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Renal Drugs

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Question
Answer
Antipyretics - Decreases temperature by acting on hypothalamus   Aspirin, Tylenol, Ibuprofen  
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Aspirin   Decreases platelet aggregation. S/E: bleeding, GI upset, renal impairment, tinnitus is sign of toxicity  
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Tylenol   4 g in 24 hour max. Does not have anti-inflammatory, does not cause bleeding, hepatoxic - use sparingly in liver disease  
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Ibuprofen   Similiar to aspirin, first choice for fever, lower risk for GI upset  
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Vitamin A   Accelerated epithelialization  
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Vitamin B   Coenzyme  
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Vitamin C   Assist in synthesis of collagen for new capillaries  
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Vitamin D   Calcium  
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Antibiotics for UTI   trimethoprim/Sulfamethoxazole, macrobid, Cipro, Nitrofurantoin  
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Trimethoprim/sulfamethoxazole   Inhibits synthesis of folic acid. Patients may have photo sensitivity. Report rash immediately (Stevens-Johnson Syndrome), sulfa allergy  
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Macrobid   Long term/long acting Nitrofurantoin  
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Cipro   Causes yeast infections in mouth or vaginal canal. Use cautiously in elderly b/c may cause confusion and psychosis. Photosensitivity. Do not give with dairy or iron supplements. Pleural Quinolone  
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Nitrofurantoin   Urinary antiseptic. Activated by enzymes in bacteria, therapeutic levels are only in urine. If GI upset take w/ meals. Photosensitivity. *Acute alveolar infiltrates: chest pain, trouble breathing, crackles in lungs  
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Antifungal meds for UTI   Flagyl, Mycelex, Mycostatin, Diflucan  
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Flagyl   Treats protozoa infections, CDIFF. May change taste of things to metallic. Harmless darkening of urine. Avoid alcohol. Given PO or IV (po treats CDIFF)  
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Mycelex   Topical or antifungal. Tx yeast infection  
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Mycostatin   Swish and spit powder. Antifungal used to Tx yeast infections  
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Diflucan   Given po. Antifungal used to treat yeast infections (candidiasis)  
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Pyridium   Urinary analgesic, not an antibiotic, will alleviate symptoms but not treat infection. Stains urine reddish/orange. long term use may cause anemia  
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Antineoplastic (Chemotherapy)   Doxrubicin, Platinol, Methotrexate, 5 Fluorouracil, Floxuridine, Gemzar, Bacille Calmette  
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Doxrubicin   Tx invasive bladder cancer. S/E: Bone marrow suppression. Red color to urine and sweat. Cardiotoxic - do not give w/ heart disease. Only give thru central line cuz if it infiltrates will cause severe tissue damage  
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Platinol   Tx invasive bladder cancer. Watch for kidney damage, monitor BUN/Creatinine. Pre-medicate with Zofran b/c causes nausea and vomiting within an hour. S/E mild to moderate bone marrow suppression and ototoxic  
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5 fluorouracil   Inhibits DNA synthesis. Only active on dividing cells. Given IV. S/E: Bone marrow suppression, neutropenia, oral/GI ulceration stomatitis (mouth gets bright red & swells), alopecia  
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Floxuridine   Similiar to 5 fluorouracil, same class different drug  
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Gemzar   Inhibits DNA synthesis (cells must be dividing). S/E: Nausea, vomiting, alopecia. Given IV, Can have infusion reaction (hypotension/flushing) if it happens decrease rate of infusion  
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Bacille Calmette   Live vaccine used for TB. Administered directly through bladder via foley. Produces local inflammatory response causing tumor regression. S/E: Dysuria, urgency/frequency, hematuria. Contraindications: Immune suppressed or active UTI  
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Bladder Agents   Ditropan, Detrol, Bentyl, Flomax, Proscar, Estrogen, Enablex, Urecholine, Vesicare  
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Anticholingeric   Ditropan, Detrol, Enablex, Urecholine, Vesicare  
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Muscarinic Receptor Antagonist   Bentyl, Enablex, Vesicare  
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Ditropan/Detrol   Used to treat urge incontinence. S/E: dry mouth, dry eyes, blurred vision, constipation. Anticholinergic  
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Bentyl   Reduces overactive bladder contraction in urge incontinence and overactive bladder. Muscarinic Receptor  
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Flomax   Reduces urethral sphincter resistance. Tx overflow incontinence. Alpha Adrenergenic Blocker  
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Proscar   Used to decrease prostate size, BPH  
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Estrogen   Local application (topical/cream) used to increase host defenses against UTI  
