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what are areas in body that trigger vomiting
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what are three pathways that lead to CTZ
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ch. 52 Pharm
Antiemetic, Antinausea drugs
| Question | Answer |
|---|---|
| what are areas in body that trigger vomiting | Vomiting center (VC) Chemoreceptor trigger zone (CTZ) Both located in the brain |
| what are three pathways that lead to CTZ | GI tract, labyrinth(inner ear), cerebral cortex |
| how do anticholinergics help as antiemetics | Bind to & block acetylcholine (ACh) receptors in the inner ear labyrinth Block transmission of nauseating stimuli to CTZ Also block transmission of nauseating stimuli from the reticular formation to the VC scopolamine- used for motion sickness |
| how do antihistamines help as antiemetics | Inhibit ACh by binding to H1 receptors Prevent cholinergic stimulation in vestibular and reticular areas, motion sickness, nonproductive cough, allergy symptoms, sedation dimenhydrinate (Dramamine) diphenhydramine (Benadryl) meclizine (Antivert) |
| how do antidopaminergic help as antiemetics | Antidopaminergic drugs Block dopamine receptors on the CTZ Also used for psychotic disorders, intractable hiccups prochlorperazine (Compazine) promethazine (Phenergan) droperidol (Inapsine): Use is controversial because of associated cardiac dysrhyth |
| how do prokinetic drugs help as antiemetics | Block dopamine in the CTZ Also stimulate peristalsis in GI tract, enhancing emptying of stomach contents Also used for GERD, delayed gastric emptying metoclopramide (Reglan)- Long-term use may cause irreversible tardive dyskinesia |
| how do serotonin blockers help as antiemetics | Block serotonin receptors. Used for patients receiving chemotherapy, postop nausea and vomiting. "On Dancer, On Prancer....Santa is bringin Zofran" dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran), palonosetron (Aloxi) |
| What are tetrahydrocannabinoids | Major psychoactive substance in marijuana Inhibitory effects on reticular formation, thalamus, cerebral cortex dronabinol (Marinol) Used for nausea & vomiting associated with chemotherapy, & anorexia associated with weight loss in AIDS patients |
| what herbal products act as antiemetics | Ginger- chemo, morning sickness, motion sickness. adverse effects: anorexia, N/V, skin reactions May increase absorption of oral medications Increase bleeding risk with anticoagulants |
| all antiemetics can do what | cause drowsy, dizzy, no alcohol, hypotension |
Created by:
palmerag
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