HIV ARV therapy Word Scramble
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Question | Answer |
Zidovudine | NRTI |
Abacavir | NRTI |
Lamivudine | NRTI |
Emtricitabine | NRTI |
Didanosine | NRTI |
Stavudine | NRTI |
Tenofovir | NRTI (nucleoTide) |
Class toxicities: lactic acidosis, hepatomegaly | NRTI |
AE: mostly myelosuppression; anemia, neutropenia, HA, malaise | ZIdovudine (AZT) |
BBW: non-cirrhotic portal HTN; AE: pancreatitis, CD4 toxicity with Tenofovir (TDF) | Didanosine (ddI) |
AE: peripheral neuropathy, mitochondrial toxicities, lipoatrophy | Stavudine (d4T) |
benign drugs with little toxicities; HA, N/V/D | Lamivudine (3TC) Emtricitabine (FTC) |
hypersensitivity--check allele; doesn't work viral load >100,00, penetrates CNS well | Abacavir (ABC) |
renal dysfunction--Fanconi's syndrome | Tenofovir (TDF) |
drugs with activity against HBV | Tenofovir Lamivudine Emtricitabine |
Efavirenz | NNRTI |
Nevirapine | NNRTI |
Delavirdine | NNRTI |
Etravirine | NNRTI |
Rilpivirine | NNRTI |
class toxicites: hepatotoxicity, rash | NNRTIs |
K103 mutations is responsible for resistance in these ARVs | Efavirenz Nevirapine Delavirdine |
Contraindicated with PPIs | Rilpivirine |
Atazanavir | PI |
Darunavir | PI |
Nelfinavir | PI |
Saquinavir | PI |
Ritonavir | PI |
Indinavir | PI |
Lopinavir | PI |
Tipranavir | PI |
Fosamprenavir | PI |
AE: Jaundice, scleral icterus, cholelithiasis, nephrolithiasis, requires acidic pH | Atazanavir |
AE: N/V/D; take with food to increase bioavail | Darunavir |
rarely used; really bad diarrhea | Nelfinavir |
rarely used; prolong QT interval | Saquinavir |
not an active PI anymore; pharmaco-enhancer | Ritonavir |
not used often; nephrolithiasis | Indinavir |
has Ritonavir in formulation; good pregnancy data | Lopinavir |
salvage drug--higher dose; AE: intracranial bleed | Tipranavir |
Raltegravir | Intergrase inhibitor |
AE: severe rash, CPK | Raltegravir |
Maraviroc | Entry inhibitor |
must be CCR5 dominant | Maraviroc |
BBW: hepatotoxicity | Maraviroc |
Fusion inhibitor; last line therapy; no DDI because it's a very large peptide | Fuzeon |
Sulfa allergy caution use of: | Darunavir Fosamprenavir Tipranavir |
AE: depression (Psychiatric disorders), insomnia, HA, rash | Rilpivirine |
Created by:
simpsonan
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