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Oncology Cabrera

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Characterized by abnormal, unrelated cell proliferation; Invade normal tissue and compete with normal cells for oxygen, nutrients, and space; Neoplasms or tumors   Cancer  
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Abnormal cells that reproduce without the regulatory mechanisms that control growth   cancer  
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Abnormal tissue or tumors   neoplasms  
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suffix that indicates a tumor   "-oma"  
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cancer of originating from epithelial cells   carcinomas  
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cancers that originate in organs that fight infection   lymphomas  
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cancers that originate in organs that form blood   leukemias  
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cancers that originate in connective tissue (bone and muscle)   sarcomas  
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tumors that are relatively harmless unless location impairs function of vital organs; do not spread to other parts of the body; may cause problems if it puts pressure on or obstructs organs   benign tumors  
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Benign tumors grow __________________. They remain localized and ____________________.   slow and steadily; encapsulated  
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When palpated, benign tumors are:   smooth, easily defined and moveable  
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Benign tumors have less profuse blood _________. Cells resemble _________ tissue. When removed, benign tumors rarely _________ and are rarely fatal.   supply; original; reoccur  
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Malignant tumors are ____________ and capable of spreading. They grow __________ and unpredictably.   invasive; rapidly  
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Malignant tumors are rarely encapsulated. When palpated, they have ________ borders and are immovable.   irregular  
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Malignant tumors have a blood supply that is ___________ than normal. The cells of a malignant tumor are not _____________ to original tissue.   greater; similar  
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Malignant tumors destroy surrounding tissue by depriving it of ________________________. Recurrence is _____________ when removed. They are _______ when not treated.   oxygen, nutrients and space; common; fatal  
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Malignant tumors may have abnormal proteins (tumor markers) on the cell surface that identifies the cell as ______________.   malignant  
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Cancer is the leading cause of death in the US. The most prevalent cancer is ___________.   lung cancer  
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Chemical agents account for ______% of all cancers.   75%  
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Environmental factors that can cause cancer:   diet, viruses, bacteria, defective genes, medical interventions  
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Major factor in cancer prevention and development:   immune system  
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4 main tumor classifications:   carcinoma, lymphoma, leukemia, sarcoma  
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pg. 213, Table 18-2    
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when malignant cells migrate from the original site   metastasis  
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Most common sites of metastasis are:   liver, brain, bone and lungs  
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Cancer may metastasize to adjacent tissue via the:   lymphatic system or by diffusion in the body cavity  
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commonly removed from the site of the original tumor to be evaluated for cancerous cells   lymph nodes  
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area where malignant cells first form   primary site  
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where the cancer has metastasized or spread to (once the cancer has metastasized; cancer treatment is more difficult and less likely to be curative)   secondary site  
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process of malignant transformation and the 3 stages   carcinogenesis; initiation, promotion, and progression  
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involves carcinogens that alter genetic structure of DNA within cells   initiation  
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repeated exposure to carcinogens transforms genetic information to form mutant cells   promotion  
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malignant cells invade adjacent tissue and metastasize   progression  
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Tumors are classified by:   their anatomic site, stage, and cell appearance and differentiation (ow cells differ from the parent cell or tissue of origin)  
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cancers that arise from fibrous connective tissue   fibroma  
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cancers that arise from fat tissue   lipoma  
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cancers that arise from smooth muscle tissues   leiomyomas  
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cancers that are usually benign:   fibroma, lipoma, leiomyoma  
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cancers that are usually malignant:   carcinoma, sarcoma, melanoma, leukemia and lymphomas  
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Cancer that arises from epithelial cells (skin, glands, linings of digestive, urinary and respiratory tracts)   carcinoma  
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Cancer that arises from connective tissue (bone, muscle and other connective tissue)   sarcoma  
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cancer that arises from pigment cells of the skin   melanoma  
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cancer that arises from blood forming tissues, lymphoid tissue, plasma cells and bone marrow   leukemias and lymphomas  
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stage of cancer where malignant cells are confined to the tissue of origin   Stage I  
