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Buzzwords

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Question
Answer
Abdominal pain, ascites, hepatomegaly   Budd-Chiari Syndrome (posthepatic venous thrombosis)  
🗑
Achilles tendon xanthoma, corneal arcus, MI before age 20   Familial hypercholesterolemia (Absent or defective LDL receptors); Autosomal dominant  
🗑
Adrenal hemorrhage, hypotension, DIC   Waterhouse-Friderichsen syndrome, 1º adrenal insufficiency (associated with Neisseria Meningitidis)  
🗑
Arachnodactyly, lens dislocation, thoracic aortic aneurysm and dissection (cystic medial necrosis of the aorta), hyperflexible joints   Marfan’s syndrome (Fibrillin defect)  
🗑
Athlete with polycythemia   2º to Erythropoietin injection  
🗑
Back pain, fever, night sweats, weight loss   Pott’s disease (Vertebral tuberculosis)  
🗑
Bilateral hilar adenopathy, uveitis   Sarcoidosis (non-caseating granulmas)  
🗑
Blue sclera   Osteogenesis imperfecta (collagen type 1 defect); Autosomal Dominant, problemas forming triple helix  
🗑
Bluish line on gingival   Burton’s line (lead poisoning)  
🗑
Bone pain, bone enlargement, arthritis   Paget’s disease of bone (increase in osteoblastic and osteoclastic activity)  
🗑
Bounding pulses, diastolic heart murmur, head bobbing   Aortic regurgitation  
🗑
“Butterfly” facial rash and Raynaud’s phenomenon in a young female   SLE  
🗑
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas   Neurofibromatosis I (Von Recklinghausen´s disease); Autosomal Dominant, Chromosome 17, NF1 gene  
🗑
Café-au-lait spots, bilateral acoustic schawnnomas, juvenile cataracts, meningiomas and ependymomas   Neurofibromatosis II; Autosomal Dominant, chromosome 22, gene NF2  
🗑
Café-au lait spots, polyostotic fibrous dysplasia, precocious puberty   McCune- Albright syndrome (mosaic G-protein signaling mutation)  
🗑
Calf pseudohypertrophy due to fibrofatty replacement of muscle   Muscular Dystrophy (most commonly Duchenne’s X-linked frameshift mutation of truncated dystrophin gene protein  
🗑
Cherry red spot on macula   Tay-Sachs (ganglioside accumulation); Niemann-Pick (sphingomyelin accumulation); central retinal artery occlusion  
🗑
Chest pain on exertion   Angina (stable: with moderate exertion; unstable: with minimal exertion)  
🗑
Chest pain, pericardial effusion/friction rub, persistent fever following MI   Dressler’s syndrome (autoimmune-mediated post MI fibrinous pericardits, 1-12 weeks after acute episode)  
🗑
Child uses arms to stand up from a squat   Gower’s sign (Duchenne muscular dystrophy)  
🗑
Child with fever develops red rash on face that spreads to body   Slapped cheeks (erythema infectiosum/fifth disease; parvovirus B19)  
🗑
Chorea, dementia, caudate degeneration:   Huntington’s disease (autosomal dominant CAG repeat expansion, boxed ventricles)  
🗑
Chronic exercise intolerance with myalgia, fatigue, painful cramps, myoglobinuria   McArdle’s Disease (muscle glycogen phosphorylase= Myophosphorylase deficiency)  
🗑
Cold intolerance   Hypothyroidism  
🗑
Conjugate lateral gaze palsy, horizontal diplopia   INO. Side where patient CANNOT ADDUCT is the damaged MLF side. B/L  
🗑
Continuous ‘machinery’ heart murmur   PDA. Close it with Indomethacin, open with Misoprostol.  
🗑
Cutaneous/dermal edema due to connective tissue deposition   Myxedema (caused by hypothyroidism, Grave’s disease (hyperthyroidism); both are periorbital.  
🗑
Dark purple skin/mouth nodules   Kaposi’s sarcoma. Usually AIDs patients or Mediterranean men. Associated with HHV-8  
🗑
Deep labored breathing/hyperventilation   Kassmaul breathing (diabetic ketoacidosis)  
🗑
Dermatitis, dementia, diarrhea   Pellagra (Niacin, B3, deficiency)  
🗑
Dilated cardiomyopathy, edema, polyneuropathy   Wet beriberi (thiamine, B1, deficiency  
🗑
Dog or cat bite resulting in infection   Pasteurella multocida (cellulitis at inoculation site)  
🗑
Dry eyes, dry mouth, arthritis   Sjogren’s syndrome (autoimmune destruction of EXOcrine glands)  
🗑
Dysphagia (esophageal webs), glossitis, iron deficiency anemia   Plummer-Vinson syndrome (may progress to esophageal squamous cell carcinoma)  
🗑
Elastic skin, hypermobility of joints   Ehlers-Danlos syndrome (type III collagen defect)  
🗑
Enlarged, hard, left supraclavicular node   Virchow’s node (abdominal metastasis)  
🗑
Erythroderma, lymphadenopathy, Hepatosplenomegaly, atypical T-cells   Sezary syndrome (cutaneous T-cell lymphoma) OR mycoses fungoides  
🗑
Facial muscle spasm upon tapping   Chvostek’s sign (hypocalcemia)  
🗑
Fat, female, forty, fertile   Acute Cholelithiasis (Gallstones)  
🗑
Fever, chills, headache, myalgia following antibiotic treatment for syphilis   Jarisch-Herxheimer reaction (rapid lysis of spirochetes results in toxin release)  
🗑
Fever, cough, conjunctivitis, coryza, diffuse rash   Measles (morbillivirus)  
🗑
