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PHAR 421
1.8
| Question | Answer |
|---|---|
| Naloxone (Narcan) | Non-selective opioid antagonist |
| What do nociceptors cause? | Na+/Ca2+ influx |
| Allodynia | Normal stimulus is perceived as pain |
| Hyperalgesia | Normal pain is perceived as worse |
| How do opioids decrease neurotransmittors? | Binds to G protein which blocks Ca2+ channels, preventing neurotransmission cascade |
| What are three contraindications for opioid use? | Asthma, hepatic disease, renal disease |
| Meperidine (Demerol) | Short-acting 5-HT blocker |
| Methadone (Dolophine) | NMDA antagonist; used in opioid dependence |
| Buprenorphine (Buprenex) | Partial mu agonist; kappa antagonist; used in opioid dependence |
| Nalorphine (Lethidrone) | Partial opioid antagonist |
| Tramadol (Ultram) | Weak mu agonist; NE and 5-HT blocker |
| Tapentadol (Nucynta) | Potent mu agonist; NE blocker |
| Pentazocine (Talwin) | Kappa agonist; weak mu agonist |
| What is balanced anesthesia? | IV + inhalation mask |
| Thiopental Sodium (Pentothal) | Short-acting barb; increase GABA-A opening duration |
| Midazolam (Versed) | Benzo; increase GABA-A opening |
| Ketamine (Ketelar) | Dissociative anesthetic; NMDA antagonist |
| Fentanyl (Sublimaze) | Opioid; mu receptor agonist |
| Etomidate (Amidate) | Benzo-like; increase GABA-A opening |
| Propofol (Diprivan) | Benzo-like; increase GABA-A opening |
| Droperidol (Inapsine) | D2 antagonist; H1 antagonist |
| Donepezil (Aricept) | Cholinesterase inhibitor (Alzheimer's) |
| Rivastigmine (Exelon) | Cholinesterase inhibitor (Alzheimer's) |
| Galantamine (Razadyne) | Cholinesterase inhibitor (Alzheimer's) |
| Memantine (Namenda) | NMDA antagonist |
| The Frank-Starling Law states: | Cardiac output increases with increased preload |
| Myositis | Myalgia with elevated creatine kinase |
| Zetia (Ezetimibe) | Decreases dietary cholesterol via inhibition of NPC1 |
| Atorvastatin (Lipitor) | HMG-CoA reductatse inhibitor |
| Cholestyramine (Questran) | Bile Acid Sequestrant: inhibits enterohepatic recirculation of bile |
| Fenofibrate (Tricor) | PPARa activator |
| Gemfibrozil (Lopid) | PPARa activator |
| PPARa activators | Increase Beta-oxidation of FFA |
| Niacin (nicotinic acid) | Adverse flushing reaction |
| Colesevelam (Welchol) | Bile Acid Sequestrant: inhibits enterohepatic recirculation of bile |
| Simvastatin (Zocor) | HMG-CoA reductase inhibitor |
| Pravastatin (Pravachol) | HMG-CoA reductase inhibitor |
| Clofibrate (Atromid) | PPARa activator |
Created by:
sdeck86
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