Hy - USMLE Buzzwords - One-Liners
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What is associated with: Starry sky pattern? | Burkitt's lymphoma
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| Which organ most commonly recieves mets? | Adrenal gland (rich blood supply)
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| What is the most common testicular tumor in children? in Men? | Yolk sac tumor, Seminoma
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| What is associated with: Auer's rods? | Acute myelocytic leukemia (AML)-M3
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| What is associated with: Aschoff's bodies? | Rheumatic fever
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| What is associated with: Birbeck granules? | Histiocytosis X
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| What is associated with: Neurofibrillary tangles? | Alzheimer's disease
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| What is associated with: Bence-Jones proteinuria? | Multiple myeloma
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| What is associated with: Cal-Exner bodies? | Granulosa/thecal cell tumor of the ovary
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| What is associated with: Cowdry type A bodies? | Herpes virus
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| What is associated with: Codman's triangle on an x-ray? | Osteosarcoma
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| What is associated with: Councilman bodies? | Toxic or viral hepatitis
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| What is associated with: Calf pseudohypertrophy? | Duchenne's muscular dystrophy
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| What is associated with: Reed-Sternberg cells? | Hodgkin's lymphoma
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| What is associated with: Heinz bodies? | G-6-PD deficiency
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| What is associated with: Homer-Wright rosettes? | Neuroblastoma
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| What is associated with: Curschmann's spirals? | Bronchial asthma (whorled mucous plugs)
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| What is associated with: Kayser-Fleischer rings? | Wilson's disease
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| What is associated with: Lewy bodies? | Parkinson's disease
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| What is associated with: Orphan Annie cells? | Papillary carcinoma of the ovary
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| What is associated with: Russell bodies? | Multiple myeloma
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| What is associated with: Reinke's crystals? | Leydig cell tumor
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| What is associated with: Blue sclera? | Osteogenesis imperfecta
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| What is associated with: Soap-bubble appearance on an x-ray? | Giant cell tumor of the bone
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| What is associated with: Pseudorosettes? | Ewing's sarcoma
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| What is associated with: Lucid interval? | Epidural hematoma
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| What is associated with: Bloody tap on lumbar puncture? | Subarachnoid hemorrhage
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| What is associated with: Pseudopalisades? | Glioblastoma multiforme
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| What is associated with: Charcot-Leyden crystals? | Bronchial asthma (eosinophil membranes)
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| What is associated with: Cafe au fait spot on the skin? | Neurofibromatosis
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| What is associated with: Streaky ovaries? | Turner's syndrome
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| What is associated with: Keratin pearls? | Squamous cell carcinoma
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| What is associated with: Signet ring cells? | Gastric carcinoma
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| What is associated with: Mallory's bodies? | Chronic alcoholism
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| What is associated with: Blue-domed cysts? | Fibrocystic change of the breast
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| What is associated with: Schiller-Duval bodies? | Yolk sac tumor
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| What is associated with: Senile plaques? | Alzheimer's disease
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| What is associated with: WBCs in the urine? | Acute cystitis
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| What is associated with: RBCs in the urine? | Bladder carcinoma
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| What is associated with: RBC casts in the urine? | Acute glomerulonephritis
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| What is associated with: WBC casts in the urine? | Acute pyelonephritis
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| What is associated with: Renal epithelial casts in the urine? | Acute toxic or viral nephrosis
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| What is associated with: Waxy casts? | Chronic end-stage renal disease
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| What is the most common: Cause of chronic metal poisoning? | Lead
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| What is the most common: Cause of congenital cyanotic heart disease? | Tetralogy of Fallot
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| What is the most common: Congenital cardiac anomaly? | Ventricular septal defect (VSD)
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| What is the most common: Cardiac tumor? | Left atrial myxoma
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| What is the most common: Vasculitis? | Temporal arteritis
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| What is the most common: Primary tumor of the liver? | Hemangioma (benign)
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| What is the most common: Primary malignant tumor of the lungs? | Adenocarcinoma (30% to 35%)
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| What is the most common: Cause of nephrotic syndrome? | Membranoproliferative glomerulonephritis
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| What is the most common: cause of nephrotic syndrome in children? | Lipoid nephrosis
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| What is the most common: Organism that causes pyelonephritis? | Escherichia coli
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| What is the most common: Renal cell cancer type? | Clear cell
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| What is the most common: Tumor of the liver? | Metastatic cancer (GI, breast, lungs)
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| What is the most common: Malignant tumor of the esophagus? | Squamous cell carcinoma
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| What is the most common: Tumor arising within the bone? | Multiple myeloma
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| What is the most common: Primary malignant tumor of the female genital tract in the world? | Cervical neoplasia
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| What is the most common: Primary malignant tumor of the female genital tract in the US? | Adenocarcinoma of the cervix
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| What is the most common: Tumor of the female genitourinary tract? | Leiomyoma
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| What is the most common: Benign tumor of the ovary? | Serocystadenoma
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| What is the most common: Benign tumor of the breast? | Fibroadenoma
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| What is the most common: Benign lesion that affects the breast? | Fibrocystic change of the breast
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| What is the most common: Malignant tumor of the breast? | Invasive ductal carcinoma
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| What is the most common: Tumor in men between the ages of 15 and 35? | Testicular tumors
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| What is the most common: Germ cell tumor in men? | Seminoma
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| What is the most common: Testicular tumor in infants and children? | Yolk sac tumor
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| What is the most common: Malignant germ cell tumor in women? | Choriocarcinoma
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| What is the most common: Solid tumor in the body? | Nephroblastoma
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| What is the most common: Acquired GI emergency of infancy? | Necrotizing enterocolitis of infancy
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| What is the most common: Primary malignant tumor of the ovary? | Serocystadenocarcinoma
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| What is the most common: Cardiac tumor of infancy? | Rhabdomyoma
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| What is the most common: Acute metal poisoning? | Arsenic
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| What is the most common: Proliferative abnormality of an internal organ? | Benign prostatic hyperplasia (BPH)
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| What is the most common: Malignant tumor in the bone of teenagers? | Osteosarcoma
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| What is the most common: Site of a cerebral infarct? | Middle cerebral artery
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| What is the most common: Cause of dementia between the ages of 60 and 90 years? | Alzheimer's disease
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| What is the most common: Primary CNS tumor in adults? | Glioblastoma multiforme
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| What is the most common: Primary CNS tumor in children? | Medullablastoma
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| What is the most common: Tumor on sun-exposed sites? | Basal cell carcinoma
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| What is the most common: Chromosomal disorder? | Down syndrome (trisomy 21)
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| What is the most common: Heart defect in Down syndrome? | Endocardial cushion defect
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| What is the most common: Chromosomal disorder involving sex chromosomes? | Kleinfelter's syndrome
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| What is the most common: Cardiac pathology in patients with SLE? | Libman-Sacks endocarditis
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| What is the most common: Cause of urinary tract obstruction? | BPH
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| What is the most common: Eye tumor in children? | Retinoblastoma
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| What is the most common: Intraspinal tumor? | Ependymoma
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| What is the most common: Lymph node affected in non-Hodgkin's lymphoma? | Periaortic lymph nodes
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| What is the most common: Renal pathology in patients with SLE? | Diffuse proliferative GN
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| What is the most common: Cause of cirrhosis in the USA? | Alcohol
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| What is the most common: Malignant tumor in women? | Breast
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| What is the most common: Cancer of the vulva? | Squamous cell carcinoma
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| What is the most common: Testicular tumor in children? | Yolk sac tumor
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| What is the most common: Benign GI tumor? | Leiomyoma
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| What is the most common: Thyroid cancer? | Papillary carcinoma
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| What is the most common: Malignancy in children? | ALL
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| What is the most common: Cause of diarrhea in children? | Rotavirus
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| What is the most common: Cause of hospitalization in children younger than 1 year of age? | Respiratory syncytial virus (RSV)
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| What is the most common: Helminthic parasite worldwide? | Ascaris lumbricoides
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| What is the most common: Cause of anovulation? | Polycystic ovaries
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| What is the most common: Cause of death in neonates? | Neonatal respiratory distress syndrome (NRDS)
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| What is the most common: Cardiac anomaly in children? | Patent ductus arteriosus (PDA)
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| What is the most common: Congenital heart defect in adults? | Atrial septal defect (ASD)
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| What is the most common: Complication of PDA? | Subacute bacterial endocarditis
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| What is the most common: Cardiac anomaly in Turner's syndrome? | Coarctation of the aorta
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| What is the most common: Cause of restrictive cardiomyopathy? | Amyloidosis
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| What is the most common: Cause of pulmonary hypertension in children? | VSD
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| What is the most common: Cause of reversible hypertension in the USA? | Alcohol abuse
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| What is the most common: Inflammatory arthritis? | Rheumatoid arthritis
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| What is the most common: Cause of spontaneous pneumothorax? | Emphysematous bleb
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| What is the most common: Cause of nonorganic pneumoconiosis? | Asbestosis
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| What is the most common: Cause of painless hematuria? | Renal cell carcinoma
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| What is the most common: Cause of hematuria? | Infection
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| What is the most common: Hematologic cause of papillary necrosis? | Sickle cell disease
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| What is the most common: Organ involved in amyloidosis? | Kidney
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| What is the most common: Cause of abnormal bleeding? | Thrombocytopenia
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| What is the most common: Cause of a nontraumatic splenic rupture? | Malaria
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| What is the most common: Cause of death in SLE? | Renal failure
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| What is the most common: Cause of infection for a patient on a ventilator? | Pseudomonas aeruginosa
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| What is the most common: Esophageal carcinoma? | Squamous cell carcinoma
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| What is the most common: Cause of chronic pancreatitis? | Alcohol abuse
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| What is the most common: Cause of infectious pancreatitis? | Mumps
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| What is the most common: Complication of nasogastric tube feeding? | Aspiration pneumonia
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| What is the most common learning disability? | Dyslexia
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| What is the most common: Cause of insomnia? | Depression
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| What is the most common: Form of necrosis? | Coagulative
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| What is the most common: Cause of blindness worldwide? | Chlamydia trachomatis
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| What is the most common: Cause of blindness in the USA? | Diabetes mellitus
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| What is the most common: Cause of the croup? | Parainfluenza virus
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| What is the most common: Cause of a cold in the winter and summer? | Coronavirus
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| What is the most common: Cause of a cold in the spring and fall? | Rhinovirus
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| What is the most common: Cause of viral pneumonia leading to death? | RSV
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| What is the most common: Pituitary tumor? | Chromophobe adenoma
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| What is the most common: Cause of panhypopituitarism? | Sheehan's syndrome
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| What is the most common: Cause of Cushing's syndrome? | Pituitary adenoma
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| What is the most common: Kidney stone type? | Calcium oxalate
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| What is the most common: Site of ischemia in the GI tract? | Splenic flexure
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| What is the most common: Cause of intestinal obstructions in adults? | Adhesions and hernias
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| What is the most common: Cause of neonatal bowel obstruction? | Hirschsprung's disease
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| What is the most common: Cause of rectal bleeding? | Diverticulosis
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| What chromosomal translocation is associated with: Chronic myeloid leukemia (CML? | Chromosome 9,22 (Philadelphia chromosome)
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| What chromosome: Ewing's sarcoma? | Chromosome 11,22
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| What chromosome: Adult familial polyposis? | Chromosome 5,21
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| What chromosome: Burkitt's lymphoma? | Chromosome 8,14
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| What chromosome: Acute promyelocytic leukemia (M3)? | Chromosome 15,17
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| What chromosome: Follicular lymphoma? | Chromosome 14,18
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| What chromosome is associated with: Cru di chat? | Chromosome 5p
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| What chromosome: Patau's syndrome? | Chromosome 13
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| What chromosome: Neurofibromatosis I? | Chromosome 17
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| What chromosome: Huntington's disease? | Chromosome 4p
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| What chromosome: Familial hypercholesterolemia? | Chromosome 19
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| What chromosome: Gaucher's disease? | Chromosome 1
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| What chromosome: Neimann-Pick disease? | Chromosome 11p
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| What chromosome: Tay-Sachs disease? | Chromosome 15q
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| What chromosome: Cystic fibrosis? | Chromosome 7
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| What chromosome: Albinism? | Chromosome llp
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| What chromosome: Chronic lymphocytic leukemia (CLL)? | Chromosome 12
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| What chromosome: Marfan's disease? | Chromosome 15
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| What chromosome: Neurofibromatosis II? | Chromosome 22q
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| What chromosome: Down syndrome? | Chromosome 21
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| What chromosome: Edward's syndrome? | Chromosome 18
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| What mineral is associated with impaired glucose tolerance? | Chromium (Cr)
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| What mineral is associated with hypothyroidism? | Iodine (I)
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| What mineral is an important component of the enzyme xanthine oxidase? | Molybdenum (Mb)
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| What vitamin deficiency has the following signs: angular stomatitis, glossitis, and cheilosis? | Riboflavin (B2) deficiency
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| What vitamin is a component of the coenzyme thiamine pyrophosphate (TPP)? | Thymine (Bl)
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| Avidin decreases the absorption of what vitamin? | Biotin. Avidin is found in raw egg whites.