Fever, night sweats, weight loss   B symptoms (lymphoma)  
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Fibrous plaques in soft tissue of penis   Peyronie’s disease (connective tissue disorder)  
🗑
Gout, mental retardation, self-mutilating behavior in a boy   Lesch-Nyhan syndrome (HGPRT deficiency, X-linked recessive)  
🗑
Green-yellow rings around peripheral cornea   Kayser-Fleischer rings (copper accumulation from Wilsons’ disease)  
🗑
Hamartomatous GI polyps, hyperpigmentation of mouth/feet/hands   Peutz-Jeghers sydrome (genetic benign polyposis that can cause bowel obstruction and increased cancer risk)  
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Hepatosplenomegaly, osteoporosis, neurologic symptoms   Gaucher’s disease (glucocerebroside deficiency)  
🗑
Hereditary nephritis, sensineural hearing loss, cataracts   Alport syndrome (mutation in alpha-chain of collagen IV)  
🗑
Hypercoagulability leading to migratory DVT and vasculitis   Trousseau’s sign (adenocarcinoma of pancreas or lung)  
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Hyperphagia, hypersexuality, hyperorality, docile   Kluver-Bucy Syndrome (bilateral amygdala lesion)  
🗑
Hyperreflexia, hypertonia, postive babinski-sign   UMN damage  
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Hypertension, Hypokalemia (low K+), metabolic alkalosis   Conn’s syndrome  
🗑
Hyporeflexia, hypotonia, atrophy   LMN damage  
🗑
Hypoxemia, polycythemia, hypercapnia   Blue bloater (chronic bronchitis: hyperplasia of mucous cells)  
🗑
Indurated ulcerated genital lesion   Non-painful: chancre from primary syphilis (Treponema pallidum)/Painful with exudate: chancroid (haemophilus ducreyi)  
🗑
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration   Niemann-Pick disease (genetic sphingomyelinase deficiency)  
🗑
Infant with hypoglycemia, failure to thrive, hepatomegaly   Cori disease (debranching enzyme deficiency)  
🗑
Infant with microcephaly, rocker-bottom feet, clenched hands, structural heart defect   Edwards syndrome(trisomy 18)  
🗑
Keratin pearls on skin biopsy   Squamous cell carcinoma  
🗑
Large rash with bull’s eye appearance   Erythma chronicum migrans from Ixodes tick bite (lyme disease-borrelia  
🗑
Lucid interval after traumatic brain injury   Epidural hematoma (middle meningeal artery rupture)  
🗑
Male child, recurrent infections, no mature B cells   Brutons disease (X-lined agammaglobulinemia) Little boys  
🗑
Mucosal bleeding with prolonged bleeding time   Glanzmann’s thrombasthenia (defect in platelet aggregation due to lack of GpIIb/IIIa)  
🗑
Multiple skin polyps, osteomas/soft tissue tumors, impacted supranumerary teeth   Gardner’s syndrome (subtype of FAP)  
🗑
Myopathy, infantile hypertrophic cardiomyopathy, exercise intolerance   Pompe’s disease (lysosomal a,1-4 glucosidase deficiency)  
🗑
Necrotizing vascultitis in lungs and necrotizing glomerulonephritis   Wegener’s C-ANCA(+) and Goodpastures (anti-basement antibodies)  
🗑
Neonate with arm paralysis following difficult birth   Erb-Duchenne Palsy  
🗑
No lactation postpartum, absent menstruation, cold intolerance   Sheehan’s syndrome (pituitary infarction)  
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Nystagmus, intention tremor, scanning speech, BL INO   MS  
🗑
Oscillating slow/fast breathing   Cheyne-Stokes respirations. Central apnea in CHF or in increase intracranial pressure  
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Painful blue fingers, toes and hemolytic anemia   cold agglutinin disease (autoimmune hemolytic anemia caused by mycoplasma infections and mono)  
🗑
Painful, pale, cold fingers and toes   Raynaud’s syndrome (vasospasm in extremities)  
🗑
Painful, raised red lesions on palms and soles   Osler’s nodes (infective endocarditis)  
🗑
Painless erythematous lesions on palms and soles   Janeway lesion (infective endocarditis)  
🗑
Painless jaundice   Cancer of pancreatic head obstructing the bile duct  
🗑
Palpable purpura on buttocks/ legs, joint painm abdominal pain in a kid   Henoch-Schonlein purpura (IgA vasculitis affecting skin and kidneys)  
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Pancreatic, pituitary and parathyroid tumors   MEN1 (autosomal dominant)  
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Pink complexion, dyspnea, hyperventilation   pink-puffer from emphysema. Centroacinar is from smoking, panacinar is a1-antitrypsin deficiency  
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Polyuria, acidosis, growth failure, electrolyte imbalances   Fanconi syndrome (proximal tubular reabsorption defect)  
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Positive anterior ¨drawer sign¨   Anterior Cruciate Ligament injury  
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Ptosis, miosis, anhidrosis   Horner’s syndrome (sympathetic chain lesion)  