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stage of cancer where cancer has spread to local area (usually the lymph nodes)   Stage II  
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stage of cancer where the tumor is larger or spread to surrounding tissues or both   Stage III  
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stage of cancer where cancer has metastasized to distant body parts   Stage IV  
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Poorly-differentiated   less like parent tissue  
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well-differentiated   looks more like parent cell  
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Seven warning signs of cancer:   change in bowel habits or bladder function; sores that do not heal; unusual bleeding or discharge; thickening or lump in breast or other body parts; indigestion or difficulty swallowing; a recent change in a wart or ole; nagging cough or hoarseness  
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Cancer is the ___________ leading cause of death.   second  
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One-half of all men and __________ of all women will develop cancer during their lives.   one-third  
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risk factors of cancer:   heredity; familial  
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factors and agents that contribute to the development of cancers:   carcinogens  
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Chemical agents account for ______% of all cancers.   75%  
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Exposure to _____________ are some carcinogens.   tobacco, asbestos, coal dust  
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environmental factors that can lead to cancer:   sunlight, radiation, pollution  
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Diets high in _____, salt smoked meats, alcohol, and __________ can increase the risk of cancer.   fat, nitrates  
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Diets high in fiber, carotene, and Vitamins __________ can reduce the risk of cancer.   A, C, E  
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Cells can change due to invasion of virus DNA and contribute to _________ cancer.   causing  
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Kaposi's sarcoma is usually cause from:   AIDS virus  
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Helicobacter pylori usually turns into:   GI cancers  
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medically prescribed interventions that can cause cancer   immunosuppressive drugs and hormone replacements  
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Prevention and early detection are key to cancer __________.   survival  
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Ways to prevent cancer:   avoid carcinogens; identify high risk people (to be screened sooner); healthy diet; intact immune system  
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Ways to screen for cancer:   self exams; regular doctor exams; know warning signs; early detection  
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tests for carcinomas of the testicals, pancreas and liver   alph-fetoprotein  
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levels are inreased with breast, pancreas, liver, kidney and colon cancer; may be elevated for no reason   carcinoembryonic antigen (CEA)  
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tests for prostate cancer, slightly elevated in benign prostate hyperplasia   prostate-specific antigen (PSA)  
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test for metastatic breast cancer   CA 15-3  
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test for gastrointestinal and pancreatic cancer   CA 19-9  
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test for ovarian cancer   CA 125  
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x-ray that gives 3-dimensional view of tissue used to determine tumor density, size and location; used in detectng many types of cancer   CT  
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x-ray where tissues are observed for changes using radioactive isotope   nuclear imaging  
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x-ray study where magetic fields are used to differentiate diseasesd tissue from healthy tissue; used to study blood flow; visualizes tumors hidden by bone   MRI  
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x-ray test that shows cross-sectional view of tissue that looks at increased concentration of isotopes in malignant cells; differentiates between benign and malignant cells   PET  
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monoclonal antibodies labeled with isotopes are injected intravenously and accumulate at the tumor site which makes tumor able to be visualized   radioimmunoconjugates  
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uses high frequency sound waves; determines if tumor is solid or fluid filled   ultrasound  
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x-rays used to look at differences in the densities of body tissues; used for bone and gastric cancers   fluoroscopy  
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most accurate diagnosis of cancerous cells; tissue samples are excised from the body and are examined microscopically   biopsy  
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types of biopsies   needle biopsy, surgical excision, tissue samples of removed mass  
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immediate examination of the cells once tumor is removed; specimen is quickly frozen into thin sheets and observed   frozen section  
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flexible tubes with special fiber cameras to look at specific body areas   endoscopy  
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endoscopic procedure that looks at the stomach   gastroscopy  
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endoscopic procedure that looks at the lungs   bronchoscopy  
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endoscopic procedure that looks at the colon   colonoscopy  
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microscopic examination of cells; used to diagnose malignancies in cells; can be obtained by needle aspiration, scraping, brushig or sputum   cytology  
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when the tumor is confined and has not invaded surrounding tissues, surgery is the primary treatment; curative treatment   surgery  
