly-defined borders, Retraction, inversion or flattening, Dimpling, Altered contour, discharge, rock-hard, edema (Peau d’orange), superficial venous pattern |
The common breast masses | fibroadenoma, cysts and cancer |
Fibroadenoma | age 15-25 (up to 50), single, round or lobular, small, soft to firm, well-defined, very mobile, nontender |
Cysts | age 30-50, multiple, round, soft to firm, well defined, mobile, tender |
Cancer | age >50, single, irregular, hard, not well defined, non-mobile, non-tender, retracts |
*Fibrocystic disease | Fibrocystic changes are also commonly palpable as nodular, rope-like densities in women aged 25-30. They may be tender or painful. They are considered benign and not a risk factor for breast cancer |
Pagets disease of the nipple | Starts as a scaly, eczema-like lesion on the nipple that may sweep, crust, or erode. A mass may be present |
Edema of skin | Peau d’orange |
The most common types of nipple discharge | are serous (thin and watery) or bloody. |
Approximately 5% of women with nipple discharge have | cancer; while 25% with a bloody discharge have cancer |
Galactorrhea | Abnormal-caused by normal pregnancy or many other causes of an elevated level of prolactin, including; stress, Hypothyroidism, Nipple stimulation (piercing), SSRIs, phenothiazines, H2 blockers, benzodiazepines, oral contraceptives, and alpha methyldopa |
Galactorrhea should be evaluated with the following tests | Pregnancy test, Prolactin level, MRI of the brain |
Why does hypothyroidism result in galactorrhea | hypothalamus senses that the thyroid hormones are low and yells at the pituitary TRH- thyrotropin releasing hormone- also inhibits release of dopamine (which inhibits prolactin)- so now it’s released= milk! |
Pts with hypothyroidism, when they stop taking their levothyroxine, get galactorrhea? | not enough dopamine to inhibit prolactin |
Male adult gynecomastia | Hyperprolactinemia, Liver disease such as cirrhosis, ↑estrogen levels, Castration, Testicular cancers that overproduce estrogen, medications, ↑ body fat which in turn produces more estrogen |
Paget- | malignant- have to remove surgically- radiation- axillary dissection |
Firm irregular mass, often appearing as an area of discoloration, History of trauma to the breast (including surgery), Painless lump | fat necrosis |
Duct Ectasia of the Breast (aka: Mammary Duct Ectasia/Plasma Cell Mastitis) | self limiting- Menopausal w:Nipple Discharge: Spontaneous, Uni or bilateral, May be sticky, greenish/brown/ bloody, pain/retraction, Mass behind nipple, may have Tenderness, Nipple retraction/inversion |
Intraductal papilloma (Papillomatosis) | concerning for malignancy- may or may not have mass- benign unilateral nipple discharge |
Cervical CA screening | age 21-65 cytology q3years, Ages 30-65- cytology plus HPV testing (for high-risk or oncogenic HPV types) every 5 yrs |
When to end cervical screening | > 65 yrs (3 consecutive negative cytology) or 2 consecutive negative results on cytology + HPV within 10 yrs before cessation of screening, (most recent test performed within 5 yrs) |
Hysterectomy | no need for cervical screening |
Bad Strains of HPV | 16, 18, 6, 11 |
most commonly reported STI in the U.S. and the most common STI in women | chlamydia |
chlamydia causes | urethritis, cervicitis, PID (inflammation distorts fallopian tube- fibrotic), ectopic pregnancy, infertility, and chronic pelvic pain. |
Ovarian CA | There are no effective screening tests to date- BRCA1 and 2 are risk factors |
Estrogen therapy alone increase the risk of | endometrial CA |
s/s ovarian CA | abdominal bloating, urinary frequency |
dysmenorrhea | Pain with menses, often with bearing down, aching, or cramping sensation in the lower abdomen or pelvis |
PMS | cluster of emotional, behavioral, and physical symptoms occurring 5 days before menses for 3 consecutive cycles |
Menopause | Absence of menses for 12 consecutive months, usually occurring between ages 48 and 55 years |
Post-menopausal bleeding | Bleeding occurring 6 months or more after cessation of menses |
Period questions | Ask about the 1st day of LMP, as well as the one prior (PMP)- exclude pregnancy! |
Primary vs secondary amenorrhea | failure to begin periods is primary amenorrhea; cessation of established periods is secondary amenorrhea |
Polymenorrhea | less than 21-day intervals between menses |
Oligomenorrhea | or infrequent bleeding |
Menorrhagia | excessive flow |
Metorrhagia | intermenstrual bleeding |
Other causes of secondary amenorrhea include | low body weight from any condition→ malnutrition, anorexia nervosa, stress, chronic illness, and hypothalamic-pituitary ovarian dysfunction |
