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Class 1 Test

Enter the letter for the matching Answer
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1.
Controlled substances
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2.
Phase 1 Drug approval process
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3.
Nephrotoxicity
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4.
What happens with impaired kidneys?
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5.
DEA
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6.
Excretion
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7.
Phase 3 drug approval process
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8.
Classification
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9.
What happens with impaired liver function?
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10.
cumulative effect
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11.
Pharmacokinetics
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12.
Narcotic analgesics
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13.
Local effect
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14.
Receptors
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15.
Therapeutic range
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16.
How does Metabolism work?
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17.
Drug-drug interactions
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18.
Role of the FDA?
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19.
Factors affecting absorption:
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20.
Phase 4 drug approval process
A.
Major: according to body system, which one it effects(cardiovascular)Minor: indicates use or purpose (antianginal)
B.
Impaired kidneys-impairs excretion- drug accumulation-ADR/toxicity. Reduce the dose, monitor kidneys (creatinine levels and I&O)
C.
drug action may be increased or decreased when 2nd drug taken. Caused by altered drug metabolism or competition for binding sites.
D.
given to larger group of people with disease (blind & DB studies occur w/ use of placebo
E.
proteins on the surface of cell membranes or in the cell
F.
Drug Enforcement Administration: enforces controlled substance act
G.
works on a specific area of body
H.
drug movement through the body. What the body does to the drug. Includes: Absorption, distribution, metabolism, excretion
I.
Delayed metabolism, drug accumulation, adverse reactions/toxicity, dose reduced. Larger dose should be used.
J.
Narcotics, depressants, stimulants, hallucinogens. High potential for abuse/ dependency. physical(withdrawal) or psychological(addiction)
K.
Action: relieve pain, inhibits the transmission of pain signals from peripheral tissues to the brain. It prevents of relieves acute/chronic pain
L.
1st dose not fully metabolized before another dose is given. can cause permanent or temporary damage to body tissues. Promote elimination, ABCs, IV, etc.
M.
It converts fat-soluable drugs into water-soluable metabolites. Enzymes also inactivate drug.
N.
given to healthy volunteers
O.
drug is marketed for general use (adverse effects, MEDWATCH, drug could still be removed)
P.
drug concentration that produces the desired effect
Q.
renal damage (adverse effect)
R.
dosage:too small, too large, correct dose, loading dose, form of dose, route,food.
S.
*regulates and monitors drug approval process*enforces drug dispensing laws (can change Rx to OTC)
T.
Elimination from body. Primarily kidneys.
Type the Answer that corresponds to the displayed Question.
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21.
What is normal range for serum albumin level (primary protein)?
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22.
Main organ of metabolism?
Type the Question that corresponds to the displayed Answer.
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23.
a drug given to reduce the toxic effects of another drug. ex. Narcan to relieve effects of morphine
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24.
drug taken on regular schedule to maintain steady drug level. ex. antihypertensive medication
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25.
a complete attachment and cellular response occur. Similar to natural processes of neurotransmitters or hormones (morphine stimulates supression of pain signals)
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26.
an excessive level of drug in blood where toxicity occurs
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27.
pre-measured, individual packaged dose
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28.
Keep drugs locked, sign-out procedure for narcotics, record drug removed, record amount used and amount left
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29.
cause a small response in cell and block other responses
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30.
Enteral: GI tract (oral, NGT, GT)Parenteral: Non-GI tract (injection, IV, topical) Absorbed faster in blood

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