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when entire tumor cannot be removed, as much as possible is removed   debulking  
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the tumor and a small amount of surrounding healthy tissues are removed   local excision  
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removes tumor, lymph nodes and any involved adjacent structures and adjacent structures and surrounding tissue that poses a risk for metastasis   wide or radical excision  
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surgery done with a local recurrence of cancer; more extensive than previous surgery   salvage surgery  
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surgery done when client is at high risk for developing cancer; usually done for breast or reproductive cancers   prophylactic surgery  
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surgery done to relieve uncomfortable symptoms or prolong life; not a cure   palliative surgery  
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high-energy ionizing radiation used to destroy cancer cells by disrupting cell function and division and alteration of DNA molecules; cell death occurs immediately or after; no more reproduction can occur   radiation therapy  
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Goal of radiation therapy:   to destroy malignant cells without permanently damaging healthy tissue  
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____________ cells are more sensitive to radiation.   Malignant  
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causes cell death; usually have daily treatments over several weeks; will be marked with marker or tattoo (do not wash); do not apply any lotions to area   external radiation  
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internal radiation where radioactive source is implanted or placed on the _________ implanted inside the patient's body; poses a ___________ to others   tumor; threat  
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internal radiation that is inserted in the body in a sealed container directy into the tumor body; can be held in place with an applicator   sealed source  
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Precautions when using internal radiation therapy:   private room (preferably lead-lined); sign on door; no children or pregnant women; limit time in room; use lead aprons, monitoring devices; 30 minutes total per shift; monitor for accidental dislodged sources  
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Precautions for unsealed sources (could be liquid, oral, Iodine 131)   wear gloves; body fluids require special considerations because radiation is excreted through urine, saliva, sweat and feces); flush more than once; use separate eating utensils; wash clothes separately;drink plenty of fluids to flush system  
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side effects of radiation   bone marrow suppression/myelosuppression; anemia; leukopenia; thrombocytopenia; alopecia; anorexia, altered taste, mouth sores (stomatitis); dry mouth; erythema to area; harm to fetus, sterility, impotence  
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low blood count   anemia  
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low WBC count (normal is 5,000 - 10,000)   leukopenia  
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low platelet count; prone to bleeding; normal is 150,000 - 450,000   thrombocytopenia  
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hair loss   alopecia  
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anorexia, altered taste, mouth sores   stomatitis  
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Chemotherapy has the _________ side effect as radiation.   same  
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uses antineoplastic agents to treat cancer cells; can be used to cure cancer, prevention of metastasis, slow growth of tumor, destroy tumor cells or relieve symptoms   chemotherapy  
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Chemotherapy must be given by ______ certified with ________________.   RN; chemo training  
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Chemo can be used to:   cure cancer, prevent metastasis, slow tumor growth, destroy tumor cells, relieve symptoms  
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Chemo agents can be _____________ or ____________.   cell cycle specific or cell cycle non-specific drugs  
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Chemotherapy can be given:   orally, IV, IM, intraperitoneally, intraarterially, intrapleurally, topically, intrathecally (in head), or directly into cavity  
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Chemo is ___________.   cytotoxic (toxic to cells)  
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chemotherapy drugs that interfere with the process of cell division   alkylating drugs and mitotic inhibitors  
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chemotherapy drugs that interfere with DNA and RNA   antineoplastic antibiotics and antimetabolites  
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chemotherapy drugs that are used in treating cancers that use hormones as growth factors   hormones  
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Chemo drugs may be used alone or:   in combinations  
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Chemotherapy cannot distinguish between:   healthy and cancerous cells  
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Side effects of chemotherapy:   N/V, alopecia, dry skin, myelosupression (supress what the bone makes - blood cells); side effects are same for chemo and radiation  
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Chemotherapy may also have toxic effects on:   lungs, heart, nerve tissue, kidneys and bladder  
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Vesicants cause tissue necrosis (extravasation)of surrounding _________________.   tissues and structures  
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Treatment of extravasation and nursing guidelines for patients receiving chemo on pg. 224    
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peripheral blood stem cell transplant; collected by apheresis   bone marrow transplantaton  
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process of separating blood into components for later reinfusion   apheresis  
