OCN exam
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each of the black spaces below before clicking
on it to display the answer.
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| show | cytokines and monoclonal antibodies
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| show | derived from mouse antibody, less effective (-momab)
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| show | derived from a combination of mouse and human antibodies (-ximab)
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| show | derived from small part mouse antibodies fused with human antibodies (-zumab)
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| show | derived from only human antibodies (-umab)
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| show | the use of agents derived from biologic sources or agents that affect biologic responses
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| innate or nonspecific immune response: mechanism of action | show 🗑
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| show | neutrophils, monocytes, macrophages, lymphocytes
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| adaptive immune response: mechanism of action | show 🗑
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| show | lymphocytes, T cells, B cells
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| humoral immunity | show 🗑
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| cell-mediated immunity | show 🗑
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| types of adaptive immunity | show 🗑
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| show | plant alkaloid
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| show | Carboplatin, Cispatin, Oxaliplatin, (Cyclophosphamide, Ifosfamide, Temozolomide, nitrogen mustard, Busulfan, Mechlorethamine, Melphalan, Procarbazine, Dacarbazine)
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| types of antitumor antibiotics (anthracyclines) | show 🗑
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| show | Carmustine, Lomustine, Streptozocin, Chlorozotocin
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| show | Irinotecan, Topotecan
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| show | Docetaxel, Paclitaxel
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| types of plant alkaloids - epipodophyllotoxin | show 🗑
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| types of plant alkaloids - vinca | show 🗑
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| show | IFN alfa, IFN gamma, IFN beta
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| types of interleukins | show 🗑
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| show | Thalidomide, Lenalidomide
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| show | antimetabolites, plant alkaloids
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| show | Azacitidine, Capecitabine, Cladribine, Cytarabine, Decitabine, Fludarabine, Fluorouracil, Gemcitabine, Methotrexate, Pemetrexed, hydroxyurea
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| action of alkylating agents | show 🗑
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| show | binds w/DNA, inhibiting DNA & RNA synthesis
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| show | breaks DNA helix, interfering w/DNA replication; crosses the blood brain barrier
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| show | inhibits viral replication, direct antiproliferation of tumor cells, modulates host immune response
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| action of interleukin 2 | show 🗑
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| show | stimulates megakaryocytopoiesis and thrombopoiesis
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| action of biologic response modifiers | show 🗑
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| show | Darbepoetin (Aranesp), Epoetin alfa (Procrit)
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| show | Filgrastim (Neupogen), Pegfilgrastim (Neulasta)
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| purpose of tumor markers | show 🗑
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| show | hand hygeine, wear gloves when working in garden, frequent oral care, avoid live vaccines or persons who have had a live vaccine in past 30 days, avoid areas of construction or renovation, clean food, avoid fresh/dried plants, use an electric razor
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| show | blow nose gently, use soft toothbrush, no dental floss, tampons, anal, or sexual intercourse if <50K, drink fluids, take stool softeners, soft diet w/non-irritating foods, report bleeding, petechiae, bruising, HA, or change in LOC
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| primary prevention | show 🗑
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| show | targets specific populations; activities such as testing or screening to identify high-risk groups - mammogram, pap test, colonoscopy, PSA
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| 4 stages of cancer cell growth | show 🗑
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| 3 patterns of cancer occurence | show 🗑
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| show | tumor marker for prostate cancer
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| show | tumor marker for liver or germ cell cancers
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| Carcinoembryonic antigen (CEA) | show 🗑
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| show | tumor marker for ovarian cancer
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| CA-15-3 | show 🗑
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| CA-19-9 | show 🗑
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| show | tumor marker for breast cancer
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| show | tumor marker for choriocarcinoma (testis, ovary, liver, pancreas, stomach, lung)
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| families at high risk for hereditary cancer | show 🗑
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| age to start colorectal cancer screening | show 🗑
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| show | 50 (45 if high risk)
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| show | monthly self breast exam - 20, mammogram - 50 (40 if high risk)
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| show | positive for BRCA1 or BRCA2, early menarche, late menopause, 1st child after age 30, mother or sister w/breast cancer, history of breast cancer
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| dietary recommendations to reduce cancer risk | show 🗑
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| tumor types | show 🗑
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| show | characteristic of a given tumor - size, depth of invasion, involvement of surrounding tissues
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| N | show 🗑
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| show | presence or absence of metastases
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| Rai system | show 🗑
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| Ann Arbor classification | show 🗑
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| types of monoclonal antibodies | show 🗑
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| Dexrazoxane (Zinecard) | show 🗑
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| show | cytoprotective agent for toxic effects of ciplatin-related renal toxicities
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| show | bleomycin, mitomycin, cyclophosphamide, methotrexate, carmustine, procarbazine, cisplatin
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| show | cisplatin
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| drugs that cause hemorrhagic cystits | show 🗑
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| show | doxorubicin, daunorubicin, epirubicin, idarubicin, mitoxantrone, cyclophosphamide (high dose), 5FU, capecitabine
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| show | irinotecan
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| show | paclitaxel, cisplatin, oxaliplatin, carboplatin
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| drugs that cause hypotension | show 🗑
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| drugs that cause neurotoxicity (central) | show 🗑
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| drugs that cause neurotoxicity (peripheral) | show 🗑
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| show | sudden onset, age 4, median survival: adults-2yrs, children-5yrs, lymphoblasts
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| acute myelogenous leukemia (AML) | show 🗑
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| show | insidious onset, age 49, median survival 3yrs, mature myelocytes
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| chronic lympocytic leukemia (CLL) | show 🗑
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| show | hyponatrema, high urine osmo, low plasma osmo, high urine sodium, intracellular edema
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| SIADH treatment | show 🗑
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| show | Ca>11, low potassium, high phosphorus, EKG changes
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| show | exercise/weight bearing activity, NS hydration, biphosphonates (pamidronate, zoledronic acid), dialysis
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| tumor lysis syndrome clinical picture | show 🗑
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| tumor lysis syndrome treatment | show 🗑
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| DIC clinical picture | show 🗑
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| show | treat underlying condition, IV hydration, oxygen therapy, blood components, plasmaphoresis
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| show | JVD, distant or muffled heart sound, decreased peripheral pulses, friction rub, maximal impulse shifted to left
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| show | drainage, elevate HOB, minimize activites, oxygen, chemo/xrt
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| show | tachypnea, diminished or absent breath sounds, friction rub, dry cough, dyspnea, chest pain, fever
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| show | drainage vis thoracentesis or chest tube, talc pleurodesis, chemo/xrt
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