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Pupil accommodates but does not react   Argyll Robertson pupil (neurosyphilis)  
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Rapidly progressive leg weakness that ascends following a GI or URI   Guillain Barre syndrome (autoimmune acute inflammatory demyelinating polyneuropathy)  
🗑
Rash on palms and soles   Coxsackie A, Secondary Sypilis, Rocky Mountain Spotted Fever  
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Recurrent colds, unusual eczema, high serum IgE   Hyper-IgE syndrome (Job’s syndrome, neutrophil chemotaxis abnormality)  
🗑
Red “current jelly”sputum in alcoholic or diabetic patients   Klebsiella pneumonia  
🗑
Red itchy, swollen rash of nipple/areola   Paget’s disease of breast (underlying neoplasm)  
🗑
Red pee in the morning, fragile RBCs   Paroxysmal nocturnal hemoglobinuria  
🗑
Renal cell carcinoma (BL) hemangioblastomas, angiomatosis, pheochromocytoma   Von Hippel-Lindau disease (dominant tumor suppressor gene mutation)  
🗑
Resting tremor, rigidity, akinesia, postural instability   Parkinson’s (nigrostriatal dopamine depletion)  
🗑
Retinal Hemorrhages with pale centers   Ruth’s spots (bacterial endocarditis)  
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Severe Jaundice in neonate   Crigler-Najjar syndrome (congential unconjugated hyperbilirubinemia)  
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Severe RLQ pain with rebound tenderness   McBurney’s sign (appendicitis)  
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Short stature, increased incidence of tumors/leukemia, aplastic anemia   Down Syndrome-Fanconi anemia (genetic loss of DNA crosslink repair, often progresses to AML  
🗑
Single palm crease   Simian Crease (Downs)  
🗑
Situs inversus, chronic sinusitis, bronchiectasis, infertility   Kartagener’s syndrome (dyenin arm defect affecting cilia)  
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Skin hyperpigmentation   Addison’s disease (primary adrenocortical insufficiency causes increase in ACTH and a-MSA production)  
🗑
Slow, progressive, muscle weakness in boys   Becker’s muscular dystrophy (X-linked missence mutation in dystrophin, less severe than Duchenne’s)  
🗑
Small irregular red spots on buccal/lingual mucosa with blue/white centers   Koplik spots (measles: rubEOla virus)  
🗑
Smooth, flat, moist white lesion on genitals   Condylomata lata (secondary syphilis)  
🗑
Splinter hemorrhages in fingernails   bacterial endocarditis  
🗑
“Strawberry tongue”   Scarlet fever, Kawasaki disease, toxic shock syndrome  
🗑
Streak ovaries, congenital heart disease, horseshoe kidney, cystic hygroma at birth   Turner Syndrome (45XO, short stature, webbed neck, lymphedema)  
🗑
Sudden swollen/painful big toe joint   Gout/podagra (hyperuricemaia)  
🗑
Swollen gums, mucous bleeding, poor wound healing, spots on skin   Scruvy (Vitamin C deficiency). Cannot hydroxylate proline/lysine for collagen synthesis  
🗑
Swollen, hard, painful finger joints   Osteoarthritis (osteophytes on PIP;bouchard’s nodes, DIP is Heberden’s nodes  
🗑
Systolic ejection murmur that is creshendo-decreshendo   aortic valve stenosis  
🗑
Thyroid and Parathyroid, pheochromocytoma   MEN 2A (autosomal dominant ret mutation)  
🗑
Thyroid tumors, pheochromocytoma, ganglioneuromatosis   MEN 2B (autosomal dominant ret mutation)  
🗑
Toe extension/fanning upon plantar scrape   Bakinski sign (UMN)  
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Unilateral facial drooping involving forehead   Bell’s palsy (LMN CN VII palsy)  
🗑
Urethritis, conjuctivitis, arthritis in male   Reactive Arthritis associated with HLA-B27  
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Vascular birthmark (port-wine stain)   Hemangioma (benign but associated with Sturge-Weber syndrome)  
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Vomiting blood following esophagogastric lacerations   Mallory Weiss syndome (alcoholic and bulemic patients)  
🗑
Waxy Casts with very low urine flow   Chronic end stage renal disease  
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WBC casts in urine   Acute pyelonephritis  
🗑
Weight loss, diarrhea, fever, adenopathy   Whipple disease (Tropheryma whippelii)  
🗑
Worst headache of my life   Subarachnoid hemorrhage  
🗑
Anticentromere antibodies   Scleroderma (CREST)  
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Antidesmoglein (epithelial antibodies)   Pemphigus vulgaris (blistering)  
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Anti-glomerular basement membrane antibodies   Goodpasture's syndrome (glomerulonephritis and hemoptysis)  
🗑
Anti-histone antibodies   Drug induced SLE (hydralazine, isoniazid, phenytoin, procainamide)  
🗑
Anti-IgG antibodies   RA (systemic inflammation, joint pannus, boutonniere deformity)  
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Anti-mitochondrial antibodies (AMAs)   Primary biliary cirrhosis (female, cholestasis, portal HTN)  
