Cancer chemo drugs
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| Actinomycin | -Intercalates into DNA and blocks RNA and DNA synthesis
-IV
-Bone marrow depression, radiation recall
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| Anastrazole | -CYP19 aromatase inhibitor
-Oral
-Toxicity related to estrogen deficiency
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| (L)Aspariginase | -Degrades asparagine in the circulation and starves tumor cells for this amino acid
-IV
-Hypersensitivity reactions
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| Bevacizumab | -Antibody against VEGF
-IV
-Hypertension, GI perforation
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| Bleomycin | -Interacts with DNA and catalyzes free radical formation and DNA destruction
-IV, IM
-Pulmonary fibrosis, skin changes, radiation recall
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| Cisplatin | -Cross-linking DNA
-IV
-Bone marrow depression, renal tubuar damage
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| Cyclophosphamide | -Alkylation and cross-linking DNA
-IV, Oral
-Bone marrow depression, male sterility, amenorrhea
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| Cytosine arabinoside | -Inhibits DNA polymerase, mis-incorporates into DNA
-IV
-Bone marrow depression
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| Doxorubicin | -Inhibit Topoisomerase II/DNA complex
-IV
-Bone marrow depression, cardiomyopathy, radiation recall
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| Etoposide | -Inhibits Topoisomerase II/DNA complex
-Oral, IV
-Bone marrow depression
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| 5-florouracil | -Inhibits thymidylate synthetase, misincorporation into DNA
-IV
-Bone marrow depression
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| Gefitnib | -EGF receptor inhibitor
-Oral
-Skin problems
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| Hydroxyurea | -Inhibits ribonucleotide reductase
-Oral
-Bone marrow depression
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| Imatinib | -Inhibits ABL tyrosine kinase
-Oral
-Fluid retention
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| Irinotecan | -Inhibits Topoisomerase I/DNA complex
-IV, Oral
-Bone marrow depression
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| Leuprolide | -GnRH analog that causes GnRH receptor down regulation
-SubQ
-Hormone withdrawal effects
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| Mechlorethamine | -Alkylation & cross-linking DNA
-IV, intracavitary
-Bone marrow depression, male sterility, amenorrhea
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| Methotrexate | -DHF reductase inhibitor
-IV, Oral, intrathecal
-Bone marrow depression
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| Paclitaxel (Taxol) | -Binds tubulin, stabilizes microtubules
-IV
-Bone marrow depression, sensory neuropathy
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| Tamoxifen | -Estrogen receptor binder
-Oral
-Hot flashes, risk increase for endometrial cancer, thromboembolic events
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| 6-Thioguanine | -Inhibits purine biosynthesis
-Oral
-Bone marrow depression
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| Trastuzumab (Herceptin) | -Binds Her2 on cancer cells and stimulates antibody-dependent cellular cytotoxicity
-IV
-Cardiotoxic
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| Vinblastine | -Grabs tubulin, prevents microtubule polymerization
-IV
-Bone marrow depression, mild peripheral neuropathy
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| Vincristine | -Grabs tubulin, prevents microtubule polymerization
-IV
-Peripheral neuropathy
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| Allupurinol | -Inhibits xanthine oxidase to prevent uric acid buildup after cell death due to cytotoxic drugs
-Oral
-Sensitivity reactions
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| Leucovorin | -5-formyl-THF, rescues methotrexate toxicity
-IM, IV, Oral
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| Filgastim (G-CSF) | -Hematopoetic agent, stimulates neutrophil production
-IV, SubQ
-Mild to moderate bone pain, skin reactions
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