Pharmacology Exam #2 Word Scramble
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Class/Condition | |
Anti-Emetics/Suppression of nausea and vomiting | Serotonin Receptor Antagonists Ondansetron, Granisetron |
Prototype: Ondansetron (Zofran): Tx. of N/V r/t anesthesia, radiotherapy. Off label: viral gastritis (children), morning sickness | |
Granisetron (PO/IV/transdermal); Dolasetron (PO/IV; in high doses IV = risk of fatal dysrhythmias); Palonosetron (PO/IV; longer half life (40 hrs) effective against delayed emesis) | |
Side Effects: HA (give tylenol), dizziness, constipation, diarrhea, increase liver enzymes, abd. pain & Torsades de Pointe | |
Interactions: Apomorphine increase r/o severe hypotension | |
Nursing Implications: Assess for N/V, abd. distension, BS b4 & during administration. Monitor ECG in patients that are hypo-kalemic, magnesemic, HF, Bradyarrhythmias or meds that prolong QT interval | |
Labs: Increased bilirubin, AST/ALT Administration: Admin. prior to emetogenic even0t (1hr b4 anesthesia), peel backing & remove tab (PO disintegrating tabs), undiluted (2mg/ml)b4 anesthesia or post-op, over 30 seconds over 2-5 min(IV) | |
Patient Teaching: Take as directed, notify MD if irregular heartbeat or involuntary movement of eyes, face or limbs occurs | |
Glucocorticoids Dexamethasone, Methylprednisolone (Solu-Medrol) | |
Action: Blocks Type-3 serotonin receptors in the CTZ (chemoreceptor trigger zone) and on afferent vagal neurons in the upper GI tract Pharmacokinetics: PO/IV administration (100% absorbed PO), hepatic excretion, half life of 3.5-5.5 hr (adults); 2.9 hr |
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