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PHAR 421


Naloxone (Narcan) Non-selective opioid antagonist
What do nociceptors cause? Na+/Ca2+ influx
Allodynia Normal stimulus is perceived as pain
Hyperalgesia Normal pain is perceived as worse
How do opioids decrease neurotransmittors? Binds to G protein which blocks Ca2+ channels, preventing neurotransmission cascade
What are three contraindications for opioid use? Asthma, hepatic disease, renal disease
Meperidine (Demerol) Short-acting 5-HT blocker
Methadone (Dolophine) NMDA antagonist; used in opioid dependence
Buprenorphine (Buprenex) Partial mu agonist; kappa antagonist; used in opioid dependence
Nalorphine (Lethidrone) Partial opioid antagonist
Tramadol (Ultram) Weak mu agonist; NE and 5-HT blocker
Tapentadol (Nucynta) Potent mu agonist; NE blocker
Pentazocine (Talwin) Kappa agonist; weak mu agonist
What is balanced anesthesia? IV + inhalation mask
Thiopental Sodium (Pentothal) Short-acting barb; increase GABA-A opening duration
Midazolam (Versed) Benzo; increase GABA-A opening
Ketamine (Ketelar) Dissociative anesthetic; NMDA antagonist
Fentanyl (Sublimaze) Opioid; mu receptor agonist
Etomidate (Amidate) Benzo-like; increase GABA-A opening
Propofol (Diprivan) Benzo-like; increase GABA-A opening
Droperidol (Inapsine) D2 antagonist; H1 antagonist
Donepezil (Aricept) Cholinesterase inhibitor (Alzheimer's)
Rivastigmine (Exelon) Cholinesterase inhibitor (Alzheimer's)
Galantamine (Razadyne) Cholinesterase inhibitor (Alzheimer's)
Memantine (Namenda) NMDA antagonist
The Frank-Starling Law states: Cardiac output increases with increased preload
Myositis Myalgia with elevated creatine kinase
Zetia (Ezetimibe) Decreases dietary cholesterol via inhibition of NPC1
Atorvastatin (Lipitor) HMG-CoA reductatse inhibitor
Cholestyramine (Questran) Bile Acid Sequestrant: inhibits enterohepatic recirculation of bile
Fenofibrate (Tricor) PPARa activator
Gemfibrozil (Lopid) PPARa activator
PPARa activators Increase Beta-oxidation of FFA
Niacin (nicotinic acid) Adverse flushing reaction
Colesevelam (Welchol) Bile Acid Sequestrant: inhibits enterohepatic recirculation of bile
Simvastatin (Zocor) HMG-CoA reductase inhibitor
Pravastatin (Pravachol) HMG-CoA reductase inhibitor
Clofibrate (Atromid) PPARa activator
Created by: sdeck86



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