Pharmacology Word Scramble
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| Question | Answer |
| Liver size and blood flow decreases with age by __ to ___% | 17-46 |
| The CYP system metabolizes over ______ of all drugs? | half |
| Why are older adults at higher risk for CYP450-related drug interactions and adverse effects? | because of polypharmacy |
| The CYP3A4 isozyme decline by approximately ___% annualy. | 8 |
| Why is the decline of the CYP3A4 isozyme clinically relevant? | Because more than 50% of drugs metabolized by the CYP system require the CYP3A4 isozyme. |
| Renal function declines by __ to __% with age. | 35-50 |
| Creatinine clearance in older adults id a good measure for what? | glomerular filtration rate |
| T or F. For older adults lower doses of opioids are recommended. | True |
| Acetaminophen increases hepatic toxicity if the total amount exceeds_________. | 4 grams in 24 hours |
| Antihistamines, antipsychotics, antidepressants, antihypertensives, anticonvulsants, and opiods are considered to be _____ depressants. | CNS |
| What is the most common hypnotic used by older adults? | benzodiazepine |
| Acutely benzodiazepines can cause what? | anterograde amnesia, delirium, paradoxical agitation |
| Chronic use of benzodiazapine can result in what? | falls and resultant fractures |
| the most prevalent form of drug induced osteoporosis is caused by which drug? | glucocorticoids |
| The elderly make up ___% of the population yet consume ____ of prescription meds and over _____ of OTC meds. | 12, one third, half |
| In elderly patients, are the effects of drugs longer or shorter in duration and why? | longer due to the decrease in hepatic and renal function |
| In elderly patients, are the effects of drugs more or less dramatic? | more |
Created by:
txst spr 2009
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