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BC3 - Hematology Problems

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Question
Answer
What 3 ways can a body have anemia   Decreased production of RBC's; Blood Loss; Increased RBC destruction  
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Anemia r/t decreased production of RBC's   Decreased hemoglobin synthesis - bone marrow is not producing enough Defective DNA synthesis - congenital (ex: Sicle cell & thalesemia)  
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Anemia r/t blood loss   Acute (ex: car wreck) Chronic (ex: GI Bleeds in elderly; menstruating women)  
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Anemia r/t increased RBC destruction   (the body destroys) Intrinsic - congenital (ex: sicle cell - genetic) Extrinsic - chemotherapy - meds - radiation  
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Physiologic Effects of Anemia   Result from tissue hypoxia and compensatory mech - (^HR); Dec O2-casrrying capacity of blood; Hgb give up O2 easier to tissues; Blood goes to vital organs first; Inc cardiac output ^HR, ^BP; Inc rate of RBC production  
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Hbg Level of Mild Anemia   10-14  
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S/S of mild anemia   Palpitations, dyspnes, diaphoresis  
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Hgb Level of Moderate Anemia   6-10  
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S/S of Moderate Anemia   Inc. Cardiopulmonary s/s - chest pain; Pallor, Jaundice, Pruritis, Changes in fingernails - spoon-shaped, pale nail beds  
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Cardiopulmonary changes r/t anemia   Tachycardia, Tachypnea, dyspnea  
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Cardiopulmonary changes r/t anemia with prolonged chronic anemia   Murmurs, bruit in carotid, Angina, MI, CHF  
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Neurologic Changes r/t anemia   HA because of lack of O2, Vertigo, Mood changes, Impaired through process  
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GI Changes r/t anemia   Anorexia, Hepatomegaly, Splenomegaly  
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Musculosketal Changes r/t anemia   Bone pain because bone marrow is stimulated and is making more RBC  
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General s/s of anemia   Fatigue, weight loss, lethargy, sensitivity to cold  
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Etiology of Iron Deficiency Anemia   Inadequate dietary intake Malabsorption Blood loss & not replacing it; Over time - GI bleed Hemolysis - breaking down cells too quickly  
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Nutrients needed for erythropoiesis   Iron, Vitamin B 12 - cobalamin, Folic Acid, Proteins, Enzymes, Minerals - Fe & Calcium  
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Nursing Implications of Iron Preps   Absorbed best in acidic environment, Cause GI Upset, Liq preps stain teeth, Constipation, Black, Tarry stools; IV preferred(irritating) but can be given Z-track)  
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Most important nursing diagnosis r/t anemia   Risk for Injury!!  
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Thalassemia   patient's make defective protein; cells are being broken down (^jaundice); Mediterranean ethnic groups  
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Thalassemia Minor   Recessive trait - little bit  
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Thalassemia Major   Poor Prognosis  
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Aplastic Anemia   Rare stem cell disorder; do not produce WBC, RBC or Platelets; Can be congenital or acquired  
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S/S of Aplastic Anemia   S/S of anemia, Bleeding, Infection  
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Etiology of Acquired Aplastic Anemia   Radiation, Chemicals, Drugs, Chemo drugs, Infection, Pregnancy, Idiopathic  
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Dx of Aplastic Anemia   A bone marrow that is called a "dry tap"  
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Tx of Aplastic Anemia   Bone marrow transplantation/ immunosuppressant drugs  
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Anemia Caused by Blood loss can be both   acute & chronic  
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Acute blood loss r/t anemia can cause   Hypovolemic shock (see dramatic symptoms); decreased O2 carrying capacity (ex: car accident)  
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Anemia caused by chronic blood loss   depletion of iron stores - body compensates (ex: GI bleed, heavy periods)  
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Def of Hemolytic Anemia   anemia caused by increased erythrocyte destruction  
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Etiology of Hemolytic Anemia   (NOT Fe Deficiency) Premature destruction of RBC Increased hematopoeisis Increased reticulocytes Normochromic, normocytic RBC's  
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Causes of Hemolytic Anemia can be   intrinsic and extrinsic  
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Causes of Intrinsic Hemolytic Anemia   RBC membrane defects, Hgb structure defect, Inherited enzyme defects  
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Causes of Extrinsic Hemolytic Anemia   Drugs, chemicals, toxins, trauma, burns  
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Definition of Sickle Cell Anemia   Homozygous recessive heredity - have to have 2 parents carry trait; African American  
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Pathophysiology of Sickle Cell Anemia   Decreased O2 tension, have abnormal Hgb, RBC's enlongated and obstruct capillaries - get stuck - occludes circulation; Ischemia and infarction  
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Manifestations of Sickle Cell   Classic s/s of anemia, Damage to organs - heart, lungs, kidneys, Priapism, Hand-foot syndrome, Susceptible to infection  
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Priapism   penile erection that won't go away - painful  
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Dactylitis   effect on hands/feet - malformed  
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Manifestations of Sickle Cell in Children   Small, short, thin, Delayed growth & development, Acute splenic sequestration, Dactylitis  
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Acute splenic sequestration   Blood gets trapped in spleen - spleen enlarges - goes into shock and can die in 30 minutes (under age 2)  
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Sickle Cell patient's can develop   blindness, Stroke, chest/abd pain, painful joints, freq. pneumonia, enlarged hearet, fever  
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Triggers of a Sickle Cell Crisis   Hypoxia, Dehydration, Infection, Overexertion, Anesthesia, Weather changes, Alcohol, Smoking  
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Tx of Sickle Cell Crisis   HOP - Hydration, Oxygenation, Pain Relief  
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Manifestations of a Sickle Cell Crisis   INTENSE PAIN, fever, Tissue hypoxia - - tissue pain & death  
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Dx of Sickle Cell Anemia   Peripheral smeal, Sickle cell preparation, Hemoglobin electrophoresis  
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Care for Patient with Sickle Cell Anemia   Rest, Analgesia, Oxygen, Hydration, Treat precipating factors, Hydroxyures, Transfusion tx if Hgb dec., Therapeutic apheresis  
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General management of Sickle Cell Anemia   Vaccination against everything, Hydration, Trigger avoidance, Prophylactic antibiotics, Bone marrow transplant, Client education, Good nutrition  
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Polycythemia means   many cells - affects all cells  
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Patho of Polycythemia   Myeloproliferative disorder - bone marrow; Increased production of cells, Increased blood viscosity & volume, Congestion of organs/tissue; splenomegaly  
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S/S of Polycythemia Vera   Hypertension, HA, Tinnitus, Blurred vision, Cyanosis, Plethora, Fatigue, Pruritus, Pain in extremities, Night sweats, Wt. Loss, Epistaxis, GI bleeding, Dizziness  
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Complications of Polycythemia   CHF, CVA, Thrombophlebitis, Hemorrhage, Hyperuricemia  
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Dx tests for Polycythemia   ^ H/H, ^WBC, basophilia, ^platelets & platelet dysfunction, ^alkaline phos, uric acid, cobalamin, ^ histamine  
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Care for a patient with Polycythemia   Phlebotomy - bleed them, Hydration, Bone marrow suppressant drugs, anti-immune drugs, Allopurinol, anti-platelets  
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Nursing care for a patient with Polycythemia   Control of COPD, Phlebotomy, Fluid management, safe medication mgmt, Prevention of thrombus formation  
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Primary Polycythemia affects   all cells  
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Secondary Polycythemia affects   RBC's only - NO itching, NO bleeding, Elevated Hct  
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Secondary Polycythemia occurs from   COPD because the lack of O2 causes increaased RBC production  
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