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3 types of apheresis   autologous (self); allogeneic (compatible donor); syngeneic (identical twin)  
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When apheresis has been done, watch vigorously for:   s/s of infection (many people die from this) because of lack of white blood cells (usually done for leukemia patients)  
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uses biologic response modifiers to stimulate the body's natural immune system to restrict and destroy cancer cells; manipulates the natural immune response by restoring, stimulating or augmenting the natural defenses   immunotherapy  
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Teach chemotherapy patients:   keep all appts; go to ER if fever of 100.4 or more; watch for bleeding; use electric razor; eat small, frequent meals; eat slowly; suck on hard candy; teach about wigs; take lid off tray before entering room; increase fluids to flush out chemo  
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Drugs that help with clotting:   platelets, Vitamin K  
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antigen injected into client in hopes to stimulate an immune response to destroy malignant cells   nonspecific immunotherapy  
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tumor cells are injected into mice to form antibodies; antibodies are removed from the spleen and cultured with more cancer cells to form more antibodies which are injected into a client to destroy tumor cells (after purification)   monoclonal antibody immunotherapy  
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immunotherapy - substances that immune system cells produce to enhance the immune system   interferons; interleukins; ematopoietic growth factors (colony stimulating factors); tumor necrosis factor  
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colony stimulating factors that are good at treating s/e of radiaion - can stimulate RBC growth or WBC growth without blood transfusions   hmatopoietic growth factors  
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type of immunotherapy - uses tems > 41.5C (106.7F) to destroy tumor cells; alters cell membrane permeability so that uptake of chemo and immunoterapeutic agents are increased; uses radio waves, ultrasound, microwaves, hot water baths   hyperthermia  
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Clients may experience local burns, tissue damage, electrolyte imbalances and neuropathies when being treated with:   hyperthermia  
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photoactive drug injected into client (porfimer/Photofrin); stored in high concentrations in malignant cells; laser light activates drugand destroys tumor; pt must stay protected from sunlight and bright indoor light for 30 days or sunburn can occur   photodynamic therapy  
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replaces altered genes with correct genes, inhibiting defective genes, and introducing substances that destroy genes or cancer cells   gene therapy  
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process that rids the body of cells that are not longer needed or defective in some way   apoptosis  
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Researchers think that tumor cells have an ______________ molecule that prevents their destrction from natural ways; are trying to find meds that block those molecules so cancer cells can die   anti-cell-death  
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number one cause of cancer cell death   lung cancer  
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Lung cancer has an increased number of diagnosis because of:   more accurate diagnosing; aging population; cigarette smoking; increased air pollution; exposure to industrial pollution  
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four major cells types involved with lung cancer:   epidermold or squamous cell; lart cell or undifferentiated; adenocarcinoma; small cell or oat cell  
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slow growing; arise from the bronchi and bronchioles leading to obstruction; metastasize to the thorax and small bowel; 25%-35% of all lung tumors   epidermold or squamous cell  
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arise in the peripheral bronchi; no well-defined growth patters; usually diagnosed as a bulky tumor mass; metastasize early to the CNS; 5% - 20% of all lung tumors   large cell or undifferentiated  
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arise from the mucus glands; patchy growth throughout lung fields; lead to malignant pleural effusion; 25%-35% of lung tumors   adenocarsinoma  
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most malignant form of lung cancer; arises from the bronchi; hypersecretes antiduiretic hormone; metastasizes to the mediastinum, liver, bone, bone marrow, CNS, adrenal glands, pancreas and other endocrine organs   small cell or oat cell (worst type)  
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symptoms do not appear until the disease is well established; long term suvival rate is low; s/s - nagging cough, bloody sputum, weight loss, SOBOE (shortness of breath on exertion)   small cell or oat cell  
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any malignant blood disorder in which the leukocytes (WBCs), usually in an immature form, proliferate unregulated; often accompanied by a decrease in erythrocytes (RBCs) and platelets   leukemia  
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Four types of leukemia   acute lymphocytic leukemia; chronic lymphocytic leukemia; acute meylogenous leukemia; chronic myelogenous leukemia  
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onset is usually younger that 5, rarely over 15; increased lymphocytes, decrease RBCs and platelets   acute lymphocytic leukemia (ALL)  
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onset is older than 40; most common type in adults; increased lymphocytes, normal or low RBCs and platelets   chronic lymphocytic leukemia (CLL)  
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decrease in myeloid formed cells (monocytes, granulocytes, RBCs and platelets); occurs in all age ranges   acute myelogenous leukemia (AML)  
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same as AML but greater number of normal cells; onset is older than 20, increasing incidence with age; genetic link   chronic myelogenous leukemia (CML)  
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s/s of leukemia   fatigue from anemia; infections; bruising; spleen and lymph enlargement; bleeding in the nose, mouth and GI tract  