Causes of abnormal bleeding | vary by age-pregnancy, cervical/ vaginal infection or cancer, cervical/endometrial polyps or hyperplasia, fibroids, bleeding d/o, and hormonal contraception or replacement |
Postcoital bleeding | suggests cervical polyps or cancer-in an older woman, atrophic vaginitis |
Primary dysmenorrhea (without an organic cause) | results from ↑ PG production during luteal phase of the menstrual cycle, when estrogen and progesterone levels decline→NSAIDS |
Secondary dysmenorrhea (with an organic cause) | causes include endometriosis, pelvic inflammatory disease (PID) & endometrial polyps |
Acute pelvic pain: The most common cause is | (ectopic pregnancy) PID, ruptured ovarian cyst, appendicitis, STIs and recent IUD insertion are red flags for PID |
mittelschmerz pain | mild ovulation pain, unilateral pain arising at mid-cycle from ovulation, ruptured ovarian cyst and tubo-ovarian abscess |
gonorrhea d/c | mucopurulent d/c, thick, yellow/green |
chlamydia d/c | mucopurulent d/c |
Trichomonas vaginalis d/c | offensive, yellowish, profuse, frothy + Itching |
bacterial vaginosis | watery, profuse, gray, fishy smelling |
TestDischarge with itching | Trichomonas vaginalis (sexual). Candidiasis (non-sexual) |
Discharge with NO itching | Chlamydia, Gonorrhea, Bacterial vaginosis |
Sexual vs non-sexual d/c | candidiasis and bacterial vasginosis are non and gonorrhea, chlamydia and trichomonas are sexually transmitted |
For desire or libido ask | “Do you have an interest in (appetite for) sex?” |
For arousal ask | “Do you get sexually aroused? Do you get wet or slippery? Do you stay too dry?” |
For orgasm ask | “Are you able to reach climax (have an orgasm or ‘come’)?” “Do you enjoy sex without that?” |
Vaginismus is | involuntary spasm of the vaginal orifice making penetration painful or even impossible |
Superficial pain (intercourse) suggests | local inflammation, atrophic vaginitis or inadequate lubrication |
Deeper pain (intercourse) may arise from | pelvic disorders or pressure on a normal ovary |
GTPAL | Gravidity (total number of pregnancies),T: number of Term pregnancies, P: Preterm pregnancies, A: Abortions (spontaneous or induced), L: Living children |
Milk the urethra for STD/d/c- STDs give you | chlamydia/ gonorrhea/ trichomonas- discharge cervicitis/urethritis (frequency, urgency, burning, dysuria) but with d/c |
Examine for Bartholin gland | labial swelling- palpate each side- vulvar glands |
Test Cervical motion tenderness | sign for PID-seen in ectopic pregnancy (this with secondary amenorrhea)- sometimes, it’s appendicitis |
Positions of the uterus | anteverted, retroverted, retroflexed |
Uterine enlargement | suggests pregnancy, uterine myomas (fibroid), or malignancy |
Nodules on the uterine surface suggests | myomas (fibroids) |
Weeks 10 to 12 of prego | Uterus within pelvis; fetal heartbeat can be detected with Doppler. |
Week 12 of prego | Uterus palpable just above symphysis pubis. |
Week 16 of prego | Uterus palpable halfway between symphysis and umbilicus; ballottement of fetus is possible by abdominal and vaginal |
Week 20 of prego | Uterine fundus at lower border of umbilicus; fetal heartbeat can be auscultated with a fetoscope. |
Weeks 24 to 26 of prego | Uterus changes from globular to ovoid shape; fetus palpable. |
Week 28 of prego | Uterus approximately halfway between umbilicus and xiphoid; fetus easily palpable. |
Week 34 of prego | Uterine fundus just below xiphoid. |
Week 40 of prego | : Fundal height drops as fetus begins to engage in pelvis. |
Epidermoid Cyst | A small, firm, round cystic nodule in the labia suggests an epidermoid cyst-yellowish in color, with a dark punctum marking the blocked opening of the gland |
Venereal Wart (Condyloma Acuminatum) | Warty lesions on the labia and within the vestibule suggest condyloma acuminata from infection with human papillomavirus |
Genital Herpes | shallow, small, painful ulcers on red bases suggest a herpes infection-Initial infection may be extensive. Recurrent infections are usually confined to a small local patch |
Syphilitic chancre | firm, painless ulcer suggests the chancre of primary syphilis-most chancres in women develop internally, they often go undetected |
Secondary Syphilis (Condyloma Latum) | Slightly raised, round or oval flat-topped papules covered by a gray exudate suggest condyloma lata, a manifestation of secondary syphilis-contagious |
Carcinoma of the Vulva | An ulcerated or raised red vulvar lesion in an elderly woman may indicate vulvar carcinoma |
