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Pharm III exam

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Question
Answer
MOA of Metronidazole   Reactive metabolite damage of DNA and other macromolecules  
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MOA of Clindamycin   In hibits protein synthesis (50s ribosome)  
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MOA of TMP/SMX   Inhibits DNA synthesis by blocking the folate pathway  
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MOA of Aminoglycosides   Inhibits protein synthesis (30s ribosome)  
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MOR of Aminoglycosides   Enzyme inactivation (bacterial acetylase, adenylase, phosphorylase), altered target, dec. uptake  
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MOA of tetracyclines   Inhibit of protein synthesis at 30S ribosomal subunit  
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MOR of Tetracyclines   Decreased uptake  
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MOA of macrolides   Inhibits RNA-dependent protein synthesis 50s ribosomal subunits  
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MOR of Macrolides   Altered target, drug efflux  
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MOA of Penicillins   Inhibit cell wall formation  
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MOR of Penicillins   Enzyme inactivation (B-lactamase), alterred penicillin binding proteins (PBPs)  
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MOA of Cephalosporins   Inhibition of cell wall formation  
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MOR of Cephalosporins   Enzyme inactivation (B-lactamase), alterred penicillin binding proteins (PBPs)(strep pneumoniae)  
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MOR of carbapenems   Generally stable in presence of most B-lactamases (pseudomonas may have some resistance)  
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MOA of Monobactams   Binds to PBPs and inhibit cell wall formation  
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MOA of Vancomycin   Inhibits cell wall formation earlier than B-lactams  
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Vancomycin Resistance   VRE, VRSA  
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MOA of Fluroquinolones   Inhibits topoisomerases II and IV, DNA can't replicate  
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MOR of FLuroquinolones   Efflux pump, Gene mutations, permeability  
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Created by: becker15
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