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| What are the four Ds of niacin deficiency? | 1. Diarrhea 2. Dermatitis 3. Dementia 4. Death
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| What mineral is an important component of glutathione peroxidase? | Selenium (Se)
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| What mineral deficiency in children is associated with poor growth and impaired sexual development? | Zinc (Zn) deficiency
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| What mineral, via excessive depositions in the liver, causes hemochromatosis? | Iron (Fe)
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| What vitamin is needed in the production of heme? | Pyridoxine (B6)
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| What vitamin is a component of the enzymes fatty acid synthase and acyl CoA? | Pantothenic acid
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| What vitamin deficiency has the following signs: homocysteinuria and methylmalonic aciduria? | Cyanocobalamin (B12) deficiency [Folic acid deficiency has only homocysteinuria as a sign.]
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| What vitamin deficiency is evidenced by the following signs: poor wound healing, loose teeth, bleeding gums, petechiae, and ecchymosis? | Ascorbic acid (vitamin C) deficiency (These are the signs of scurvy.)
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| What vitamin is given as prophylactic treatment for patients who suffer from alcoholism? | Thiamine (B1)-to prevent Wernicke's encephalopathy and Korsakoff's encephalopathy
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| What are the three carboxylase enzymes that require biotin? | 1. Pyruvate 2. Acetyl CoA 3.Propionyl CoA carboxylase
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| What vitamin requires intrinsic factor (IF) for absorption? | Cyanocobalamin (B12)
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| What mineral is a component of cytochrome a/a3? | Copper (Cu)
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| Leukopenia, neutropenia, and mental deterioration are signs of what mineral deficiency? | Copper (Cu) deficiency
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| What vitamin deficiency causes a glove-and-stocking neuropathy seen in alcoholics? | Pyridoxine (B6) deficiency
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| What mineral deficiency involves blood vessel fragility? | Copper (Cu) deficiency
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| Megaloblastic anemia and thrombocytopenia are signs of what vitamin deficiency? | Folic acid deficiency
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| What is the antidote for an overdose with: Carbon monoxide? | Oxygen
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| What is the antidote for an overdose with: Mercury? | Dimercaprol
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| What is the antidote for an overdose with: Isoniazid? | Pyridoxine
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| What is the antidote for an overdose with: Atropine? | Physostigmine
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| What is the antidote for an overdose with: Arsenic? | Dimercaprol, D-penicillamine
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| What is the antidote for an overdose with: Digoxin? | Antidigoxin Fab fragments
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| What is the antidote for an overdose with: Gold? | Dimercaprol
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| What is the antidote for an overdose with: Ethylene glycol? | Ethyl alcohol
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| What is the antidote for an overdose with: Opiates/narcotics? | Naloxone, naltrexone
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| What is the antidote for an overdose with: Organophosphates? | Atropine, 2-PAM
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| What is the antidote for an overdose with: Warfarin? | Vitamin K
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| What is the antidote for an overdose with: Copper? | D-Penicillamine
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| What is the antidote for an overdose with: Heparin? | Protamine sulfate
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| What is the antidote for an overdose with: Iron? | Deferoxamine
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| What is the antidote for an overdose with: Cyanide? | Amyl nitrate, sodium nitrate, or sodium thiosulfate
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| What is the antidote for an overdose with: Methyl alcohol? | Ethyl alcohol
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| What is the antidote for an overdose with: Acetaminophen? | N-Acetylcysteine
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| What is the antidote for an overdose with: Nitrates? | Methylene blue
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| What is the antidote for an overdose with: Lead? | EDTA (calcium disodium edetate), dimercaprol, succimer
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| What structure is derived from the prochordal plate? | The mouth
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| What is the only organ supplied by the foregut artery that is of mesodermal origin? | Spleen
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| In which direction and how far does the gut rotate? | Counterclockwise 270 degrees
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| What structure connects the primitive gut to the yolk sac? | The yolk stalk (vitelline duct)
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| What is the artery of the embryonic foregut? | The celiac artery
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| When does the primitive gut herniate out of the embryo? | 6 weeks
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| When does it return back into the embryo? | 10 weeks
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| What two pathologic conditions occur when the gut does not return to the embryo? | Omphalocele and gastroschisis
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| Around what structure does the midgut rotate? | Superior mesenteric artery
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| What three things cause the indifferent gonad to become a testis? | 1.Testis-determining factor (TDF) from the short arm of the Y chromosome 2.Miillerian inhibiting factor (MIF) from Sertoli cells 3.Testosterone from Leydig cells
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| Where does the embryologic foregutend? | At the first part of the duodenum
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| What is the artery of the embryonic hindgut? | The inferior mesenteric artery
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| What three embryonic cell layers form the chorion? | 1. Cytotrophoblast 2. Symcytiotrophoblast 3. Extraembrvonic mesoderm
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| Which neuropore closes last? | Caudal-and it is the first to open, too.
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| What is the artery of the embryonic midgut? | The superior mesenteric artery
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| From where are nephrons derived embryonically? | Metanephros
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| What are the five derivatives of the ventral mesentery? | 1. Falciform ligament 2. Hepatoduodenal ligament 3. Hepatogastric ligament 4 and 5. Coronary and triangular ligaments of the liver. All else is derived from the dorsal mesentery.
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| When do the septum primum and the septum secundum of the heart fuse? | After birth
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| The cerebral cortex is a derivative of what? | The telencephalon
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| What is the adult structure found in the embryo as the: Umbilical vein? | Ligamentum teres
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| What is the adult structure found in the embryo as the: Ductus venosus? | Ligamentum venosum
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| What is the adult structure found in the embryo as the: Foramen ovule? | Fossa ovule
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| What is the adult structure found in the embryo as the: Ductus arteriosus? | Ligamentum arteriosum
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| What is the adult structure found in the embryo as the: Umbilical artery? | Medial umbilical ligament
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| Where does the hindgut end? | At the superior portion of the anal canal
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| Where does the midgut end? | At the right two thirds of the transverse colon
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| From where is the tongue musculature derived? | Occipital somites
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| What two branchial arches contribute to the formation of the anterior two thirds of the tongue? | First and some of the second
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| What are the two fourth pharyngeal pouch derivatives? | Superior parathyroid glands and the ultimobranchial body
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| What two structures are derived from the fourth aortic arch? | Arch of the aorta and the right subclavian artery
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| What adult structures are derived from preotic somites? | Muscles of the internal eye
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| What structure is derived from the first pharyngeal pouch? | The middle ear
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| What two branchial arches contribute to the posterior two thirds of the tongue? | Third and part of the fourth
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| What are the two third pharyngeal pouch derivatives? | Inferior parathyroid glands and the thymus
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| What structure is derived from the first aortic arch? | Maxillary artery
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|
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| From what are the urinary bladder and the urethra derived? | Urogenital sinus
🗑
|
||||
| From what are the pulmonary trunk and the ascending aorta derived? | Truncus arteriosum
🗑
|
||||
| What disorder will result when there is a failure of the urachus to close, causing a leakage of urine out of the umbilicus? | Urachal fistula
🗑
|
||||
| The common carotid and the internal carotid arteries are derivatives of what embryonic structure? | Third aortic arch
🗑
|
||||
| The palatine tonsils are derived from what embryonic structure? | Second pharyngeal pouch
🗑
|
||||
| What are the sixth aortic arch derivatives? | Right and left pulmonary arteries and the ductus arteriosus
🗑
|
||||
| The stapedial artery is derived from what? | Second aortic arch
🗑
|
||||
| The mesonephric ducts contribute to what renal structures? | The collecting ducts, calyx, renal pelvis, and ureters
🗑
|
||||
| Of what embryonic structureis the coronary sinus a derivative? | The left horn of the sinus venosus
🗑
|
||||
| What cranial nerve (CN) is associated with the: First pharyngeal arch? | CN V
🗑
|
||||
| What cranial nerve (CN) is associated with the: Second pharyngeal arch? | CN VII
🗑
|
||||
| What cranial nerve (CN) is associated with the: Third pharyngeal arch? | CN IX
🗑
|
||||
| What cranial nerve (CN) is associated with the: Fourth pharyngeal arch? | CN X
🗑
|
||||
| What cranial nerve (CN) is associated with the: Fifth pharyngeal arch? | None-it degenerates
🗑
|
||||
| What cranial nerve (CN) is associated with the: Sixth pharyngeal arch? | CN X
🗑
|
||||
| From where is the external auditory meatus derived? | First pharyngeal groove
🗑
|
||||
| From where is the smooth portion of the right atrium derived? | Right horn of the sinus venosus
🗑
|
||||
| Meckel's diverticulum is a remnant of what embryonic structure? | Vitelline duct (yolk stalk)
🗑
|
||||
| The pons and cerebellum are derived from what portion of the embryonic neural tissue? | Metencephalon
🗑
|
||||
| The medulla is a derivative of what portion of the embryonic neural tissue? | Myelencephalon
🗑
|
||||
| What structure "tells" the overlying cells to begin neurulation? | The notochord
🗑
|
||||
| What structure splits the cloacal membrane, resulting in the formation of the perineum? | Urorectal septum
🗑
|
||||
| In the adult, the thoracic veins are derived from what structure? | The cardinal veins
🗑
|
||||
| The gastrointestinal tract and abdominal veins are derived from what structure? | Vitelline veins
🗑
|
||||
| From what is the thyroid gland derived? | The floor of the endoderm (the posterior aspect of the tongue)
🗑
|
||||
| The thalamus and its related structures are derivatives of what? | The diencephalon
🗑
|
||||
| Transcriptionally active DNA is known as what? | Euchromatin
🗑
|
||||
| Transcriptionally inactive DNA is called? | Heterochromatin
🗑
|
||||
| What is the only histone not found inside the nucleosomes? | H1 histone-Its function is to bind nucleosomes together.
