Pharm Ch 40 diuretics
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| general MOA of diuretics | generally blockade of Na and Cl reabsorption
🗑
|
||||
| Three classes of diuretics | *loop diuretics - high ceiling
*thiazides
*K sparing (aldosterone blockers, non-aldosterone blockers)
*osmotic
🗑
|
||||
| what are the most effective diuretic, with highest ceiling, that doesn't plateau with dose | Loop diuretics are all of this
🗑
|
||||
| SOA of loop diuretics | ascending Loop of Henle
🗑
|
||||
| MOA of loop diuretics | blocks Na/Cl reabsorption in ascending Loop of Henle. medulla less hypertonic, more water in urine.
🗑
|
||||
| Loop diuretics are indicated for these pts | *pulmonary edema, edematous states
*HTN, especially renal impaired
🗑
|
||||
| Which class of diuretics is safe for renal impaired HTN | Loop diuretics - furosemide, bumetanide, torsemide
🗑
|
||||
| how are loop diuretics administered | They have rapid onset where IV admin > po admin
🗑
|
||||
| What drug class has interactions with digoxin and lithium | Loop Diuretics have these interactions
🗑
|
||||
| What drug class has interactions with NSAIDs, K+ sparing antidiuretics and antihypertensives | Loop diuretics have these interactions
🗑
|
||||
| Watch first dose effect of othorthostatic hypoTN - name 3 drugs in this class | watch this SE for furosemide, bumetanide, torsemide
🗑
|
||||
| what drug class has the 'hypo---' ADRS | Loop diuretic ADRs ---hypo - vol/natremia/kalemia/chloremia/Mg/Ca and alkalosis
🗑
|
||||
| what drug class has the 'hyper---' ADRs in addition to otototoxicity | Loop diuretics have mild/ST HYPER---glycemia/lipidemia/uricemia
🗑
|
||||
| are Loop diuretics often given in combination | yes, often given in combination
🗑
|
||||
| furosemide class | loop diuretic
🗑
|
||||
| bumetanide class | loop diuretic
🗑
|
||||
| torsemide class | loop diuretic
🗑
|
||||
| What class of drug peaks in 4-6 hours | Thiaziade drug class
🗑
|
||||
| MOA of thiazides | block reabsorption of Na/Cl in DCT & asecending LofH?
🗑
|
||||
| Thiazides indicated for which pts | Indicated for HTN, edema
*less effective than loop diuretics in renal impairment
🗑
|
||||
| ADRs of thiazides | less pronounced first dose hypoTN effect, overall ADRs the same but less pronounced due to lower maximum effect. no ototoxicity
🗑
|
||||
| Let's review lesser effect of thiazide ADRs | dehydration, all the 'hypos' and 'hypers'. but no ototoxicity
🗑
|
||||
| Do thiazides have same interactions, but to a lesser effect, as loop diuretics? | Yes, lesser but present interactions for digoxin, lithium, NSAIDs, K sparing and antihypertensive drugs
🗑
|
||||
| name 4 thiazide drugs | *hydrochlorothiazide
*chlorothiazide
*chorothalidone
*metolazone
🗑
|
||||
| hydrochlorothiazide class | thiazide - most widely used
🗑
|
||||
| chlorothiazide class | thiazide - oral, IV
🗑
|
||||
| chlorothalidone class | thiazide - longer acting
🗑
|
||||
| metolazone class | thiazide class
🗑
|
||||
| Two sub-classes of K-sparing diuretics | Aldosterone blockers, non-aldosterone blockers
🗑
|
||||
| what class of drug is it unusual to be on alone due to SE of weakeness | aldosterone blockers least likely to be admin solely
🗑
|
||||
| What class of drug is most often combined with another diuretic | K+ sparing diuretics most often combined when pt needs to conserve K
🗑
|
||||
| K sparing diuretics indicated for | Indicated for severe HF, some HTN, hyperaldosteronism
🗑
|
||||
| MOA of K sparing diuretics | both subclasses prevent the exchange of Na reabsorption/K secretion in COLLECTING DUCT. non-aldosterone blockers do this DIRECTLY while aldosterone blockers do this INDIRECTLY
🗑
|
||||
| which drug class has delayed effects due to 2nd messenger mechanism | K sparing adlosterone blockers have this delayed effect
🗑
|
||||
| what drug class has a MAJOR concern for hyperkalemia, especially for RF pts | K sparing diuretics have this concern - both aldosterone/non-aldosterone blockers
🗑
|
||||
| name 2 aldosterone antagonists | *spironolactone, eplerenone
🗑
|
||||
| what drug has estrogen effects bwo its chemical structure | spironolactone has this effect
🗑
|
||||
| spironolactone class | K sparing aldosterone blocker
🗑
|
||||
| eplerenone class | K sparing aldosterone blocker
🗑
|
||||
| which subclass of K sparing diuretic has QUICKEST onset | non-aldosterone blocker doesn't use 2nd messenger, otherwise same MOA
🗑
|
||||
| class of triamterene | K sparing non-aldosterone blocker
🗑
|
||||
| class of amiloride | K sparing non-aldosterone blocker
🗑
|
||||
| MOA of osmotic diuretic | drug IS filtered through glomerulus but NOT reabsorbed --> stays in filtrate --> exerts osmotic effect to draw water into lumen of nephron
🗑
|
||||
| osmotic diuretics indicated for | *Renal failure - prevention/tx
*Increased ICP
*Increased intraocular pressure
🗑
|
||||
| mannitol is an osmotic diuretic that has an ADR of edema. How can this be | because it is filtered out at every capillary bed EXCEPT those in the brain. When filtered out of peripheral capillaries it pulls fluid into third space --> edema
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
lorrelaws
Popular Nursing sets