🗑
Antineutrophil cytoplasmic antibodies (ANCAs)   Vasculitis: c-ANCA in Wegener's and p-ANCA in microscopic polyangitis, Churg-Strauss  
🗑
ANA (Anti-Smith and anti-dsDNA) is associated with what disease?   SLE (type III hypersensitivity)  
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Antiplatelet antibodies   Idiopathic thrombocytopenic purpura (ITP)  
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Anti-topisomerase antibodies   Diffuse systemic scleroderma  
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Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies   Celiac disease (diarrhea, distension, weight loss)  
🗑
¨Apple core¨lesion on abdominal x-ray   Colorectal cancer (usually left sided)  
🗑
Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblasts   Auer rods. Acute Myelogenous Leukemia, AML. Especially the M3 type= t(15;17)  
🗑
Bacitracin resistant   Streptococcus agalactiae, group B  
🗑
Bacitracin sensitive   Streptococcus pyogenes, group A  
🗑
¨Bamboo spine¨ on X-ray   Ankylosing spondylitis (chronic inflammatory arthritis, HLA-B27+)  
🗑
Basophilic nuclear remnants in RBC   Howell-Jolly bodies (due to splenectomy or non-functional spleen)  
🗑
Basophilic stippling of RBC   Lead poisoning or sideroblastic anemia  
🗑
Bloody tap on LP   Subarachnoid Hemorrhage  
🗑
¨Boot shaped heart¨ on x-ray   Tetralogy of Fallot, RVH  
🗑
Branching gram positive rods with sulfur granules   Actinomyces israelii (anaerobe, NOT acid fast, resembles Fungi)  
🗑
Bronchogenic apical lung tumor   Pancoast tumor; can compress the sympathetic ganglion and cause Horner's syndrome  
🗑
¨Brown¨ tumor of bone   Hemorrhage (hemosiderin) causes the brown color of osteolytic cysts. Due to 1) Hyperparathyroidism and 2) Osteitis fibrosa cystica  
🗑
Cardiomegaly with apical atrophy   Chaga's disease (Trypanosoma cruzi)  
🗑
Cellular crescents in Bowman's capsule   Rapidly progressive crescentic glomerulonephritis  
🗑
Chocolate cyst of ovary   Endometriosis (frequently involves both ovaries)  
🗑
Circular grouping of dark tumor cells surrounding pale neurofibrils   Homer Wright rosettes (neuroblastoma, medulloblastoma and retinoblastoma)  
🗑
Colonies of pseudomonas in the lung   Cystic fibrosis (AR Mutation to CFTR resulting in fat-soluble vitamin deficiency and mucous plugs) Chromosome 7  
🗑
DECREASED alpha-fetoprotein in amniotic fluid or maternal serum   Down Syndrome (trisomy 21) and Edward Syndrome (trisomy 18)  
🗑
Degeneration of Dorsal columns   Tabes dorsalis (Tertiary syphilis). Test spinal fluid with VDRL or RPR  
🗑
Depigmentation of neurons in Substantia Nigra   Parkinson's disease (Basal ganglia; rigidity, resting tremor, bradykinesia)  
🗑
Desquamated epithelium casts in sputum   Curschmann's spirals (bronchial asthma and can result in whorled mucous plugs)  
🗑
Disarrayed granulosa cells in eosinophilic fluid   Call-Exner bodies (granulosa-theca cell tumor of ovary)  
🗑
Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia   Koilocytes (HPV; predisposes to cervical cancer)  
🗑
Enlarged cells with intranuclear inclusion bodies, ¨Owl´s Eye¨inclusions   CMV (HHV-5; latent in Mononuclear Cells)  
🗑
Enlarged thyroid cells with ground glass nuclei   Orphan Annie cells: papillary carcinoma of the thyroid  
🗑
Eosinophilic cytoplasmic inclusion in liver cell   Mallory bodies (alcoholic liver disease)  
🗑
Eosinophilic cytoplasmic inclusion in nerve cell   Lewy body (Parkinson's)  
🗑
Eosinophilic globule in liver   Councilman body (toxic or viral hepatitis, often Yellow Fever)  
🗑
Eosinophilic inclusion bodies in cytoplasm of hippocampus nerve cells   Rabies Virus (Lyssavirus)  
🗑
Extracellular amyloid deposition of gray matter in the brain   Senile Plaques (Alzheimer's)  
🗑
Giant B cells with bilobed nuclei and prominent inclusions   Reed-Sternberg cells (Hodgkin's lymphoma)  
🗑
Glomerulus like structure surrounding vessel in germ cells   Schiller-Duval bodies (Yolk Sac tumor)  
🗑
¨Hair on end¨ or Crewcut appearance on X-ray   B-thalassemia or sickle cell due to marrow expansion  
🗑
hCG elevated   Choriocarcinoma, hydatiform mole (occurs with and without embryo)  
🗑
Heart nodules (granulomas)   Aschoff bodies (Rheumatic fever)  
🗑
Heterophile antibodies   EBV- infectious mononucleosis  
🗑
Hexagonal, double pointed needle-like crystals in bronchial secretions   Charcot-Leyden crystals (eosinophilic granules) in bronchial asthma  
🗑
High level of D-dimers   DVT, PE, DIC  
🗑
Hilar adenopathy, peripheral granulomatous lesion in middle or lower lobe that can calcify   Ghon complex in primary TB  
🗑
Honeycomb lung on x-ray/CT   Interstitial fibrosis  
🗑
Hypersegmented neutrophils   Megaloblastic anemia (B12 deficiency, neurologic symptoms, folate deficiency= no neurologic symptoms  
🗑
Hypochromic, microcytic anemia   Iron deficiency anemia, lead poisoning, thalassemia (HbF sometimes present)  
