Major Diuretics Word Scramble
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| Question | Answer |
| Mannitol | Osmotic diuretic, ↑ tubular fluid osmolarity --> ↑ urine flow |
| Acetazolamide | Carbonic anhydrase inhibitor. Causes self-limited NaHCO3 diuresis and reduction in total body HCO-3 stores. Acts at proximal convoluted tubule. ACIDazolamide causes ACIDosis! |
| Furosemide | Sulfonamide loop diuretic. Inhibits costransport system (Na+, K++, 2 Cl-) of thick ascending limb. Abolishes hypertonicity of medulla, preventing concentration of urine. ↑ Ca++ excretion (Loops Loose CaLcium!) |
| Ethacrynic acid | Phenoxyacetic acid derivative. Same mechanism as furosemide. Used in pts with sulfa allergy. |
| Hydrochlorothiazide | Thiazide diuretic. Inhibits NaCl reabsorption in early distal tubule, reducing diluting capacity of nephron. ↓ Ca++ excretion. |
| Amiloride, triamterene | Na-channel blocking class of K+-sparing diuretics. Work in cortical collecting duct. Block Na+ reabsorption and K+ and H+ secretion. |
| Spironolactone | Competitive aldosterone receptor antagonist in cortical collecting duct. Reduces Na+ reabsorption and K+ and H+ secretion. |
| ↑ Urine NaCL | All diuretics |
| ↑ Urine K+ | All diuretics except K+-sparing |
| ↑ Blood pH (alkalosis) | Loop diuretics, thiazides |
| ↓ Blood pH (acidosis) | Carbonic anhydrase inhibitors, K+-sparing |
| ↑ Urine Ca++ | Loop diuretics |
| ↓ Urine Ca++ | Thiazides |
Created by:
golfspy
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