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Phar - Cancer Chemo
Cancer chemo drugs
| Question | Answer |
|---|---|
| Actinomycin | -Intercalates into DNA and blocks RNA and DNA synthesis -IV -Bone marrow depression, radiation recall |
| Anastrazole | -CYP19 aromatase inhibitor -Oral -Toxicity related to estrogen deficiency |
| (L)Aspariginase | -Degrades asparagine in the circulation and starves tumor cells for this amino acid -IV -Hypersensitivity reactions |
| Bevacizumab | -Antibody against VEGF -IV -Hypertension, GI perforation |
| Bleomycin | -Interacts with DNA and catalyzes free radical formation and DNA destruction -IV, IM -Pulmonary fibrosis, skin changes, radiation recall |
| Cisplatin | -Cross-linking DNA -IV -Bone marrow depression, renal tubuar damage |
| Cyclophosphamide | -Alkylation and cross-linking DNA -IV, Oral -Bone marrow depression, male sterility, amenorrhea |
| Cytosine arabinoside | -Inhibits DNA polymerase, mis-incorporates into DNA -IV -Bone marrow depression |
| Doxorubicin | -Inhibit Topoisomerase II/DNA complex -IV -Bone marrow depression, cardiomyopathy, radiation recall |
| Etoposide | -Inhibits Topoisomerase II/DNA complex -Oral, IV -Bone marrow depression |
| 5-florouracil | -Inhibits thymidylate synthetase, misincorporation into DNA -IV -Bone marrow depression |
| Gefitnib | -EGF receptor inhibitor -Oral -Skin problems |
| Hydroxyurea | -Inhibits ribonucleotide reductase -Oral -Bone marrow depression |
| Imatinib | -Inhibits ABL tyrosine kinase -Oral -Fluid retention |
| Irinotecan | -Inhibits Topoisomerase I/DNA complex -IV, Oral -Bone marrow depression |
| Leuprolide | -GnRH analog that causes GnRH receptor down regulation -SubQ -Hormone withdrawal effects |
| Mechlorethamine | -Alkylation & cross-linking DNA -IV, intracavitary -Bone marrow depression, male sterility, amenorrhea |
| Methotrexate | -DHF reductase inhibitor -IV, Oral, intrathecal -Bone marrow depression |
| Paclitaxel (Taxol) | -Binds tubulin, stabilizes microtubules -IV -Bone marrow depression, sensory neuropathy |
| Tamoxifen | -Estrogen receptor binder -Oral -Hot flashes, risk increase for endometrial cancer, thromboembolic events |
| 6-Thioguanine | -Inhibits purine biosynthesis -Oral -Bone marrow depression |
| Trastuzumab (Herceptin) | -Binds Her2 on cancer cells and stimulates antibody-dependent cellular cytotoxicity -IV -Cardiotoxic |
| Vinblastine | -Grabs tubulin, prevents microtubule polymerization -IV -Bone marrow depression, mild peripheral neuropathy |
| Vincristine | -Grabs tubulin, prevents microtubule polymerization -IV -Peripheral neuropathy |
| Allupurinol | -Inhibits xanthine oxidase to prevent uric acid buildup after cell death due to cytotoxic drugs -Oral -Sensitivity reactions |
| Leucovorin | -5-formyl-THF, rescues methotrexate toxicity -IM, IV, Oral |
| Filgastim (G-CSF) | -Hematopoetic agent, stimulates neutrophil production -IV, SubQ -Mild to moderate bone pain, skin reactions |
Created by:
bamcginty
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