🗑
INCREASED alpha-fetoprotein in amniotic fluid/maternal serum   1) Dating error, multiple gestation 2) (NTD): anencephaly, spina-bifida 3) Abdominal Wall defects: Gastroschisis, Omphalocele  
🗑
Increased uric acid levels   Gout, Lesh-Nyhan syndrome, tumor lysis syndrome, loop and thiazine diuretics  
🗑
Intranuclear eosinophilic droplet-like bodies   Cowdry type A bodies (HSV and CMV)  
🗑
Iron containing nodules in alveolar septum   Ferruginous bodies (asbestos increases the chance for Mesothelioma)  
🗑
Large lysosomal vesicles in phagocytes, immunodeficiency   Chediak Higashi (failure of phagolysosome formation), Autosomal recessive  
🗑
¨Lead pipe¨ appearance of colon on x-ray   Ulcerative Colitis (loss of haustra)  
🗑
Linear appearance of glomeruli on immunofluorescence   Goodpasture's syndrome (Glomerulonephritis + hemoptysis)  
🗑
Low serum ceruloplasmin   Wilson's disease (hepatolenticular degeneration), AR chromosome 13  
🗑
¨Lumpy-bumpy¨ on Immunofluorescence due to IgG, IgM and C3 deposition along GBM and Mesangium   Acute Poststreptococcal glomerulonephritis (Associations: Type III hypersensitivity; Children; 2 weeks after pharynx or skin infection with Group A strep)  
🗑
Lytic (¨Hole punched¨) bone lesions on x-ray   Multiple Myeloma (Monoclonal Plasma Cell cancer)  
🗑
Mammary gland (¨blue domed¨ ) cyst   Fibrocystic change of the breast  
🗑
Monoclonal antibody spike   1) Multiple Myeloma; usually IgG (55%), IgA (25%) 2) MGUS 3) Waldenstrom Macroglobulinemia M spike= IgM 4) Primary Amyloidosis  
🗑
Monoclonal Ig Light Chains in urine   Bence Jones proteins in Multiple Myeloma  
🗑
Mucin-filled cell with peripheral nucleus   Signet ring (gastric carcinoma)  
🗑
Needle shaped, negatively birefringent crystals   Gout (monosodium urate crystals)  
🗑
Nodular hyaline deposits in glomeruli   Kimmelstiel-Wilson nodules (Diabetic Nephropathy)  
🗑
Novobiocin sensitive   Staphylococcus epidermidis  
🗑
Novobiocin resistant   Staphylococcus saphrophyticus  
🗑
¨Nutmeg¨ liver   Chronic passive congestion of liver due to Right Heart Failure  
🗑
¨Onion skin¨ periosteal reaction   Ewing´s sarcoma (malignant round cell tumor)  
🗑
Periosteum raised from bone creating triangular area   Codman's triangle on x-ray (osteosarcoma, Ewing´s Sarcoma, Pyogenic Osteomyelitis)  
🗑
Podocyte fusion or ¨effacement¨ on EM   Minimal change disease (child with nephrotic syndrome)  
🗑
Polished 'ivory like' appearance of bone at cartilage erosion   Eburnation (osteoarthritis resulting in bony sclerosis)  
🗑
Protein aggregates in neurons from hyperphosphorylation of protein tau   Neurofibrillary tangles= Alzheimer's disease and Pick´s Bodies= Pick´s disease  
🗑
Pseudopalisading tumor cells on brain biopsy   Glioblastoma multiforme  
🗑
RBC casts in urine   Acute glomerulonephritis  
🗑
Rectangular, crystal-like, cytoplasmic inclusions in Leydig Cells   Reinke crystals (Leydig cell tumor)  
🗑
Renal epithelial casts in urine   Acute toxic/viral Nephrosis  
🗑
Rhomboid crystals, postively birefringent   Pseudogout (calcium pyrophosphate dihydrate crystals)  
🗑
Rib notching   Coarctation of the Aorta  
🗑
Ring enhancing brain lesion in AIDS   Toxoplasma gondii, Brain Abscesses. CD4+<100  
🗑
Sheets of medium-sized lymphoid cells with scattered pale, tingible body-laden macrophages "starry sky appearance on histology"   Burkitt Lymphoma, t(8:14) c-myc activation, associated with EBV- ¨black sky¨made up of malignant cells  
🗑
Silver staining spherical aggregation of tau proteins in neurons   Pick bodies (Pick's disease is a progressive dementia, changes in personality) Frontotemporal  
🗑
¨Soap bubble¨ in femur or tibia on x-ray   Giant cell tumor, generally benign  
🗑
¨Spikes¨ on basement membrane, ¨dome-like¨ subepithelial deposits   Membranous glomerulonephritis that may progress to nephrotic syndrome  
🗑
Stacks of RBCs   Rouleaux formation (high ESR, Multiple Myeloma)  
🗑
Stippled vaginal epithelial cells   Clue cells (Gardnerella vaginalis)  
🗑
Tennis racket shaped cytoplasmic organelles (EM) in Langerhan's cells   Birbeck granules (Langerhans cell histiocytosis or Histiocytosis X: eosinophilic granuloma)  
🗑
Thrombi made of white/red layers   Lines of Zahn (arterial thrombosis, layers of platelets/RBC)  
🗑
¨Thumb sign¨ on lateral x-ray   Epiglottitis (H. Influenza)  
🗑
Thyroid-like appearance of kidney   Chronic bacterial pyelonephritis  
🗑
¨Tram-track¨ appearance on LM   Membranoproliferative glomerulonephritis  
🗑
Triglyceride accumulation in liver cell vacuoles   Fatty liver disease (alcholic or metabolic syndrome)  
🗑
WBC that look¨smudged¨   CLL (almost always B-cell, affects elderly)  
🗑
¨Wire-loop¨ glomerular capillary appearance on LM   Lupus nephropathy  
🗑
Yellow CSF on LP   Xanthochromia (previous Subarachnoid Hemorrhage)  
🗑