🗑
|
||||
| What coating protects proteins from intracellular degradation? | Clathrin coating
🗑
|
||||
| A nucleosome is made up of what two components? | Histories and DNA
🗑
|
||||
| What are the four functions of smooth endoplasmic reticulum (SER)? | 1. Steroid synthesis 2. Drug detoxification 3. Ca2+ handling 4. TAG resynthesis
🗑
|
||||
| What are the long microvilli found in the inner ear and the male reproductive tract called? | Stereocilia
🗑
|
||||
| What cell junction type allows for communication between two adjacent cells? | Gap junctions (nexus)
🗑
|
||||
| Where are the enzymes for ATP production and the ETC located? | Inner fold of the mitochondria membrane
🗑
|
||||
| What cell membrane structure increases the surface area of a cell and has actin randomly assorted within its structure? | Microvillus
🗑
|
||||
| What is the function of desmosomes? | To hold adjacent cells together (i.e., adhesion)
🗑
|
||||
| What is the microtubule configuration of a basal body? | 9 + 0 microtubule arrangement
🗑
|
||||
| What are the four components of the basement membrane? | 1. Laminin 2. Heparan sulfate (heparitin sulfate) 3. Fibronectin 4. Type IV collagen
🗑
|
||||
| The proteins that are to stay within the cell are produced by what organelle? | Free polysome (polyribosome)
🗑
|
||||
| What is the lysosomal post- translational modification of proteins? | Phosphorylation of mannose residues
🗑
|
||||
| What cell surface modification of ependymal cells and respiratory epithelium has a 9 + 2 microtubular configur- ation and movement as its function? | Cilia
🗑
|
||||
| What protein binds hemidesmosomes to the basal lamina? | Integrin
🗑
|
||||
| What intermediate filament is found in the zona adherens? | Actin
🗑
|
||||
| The proteins to be exported or incorporated into the lysosome are produced by what organelle? | Bound polysome (polyribosome), attached to rough endoplasmic reticulum (RER)
🗑
|
||||
| What is the function of the zonula occludens and the zonula adherens? | To provide attachment between contiguous cells and to maintain a semipermeable barrier
🗑
|
||||
| The following intermediate filaments are associated with what cell types: Desmin? | Muscle cells
🗑
|
||||
| The following intermediate filaments are associated with what cell types: Cytokeratins? | Epithelial cells
🗑
|
||||
| The following intermediate filaments are associated with what cell types: Vimentin? | Mesenchymal cells
🗑
|
||||
| The following intermediate filaments are associated with what cell types: Neurofilaments? | Neurons
🗑
|
||||
| The following intermediate filaments are associated with what cell types: Glial filaments? | Astrocytes
🗑
|
||||
| The basal lamina + the reticular lamina = what? | The basement membrane
🗑
|
||||
| What is the name of the organelle where collagen is made? | Rough endoplasmic reticulum (RER)
🗑
|
||||
| What vitamin is needed for the hydroxylation of proline and lysine in collagen synthesis? | Vitamin C - Survy
🗑
|
||||
| What are the two amino acids that cross-link elastin molecules? | Desmosine and isodesmosine
🗑
|
||||
| What is the major inorganic component of bone? | Hydroxyapatite
🗑
|
||||
| What cell in bone is a part of the mononuclear phagocytic system? | Osteoclasts
🗑
|
||||
| What are the two types of cells located in the perichondrium of cartilage? | Fibroblasts and chondroblasts
🗑
|
||||
| What cell in the CNS is part of the mononuclear phagocytic system? | Microglia
🗑
|
||||
| What substance, found in eosinophils, is toxic to parasitic worms? | Major basic protein
🗑
|
||||
| Where is tropocollagen aggregated to form a collagen fibril? | Extracellularly
🗑
|
||||
| What cell surface extension allows osteocytes in the lacunaeto "talk" to each other? | Canaliculi
🗑
|
||||
| What cell type produces myelin in the CNS? | Oligodendrocytes
🗑
|
||||
| In which ventricles is/are choroid plexus found? | All four ventricles
🗑
|
||||
| What muscle type has calmodulin? | Smooth muscle
🗑
|
||||
| What element is needed for the proper alignment of the tropocollagen molecules? | Copper (Cu+)
🗑
|
||||
| What is added to the procollagen molecules to prevent intracellular precipitation? | Registration peptides
🗑
|
||||
| In what tissue can you find intercalated disks? | Cardiac muscle
🗑
|
||||
| What are intercalated disks? | Dense bands containing intercellular junctions that link adjacent cells mechanically and electrically
🗑
|
||||
| Of what are intercalated disks composed? | Fascia adherens (mainly) Desmosomes Gap junctions
🗑
|
||||
| What are the proteoglycans of cartilage and bone? | Chondroitin sulfate and keratan sulfate
🗑
|
||||
| What is the only glycosamino- glycan (GAG) that binds to the linker portion of the proteoglycan? | Hyaluronic acid (all sulfates bind to the core portion)
🗑
|
||||
| What is the portion of an axon that lacks myelin and is rich in Na+/K+ pumps? | Node of Ranvier
🗑
|
||||
| What type of CNS cells have cilia, line the ventricles, and contribute to the blood-brain barrier? | Ependymal cells
🗑
|
||||
| What are the largest glial cells in the CNS (Hint: They contribute to the blood- brain barrier.)? | Astrocytes
🗑
|
||||
| Myelin is produced by what type of PNS cells? | Schwann cells
🗑
|
||||
| What is the dominant cell type in the lacunae of cartilage? | Chondrocytes
🗑
|
||||
| What structure runs perpendicular to the Haversian canals in the bone? | Volkmann's canal
🗑
|
||||
| What are the three reasons for the effectiveness of the blood-brain barrier? | 1. Tight junctions 2. Capillaries that lack fenestration 3. Very selective pinocytosis by the capillaries
🗑
|
||||
| What types of muscle have troponin? | Skeletal and cardiac
🗑
|
||||
| What type of muscle is uninuclear and nonstriated? | Smooth muscle - it lacks T tubules and has gap junctions
🗑
|
||||
| On what area of the spleen are the APCs located? | Marginal zone
🗑
|
||||
| What is the dominant cell type in the red pulp of the spleen? | Red blood cells
🗑
|
||||
| On what area of the lymph node can you locate plasma cells? | Medulla
🗑
|
||||
| What is the name of the area in the thymus where T cells are produced? | Hassall's corpuscle
🗑
|
||||
| What type of muscle is striated and multinuclear? | Skeletal muscle- it of T tubules and SR at the A-I junction
🗑
|
||||
| In what region of the spleen are the germinal centers located? | White pulp-where B cell differentiation takes place
🗑
|
||||
| What layer of the skin is missing in thin skin? | Stratum lucidum
🗑
|
||||
| What are the phagocytic cells of the GI tract called? | Paneth cells (Paneth's granular cells)
🗑
|
||||
| Which immunoglobulin is secreted by the plasma cells in the GI tract? | IgA
🗑
|
||||
| In what area of the spleen are the T cells located? | Periarterial lymphatic sheath (PALS)
🗑
|
||||
| In what area of the lymph node are the T cells and the APCs located? | Paracortical (thymic-dependent) area
🗑
|
||||
| What type of muscle is striated, branched, and uninuclear? | Cardiac muscle-dyadic T tubules with SR at the Z line
🗑
|
||||
| What does the tunica intima of arteries have that veins do not? | An internal elastic lamina
🗑
|
||||
| What two layers of skin makeup the malphighian layer? | Stratum basalis and spinosus (mitotic area)
🗑
|
||||
| What type of skin cells have the mature melanin granules? | Keratinocytes. Melanocytes inject melanosomes into the keratinocytes and mature there.
🗑
|
||||
| What type of skin cells are part of the mononuclear phagocytic system? | Langerhans' cells
🗑
|
||||
| What cells of the epidermis, derived from the neural crest, act as mechano- receptors? | Merkel's cells (Merkel's tactile cells)
🗑
|
||||
| What layer of the epidermis acts as a sealant to protect against desiccation? | Stratum granulosum
🗑
|
||||
| What layer of the skin is composed of non-nucleated cells full of keratin? | Stratum corneum
🗑
|
||||
| What are the antigen- presenting cells in the Peyer's patches of the GI known as? | M cells
🗑
|
||||
| What are the three "tunica" layers of a blood vessel wall? | 1. Tunica intima 2. Tunica media 3. Tunica adventitia
🗑
|
||||
| Within what layer of the heart are the nerves and conducting fibers located? | Subendocardial space
🗑
|
||||
| Which organs have fenestrated capillaries with diaphragms? | Kidney, Intestines, Endocrine organs
🗑
|
||||
| What secondary lymphoid tissue is encapsulated and has germinal centers? | Peyer's patches
🗑
|
||||
| What organs have sinusoid capillaries (leakiest type)? | Liver, Bone marrow, Spleen
🗑
|
||||
| What type of vessel has a thick tunica media? | Arteries. Veins have a thick tunica adventitia.
🗑
|
||||
| Is the spleen a capsulated organ with trabeculae? | Yes-although it does not have cortical or medullary regions
🗑
|
||||
| What secondary lymphoid organ is found just below the stratified squamous epithel- ium and is partially capsulated? | Tonsils
🗑
|
||||
| What type of capillary lacks fenestrations and has pinocytotic vesicles? | Continuous capillary
🗑
|
||||
| What region of the body has fenestrated capillaries without diaphragms? | Kidney glomeruli
🗑
|
||||
| Does the thymus have germinal centers? | No. Germinal centers are associated with B cells.
🗑
|
||||
| What cell of the liver is part of the mononuclear phagocytic system? | Kupffer cells
🗑
|
||||
| What papillae are respons- ible for sweet taste? | Circumvalate papillae
🗑
|
||||
| What are the three epi- dermal derivatives? | 1. Nails 2. Hair 3. Sweat glands (both apocrine and sebaceous)
🗑
|
||||
| What papillae send their senses via chorda tympani of CN VII? | Fungiform papillae
🗑
|
||||
| What is the area of mitotic activity in the GI tract? | The crypts of Lieberkuhn
🗑
|
||||
| What cells of the GI tract secrete HCl and intrinsic factor? | Parietal cells of the stomach
🗑
|
||||
| What type of sweat gland is under cholinergic stimulation? | Eccrine gland
🗑
|
||||
| What gland produces a serous secretion that is approximately 20% of the total saliva produced? | Parotid gland
🗑
|
||||
| What papillae are touch receptors on the tongue and send their sensations via CN V3 (mandibular division)? | Filiform papillae
🗑
|
||||
| Secretin and CCK are produced in what portion of the GI tract? | Small intestine
🗑
|
||||
| What cells of the stomach secrete pepsinogen? | Chief cells
🗑
|
||||
| What cell type produces dentin of the teeth? | Odontoblasts (neural crest)
🗑
|
||||
| What cell type produces enamel of the teeth? | Ameloblasts (ectoderm)
🗑
|
||||
| What gland produces 70% of the total salivary secretions and is a mixture of serous (predominantly) and mucous alveoli and secretory units? | Submandibular gland
🗑
|
||||
| What type of cells of the respiratory system secrete surfactant? | Type II pneumocytes
🗑
|
||||
| What zone of the liver is the first to be affected in times of hypoxia? | Central region (around the central vein)
🗑
|
||||
| In what region of the respiratory system do you first see Clara cells? | Terminal bronchioles
🗑
|
||||
| What substance does the juxtaglomerular cells of the kidney secrete in response to low blood pressure? | Renin
🗑
|
||||
| In what region of the liver is fat stored? | Space of Disse -Ito cells and Vit A also
🗑
|
||||
| In what region of the GI tract does exfoliation take place? | At the tip of the villi
🗑
|
||||
| What are the mucus secreting cells in the respiratory tract above the level of the terminal bronchioles? | Goblet cells
🗑
|
||||
| What cells of the distal convoluted tubule are sensitive to the low ion content of the urine? | Macula densa
🗑
|
||||
| What cells comprise 95% of the alveolar surface and are responsible for gas exchange? | Type I pneumocytes
🗑
|
||||
| What are the two hormones secreted by the posterior pituitary gland via the para- ventricular supranuclei? | ADH and oxytocin
🗑
|
||||
| What area of the nephron is impermeable to water? | Ascending limb of the loop of Henle
🗑
|
||||
| What region of the kidney is affected by ADH? | Collecting duct for water reabsorption- but the DCT is also affected by ADH
🗑
|
||||
| What portion of the kidney actively pumps Cl- out of the tubule? | Thick ascending limb of the loop of Henle
🗑
|
||||
| What region of the kidney has a countercurrent multi- plier producing a gradient of hypertonicity in the tubule lumen? | Loop of Henle
🗑
|
||||
| What region of the liver is first affected in toxic doses of drugs? | Peripheral zone (because extraction of substances occurs there first)
🗑
|
||||
| What are the two acidophilic hormones secreted by the adenohypophysis? | GH and prolactin "(,Pp;~
🗑
|
||||
| In what region of the kidney does the greatest extraction of nutrients occur? | Proximal convoluted tubule (-66% of nutrient extraction occurs here)
🗑
|
||||
| What cells of the thyroid gland secrete calcitonin? | Parafollicular C cells (new4 ash,
🗑
|
||||
| What cells of the adrenal gland are neural crest derivatives? | Chromaffin cells (adrenal medulla)
🗑
|
||||
| What cells secrete glucagon? | Alpha cells of the islet of Langerhans
🗑
|
||||
| What hormone inhibits glucagon release and pancreatic exocrine secretions? | Somatostatin
🗑
|
||||
| What hormone causes milk letdown? | Oxytocin
🗑
|
||||
| Low levels of what hormone stimulates the uterus to go into its proliferative stage? | Estrogen
🗑
|
||||
| What cells of the genito- urinary system secrete testosterone? | Leydig cells (stimulated by LH)
🗑
|
||||
| What is the mucus-secreting gland in the male reproductive system? | Bulbourethral glands (Cowper's glands)
🗑
|
||||
| Elevated levels of what hormone cause the endometrium to enter the secretory phase of the female cycle? | Progesterone
🗑
|
||||
| What are the cells of the parathyroid gland that produce parathyroid hormone (PTH)? | Chief cells
🗑
|
||||
| What hormone produced during the night causes a decrease in gonadal function? | Melatonin
🗑
|
||||
| Where is melatonin produced? | Pineal gland
🗑
|
||||
| What are the four basophilic hormones released from the adenohypophysis? | 1. Adrenocorticotrophic hormone (ACTH) 2. Thyroid-stimulating hormone (TSH) 3. Luteinizing hormone (LH) 4. Follicle-stimulating hormone (FSH)
🗑
|
||||
| What cells form the blood-testis barrier? | Sertoli's cells
🗑
|
||||
| What is the chromosome number of-G1? | 46 (2n)
🗑
|
||||
| What is the chromosome number of-S phase? | 46 (4n)
🗑
|
||||
| What is the chromosome number of-G2? | 46 (4n)
🗑
|
||||
| What is the chromosome number of-Mitosis? | 46 (4n) to 46 (2n)
🗑
|
||||
| What is the chromosome number of a primary spermatocyte? | 46 (4n)
🗑
|
||||
| In females, meiosis is arrested twice - when and at what stages of meiosis? | 1. First, in utero at prophase I, 2. Second, at ovulation in metaphase II
🗑
|
||||
| What cell is under control of FSH and testosterone; secretes inhibin, MIF, and androgen-binding protein; and phagocytizes the excess cytoplasm of the spermatid? | Sertoli cell
🗑
|
||||
| What must occur for an egg to complete ovulation? | It needs to be fertilized by a sperm. If it is not, the egg is released in metaphase II and meiosis is incomplete.
