Antiemetic, Antinausea drugs
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| show | Vomiting center (VC)
Chemoreceptor trigger zone (CTZ)
Both located in the brain
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| what are three pathways that lead to CTZ | show 🗑
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| show | Bind to & block acetylcholine (ACh) receptors in the inner ear labyrinth
Block transmission of nauseating stimuli to CTZ
Also block transmission of nauseating stimuli from the reticular formation to the VC
scopolamine- used for motion sickness
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| how do antihistamines help as antiemetics | show 🗑
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| show | Antidopaminergic drugs
Block dopamine receptors on the CTZ
Also used for psychotic disorders, intractable hiccups
prochlorperazine (Compazine)
promethazine (Phenergan)
droperidol (Inapsine): Use is controversial because of associated cardiac dysrhyth
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| how do prokinetic drugs help as antiemetics | show 🗑
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| how do serotonin blockers help as antiemetics | show 🗑
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| show | Major psychoactive substance in marijuana
Inhibitory effects on reticular formation, thalamus, cerebral cortex
dronabinol (Marinol)
Used for nausea & vomiting associated with chemotherapy, & anorexia associated with weight loss in AIDS patients
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| what herbal products act as antiemetics | show 🗑
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| all antiemetics can do what | show 🗑
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