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Enablex   Used for overactive bladder. Avoid w/ liver failure. S/E: dry mouth, dry eyes, blurred vision, constipation. Muscarinic Receptor, Anticholingeric  
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Urecholine   Used for urinary retention. Relaxes muscles and increases voiding pressure. S/E: rare  
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Vesicare   Tx: overactive bladder and urge incontinence. Avoid w/ liver failure. S/E: Dry mouth, dry eyes, blurred vision, constipation. Anticholinergic  
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Agents to treat Hyperkalemia   Kayexalate, calcium gluconate, sodium bicarbonate, Insulin & D50  
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Kayexalate   Can give orally or thru retention enema. Liquid given in grams. Will cause diarrhea and Na+ & H2O retention. Do not give orally if bowel issues. Watch for constipation. Don't give if CHF  
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Calcium Gluconate   Ca+ given IV push or IV piggyback. 10 acc amp. Cardioprotective, if given to quickly BP will rise  
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Sodium Bicarbonate   Given in large vein and pushes K+ back into cell. Thick and hard to push(costic)  
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Insulin & D50   Given first b/c insulin drops blood sugar. Does not treat hyperkalemia, Dextrose 50 g glucose. Treats hyperkalemia, pushes K+ back into cell  
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Meds for Renal Failure   Mucomyst, Renagel, Phoslo, Sensipar, Calcitrol, Fosrenol, Magnesium Oxide, Midodrine  
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Mucomyst   Kidney protector. Protects kidneys from IV dye  
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Renagel   Ca+ free phospate binder. Does not increase Ca+ levels. Expensive. Give to patients with cardiovascular risks. Binds to biosalts in intestine and decreases cholesterol  
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Phoslo   Ca+ based phosphate binder, "giving Ca+". Cheap. Give to patients who do not have cardiovascular risks. Decrease Phos Increase Ca+  
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Sensipar   Works in parathyroid gland. Prevents hyperparathyroidism in end stage renal disease. Only used on patients on dialysis  
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Calcitrol   Active form of Vit D. Give in addition to Renagel, Phoslo, and Sensipar if Ca+ level decrease  
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Fosrenol   Ca+ free phosphate binder. Expensive give to patients with cardiovascular risks  
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Magnesium Oxide   Replaces magnesium and alleviates constipation  
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Midodrine   Increases BP during dialysis  
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Lasix/Bumex   Work in loop of henle to secrete excess fluid (potassium), causes hypokalemia  
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Epogen/Procrit   Stimulates RBC production. Given subcut on days of dialysis. Natural replacement of erythorpoietin that kidneys make. Will not see increase in hgb for 2-3 weeks  
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Aranesp   Longer acting so it isn't given as frequently, depends on hemoglobin level  
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Iron Sucrose   Can be given with or without erythorpoietin. Watch for hypotension. Iron supplement given IV  
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Sodium Ferric Gluconate   Must give with erythorpoietin. Can have severe allergic reaction so give test dose. Watch for hypotension, flushing, chest/back pain. If test dose goes okay can give full dose. Iron supplement given IV  
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Isotonic Solutions   0.9 NS, Ringers Solution, Lactated Ringers  
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Hypertonic Solutions   3% NaCl  
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Hypotonic Solutions   0.45, D5W  
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0.9 NS   Only fluid you can use w/ blood products. Used to keep fluid in vascular space  
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0.45 NaCl   Fluid goes into tissue (rehydrates tissue)  
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3% NaCl   Used to treat severe hyponatremia. Given slowly on IV pump, watch patient carefully  
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Ringers Solution   Has some electrolytes. Stays in vascular space  
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Lactated Ringers   Has some bicarbonate, no free water or calories, just replaces vascular volume loss  
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D5W   Has 170 cal/L. Will not stay in vascular space, rarely given  
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Albumin   Protein, not given as a nutrition supplement but to pull fluids into vascular space which will maintain BP. Comes in 5% (250 mL) or 25% (50mL). Some will see this as blood product. Given during dialysis and to maintain BP  
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Potassium Chloride po   Large white pill that is hard on stomach (GI upset) so give with food. Enteric coated yellow pill protects stomach  
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Potassium Chloride IV   Add to IV fluid. 40 meq/L = maintenance fluid. Peripheral IV = 10 meq/hr. Burns peripherally, get doctors order for lidocaine. Central line = 20 meq/hr b/c there is more blood flow  
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