Cystocele | bulge of the upper two-thirds of the anterior vaginal wall, together with the bladder above it-results from weakened anterior supporting tissues-from urinary bladder |
Cystourethrocele | the entire anterior vaginal wall together with the bladder and urethra, produces the bulge, a cystourethrocele is present. A groove sometimes defines the border |
Rectocele | a herniation of the rectum into the posterior wall of the Urethral Caruncle: |
A urethral caruncle | small red benign tumor visible at the posterior urethral meatus- postmenopausal women-no symptoms |
Prolapse of the Urethral Mucosa | swollen red ring around the urethral meatus- before menarche or after menopau se. |
Bartholin Gland Infection | trauma, gonococci, anaerobes like bacteroids and peptostreptococci, and C.trachomatis- appears as a tense, hot, very tender abscess. |
Trichomonas vaginitis | A protozoan, often sexually acquired,Yellowish- green, profuse, malodorous, red vulva, normal/red vagina, lab: Saline wet mount, Metronidazole tx |
Candidal vaginitis | yeast r/t antibiotic use, white, curdy, itchy, no smell, vaginal soreness, dysuria, dyspareunia- red and white patches, vulva red/swollen, KOH for hyphae, Vaginal nystatin or clotrimazole |
Bacterial vaginosis | Anaerobic bacteria, Gray/white, thin, scant, malodorous, fishy, Saline wet mount, whiff test, metronidazole, vagina/vulva normal |
Gonorrhea | Neisseria gonorrheae, Gr – bacteria, mucopurulent, thick, yellow/green, s,s of urethritis/ cervicitis, dyspareunia, May be red/ swollen, burning, gram stain and culture, newer PCR, Ceftriaxone + Azithromycin |
Chlamydia | Intracellular patho-genic bacteria, mucopurulent, s/s of urethritis/ cervicitis, dyspareunia, looks normal, only d/c, Nucleic acid amplification test, Azithromycin or doxycycline |
Cervical Polyp | usually arises from endocervical canal, becoming visible only when it protrudes through cervical os-bright, red, soft, and rather fragile-benign but may bleed |
Mucopurulent Cervical Discharge/cervicitis | Purulent yellow discharge emerging from the cervical os by Chlamydia trachomatis or Neisseria gonorrheae- may occur w/o s/s |
An anteverted uterus | Lies in a forward position at roughly a right angle to the vagina.This is the most common position |
An anteflexed uterus | A forward flexion of the uterine body in relation to the cervix.Often coexists with anteversion |
A retroverted uterus | Is tilted posteriorly with its cervix facing anteriorly |
A retroflexed uterus* | Has a posterior tilt that involves the uterine body but not the cervix |
A uterus that is retroflexed or retroverted may be felt | only through the rectal wall; some cannot be felt at all |
Myomas of the Uterus (Fibroids) | very common benign uterine tumors- single or multiple and vary greatly in size-is confused with an ovarian mass or retroflexed uterus. |
Prolapse of the uterus results from | weakness of the supporting structures of the pelvic floor and is often associated with a cystocele and rectocele-uterus becomes retroverted and descends down the vagina |
In first-degree prolapse, the cervix is | still well within the vagina |
In second-degree prolapse | cervix it is at the introitus |
In third-degree prolapse (procidentia) | the cervix and vagina are outside the introitus: |
Ectopic pregnancy | Abnormal bleeding, Low back pain, Mild cramping on one side, Pain in lower abdomen/pelvis, lightheaded or syncope, Pain felt in shoulder area, Severe, sharp, and sudden pain in the lower abdomen, Cervical motion tenderness, surgical emergency |
PID | Symptoms may be mild or absent, Unusual vaginal discharge-foul odor-painful intercourse, painful urination, irregular menstrual bleeding, pain in the right upper abdomen |
Acute PID | produces very tender, bilateral adnexal areas; the pt guards and usually cannot tolerate bimanual examination |
S/s of chronic PID are | bilateral, tender, irregular, and fairly fixed adnexal areas |
PID | Infection of the uterus, fallopian tubes, and other reproductive organs; a common and serious complication of some sexually transmitted infections-Often caused by Neisseria gonorrheae and Chlamydia trachomatismay be acute or chronic |
Polycystic Ovarian Syndrome (PCOS) | Abnormal metabolism of androgens/estrogens; results in ovarian cysts- Most common cause of infertility-one of the most common endocrine disorders of reproductive-age women |
Polycystic Ovarian Syndrome (PCOS) | Menstrual irregularity, infertility, hirsutism, acne. Obesity and metabolic syndrome- associated with Heart and blood vessel complications, diabetes, uterine CA, sleep apnea, metabolic syndrome |
Created by:
arsho453
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