🗑
|
||||
| What is the chromosome number at the end of meiosis I? | 23 (2n)-it is the reductive phase of meiosis.
🗑
|
||||
| What is the major androgen released from the zona reticularis? | Dehydroepiandrosterone (DHEA)
🗑
|
||||
| What hormone causes an increase in the accumulation of adipose and collagenous tissue of the breast and an increase in the branching of the ducts of the breast? | Estrogen
🗑
|
||||
| What promotes further prolactin and oxytocin release? | Suckling
🗑
|
||||
| What part of the placenta is derived from the mother? | Decidua basalis
🗑
|
||||
| What is the most common site of fertilization? | Ampulla of the fallopian tube
🗑
|
||||
| What is the only cranial nerve that comes off the dorsal surface of the brain stem? | CN IV
🗑
|
||||
| What type of fiber is carried in the dorsal root? | Sensory or motor. Sensory only
🗑
|
||||
| How would a lower motor neuron (LMN) lesion present? | Hyporeflexia, fasiculations and flaccid paralysis (always ipsilateral)
🗑
|
||||
| What is the name of the brain stem tract in which the dorsal columns run? | Medial lemniscus
🗑
|
||||
| What is the ability to tell what something is without looking at it and using only your hands? | Stereognosis
🗑
|
||||
| In what tract do pain and temperature fibers run? | Spinothalamic tract
🗑
|
||||
| What gyrus in the cerebral cortex receives information from fibers of the dorsal column tract? | Postcentral gyrus
🗑
|
||||
| What area of the brain is responsible for contralateral gaze? | Frontal eye field (Brodmann area 8)
🗑
|
||||
| What is the thalamic relay nucleus for the visual system? | Lateral geniculate body (LGB)
🗑
|
||||
| What is the function of the ossicles? | They increase the intensity of sound
🗑
|
||||
| What muscle in the eye is responsible for accommodation? | Ciliary muscle
🗑
|
||||
| What area of the eye has the greatest visual acuity? | Fovea (it is made up soley of cones)
🗑
|
||||
| What cell type in the eye is for color vision? | Cones (Cones and color)
🗑
|
||||
| If there is macula sparing in a visual deficit, where is the lesion? | In the occipital lobe of the cerebral cortex (optic radiations)
🗑
|
||||
| ... | Which way do the eyes drift in a frontal eye field lesion?
🗑
|
||||
| To the side of the lesion | What is the thalamic relay nucleus that CN V needs to "speak" to in order to pass its information on to the cerebral cortex?
🗑
|
||||
| Ventroposteromedial (VPM) | Cell bodies of what fibers are found in the mesencephalic nucleus of CN V?
🗑
|
||||
| Proprioception of the face (CN V) and motor (jaw jerk reflex) | If a patient presented with an LMN lesion in CN V, CN VII, or CN XII, what would you see?
🗑
|
||||
| Ipsilateral paresis | What is the motor relay nucleus of the thalamus?
🗑
|
||||
| Ventrolateral (VL) nucleus of thalamus | What is the only cell type to leave the cerebellum?
🗑
|
||||
| Purkinje (inhibitory) - GABA | If a patient presented with a right-sided cerebellar lesion, which way would the patient fall if he closed his eyes?
🗑
|
||||
| To the right | What is the function of the superior olivary nucleus?
🗑
|
||||
| To localize and detemine the nature of sounds (Sound and superior start with S.) | If a patient presents with a left nystagmus, where is the lesion?
🗑
|
||||
| On the right, because the nvstagmus is named for the fast component, and the fast component is to the unaffected side. | What region of the cerebellum is responsible for the planning of movements?
🗑
|
||||
| Cerebellar hemisphere | What is the thalamic relay nucleus for the limbic system?
🗑
|
||||
| Anterior nucleus | What fluid is found in the anterior chamber of the eye?
🗑
|
||||
| Aqueous humor | What is the dividing line between the anterior and posterior chambers of the eye?
🗑
|
||||
| The lens | If there is a total anopsia of the left eye, where is the lesion?
🗑
|
||||
| Optic nerve of the left eye | What is the center for ipsilateral gaze?
🗑
|
||||
| The paramedian pontine reticular formation (PPRF) | What fluid of the inner ear has an electrolyte content like that of the extracellular fluid compartment (ECF)?
🗑
|
||||
| Perilymph | What is the thalamic relay nucleus for the auditory system?
🗑
|
||||
| MGB | What region of the cerebellum is responsible for balance and eye movement?
🗑
|
||||
| Flocculonodular lobe | What is the only cell in the cerebellum to have an excitatory neurotransmitter?
🗑
|
||||
| Granule cell | What does the nystagmus look like if cold water is placed in the right ear?
🗑
|
||||
| Slow drift to the right, fast drift to the left | COWS = Cold Opposite - Warm Same (named in reference to the fast component)
🗑
|
||||
| Information from the cerebellum leaves via what? | Superior cerebellar peduncle
🗑
|
||||
| In what portion of the internal capsule are you if you can see the caudate nucleus? | Anterior limb
🗑
|
||||
| What type of memory is lost in a hippocampal lesion? | Long-term memory
🗑
|
||||
| In what region of the brain stem does the corticospinal tract cross over? | Medullary decussation
🗑
|
||||
| From what gyrus of the brain does the corticospinal tract originate? | Precentral gyrus
🗑
|
||||
| What type of fibers are carried in the ventral rami? | Both sensory and motor (from the spinal nerve on both sensory and motor fibers)
🗑
|
||||
| What are the hallmark signs of an upper motor neuron (UMN) lesion? | 1. Hyperreflexia 2. Spastic paralysis 3. Positive Babinski sign
🗑
|
||||
| What tract carriers fibers for voluntary refined movements of the distal extremities? | Corticospinal tract
🗑
|
||||
| What is the name of the tract in which the dorsal columns from the lower extremities run? | Fasciculus gracilis (It is medial of the two tracts on a cross-section of the spinal cord; the lateral tract is the fasciculus cuneatus.) Remember: Lower extremities dancing-graceful-gracilis.
🗑
|
||||
| What is the function of the superior colliculi? | Cell bodies that are to be relayed to the thalamus for sight are found there. (Sight and superior start with S.)
🗑
|
||||
| In order for sensory information from the dorsal columns and the spinothalamic tract to get to the cerebral cortex, they must use what thalamic relay nucleus? | Ventroposterolateral (VPL)
🗑
|
||||
| In which region of the spinal cord does the spinothalamic tract cross over? | Ventral white commissure (VWC)
🗑
|
||||
| Sensory information from the spinothalamic tract sends its information to what region of the cerebral cortex? | Postcentral gyrus
🗑
|
||||
| In which region of the brain stem do the dorsal columns cross over? | Lower medulla (synapse on nucleus gracilis or cuneatus)
🗑
|
||||
| What tract carries conscious proprioception,fine touch, two-point discrimination, and vibratory sense? | Dorsal column tract (all senses except pain and temperature)
🗑
|
||||
| What tract of the spinal cord carries dorsal column information from the upper extremities? | Fasciculus cuneatus
🗑
|
||||
| If the right side of the corticobulbar tract to the muscles of facial expression were damaged, where would the deficit be seen? | In the contralateral lower face (left)
🗑
|
||||
| If the corticobulbar tract for CN V and CN XII were cut on the right side, where would the lesion be? | There would be no deficit, because the corticobulbar tract receives bilateral input.
🗑
|
||||
| What type of fibers are carried in the ventral root? | Motor only
🗑
|
||||
| What peduncle(s) carry information into the cerebellum? | Inferior and middle cerebellar peduncles
🗑
|
||||
| Cell bodies of what fibers are found in the trigeminal ganglion? | Touch, pain, and temperature
🗑
|
||||
| When the head moves, what causes the eyes to move in the opposite direction? | Vestibular system
🗑
|
||||
| Unconscious proprioception, body sense, and motor execution are functions of what part of the cerebellum? | Vermis and intermediate lobe
🗑
|
||||
| What three structures contain perilymph? | 1. Scala tympani 2. Scala vestibuli 3. Semicircular canals
🗑
|
||||
| The gravity receptors for changes in the position of the head are located in what part of the inner ear? | Saccule and utricle
🗑
|
||||
| What cells are for black and white vision (night vision)? | Rods
🗑
|
||||
| What is the fluid of the posterior compartment of the eye? | Vitreous humor
🗑
|
||||
| What type of fluid in the inner ear has the consistency of intracellular fluid (ICF)? | Endolymph (high levels of K+)
🗑
|
||||
| Name three lesions that can cause left homonymous hemianopsia? | 1. Lesion of the right optic tract 2. Lesion of the lateral geniculate body (LGB) 3. Lesion of the optic radiation
🗑
|
||||
| What lesion produces a tremor upon movement? | A cerebellar lesion
🗑
|
||||
| What part of the inner ear is sensitive to angular acceleration and deceleration? | Semicircular canals
🗑
|
||||
| What is the normal volume of CSF? | Approximately 140 ml
🗑
|
||||
| What muscle of the eye is under parasympathetic control? | Sphincter pupillae (part of iris)
🗑
|
||||
| What cranial nerve receives sensory information from the cornea? | CN VI (ophthalmic division)
🗑
|
||||
| What artery supplies blood to the trunk and the lower extremities on a homunculus map of the cerebral cortex? | Anterior cerebral artery
🗑
|
||||
| What structures of the inner ear contain endolymph? | 1. Scala media 2. Semicircular ducts 3. Saccule Utricle
🗑
|
||||
| With what type of lesions do you see tremors at rest? | Lesions of the basal ganglia
🗑
|
||||
| What muscle of the eye is under sympathetic control? | Dilator pupillae (part of the iris)
🗑
|
||||
| Where is the lesion if the patient presents with a right nasal hemianopsia? | Right internal carotid artery compression on the optic chiasm
🗑
|
||||
| What part of the inner ear functions in head movement? | Semicircular ducts
🗑
|
||||
| What part of the internal capsule are you in if you see the thalamus? | Posterior limb of the internal capsule
🗑
|
||||
| What region of the basal ganglia is affected in Parkinson's disease? | Substantia nigra (degeneration)
🗑
|
||||
| Hemorrhagic destruction of the contralateral subthalamic nuclei results in what disorder? | Herniballismus (wild flailing movements)
🗑
|
||||
| Slow writhing movements (athetosis) are caused by what? | Hypermyelinization of the corpus striatum and the thalamus (seen in cerebral palsy)
🗑
|
||||
| Atrophy of the striatum of the basal ganglia results in what? | Chorea (involuntary quick movements)
🗑
|
||||
| What tracts are found in the genu of the internal capsule? | Corticobulbar tracts
🗑
|
||||
| What tracts are found in the posterior limb of the IC? | Corticospinal Spinothalamic Dorsal column Thalamocortical
🗑
|
||||
| What tracts are found in the anterior limb of the IC? | Thalamocortical tracts
🗑
|
||||
| If warm water is placed in the right ear, what does the nystagmus look like? | Slow drift to the left and fast drift to the right (COWS = Cold Opposite & Warm Same)
🗑
|
||||
| What lesion causes a bitemporal hemianopsia? | Optic chiasm lesion
🗑
|
||||
| What area of the brain is known as the motor speech area? | Broca's area
🗑
|
||||
| What does Meyer's loop lesion cause? | Contralateral homonymous superior quadrantopia
🗑
|
||||
| Blood supply to the head/neck area and the upper limb on a homunculus map in the cerebral cortex comes from what artery? | Middle cerebral artery
🗑
|
||||
| What area of the brain is known for language comprehension? | Wernicke's area
🗑
|
||||
| Where is the lesion if the patient presents with a right homonymous inferior quadrantanopia? | Left upper loop lesion
🗑
|
||||
| What region of the cerebellum is affected if a patient has dystaxia of the legs and trunk during walking? | Anterior vermis (It is most commonly caused by chronic alcohol abuse.)