Absence seizures treatment   Ethosuximide (Blocks thalamic T-type Ca+2 channels)  
🗑
Acute Gout treatment   NSAIDS, Colchicine  
🗑
Acute Promyelocytic Leukemia (M3)   All-trans retinoic acid  
🗑
ADHD   Methylphenidate, amphetamines  
🗑
Alcohol Abuse   AA + disulfram,naltrexone or acamprosate for patient. Al-Anon for family  
🗑
Alcohol Withdrawal   Benzodiazepines  
🗑
Anorexia   SSRIs  
🗑
Anticoagulation during pregnancy   Heparin  
🗑
Anxiety   Buspirone  
🗑
Arrhythmia in damaged cardiac tissue   Class IB anti-arrhythmic (lidocaine, mexiletine, tocainide)  
🗑
B12 Deficiency   B12 supplementation (work up cause with Schilling test)  
🗑
Benign Prostatic Hyperplasia   Tamsulosin, Finasteride  
🗑
Bipolar Disorder   ¨Mood Stabilizers¨(e.g Lithium, Valproic acid, Carbamazepine) + Atypical antipsychotics  
🗑
Breast cancer in POSTMENOPAUSAL women   Aromatase inhibitor (Anastrozole)  
🗑
Buerger's disease   Smoking Cessation  
🗑
Bulemia   SSRIs  
🗑
Candida albicans   Amphotericin B (systemic), nystatin (oral thrush, esophagitis), azoles (vaginitis)  
🗑
Carcinoid syndrome   Octreotide (Somatostatin analog)  
🗑
Chlamydia trachomatis   Doxycycline (+ ceftriaxone for gonorrhea co-infection), erythromycin eye drops (prophylaxis in infants)  
🗑
Chronic Gout   Probenecid (underexcretor), Allopurinol (over-producer)  
🗑
Chronic hepatitis   IFN-alpha  
🗑
Chronic Myelogenous Leukemia   Imatinib  
🗑
Clostridium botulinum   Anti-toxin  
🗑
Clostridium difficile   Oral Metronidazole; if refractory, Oral Vancomycin  
🗑
Clostridium tetani   Anti-toxin +vaccine booster +diazepam  
🗑
Crohn's disease   Corticosteriods, Infliximab (monoclonal antibody to TNF-alpha)  
🗑
Cryptococcus neoformans   Fluconazole (prophylaxis in AIDS)  
🗑
CMV   Ganciclovir (Guanosine analog; inhibits viral DNA Polymerase)  
🗑
Depression   SSRIs (first line)  
🗑
Diabetes insipidus   Desmopressin (central); hydrochlorothiazide, indomethacin, amiloride (nephrogenic)  
🗑
Diabetes type I (Autoimmune destruction beta cells)   Low sugar diet + insulin replacement  
🗑
Diabetes type II (progressive pancreatic beta cell failure)   Diet, oral hypoglycemics and possible insulin  
🗑
Diabetic Ketoacidosis   Fluids, insulin, K+  
🗑
Enterococci   Vancomycin/ampicillin + aminoglycoside  
🗑
Erectile Dysfunction   Sildenafil (inhibits Phosphodiesterase 5)  
🗑
ER-positive breast cancer   Tamoxifen (Selective Estrogen Receptor Modulator- SERMs)  
🗑
Ethylelene glycol/methanol intoxication   Fomepizole (alcohol dehydrogenase inhibitor)  
🗑
Folate deficiency   Folate  
🗑
Haemophilus influenzae B   Rifampin, prophylaxis (inhibits DNA-dependent RNA polymerase)  
🗑
Hemorrhagic Cystitis caused by Cyclophosphamide can be PREVENTED with   Mesna (Thiol group of Mesna binds Acrolein)  
🗑
Heparin Toxicity, Acute   Protamine sulfate  
🗑
HER2/NEU positive breast cancer   Trastuzumab (Monoclonal antibody against HER-2 (c-erbB2), a tyrosine kinase receptor)  
🗑
Hyperaldosteronism   Spironolactone, K+ Sparing Diuretic (Competitive Aldosterone Receptor Antagonists in the Cortical Collecting Tubule)  
🗑
Hypercholesteremia   Statins, 1st Line (HMG-CoA reductase inhibitor)  
🗑
Hypertriglyceridemia   Fibrate  
🗑
Immediate anti-coagulation   Heparin  
🗑
Infertility   Leuprolide (GnRH analog), GnRH (pulsatile)  
🗑
Influenza   Rimantadine/Oseltamivir (inhibit Influenza neuraminidase)  
🗑
Legionella Pneumonia   Erythromycin (Macrolide; bacteriostatic; inhibits protein synthesis by blocking translocation. It binds 23S rRNA or the 50S ribosomal subunit  
🗑
Long term anticoagulation   Warfarin (Interferes with gamma-carboxylation of Vit K-dependent clotting factors: 2,7,9,10 and proteins C and S  
🗑
Malaria   Chloroquine/mefloquine (blood schizont) and Primaquine (liver hypnozoite)  
🗑
Malignant hyperthermia (caused by:Inhaled Anesthetics EXCEPT, Nitrous Oxide and Succinylcholine)   Dantrolene (prevents release of Ca+2 from sarcoplasmic reticulum of skeletal muscle)  
🗑
Medical Abortion   Mifepristone (anti-Progestin)  
🗑
Migraine   Sumatriptan (Serotonin 1B/1D agonist)  
🗑
MRSA   Vancomycin (inhibits cell wall peptidoglycan formation by binding D-ala D-ala )  
🗑
Multiple Sclerosis   B-interferon  
🗑
TB   RIPE: Rifampin, INH, Pyrazinamide, Ethambutol,  
🗑
Neisseria gonorrhoeae   Ceftriaxone (add doxycycline to cover likely concurrent Chlamydia)  
🗑
Neisseria meningitidis   Pennicillin/ceftriaxone, and rifampin for prophylaxis  
🗑
Neural tube defect PREVENTION   Folate  
🗑
Osteomalacia/Rickets   Vitamin D supplementation  
🗑
Patent ductus arteriosus   Indomethacin  
🗑
Pheochromoctoma   Alpha-antagonists (e.g Phenoxybenzamine)  
🗑
Pneumocystis- jiroveci   TMP-SMX (prophylaxis in AIDS)  
🗑
Prolactinoma   Bromocriptine (dopamine agonists)  
🗑
Prostate cancer and uterine fibroids   Leuprolide, GnRH (continuous)  
🗑
Prostate carcinoma   Flutamide  
🗑
Pseudomonas aeruginosa   Anti-pseudomonal penicillin +aminoglycoside  