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treatment for leukemia   chemotherapy; bone marrow transplant; stem cell transplant  
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malignancy involving the plasma cells of B-lymphocyte cells in the bone marrow; prognosis is poor with estimated survival rate of 1-5 years   multiple myeloma  
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pathophysiology of multiple myeloma   abnormal plasma cells release osteoclast acivating factor; esteoclast breaks down bone cells; increases blood calcium; greatly increases risk of fractures; releases proteins that damage kidneys and reduce production of antibodies  
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treatment for multiple myeloma   steroids (can slow bone growth) and chemotherapy; bone marrow transplants; stem cell transplants; treatment does not cure, but prolongs life  
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cancer that affects the lymphatic system   lymphoma  
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two types of lymphomas:   Hodgkin's and Non-Hodgkins  
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lymphoma - age of onset is 15-40 and then older than 55; has Reed-Sternberg cells; orderly growth; more curable   Hodgkins  
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lymphoma - thirty subtypes; peaks after 50; no Reed-Sternberg cells; B and T cell origins; metastasis is common; less curable   Non-Hodgkins  
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lymphomas are treated with:   radiation; chemotherapy; immunotherapy with monoclonal antibodies (tumor fighting antibodies); bone marrow transplant  
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named for cell type and area of the brain; account for a small percentage of cancer deaths; about 50% are malignant; benign tumors can be fatal because of increased ICP and damage to surrounding tissues   brain tumors  
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s/s of brain tumors are related to:   the area of the brain that is invaded by the tumor  
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most common type of brain tumor   glioma  
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most aggressive brain tumor   glioblastoma  
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treatment of brain cancer   surgical removal if possible; limited radiation; some chemotherapy  
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approximately 75% develop in the sigmoid colon and rectum; genetics; lifestyle and environmental factors contribute; many develop from benign adenomas   cancer of the GI tract  
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rarely begins in the liver; chemotherapy is the main treatmen, but is usually considered palliative treatment   cancer of the liver  
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fatal - usually less than a year; quickly spreads to duodenum, stomach, spleen and left adrenal gland   cancer of the pancreas  
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for cancer in the head of the pancreas, s/s include:   pain, jaundice, weight loss, N/V and diarrhea  
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for cancer in the tail of the pancreas, s/s include:   GI bleed or back pain  
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treatment for pancreatic cancer -   if cancer is in the head of the panreas, surgery may be an option; radiation and chmotherapy may prolong life  
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accounts for 3% of cancer; may reach considerable size before etection; s/s include anemia, weakness and weight loss; late s/s are gross hematuria (peeing blood) and flank pain   cancer of the kidney  
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treatment for cancer of the kidney   removal of the kidney (nephrectomy); not responsive to chemotherapy or radiation, however radiation may be used as a palliative measure  
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occurs most often in men, 50 to 70 years old; risk factors include cigarette smoking and exposure to rubber and cable chemicals; s/s include painless intermittent hematuria, bladder irritability and infections   cancer of the bladder  
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treatment of cancer of the bladder   partial or total cystectomy; may require urostomy; chemotherapy  
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abnormal osteoblast or myeloblast (marrow cells) that exhibit rapid and uncontrolled growth; usually located around the knee in the distal femur or proximal fibula; s/s/ include pathological break, limp, or abnormal gait   bone cancer  
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treatment for bone cancer   amputation, chemotherapy, radiation  
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endometrial cells that migrate out of the uterus and attach to toher organsi in the pelvic cavity; builds and bleeds like the tissue within the uterus, causing pain and local inflammation; considered benign unterine growth   endometriosis  
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complications of endometriosis   obstruction of organs in plevic area (bladder, bowels, urethra)  
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treatment of endometrisis   drugs that decrease endometrionic growth; laparoscopy; hysterectomy  
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after a hysterectomy, monitor for:   bleeding - main post-op complication  
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most prevalent form of cancer in women; in early stages, survival rate is greater than 90%; 80% of breast lumps are benign   breast cancer  
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types of breast cancer:   ductual carcinoma; lobular carcinoma; medullary carcinoma; mucinous carcinoma; tubular ductal carcinoma; inflammatory breast cancer  
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Breast cancer may be in any part of the breast, but 48% are locted in the _________________ and 17% are located in the ________________.   upper outer quadrant; nipple area  
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When palpating, breast cancer can feel like:   a painless mass, firm, irregular shaped, fixed to underlying structures  
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__________ women have the highest incidence of breast cancer, but ___________ women are most likely to die from breast cancer.   white; black  