🗑
|
||||
| Where is the lesion in a patient who presents with a broad-based gait, hypotonia, intention tremors, nystagmus, and ataxia? | Cerebellum
🗑
|
||||
| What are the functions of the external auditory meatus? | Sound collection and protection of the tympanic membrane
🗑
|
||||
| What is the function of the inferior colliculi? | To receive bilateral auditory input and arrange the input tonotopically
🗑
|
||||
| If a patient presents with nystagmus, dystaxia, and hypotonia of the ipsilateral limbs, what area of the cerebellum is affected? | Hemisphere
🗑
|
||||
| What lesion of the cerebellum is usually caused by an ependymoma or medulloblastoma, resulting in dystaxia of the trunk with an inability to maintain an upright posture? | Posterior vermis lesion
🗑
|
||||
| What spinal cord injury results in flaccid paralysis and muscle atrophy? | Polio (bilateral ventral horn lesion)
🗑
|
||||
| What spinal cord lesion results in a lower motor neuron (LMN) lesion at the level of the lesion and an upper motor neuron (UMN) lesion below the level of the lesion? | Amyotrophic lateral sclerosis (ALS)-Lou Gehrig's disease
🗑
|
||||
| What arterial occlusion would result in a loss of all tracts in the spinal cord except the dorsal columns? | Anterior spinal artery occlusion (posterior spinal artery supplies the dorsal columns)
🗑
|
||||
| What spinal cord lesion results in a bilateral loss of pain and temperature at the level of the lesion? | Syringomyelia (VWC lesion)
🗑
|
||||
| What spinal cord lesion causes a bilateral dorsal column loss below the level of the lesion? | Tabes dorsalis (neurosyphilis)
🗑
|
||||
| What disease is associated with demyelination of the dorsal column, spinocerebellar tract, and corticospinal tract? | Subacute combined degeneration
🗑
|
||||
| What arterial occlusion results in contralateral spastic hemiparesis, contralateral spastic lower face, and ipsilateral oculomotor palsy (dilated, ptosis, eye down and out)? | Posterior cerebral artery occlusion (ventral midbrain syndrome)
🗑
|
||||
| What syndrome is associated with an ipsilateral UMN lesion below the level of the lesion, ipsilateral dorsal column loss at and below the level of the lesion, an LMN lesion at the level of the lesion, bilateral loss of pain and temperature at the level an | Brown-Sequard syndrome (heimisection of the spinal cord)
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Contralateral spastic hemiparesis of the body? | Vertebral artery-pyramid
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Contralateral loss of position and vibration? | Vertebral artery-medial lemniscus
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Ipsilateral paralysis of the tongue? | Vertebral artery-CN XII
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Ipsilateral limb ataxia? | Anterior inferior cerebellar artery-inferior cerebellar peduncle
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Ipsilateral pain and temperature loss of the face? | Anterior inferior cerebellar artery-spinal nucleus of CN V
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Contralateral pain and temperature of the body? | Anterior inferior cerebellar artery- spinotbalamic tract
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Nystagmus away from the lesion? | Anterior inferior cerebellar artery- vestibular nuclei
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Ipsilateral Horner's syndrome? | Anterior inferior cerebellar artery- descending autonomics
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Ipsilateral facial paralysis? | Anterior inferior cerebellar artery-CN Vll
🗑
|
||||
| What arterial occlusion results in the following syndromes (Name artery and specific region.): Deafness? | Anterior inferior cerebellar artery-CN VIll
🗑
|
||||
| What is the name for the most prominent spinous process in the spine? | Vertebra prominens (C7 in 70% of cases, C6 in 20%, T1 in 10%)
🗑
|
||||
| What portion of the intervertebral disk is a remnant of the notochord? | Nucleus pulposus
🗑
|
||||
| What three muscles comprise the erector spinae? | 1. Iliocostalis 2. Longissimus 3. Spinalis
🗑
|
||||
| What are the names given to the first and second cervical vertebrae? | C1-atlas C2-axis
🗑
|
||||
| To what vertebral level does the spinal cord extend? | LI to L2
🗑
|
||||
| What is the name of the extension of the dura mater that attaches at the level of S2? | External filum terminale
🗑
|
||||
| How many pairs of spinal nerves exit from the spinal cord? | 31 pairs
🗑
|
||||
| What is the name of the region where the manubrium and the body of the sternum articulate? | Sternal angle of Louis
🗑
|
||||
| What muscle originates from the third to the fifth ribs and inserts into the coracoid process? | Pectoralis minor
🗑
|
||||
| Damage to what nerve will give you "winged scapula'."? | Long thoracic nerve To avoid confusing long thoracic nerve and lateral thoracic artery: Long has an "n" for nerve; lateral 3 & has an "a" for artery.
🗑
|
||||
| The ventral rami of what regions of the spinal cord make up the brachial plexus? | C5-TI
🗑
|
||||
| What bone houses the ulnar groove? | Humerus (between the medial epicondyle and the trochlea)
🗑
|
||||
| What muscle initiates Abduction of the arm? | Supraspinakis
🗑
|
||||
| What muscle acts in all ranges of motion of the arm? | Deltoid
🗑
|
||||
| What nerve is damaged if a patient presents with "wrist drop"? | Radial nerve
🗑
|
||||
| What forms the anatomic snuff box? | Extensor pollicis longus, abductor pollicis longus, extensor pollicis brevis
🗑
|
||||
| What vein, in the antecubital fossa, forms the communica- tion between the basilic vein and the cephalic vein? | Median cubital vein (most common site for venipuncture)
🗑
|
||||
| What two muscles are inner- vated by the axillary nerve? | Deltoid and teres minor
🗑
|
||||
| What nerve is compromised in carpal tunnel syndrome? | Median nerve
🗑
|
||||
| In what compartment of the thigh is the profundus femoris artery found? | Anterior compartment (it's the blood supply to the posterior compartment)
🗑
|
||||
| Foot drop is caused by a compromise in what nerve? | Common peroneal nerve
🗑
|
||||
| What nerve is damaged if the patient cannot ADduct the thigh? | Obturator nerve (nerve to the medial compartment of the thigh)
🗑
|
||||
| What is the longest muscle of the body? | Sartorius
🗑
|
||||
| What two nerves innervate the pectineus muscle? | Femoral and obturator nerves
🗑
|
||||
| What superficial vein empties into the popliteal fossa? | Short saphenous vein
🗑
|
||||
| What is the artery of the anterior compartment of the leg? | Anterior tibia] artery
🗑
|
||||
| What nerve supplies the lateral compartment of the leg? | Superficial peroneal nerve
🗑
|
||||
| What sensory nerve are you testing when you touch the first web space of the toes? | Deep peroneal nerve
🗑
|
||||
| The peroneal artery is a branch of what artery? | Posterior tibial
🗑
|
||||
| Inflammation of the pre- patellar bursa is often referred to as what? | Housemaid's knee
🗑
|
||||
| What is the prominent "bump" on the lateral aspect of the knee? | Head of the fibula
🗑
|
||||
| How many ribs articulate with the sternum? | Seven (Ribs 8, 9, and 10 articulate with the costal cartilage of rib 7.)
🗑
|
||||
| What is the part of the lung that extends above the level of the first rib? | The cupula
🗑
|
||||
| What type of pleura is adherent to the surface of the organ? | Visceral pleura
🗑
|
||||
| How many lobes does the right lung have? | Three
🗑
|
||||
| How are they separated? | By the oblique and the transverse fissures
🗑
|
||||
| Into what chamber of the heart do the pulmonary veins empty? | Left atrium (Remember-the pulmonary veins carry oxygenated blood.)
🗑
|
||||
| What is the only valve in the heart that has two cusps? | Mitral (bicuspid) valve
🗑
|
||||
| What vein travels with the right coronary artery? | Small cardiac vein
🗑
|
||||
| At what vertebral level does the trachea bifurcate? | T4-T5 (It is known as the carina.)
🗑
|
||||
| What attaches the cusps of the valves to the papillary muscles in the heart? | Chordae tendineae
🗑
|
||||
| Around what thoracic structure does the right recurrent laryngeal nerve loop before ascending into the larynx? | Right subclavian artery
🗑
|
||||
| At what vertebral level does the esophagus originate? | C6
🗑
|
||||
| At what level does the abdominal aorta bifurcate into the common iliac arteries? | L4-L5
🗑
|
||||
| The obturator artery is a branch of what major artery? | Internal iliac artery
🗑
|
||||
| What is the first branch off the abdominal artery? | Inferior phrenic artery
🗑
|
||||
| Into what vessel does the right gonadal vein drain? | The inferior vena cava
🗑
|
||||
| Into what vessel does the left gonadal vein drain? | The left renal vein
🗑
|
||||
| At what vertebral level does the common carotid artery bifurcate? | C4
🗑
|
||||
| At what vertebral level is the hyoid bone found? | C3
🗑
|
||||
| The ophthalmic artery is a branch of what vessel? | Internal carotid artery
🗑
|
||||
| What forms the portal vein? | The union of the superior mesenteric and the splenic veins
🗑
|
||||
| Where does the inferior mesenteric vein drain? | The splenic vein
🗑
|
||||
| What vein is formed by the union of the right and left brachiocephalic veins? | Superior vena cava
🗑
|
||||
| What is the only muscle in the larynx that is not inner- vated by the recurrent laryn- geal nerve? | Cricothyroid (It's innervated by the external laryngeal nerve.)
