USMLE - Pharm Word Scramble
|
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Question | Answer |
What are agonists? | Drugs that ACTIVATE receptors |
What are full vs. partial agonists? | Full agonists produce a maximal response. Partial agonists cannot and are less effective. |
Potentiation of an agonist shifts the dose-response curve to L or R? | Left |
Antagonism of an agonist shifts the dose-response curve to L or R? | Right |
What is the ED50? | The dose of a drug that is effective in 50% of the patient population |
A steep slope for a cumulative dose response curve means what? | There is little variability in drug response in a given population. The less steep the slope, the greater the variability in patient sensitivity to the effects of a drug. |
What is the TD50? | The dose that is toxic to 50% of the patient population. |
What is the LD50? | The dose that is lethal to 50% of the patient population. |
What is the therapeutic index? | Evaluates the relative safety of a drug. |
A drug with a lower therapeutic index means what? | That the doctor needs to be more careful in the dosing of the drug for a patient because there is only a small therapeutic window in terms of the dosing. |
What happens when an agonist binds to a Gs receptor? | activation of adenylyl cyclase --> increase in cAMP |
Mnemonic to remember the G-protein-coupled ANS receptors. | Kiss and kick til you're sick of sex. qiss qiq siq sqs = a1 a1 B1 B2, M1 M2 M3, D1 D2 H1, H2 V1 V2 |
What happens when Gi receptors are stimulated? | inhibition of adenylyl cyclase --> decrease in cAMP |
What happens when Gq receptors are stimulated? | activation of phospholipase C |
What happens when endothelial cells release NO? | NO --> activation of guanylyl cyclase --> increases cGMP in smooth muscle --> myosin light chains are dephosphorylated --> myosin can't interact with actin --> vasodilation |
Created by:
christinapham
Popular USMLE sets