🗑
Pulmonary arterial hypertension (Idiopathic)   Sildenafil, Bosentan, Epoprostenol  
🗑
Rickettsia rickettsii   Doxycycline, Cloramphenicol (especially in the context of aplastic anemia)  
🗑
Ringworm infections   Terbinafine, griseofulvin, imidazole  
🗑
Schizophrenia-negative symptom   5-HT2A antagonists (Olamzapine)  
🗑
Schizophrenia-positive symptoms   D2 receptor antagonists (1st and 2nd generation antipsychotics)  
🗑
SIADH   Demeclocycline, lithium, vasopressin receptor antagonists  
🗑
Sickle cell anemia   Hydroxyurea (increases fetal hemoglobin)  
🗑
Sporothrix schenckii   Oral Potassium Chloride  
🗑
Stable angina   Sublingual nitroglycerin  
🗑
Staph aureus   MSSA: nafcillin, oxacillin, dicloxacillin (antistaphylococcal penicillins); MRSA: Vancomycin  
🗑
Streptococcus bovis   Penicillin prophylaxis; Evaluation for Colon Cancer if linked to Endocarditis  
🗑
Streptococcus pneumoniae   Penicillin/cephalosporin (systemic infection or pneumonia)/Vancomycin (Meningitis)  
🗑
Streptococcus pyogenes   Penicillin prohphylaxis  
🗑
Temporal arteritis   High Dose steroids  
🗑
Tonic-Clonic Seizures   Phenytoin, Valproate, Carbamazepine  
🗑
Toxoplasma gondii   Sulfonamide + pyrimethamine  
🗑
Treponema pallidum   Penicillin  
🗑
Trichomonas vaginalis   Metronidazole (patient + partner)  
🗑
Ulcerative colitis   5-ASA, infliximab  
🗑
UTI prophylaxis   TMP-SMX  
🗑
Warfarin Toxicity   Fresh frozen plasma (acute) and Vitamin K (chronic)  
🗑
Wegener's Granulomatosis   Cyclophosphamide, corticosteriods  
🗑
Clear cell adenocarcinoma of the vagina   DES exposure in utero  
🗑
Congenital adrenal hyperplasia with hypotension   21-hydroxylase deficiency  
🗑
Congenital conjugated hyperbilirubinemia (black liver)   Dubin-Johnson syndrome (inability of hepatocytes to secrete conjugated bilirubin into bile)  
🗑
Constrictive pericarditis   Tuberculosis (developing world), SLE in developed world  
🗑
Coronary artery involved in thrombosis   LAD>RCA>LCA  
🗑
Cretinism   Iodine deficit/Congenital hypothyroidism  
🗑
Cushings syndrome   *Iatrogenic Cushing´s (from Corticosteroid therapy) *Adrenocortical Adenoma (secretes excess cortisol) *ACTH secreting pituitary adenoma *Paraneoplastic Cushing´s (due to ACTH secretion by tumors)  
🗑
Cyanosis (early, less common)   Tetralogy of Fallot, transposition of great vessels, truncus arteriosus  
🗑
Cyanosis (late, more common)   VSD, ASD, PDA  
🗑
Death in CML   Blast crisis  
🗑
Death in SLE   Lupus nephropathy  
🗑
Dementia   Alzheimer's/ Multiple infarcts  
🗑
Demyelinating disease in young women   MS  
🗑
DIC   Gram negative sepsis, obstetric complications, cancer, burns, trauma, major surgery  
🗑
Dietary deficit   Iron  
🗑
Diverticulum in pharynx   Zenker's diverticulum (diagnosed by barium swallow)  
🗑
Ejection click   Aortic/pulmonic stenosis  
🗑
Esophageal cancer   Squamous cell carcinoma (worldwide) Adenocarcinoma (US)  
🗑
Food poisoning (exotoxin mediated)   S aureus, B. cereus  
🗑
Glomerulonephritis in adults   Berger's disease (IgA nephropathy)  
🗑
Gynecologic malignancy   Endometrial carcinoma (US), Cervical carcinoma (worldwide)  
🗑
Heart murmur, congential   Mitral valve prolapse  
🗑
Heart valve in bacterial endocarditis   Mitral (rheumatic fever), tricuspid (IV drug use), aortic (second affected in rheumatic fever)  
🗑
Helminth infection (US)   1) Enterobius vermicularis 2) Ascaris lumbricoides  
🗑
Hematoma- Epidural   Rupture of middle meningeal artery (trauma), lentiform shaped  
🗑
Hematoma-Subdural   Rupture of bridging veins (crescent shaped)  
🗑
Hemochromatosis   Multiple blood transfusions or hereditary HFE mutation that can result in CHF, bronze diabetes and increased risk for Hepatocellular Carcinoma  
🗑
Hepatocellular carcinoma   Cirrhotic liver (associated with both hepatitis B and C and with alcoholism)  
🗑
Hereditary bleeding disorder   von-Willebrand disease (autosomal dominant)  
🗑
Hereditary harmless jaundice   Gilbert's syndrome (benign congenital unconjugated hyperbilirubinemia)  
🗑
HLA-B27   Ankylosing spondylitis, Reiter's syndrome, ulcerative colitis, psoriasis  
🗑
HLA-DR3 or DR4   Diabetes Mellitus type 1, RA, SLE  
🗑
Holosystolic murmur   VSD, tricuspid regurgitation, mitral regurgitation  
🗑
Hypercoagulability, endothelial damage, blood stasis   Virchow's triad (results in venous thrombosis)  
🗑
Secondary hypertension   Renal Disease  
🗑
Hypoparathyroidism   Accidental excision during thyroidectomy  
🗑
Hypopituitarism   pituitary adenoma (usually bengin)  
🗑
Infection secondary to blood transfusion   Hepatitis C  
🗑
Infections in chronic granulomatous disease   Staph aureus, E Coli, Aspergillus (catalase positive)  
🗑
Kidney stones-radiopaque   Calcium  
🗑
Kidney stones-radiopaque, urease positive   Struvite (ammonium), formed by urease positive organisms such as proteus vulgaris or staphyloccus  
🗑
Kidney stones-radiolucent   Uric acid  