🗑
|
||||
| The folds of the mucosa of the stomach are known as what? | Rugae
🗑
|
||||
| What is the artery of the embryonic foregut? | Celiac artery
🗑
|
||||
| What comprises the portal triad? | 1. Common bile duct 2. Hepatic artery 3. Portal vein
🗑
|
||||
| What structures differentiate the anatomic right and left lobes of the liver? | Ligamentum teres and ligamentum venosum
🗑
|
||||
| What structure "runs" along the transverse processes of the lumbar vertebrae? | Ureters
🗑
|
||||
| To enter into the lesser peri-toneal sac, you must traverse through what foramen? | Foramen of Winslow
🗑
|
||||
| What is another name for the rectouterine pouch? | Pouch of Douglas
🗑
|
||||
| What bones comprise the acetabulum? | Pubis, ilium, and ischium
🗑
|
||||
| What two ligaments of the uterus are remnants of the gubernaculum? | Bound and ovarian ligaments
🗑
|
||||
| What muscles comprise the deep perineal space (the urogenital diaphragm)? | Deep transverse perineal and sphincter urethrae
🗑
|
||||
| What three ligaments com- prise the broad ligament of the uterus? | 1. Mesosalpinx 2. Mesovarium 3. Mesometrium
🗑
|
||||
| What structure traverses the diaphragm at the level of T8? | IVC
🗑
|
||||
| What are the components of the pudendal canal? | Pudendal nerve and internal pudendal artery and vein
🗑
|
||||
| What range of movements can be performed at the metacarpal/phalangealjoint? | Flexion/extension, ABduction, and ADduction
🗑
|
||||
| A fracture of the surgical neck of the humerus will most likely damage what nerve? | Axillary nerve
🗑
|
||||
| What compartment of the lower extremity allows flexion of the hip and extension of the knee? | Anterior compartment of the thigh
🗑
|
||||
| What nerve roots comprise the lumbosacral plexus? | L4 to S4
🗑
|
||||
| What is the function of gray rami communicans? | They are postganglionic sympathetic axons.
🗑
|
||||
| What compartment of the lower extremities allows ADduction of the thigh and flexion of the hip? | Medial compartment of the thigh
🗑
|
||||
| What are the only splanchnics in the body that carry preganglionic parasympathetic fibers? | Pelvic splanchnics (P begins preganglionic, parasympathetic, and pelvic.)
🗑
|
||||
| What postganglionic parasympathetic ganglion is associated with CN III? | Ciliary ganglion
🗑
|
||||
| What is the name of the ganglion that houses the cell bodies for the postganglionic sympathetic fibers to the head and neck? | Superior cervical ganglion
🗑
|
||||
| What two muscles do you test to see if CN XI is intact? | Trapezius and sternocleidoinastoid
🗑
|
||||
| What component of the corneal reflex is lost in a CN VII deficit? | Motor aspect
🗑
|
||||
| Toward what side would the uvula point if the right CN X were damaged? | The left (points to the unaffected side)
🗑
|
||||
| What is the name of the urinary bladder where the ureters enter and the urethra exits? | Urinary trigone
🗑
|
||||
| What is the only organ in the body supplied by preganglionic sympathetic fibers? | Adrenal rnedulla
🗑
|
||||
| The pudendal canal is formed by splitting the fascia of what muscle? | Obturator internus
🗑
|
||||
| What is the name of the duct formed by the union of the vas deferens and the duct of the seminal vesicle? | Ejaculatory duct
🗑
|
||||
| What are the fingerlike projections at the end of the fallopian (uterine) tubes? | Fimbriae
🗑
|
||||
| Where is the seminal vesicle located? | On the posterior aspect of the urinary bladder
🗑
|
||||
| What vessel can be found atop the scalene anterior? | Subclavian vein
🗑
|
||||
| What muscle divides the anterior from the posterior triangles of the neck? | Sternocleidomastoid
🗑
|
||||
| Where does the parotid (Stenson's) duct enter the oral cavity? | Opposite the second upper molar tooth
🗑
|
||||
| What is the function of the arachnoid granulations? | Resorb CSF into the blood
🗑
|
||||
| What muscle is the most superiorly situated muscle in the orbit? | Levator palpebrae superioris
🗑
|
||||
| What is the triad of Horner's syndrome? | Miosis, ptosis, and anhydrosis
🗑
|
||||
| What bone of the middle ear articulates with the tympanic membrane? | Malleus
🗑
|
||||
| What chamber of the eye is located between the iris and the lens? | Posterior chamber
🗑
|
||||
| What bone houses the ear? | Temporal bone
🗑
|
||||
| What is the only muscle of the tongue not innervated by the hypoglossal nerve? | Palatoglossus
🗑
|
||||
| Where does the nasolacrimal duct terminate? | Inferior meatus of the nasal cavity
🗑
|
||||
| What gland is found in the muscular triangle of the neck? | Thyroid gland
🗑
|
||||
| What two regions of the vertebral column are con- sidered primary curvatures? | Thoracic and sacral
🗑
|
||||
| What are the only muscles in the body innervated by dorsal rami? | Intrinsic (deep) muscles of the back (All other muscles are innervated by ventral rami.)
🗑
|
||||
| What is the portion of the second cervical vertebra that projects superiorly to act as the body for C1? | Odontoid (dens) process
🗑
|
||||
| What is the actual space that contains CSF? | Subarachnoid space
🗑
|
||||
| What is the protective covering that is adherent to the spinal cord and CNS tissue? | Pia mater
🗑
|
||||
| What is the name of the spinal cord that passes within the subarachnoid space that forms the spinal nerves that exit the lumbar and sacral foramina? | Cauda equina
🗑
|
||||
| What are the names ligaments that would pierced, in order, by a lumbar puncture? | 1. Supraspinous ligament 2. Interspinous ligament 3. Ligamentum flavum
🗑
|
||||
| What is the inferiormost segment of the sternum? | Xiphoid process
🗑
|
||||
| True or false-the pectoralis major medially rotates the arm? | True; it also ADducts and flexes the arm.
🗑
|
||||
| What are the borders of the axillary artery? | Lateral border of the first rib to the inferior border of the teres major
🗑
|
||||
| What vessels arise from the three segments of the axillary artery? | 1. Superior thoracic artery 2. Lateral thoracic artery and thoracoacromial trunk 3. Subscapular artery, and the anterior and posterior humeral circumflex One artery from the first segment, two arteries from the second segment, and three arteries from the
🗑
|
||||
| What muscle is the main lateral rotator of the arm? | Infraspinatus muscle
🗑
|
||||
| What innervates the flexor compartment of the arm? | Musculocutaneus nerve
🗑
|
||||
| What nerve is most commonly affected when there is a fracture of the midshaft of the humerus? | Radial nerve C deer "(Int4.1 a .
🗑
|
||||
| What vein courses along the medial aspect of the forearm? | Basilic vein
🗑
|
||||
| What is the blood vessel in the upper extremity most commonly palpated while taking a pulse? | Radial artery
🗑
|
||||
| What is the nerve supply to the forearm? | Median nerve (except for the flexor carpi ulnaris and flexor digiti profundus muscles of the pinkie and ring finger, which are supplied by the ulnar)
🗑
|
||||
| What are the "LOAF" muscles of the hand? | LOAF stands for the muscles of the hand innervated by the median nerve: Lumbricales, Opponens pollicis, Abductor pollicis brevis, and Flexor pollicis brevis; All other intrinsic muscles in the hand are innervated by the ulnar nerve
🗑
|
||||
| What muscles in the hand ADduct the fingers? | The palmer interosseus adducts, whereas the dorsal interosseus abducts (PAD and DAB)
🗑
|
||||
| In order to pronate the hand, what bones need to cross? | Radius crosses over the ulna
🗑
|
||||
| At what point does the femoral artery become the popliteal artery? | When it traverses the adductor hiatus
🗑
|
||||
| Loss of ABduction of the lower limbs results in Trendelenburg gait; what nerve is compromised to cause this? | Superior gluteal nerve
🗑
|
||||
| What two arteries join together to form the super- ficial and deep palmar arches of the hand? | Uhiar and radial arteries (ulnar is the main supplier)
🗑
|
||||
| What muscle "fills" the greater sciatic foramen? | Piriformis
🗑
|
||||
| What nerve is affected when a patient has difficulty rising from a sitting position? | Inferior gluteal nerve (nerve to the gluteus maximus)
🗑
|
||||
| Why are IM injections in the gluteal mass given in the upper outer quadrant? | To avoid damage to the sciatic nerve
🗑
|
||||
| What two nerves innervate the adductor magnus? | Obturator and tibial nerves
🗑
|
||||
| What two nerves innervate the biceps femoris? | Common peroneal and tibial nerves
🗑
|
||||
| Going from lateral to medial, what structures pass deep to the inguinal ligament? | NAVEL-Nerve, Arterv, Vein, Empty space, and Lacunar ligament or Lymphatics
🗑
|
||||
| What artery turns into the dorsalis pedis when it crosses the extensor retinaculum? | Anterior tibial artery
🗑
|
||||
| What is the nerve for the anterior compartment of the leg? | Deep peroneal nerve
🗑
|
||||
| What is the artery for the posterior compartment of the leg? | Posterior tibial arterv
🗑
|
||||
| Where is the "magical plane" that divides the superior from the inferior media- stinum? | A horizontal line from T4-T5 to the sternal angle of Louis
🗑
|
||||
| What vein drains the lower third of the thoracic wall? | Hemiazygous vein
🗑
|
||||
| If you were to do a pleural tap, what region of the intercostal space would your needle enter? | The superior border of the rib
🗑
|
||||
| Why? | Because the neurovascular bundle is located on the inner surface of the inferior border of the rib
🗑
|
||||
| What muscles of the foot are supplied by the medial plantar nerve (Hint: Think about the median nerve distribution in the hand.)? | LAFF-Lumbricalis (1st), Abductor hallucis, Flexor 3X hallucis brevis, Flexor digitorum brevis. All other intrinsic muscles in the foot are supplied by the lateral plantar nerve.
🗑
|
||||
| What remnant of the middle lobe of the lung is found on the left side? | The lingula
🗑
|
||||
| The ventral rami of what cervical vertebrae innervate diaphragm? | C3, C4, and C5 keep the diaphragm alive!
🗑
|
||||
| At the level of rib 6, the internal thoracic artery divides into what two arteries? | Musculophrenic and superior epigastric arteries
🗑
|
||||
| What portion of the peri- cardium is adherent to the tunica adventitia of the great vessels? | Fibrous pericardium
🗑
|
||||
| The left anterior descending artery of the heart travels with what vein? | Great cardiac vein
🗑
|
||||
| What is the largest muscle in the body? | Gluteus maximus
🗑
|
||||
| The middle cardiac vein of the heart travels with what artery? | Posterior intraventricular artery
🗑
|
||||
| What is the ratio of the myocardial thickness of the atria: right ventricle: left ventricle? | 1:03:09
🗑
|
||||
| What chamber of the heart comprises the: Sternal surface? | Right ventricle
🗑
|
||||
| Diaphragmatic surface? | Right ventricle and left ventricle
🗑
|
||||
| Left margin? | Left ventricle and left atrium
🗑
|
||||
| Right margin? | Right atria
🗑
|
||||
| Base? | Left atria
🗑
|
||||
| What structure does the left recurrent laryngeal nerve loop around before it ascends into the larynx? | The arch of the aorta
🗑
|
||||
| At what point does the axillary artery become the brachial artery? | When it crosses the teres major
🗑
|
||||
| What is the anatomic posi- tioning of the right and left gastric nerve plexus of the esophagus as they pass through the diaphragm? | LARP-Left goes Anterior and Right goes Posterior (because of the rotation of the gut -Remember your embryology!)
🗑
|
||||
| What muscles comprise the rotator cuff? | SITS-Subscapularis, Infraspinatus, Teres minor, & Supraspinatus
🗑
|
||||
| What are the five branches off the median cord of the brachial plexus? | Four Ms and a U- 1. Median 2. Medial antebrachial 3. Medial pectoral 4. Medial brachial cutaneus 3X 5. Ulnar
🗑
|
||||
| What are the five branches off the posterior cord of the brachial plexus? | STARS- 1. Upper Subscapularis 2. Thoracodorsal 3. Axillary ; & 4. Radial 5. Lower Subscapularis
🗑
|
||||
| What are the three branches off the lateral cord of the brachial plexus? | 1. Lateral pectoral 2. Lateral head of the median 3. Musculocutaneus
🗑
|
||||
| What are the four branches off the brachial plexus that arise prior to the first rib? | 1. Dorsal scapular 2. Suprascapular 3. Long thoracic 4. Nerve to subclavius
🗑
|
||||
| What nerve innervates the extensor compartment of the arm? | Radial nerve (It also innervates the extensor compartment of the forearm.)
🗑
|
||||
| What muscles insert in/on the intertubercular groove of the humerus? | Lady between two Majors- latissimus dorsi, pectoralis major, and teres major
🗑
|
||||
| What artery is found in the lateral compartment of the leg? | None. The peroneal artery is in the posterior compartment of the leg.
