Adrenocorticoid Info Word Scramble
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Question | Answer |
C and D rings are ________ important than A and B rings for receptor binding. | More |
Bulky substituents on the B-side of molecule ________ glycogenic activity, but not if on ..... | abolishes, the alpha side |
Needed components required for sodium retaining activity | Alpha side interaction at the A, C, and D rings plus ketol side chain |
Alpha methyl groups in position 6 and 16 ________ glucocorticoid activity. | Increase |
2 Alpha methyl _________ sodium retention | Reduces |
Important for drug - glucocorticoid receptor interaction | 11 beta -OH |
Increases glucocorticoid activity and slows oxidation of 11 beta -OH | 9 alpha -F |
Relationship from greatest to least glucocorticoid activity with 6 and 9 alpha -F and the presence of both | 6 + 9 > 9 > 6 |
Relationship of urinary sodium increase with 9 alpha halogens | F > Cl > Br |
Relationship for topical inflammatory activity with 9 alpha halogens | Br > Cl > F |
Making the 17 alpha hydroxy an ester or tying it up as an acetonide _________ glucocorticoid receptor affinity and ___________ activity | enhances, anti-inflammatory |
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gillesec
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