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late s/s of breast cancer:   dimpling of skin, nipple discharge, retraction of nipple, edema, differences in nipple size, lymph nodes may be enlarged  
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routine screening for breast cancer:   physical exam every 3 years until 40, then yearly; base-line mammogram at 40; monthly self exams (after each period - if post menopausal, same day each month)  
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treatment for breast cancer:   lumpectomy; simple mastectomy (all breast tissue - no lymph nodes); radical mastectomy (all breast, axillary lymph nodes, pectoralis major - pg 852); removal of lymph nodes pg 852-853  
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after breast cancer surgery:   cancer is staged and determined whether or not it is estrogen receptor positive; radiation therapy; chemotherapy; reconstructive surgery may be done, using the pectoral muscle or abdomen muscles  
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If breast cancer is estrogen receptor positive, madication is given to suppress estrogen   Tamoxifin  
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after breast cancer surgery:   no needle sticks to affected side; no blood pressures to affected side; elevation of affected arm; no lifting with affected arm  
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metastasizes widely to the abdomen through the peritoneal fluid; incidence is low, mortality is high; vague or no symptoms until the cancer is well advanced; most s/s are attributed to the GI tract   ovarian cancer  
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treatment for ovarian cancer   if confine to ovaries, surgical removal, chemotherapy and radiation  
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rare cancer; can be caused byHPV or genital herpies; s/s are pruritis and burning, white patches (vulvar) and vaginal bleeding (vaginal)   vulvar cancer and vanginal cancer  
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treatment of vulvar cancer and vanginal cancer   surgical removal; chemotherapy; radiation  
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most common in men older than 50; thrid most common cause of cancer deaths in men; grows slowly; high survival rate if detected early; cause is unknow but r/t diets high in fat   prostate cancer  
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s/s of prostate cancer   decreased urinary flow and difficulty starting stream (early sign); back pain; hematuria (blood in urine); hemospermia; erectile dysfunction  
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diagnosis of prostate cancer:   rectal exam; elevated PSA (prostate-specific antingen);biopsy; IVP (Intravenous Polygram to watch urinary flow) to detect urinary tract dysfunction  
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treatment of prostate cancer:   prostatectomy (TURP - Transurethral Resection of Prostate); bilateral orhiectomy; hormone therapy; radiation  
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rare cancer; occurs more often in uncircumcised men; treatment includes tumor excision, chemo, and radiation; advanced requres amputation of the penis, testes and scrotum   cancer of the penis  
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rapidly metastasizing malignancy; occurs between 18 and 40; involve sperm forming germ cells   cancer of the testes  
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s/s of cancer of the testes   gradual or sudden swelling of the scrotum; hard, non-tender lump felt on palpation; aching in testes; abdominal pain (late sign)  
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treatment of cancer of the testes   orchiectomy and ligation of the affected testicle (sperm can be frozen for later use); chemotherapy; radiation;  
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most common type of cancer in the US; increased exposure to UV radiation increases risk   cancer of the skin (although most people die from lung cancer)  
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3 types of skin cancer:   basal cell carcinoma; squamous cell carcinoma; malignant melanoma  
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most common skin cancer; small, shiny gray or yellow plaque; slow growing, rarely metastasizes; commonly recurs   basal cell carcinoma  
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skin cancer that occurs in sun exposed areas such as ear, nose, hands, scalp; scaly, elevated lesion with irregular borders; shallow ulcerations form if untreated; can metastasize through the blood and lymph   squamous cell carcinoma  
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skin cancer that arises from pre-existing moles anywhere on the body; raised brown or black lesions; poor prognosis because of distant metastases   malignant melanoma  
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s/s of skin cancer    
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treatment for skin cancer:   surgical excision, cryosurgery or radiation therapy for basal cell adn squamous cell; radical excision of tumor and adjacent tissues and chemotherapy for melanoma; skin grafting may be necessary  
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nursing managment of the client with skin cancer:   pain and comfort - pain can be from obstruction or nerve compression by a tumor; fatigue (from chemo)  
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S/S of infecton caused by treatment of cancer   fever; elevated WBC count; pain, redness; drainage  
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Other symptoms client being treated for cancer may have:   bleeding (use electric razor); immobility; alterations in body image; changes in psychological and mental status; grieving; emotional support to client and family; side effects of chemotherapy and radiation  
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Client and family teaching with cancer:   medicatins, treatment and procedures (teach pts what to expect from treatment and procedures); adverse effects associated with treatment; resources for support; follow-up needed after discharge from the hospital  
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When treating pt with cancer, you must allow time for clients to express their feelings or discuss home care.    
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Teach pt to go watch for s/s of infection - go to ER if fever is over:   100.4  
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