🗑
|
||||
| What muscle laterally rotates the femur to "unlock" the knee? | Popliteus
🗑
|
||||
| What bursa is inflamed in "clergyman's knee"? | Infrapatellar bursa
🗑
|
||||
| Where does the great saphenous vein terminate? | In the femoral vein
🗑
|
||||
| What comprises the "unhappy triad" of the knee? | 1. Medial collateral ligament 2. Medial meniscus 3. Anterior cruciate ligament (ACL) The severity of injury to these ligaments is ranked from bad to worst in relation to how many of them are damaged, and they are usually damaged in the order listed.
🗑
|
||||
| What are the two branches off the external iliac artery before it becomes the femoral artery? | Circumflex iliac and inferior epigastric arteries
🗑
|
||||
| From which three sources does the adrenal gland get its blood supply? | 1. Superior suprarenal artery (off inferior phrenic artery) 2. Directly off the abdominal aorta as the middle suprarenal artery 3. Inferior suprarenal artery off the renal artery
🗑
|
||||
| What are the three branches off the celiac artery? | 1. Common hepatic artery 2. Splenic artery 3. Left gastric artery
🗑
|
||||
| What are the three main branches off the inferior mesenteric artery? | 1. Left colic artery 2. Superior rectal artery 3. Sigmoid artery
🗑
|
||||
| The inferior thyroid artery is a branch of what vessel? | Thyrocervical trunk
🗑
|
||||
| What is the area of the carotid artery that is an 02 receptor? | Carotid body (The carotid sinus is a pressure receptor.)
🗑
|
||||
| What arteries join together forming the basilar artery? | Left and right vertebral arteries
🗑
|
||||
| What is the major difference between the veins in the face and the veins in the rest of the body? | No valves and no smooth muscle in the walls of the veins in the face
🗑
|
||||
| At what point does the sig- moid sinus become the internal jugular vein? | When it crosses the jugular foramina
🗑
|
||||
| What connects the lateral ventricles to the third ventricle? | Foramen of Monro
🗑
|
||||
| What connects the third and the fourth ventricles together? | Cerebral aqueduct
🗑
|
||||
| How does cerebrospinal fluid leave the fourth ventricle? | Through the foramina of Magendie (medial) and Luschka (lateral) M in Magendie = medial; L in Luschka = lateral.
🗑
|
||||
| What is the lymphatic drainage of the gonads? | Lumbar trunk nodes (Lymphatic drainage follows blood supply.)
🗑
|
||||
| What is the lymphatic drainage of the pelvic organs? | Internal iliac nodes
🗑
|
||||
| What are the five clinical signs of portal hypertension? | 1. Caput medusae 2. Hemorrhoids 3. Retroperitoneal varices 4. Splenomegaly 5. Esophageal varices
🗑
|
||||
| What is the region of the body where all tonsillar tissue can be found? | Waldeyer's ring
🗑
|
||||
| What are the three functions of the nasal cavity? | It warms, moistens, and filters inspired air.
🗑
|
||||
| What region of the pharynx does the eustachian tube enter? | Nasopharynx
🗑
|
||||
| In which segment of the duodenum is the ampulla of Vater located? | Second segment
🗑
|
||||
| The duodenal/jejunal flexure is suspended from the posterior abdominal wall by what? | Ligament of Treitz
🗑
|
||||
| What are the three anatomic characteristics that differen- tiate the large bowel from the small bowel and the rectum? | 1. Tinea coli 2. Haustra 3. Epiploic appendages
🗑
|
||||
| What is the artery of the embryonic midgut? | Superior mesenteric artery
🗑
|
||||
| What two ligaments together comprise the lesser omentum? | Gastrohepatic and hepatoduodenal
🗑
|
||||
| The quadrate and the caudate lobes are part of what side of the anatomic liver? | The right
🗑
|
||||
| What is the artery of the embryonic hindgut? | Inferior mesenteric artery
🗑
|
||||
| The hepatic duct and the cystic duct come together to form what? | Common bile duct
🗑
|
||||
| What muscle forms the "bed" for the kidney? | Quadratus lumborum
🗑
|
||||
| What ligament of the uterus houses the ovarian vessels? | Suspensory ligament of the ovary
🗑
|
||||
| What three muscles comprise the pes anserinus? | 1. Sartorius 2. Gracilis 3. Semitendinous
🗑
|
||||
| What are the 10 retro- peritoneal organs? | 1. Duodenum 2. Ascending Colon 3. Ureters 4. Pancreas 5. Suprarenals 6. Descending colon 7. Aorta 8. Kidneys 9. Rectum 10. Inferior vena cava
🗑
|
||||
| What is the only cranial nerve with the ability to regenerate? | CN I
🗑
|
||||
| What duct transmits secretions from the sub- mandibular gland to the oral cavity? | Wharton's duct
🗑
|
||||
| What are the boundaries of the posterior triangle of the neck? | The stern ocleidomastoid, the trapezius, and the clavicle
🗑
|
||||
| What are the contents of the adductor canal? | Femoral artery and vein and saphenous nerve
🗑
|
||||
| What are the contents of the submandibular triangle of the neck? | Submandibular gland, facial artery and vein, nerve to the mylohyoid
🗑
|
||||
| What carpal bones articulate with the radius? | Scaphoid and lunate
🗑
|
||||
| What are the borders of the anterior triangle of the neck? | Sternocleidomastoid, mandible, and midline of the neck
🗑
|
||||
| What are the six cranial nerves that innervate structures in the orbit? | 1. CN II-vision 2. CN Vl-sensory (ophthalmic division) 3. CN VII-lacrimal gland LR6 (S04)3 (to remember nerves below): 4. CN VI-lateral rectus 5. CN IV-superior oblique 6. CN III-all other muscles of the eye
🗑
|
||||
| What muscle keeps the stapes taut against the oval window? | Stapedius muscle
🗑
|
||||
| What area of the posterior aspect of the eye has no photo receptors? | The optic disk is the blind spot.
🗑
|
||||
| What muscles are found in the superficial perineal pouch? | Superficial transverse perineal, ischiocavernous, and bulbocavernous muscles
🗑
|
||||
| What gland is found in the deep perineal pouch in men? | Bulbourethral gland; no gland is found in this pouch in women.
🗑
|
||||
| What pouch of the peri- neum houses the superficial fascia and the inferior fascia? | The deep perineal pouch (same as the urogenital diaphragm)
🗑
|
||||
| What gland is found in the superficial perineal pouch in men and women? | None in men, the greater vestibular gland in women
🗑
|
||||
| What are the five structures that traverse the spermatic cord? | 1. Pampiniform plexus of veins 2. Vas deferens 3. Testicular artery 4. Nerves 5. Lymphatics
🗑
|
||||
| What are the borders of Hesselbach's triangle? | Rectus abdominis medially, Inferior epigastric vessels laterally, Inguinal ligament as the base
🗑
|
||||
| Which type of hernia goes through both the deep inguinal and superficial inguinal ring? | Indirect; a direct hernia goes directly through Hesselbach's triangle
🗑
|
||||
| What structure(s) traverse the diaphragm at the level of T10? | Esophagus and gastric plexus of nerves
🗑
|
||||
| What structure(s) traverse the diaphragm at the level of T12? | Aorta, azygous vein, and thoracic duct Remember: One at Ts, two at Tlo,three at T,Z.
🗑
|
||||
| What compartment of the lower extremity allows flexion of the toe, inversion of the foot, and plantar flexion of the foot? | Posterior compartment of the leg
🗑
|
||||
| How are the arm and the forearm positioned in "waiter's tip hand"? | The arm is medially rotated, and the forearm is extended and pronated.
🗑
|
||||
| What is the function of white rami communicans? | They are preganglionic sympathetic axons. They are white because they are myelinated.
🗑
|
||||
| What compartment of the lower extremity allows extension of the hip and flexion of the knee? | Posterior compartment of the thigh
🗑
|
||||
| What compartment of the lower extremity allows dorsiflexion, extension of the toes, and inversion of the foot? | Anterior compartment of the leg
🗑
|
||||
| What cervical nerves comprise the cervical plexus? | C1 to C4
🗑
|
||||
| What compartment of the lower extremity allows eversion and plantar flexion of the foot? | Lateral compartment of the leg
🗑
|
||||
| If the left hypoglossal nerve was damaged, which way would the tongue point? | To the left (The uvula points to affected side.)
🗑
|
||||
| In women, what is the name of the pouch between the bladder and the uterus called? | Uterovesical pouch
🗑
|
||||
| What component of the pelvic diaphragm forms the rectal sling (muscle of continence)? | Puborectalis
🗑
|
||||
| What is the name of the comma-shaped structure that is attached to the posterior aspect of the testes? | Epididymis
🗑
|
||||
| What is the structure of the uterus that projects above the opening of the uterine tubes? | Fundus
🗑
|
||||
| What is the region of the fallopian tube where fertilization most commonly occurs? | Ampulla
🗑
|
||||
| How can you access the lowermost point in the peritoneal cavity in women? | Via the posterior fomix of the vagina
🗑
|
||||
| Which type of hemorrhoids are painful? | External hemorrhoids; internal hemorrhoids lack pain fibers.
🗑
|
||||
| What are the five terminal branches of the facial nerve? | 1. Temporal 2. Zygomatic 3. Buccal 4. Mandibular 5. Cervical (Two Zebras Bit My Clavicle.)
🗑
|
||||
| What two vessels come together to form the external jugular vein? | 1. Posterior auricular vein 2. Posterior division of the retromandibular vein
🗑
|
||||
| What is the position of the eyeball if CN VI is lost? | Adducted
🗑
|
||||
| The thyroid gland receives blood from what two different sources? | 1. Inferior thyroid off the thyrocervical trunk 2. Superior thyroid artery off the external carotid artery, and sometimes off the arch of the aorta as the thyroid ima artery
🗑
|
||||
| What postganglionic para-sympathetic ganglia is associated with: CN VII? | COPS Submandibular ganglion
🗑
|
||||
| What postganglionic para-sympathetic ganglia is associated with: CN IX? | Pterygopalatine and otic ganglion
🗑
|
||||
| What postganglionic para-sympathetic ganglia is associated with: CN X? | Terminal ganglion
🗑
|
||||
| What type of fibers are carried in the thoracic and lumbar splanchnics? | Preganglionic sympathetic fibers
🗑
|
||||
| How are preganglionic parasympathetic fibers carried to the embryonic hindgut? | Via pelvic splanchnics
🗑
|
||||
| What is the only portion of CN V that carries motor fibers? | Mandibular division (V3)
🗑
|
||||
| What portion of CN V is affected if the corneal reflex is lost? | Ophthalmic division (VI)
🗑
|
||||
| What cranial nerve is affected if you have a laterally deviated eye that is dilated with a ptosed eyelid? | CN III
🗑
|
||||
| Which cranial nerves are found in the midline of the brain stem? | CN I, 11, 111, VI, and XII ARN Add 1 + 1 = 2, 1 + 2 = VXF 3,1+2+3=6,1+2+ 3+6=12
🗑
|
||||
| What are the four muscles of mastication? | 1. Masseter 2. Temporalis 3. Medial pterygoid 4. Lateral pterygoid
🗑
|
||||
| What happens to prevalence as: Incidence increases? | Increases
🗑
|
||||
| What happens to prevalence as: Duration increases? | Increases
🗑
|
||||
| What year of marriage is the peak year for divorce? | Fourth year
🗑
|
||||
| What is the formula for IQ? | MA/CA x 100 (MA = mental age, CA = chronologic age)
🗑
|
||||
| What are the three stages that children (aged 7 months to 5 years) go through when they are separated from a primary caregiver for a prolonged period of time? | 1. Protest 2. Despair 3. Detachment
🗑
|
||||
| In statistics, what is the measured rate for: A whole population? | Crude rate
🗑
|
||||
| A subgroup of a population? | Specific rate
🗑
|
||||
| What percentage of suicides are committed by white men? | 66%
🗑
|
||||
| What is the primary method of nonverbal communication of emotional states? | Facial expression (the second is vocal intonation)
🗑
|
||||
| In what age group is illness perceived as a punishment? | 0 to 5 years
🗑
|
||||
| In screening tests, what happens to sensitivity as incidence increases? | Nothing; screening tests have nothing to do with incidence.