🗑
Late cyanotic shunt; uncorrected L->R becomes R->L   Eisenmenger's syndrome. Caused by ASD, VSD, PDA and results in pulmonary HTN/polycythemia  
🗑
Lysosomal storage disease   Gaucher's disease  
🗑
Male cancer   Prostatic carcinoma  
🗑
Malignancy associated with non-infectious fever   Hodgkin's Lymphoma  
🗑
Malignant skin tumor that rarely metastasizes   Basal cell carcinoma  
🗑
Mental retardation (genetic)   1. Down syndrome 2. Fragile X syndrome  
🗑
Metastases to bone   Prostate (blastic),Breast (lytic and blastic)> lung> thyroid  
🗑
Metastases to brain   Lung> breast> genitourinary> osteosarcoma> melanoma> GI  
🗑
Metastases to liver   Colon>> stomach> pancreas  
🗑
Mitochondrial inheritance   Disease occurs in both daughters and sons; inherited through mother ONLY  
🗑
Mitral valve stenosis   Rheumatic heart diease  
🗑
Mixed UMN and LMN disease   Amyotrophic Lateral Sclerosis= ALS  
🗑
Myocarditis   Coxsackie B  
🗑
Neoplasm in Kids   ALL and cerebellar medulloblastoma  
🗑
Nephrotic syndrome; African American Adults   Focal Segmental glomerulosclerosis  
🗑
Nephrotic syndrome in Caucasian adults   Membranous Nephropathy; commonly associated with solid tumors. Work up for colon cancer  
🗑
Nephrotic syndrome in Kids   Minimal change diease; associated with infections and vaccinations. Treat with steriods  
🗑
Neuron migration failure   Kallman syndrome  
🗑
Nosocomial pneumonia   Klebsiella, E. Coli, Pseudomonas aeruginosa  
🗑
Obstruction in male urinary tract   BPH  
🗑
Opening snap   Mitral stenosis  
🗑
Opportunistic infection in AIDS   Pneumocystis jiroveci pneumonia  
🗑
Osteomyelitis   S. aureus  
🗑
Osteomyelitis in sickle cell disease   Salmonella  
🗑
Osteomyelitis with IV drug use   Pseudomonas, S. aureus  
🗑
Ovarian metastasis from gastric carcinoma or breast cancer   Krukenberg tumor (mucin secreting signet-ring cells)  
🗑
Ovarian tumor that is benign and bilateral   Serous cystadenoma  
🗑
Pancreatitis, acute   Gallstones, alcohol  
🗑
Pancreatitis, chronic   Alcohol (adults) and CF in Kids  
🗑
Hematological malignancy in kids   ALL  
🗑
Hematological malignancy in adults   CLL and AML (60) and CML ages 30-60  
🗑
PID   Neisseria gonorrhoeae (monoarticular arthritis)  
🗑
Philadelphia chromosome t(9:22), bcr-abl   CML, sometimes associated with ALL and AML  
🗑
Pituitary tumor   Prolactinoma and somatoropic acidophilic adenoma  
🗑
Primary amenorrhea   Turner syndrome (45 XO)  
🗑
Primary bone tumor in adults   Multiple myeloma  
🗑
Primary hyperaldosteronism   Adenoma of adrenal cortex  
🗑
Primary hyperparathyroidism   adenomas, hyperplasia, carcinoma  
🗑
Primary liver cancer   Heptocellular carcinoma from chronic hepatitis, cirrhosis, hemochromatosis and alpha-1 anti-tryspin  
🗑
Pulmonary HTN   COPD  
🗑
Recurrent inflammation/thrombosis of small and medium vessels in extremities   Buerger's diease, stronly associated with tobacco  
🗑
Renal tumor associated with von-Hippel-Lindau, adult polycystic kidney disease   Renal cell carcinoma  
🗑
What paraneoplastic syndromes is Renal Cell Carcinoma associated with?   EPO, renin, PTH, ACTH  
🗑
Right heart failure due to a pulmonary cause   Cor pulmonale  
🗑
S3   increased ventricular filling due to L-> R shunt, mitral regurg, LV failure, CHF  
🗑
S4   Stiff hypertrophic ventricle, aortic stenosis and restrictive cardiomyopathy  
🗑
Secondary hyperparathyroidism   Hypocalcemia of chronic kidney disease  
🗑
STD   Chlamydia, usually co-infected with gonorrhea  
🗑
SIADH   small cell carcinoma of lung  
🗑
Site of diverticula   Sigmoid colon  
🗑
Most common site of atherosclerosis   Abdominal aorta  
🗑
Stomach cancer   Adenocarcinoma  
🗑
Stomach cancer with high gastrin levels   Zollinger-Ellison syndrome (gastrinoma of duodenum or pancreas)  
🗑
t(14:18)   Follicular carcinoma with bcl-2 activation  
🗑
t(18:14)   Burkitt lymphoma with c-myc activation  
🗑
t(9:22)   Philadelphia chromosome  
🗑
Temporal arteritis   risk of ipsalateral blindness due to thrombosis of opthalmic artery, polymyalgia rheumatics  
🗑
Testicular tumor   Seminoma  
🗑
Thyroid cancer   papillary carcinoma  
🗑
Tumor in women   Leiomyoma (estrogen dependant, not pre-cancerous)  
🗑
Tumor of infancy   hemangioma, usually regresses spontaneously by childhood  
🗑
Tumor of adrenal medulla in adults   Pheochromocytoma (usually benign)  
🗑
Tumor of adrenal medulla in kids   Neuroblastoma (malignant)  
🗑
Type of non-Hodgkin's (common)   Nodular sclerosis  
🗑
non-Hodgkins   Diffuse large cell  
🗑
UTI   E coli, Staphlococcus saphrophyticus (young women)  
🗑
Viral encephalitis affecting temporal lobe   HSV-1  
🗑
Vitamin Deficiency in US   Folic acid. Pregnant women at high risk, body stores 3-4 month supply, prevents NTD  
🗑
Can be caused by alpha-1 antitrypsin deficiency, resulting in excess elastase activity   Emphysema  
🗑


   

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