PHAR 421 Word Scramble
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Question | Answer |
Naloxone (Narcan) | Non-selective opioid antagonist |
What do nociceptors cause? | Na+/Ca2+ influx |
Allodynia | Normal stimulus is perceived as pain |
Hyperalgesia | Normal pain is perceived as worse |
How do opioids decrease neurotransmittors? | Binds to G protein which blocks Ca2+ channels, preventing neurotransmission cascade |
What are three contraindications for opioid use? | Asthma, hepatic disease, renal disease |
Meperidine (Demerol) | Short-acting 5-HT blocker |
Methadone (Dolophine) | NMDA antagonist; used in opioid dependence |
Buprenorphine (Buprenex) | Partial mu agonist; kappa antagonist; used in opioid dependence |
Nalorphine (Lethidrone) | Partial opioid antagonist |
Tramadol (Ultram) | Weak mu agonist; NE and 5-HT blocker |
Tapentadol (Nucynta) | Potent mu agonist; NE blocker |
Pentazocine (Talwin) | Kappa agonist; weak mu agonist |
What is balanced anesthesia? | IV + inhalation mask |
Thiopental Sodium (Pentothal) | Short-acting barb; increase GABA-A opening duration |
Midazolam (Versed) | Benzo; increase GABA-A opening |
Ketamine (Ketelar) | Dissociative anesthetic; NMDA antagonist |
Fentanyl (Sublimaze) | Opioid; mu receptor agonist |
Etomidate (Amidate) | Benzo-like; increase GABA-A opening |
Propofol (Diprivan) | Benzo-like; increase GABA-A opening |
Droperidol (Inapsine) | D2 antagonist; H1 antagonist |
Donepezil (Aricept) | Cholinesterase inhibitor (Alzheimer's) |
Rivastigmine (Exelon) | Cholinesterase inhibitor (Alzheimer's) |
Galantamine (Razadyne) | Cholinesterase inhibitor (Alzheimer's) |
Memantine (Namenda) | NMDA antagonist |
The Frank-Starling Law states: | Cardiac output increases with increased preload |
Myositis | Myalgia with elevated creatine kinase |
Zetia (Ezetimibe) | Decreases dietary cholesterol via inhibition of NPC1 |
Atorvastatin (Lipitor) | HMG-CoA reductatse inhibitor |
Cholestyramine (Questran) | Bile Acid Sequestrant: inhibits enterohepatic recirculation of bile |
Fenofibrate (Tricor) | PPARa activator |
Gemfibrozil (Lopid) | PPARa activator |
PPARa activators | Increase Beta-oxidation of FFA |
Niacin (nicotinic acid) | Adverse flushing reaction |
Colesevelam (Welchol) | Bile Acid Sequestrant: inhibits enterohepatic recirculation of bile |
Simvastatin (Zocor) | HMG-CoA reductase inhibitor |
Pravastatin (Pravachol) | HMG-CoA reductase inhibitor |
Clofibrate (Atromid) | PPARa activator |
Created by:
sdeck86
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