🗑
|
||||
| What are the four exceptions to informed consent? | 1. Emergency 2. Waiver by parents 3. Competency (only courts determine) 4. Short-term intervention
🗑
|
||||
| In what age group are children more afraid of mutilation or separation from a parent than of death? | 4 to 6 years of age
🗑
|
||||
| Which variable can an experimenter manipulate? | Independent variable
🗑
|
||||
| What percentage of dementia cases are caused by Alzheimer's disease? | 66%
🗑
|
||||
| When is the only time that it is okay to break doctor- patient confidentiality? | If there is a threat of harm to others (Tarasoff's Duty to Warn)
🗑
|
||||
| Do newborns perceive a three dimensional world? | It is believed that newborns DO perceive a three-dimensional world, because in experiments they react defensively when an object is thrust in front of their faces.
🗑
|
||||
| What stage of sleep is associated with high pulse, blood pressure, and respiration rates, and is characterized by increased brain oxygen use, penile erection in males, and total paralysis of the skeletal muscles? | REM sleep (Remember as: Awake brain & paralyzed body.)
🗑
|
||||
| What three circumstances allow a child to be committed to institutional care? | 1. The child poses an imminent danger to self or others. 2. The child is unable to care for himself daily (at the appropriate developmental level). 3. The parents/guardians have absolutely no control over the child, or will not promise to ensure the child
🗑
|
||||
| What is the leading cause of death in African American men between the ages of 15 and 24 years of age? | Homicide
🗑
|
||||
| What is the pattern of motor development? | Grasp before release Palms up before palms down Proximal to distal progression Ulnar to radial progression
🗑
|
||||
| What stage of sleep is associated with slow pulse and respiratory rates, a decrease in blood pressure, and involuntary skeletal muscle contractions? | Non-rapid eye movement (NREM) sleep (Remember as: Idle brain in an awake body.)
🗑
|
||||
| What type of study is prospective-that is, it "looks to see who gets sick" by defining a population at risk of being exposed to a disease? | Cohort study (also called prospective, follow-up, longitudinal, or incidence study)
🗑
|
||||
| What percentage of babies with an HIV-positive mother will test HIV-positive at birth? | 100%. At birth the mother's HIV-infected cells can be detected in the baby's serum. Six months later, however, only 30% of these babies test positive.
🗑
|
||||
| What disorder begins before 30 years of age; occurs predominantly in women; and presents with multiple medical complaints, with at least four pain symptoms, two gastrointestinal symptoms, one sexual symptom, and one neurological symptom? | Somatization disorder (Symptoms are NOT intentionally produced.)
🗑
|
||||
| What is the progression of copying shapes? | Circle, cross, rectangle, square, triangle (alphabetic order)
🗑
|
||||
| What stage of sleep occupies the most time? | Stage 2
🗑
|
||||
| What statistical analysis is used when you want to bring together many different variables to determine one conclusion? | Meta-analysis
🗑
|
||||
| What is the leading cause of school dropouts among girls? | Pregnancy
🗑
|
||||
| What is the name of the somatoform disorder in which the person has symptoms or deficits suggestive of a medical condition, which are initiated or made worse by stressors? | Conversion disorder (The male-to-female ratio is about 1:5.)
🗑
|
||||
| In what stage of psychosexual development (according to Freud) do children resolve the Oedipus complex? | Latency stage (6 to 12 years)
🗑
|
||||
| On what part of the body does sleep deprivation have the greatest effect? | Cerebral cortex
🗑
|
||||
| What is the square of the standard deviation? | Variance
🗑
|
||||
| What is the application of an unavoidable stimulus followed by an animal's failure to cope (when coping would otherwise be possible) known as? | Learned helplessness (e.g., Skinner box)
🗑
|
||||
| In what somatoform disorder does the person present with a fear of illness despite appropriate medical evaluation and reassurance, and often uses the opening line "I think I have . . . "? | Hypochondriasis
🗑
|
||||
| In biostatistics, what are the three criteria required to increase power? | 1. Large sample size 2. Large effect size 3. Type I error is greater
🗑
|
||||
| True or false-IQ is a predictor of academic achievement? | True-it is a predictor but not an indicator.
🗑
|
||||
| At what age does IQ become stable? | Age 5
🗑
|
||||
| On the psychosocial stressor scale, what factor receives the highest rating? | Death of a spouse
🗑
|
||||
| What is the term for the biologic predisposition to be sensitive to particular stimuli and to associate them with an unconditioned stimulus? | Preparedness
🗑
|
||||
| In what somatoform disorder with two subtypes does the patient experiences pain in a body part without any discernible organic cause (One subtype is associated with psychological factors, and the other with both physical and psychological factors.)? | Pain disorder
🗑
|
||||
| In what type of somatoform disorder does a person have an unrealistically negative evaluation of some aspect of his or her personal appearance? | Body dysmorphic disorder
🗑
|
||||
| At what stage of psychosexual development (according to Freud) do children fear castration? | Phallic stage (4 to 6 years)
🗑
|
||||
| True or false-only men have sexual refractory periods? | True-some women can have multiple successive orgasms without a break.
🗑
|
||||
| What is the term for involuntary vulgar or obscene utterances? | Coprolalia (seen 30% of the time as a feature of Tourette's syndrome)
🗑
|
||||
| At what stage of cognitive development (according to Piaget) do children: See death as irreversible? | Concrete operations (6 to 12 years)
🗑
|
||||
| At what stage of cognitive development (according to Piaget) do children: Have abstract thinking? | Formal operations ( > 12 years)
🗑
|
||||
| At what stage of cognitive development (according to Piaget) do children: Lack law of conservation and are egocentric? | Preoperational (2 to 6 years)
🗑
|
||||
| What hormone is inhibited by sleep? | TSH
🗑
|
||||
| With what stage of sleep are nightmares associated? | REM=`remember them" ;
🗑
|
||||
| With what stage of sleep are night terrors associated? | Stage 4-they are not remembered
🗑
|
||||
| What percentage of patients with HIV have AIDS dementia complex before death? | 70% to 95%
🗑
|
||||
| What is the triad of normal pressure hydrocephalus? | Dementia, gait apraxia, and urinary incontinence
🗑
|
||||
| What category of symptoms of schizophrenia associated with muscarinic receptors include affective flattening, social withdrawal, apathy, anhedonia, poverty of thought and of content of speech, and lack of interest? | Negative symptoms (type II)
🗑
|
||||
| In biostatistics, what type of error is due to chance? | Random error
🗑
|
||||
| Dementia is associated with a decrease in what neurotransmitter in the amygdala, hippocampus, and temporal neocortex? | Acetylcholine (ACh)
🗑
|
||||
| Name the incurable disease affecting adults which is a spongiform encephalopathy caused by a prion ; is fatal usually within 1 year of onset; results in cortical and cerebellar atrophy; and is characterized by a rapidly progressive dementia with myoclonus | Creutzfeldt-Jakob disease
🗑
|
||||
| What disease, occurring in patients approximately 40 years of age, is characterized by autosomal dominant inheritance associated with chromosome 4, atrophied caudate nucleus, choreoathetoid movements, and progressive dementia (Hint: Patients commonly comm | Huntington's chorea
🗑
|
||||
| What DSM-IV axis II diagnosis would the following patient fulfill: perfectionist, male, first born, preoccupied with rules, harsh discipline upbringing, lacks sense of humor, inflexible, miserly? | Obsessive-compulsive
🗑
|
||||
| What symptoms of schizophrenia associated with dopamine receptors include delusions, hallucinations, and agitation? | Positive symptoms (type I)
🗑
|
||||
| In biostatistics, what type of error has unanticipated factors that obscure the relationship and cause a bias? | Confounding error
🗑
|
||||
| What is the most frequently occurring value in a set? | Mode
🗑
|
||||
| What is the difference between the highest and the lowest scores in a set? | Range
🗑
|
||||
| What type of study has diffusional effects if you separate the groups and test the entire population? | Community trial
🗑
|
||||
| What type of study is under the greatest possible degree of control of the investigator? | Experimental study
🗑
|
||||
| In what type of skew is the tail to the right and the mean greater than the median? | Positive skew
🗑
|
||||
| In what type of error is the null hypothesis rejected when it is true? | Type I error (alpha error)
🗑
|
||||
| If the P-value is less than or equal to .05, what do you do to the null hypothesis? | Reject it
🗑
|
||||
| What is the single best predictor of suicide? | Previous suicide attempt
🗑
|
||||
| What is the leading cause of death in men between the ages of 25 and 44 years of age? | AIDS
🗑
|
||||
| What is the foremost cause of cancer death in both men and women? | Lung cancer
🗑
|
||||
| What are the top three causes of infant mortality? | 1. Birth defects 2. Low birth weight 3. SIDS
🗑
|
||||
| What is the most common form of sexually transmitted disease (STD)? | Human papilloma virus (HPV) infection
🗑
|
||||
| What is the primary cause of injury to American women? | Domestic abuse
🗑
|
||||
| What is the leading cause of preventable mental retardation? | Fetal alcohol syndrome
🗑
|
||||
| What is the most abused drug for people of all ages? | Alcohol
🗑
|
||||
| What is the most common bacterial STD? | Chlamydia trachomatis infection
🗑
|
||||
| How many teenagers become pregnant each year? | 1,000,000
🗑
|
||||
| What drug is used to prevent alcohol consumption by blocking aldehyde dehydrogenase? | Disulfiram
🗑
|
||||
| Which drug is used to treat opiate withdrawal, attention deficit hyperactive disorder (ADHD), and sometimes Tourette's syndrome? | Clonidine
🗑
|
||||
| Which drug is used to treat the respiratory depression associated with an overdose of opioids? | Naloxone or naltrexone
🗑
|
||||
| Which opioid agonist, more addictive than heroin, is used in the treatment of heroin dependence? | Methadone
🗑
|
||||
| What type of reinforcement strengthens each response and involves fast learning and fast extinction? | Continuous reinforcement
🗑
|
||||
| According to operant conditioning theory, what type of reinforcement is occurring in avoidance behaviors such as phobias and compulsive rituals? | Negative reinforcement
🗑
|
||||
| What form of learning occurs when, for example, a child watches her mother react in fear to a snake, and learns to be afraid of snakes? | Modeling or observational learning
🗑
|
||||
| What is the term for silently removing a reinforcement without the patient's awareness? | Fading
🗑
|
||||
| What is the name of the technique used to treat avoidance or obsessive-compulsive behaviors, in which patients are gradually confronted with the objects or situations they fear? | Exposure
🗑
|
||||
| In what type of conditioning is the stimulus that produces a deviant behavior paired with an unpleasant stimulus? | Aversive conditioning
🗑
|
||||
| What is the term for removal of a stimulus in order to stop a behavior? | Extinction
🗑
|
||||
| True or false according to social learning theory, people who believe that luck, chance, or the actions of others control their fate have an internal locus of control? | False-these beliefs are characteristic of people with an external locus of control.
🗑
|
||||
| Which IQ test is used for children between 4 and 6 years of age? | Wechsler Preschool and Primary Scale of Intelligence (WPPSI)
🗑
|
||||
| What is the most widely used projective test? | Rorschach ink blot test
🗑
|
||||
| What is the range of the low-average IQ? | 80 to 89
🗑
|
||||
| What term describes the ability of a test to measure something consistently? | Reliability
🗑
|
||||
| What is the name of the most widely used personality test consisting of 550 true/ false questions, in which the overall score is more important than an evaluation on an individual scale? | Minnesota Multiphasic Personality Inventory (MMPI)
🗑
|
||||
| What was the first formal IQ test, which is used for persons 2 to 18 years of age, proves best for children who are 6 years of age, and is used for the very bright or the impaired? | Stanford-Binet scale
🗑
|
||||
| What is the range of the borderline IQ? | 70 to 79
🗑
|
||||
| What court case decided by the New York Court of Appeals is know as the "best interest standard" case (In the situation of an incompetent patient, this case supports decision making based on what a reasonable person would want, given the patient's conditi | Brother Fox (Eichner v. Dillon)
🗑
|
||||
| What court case states that a woman has a right to privacy and to abort a fetus? | Roe v. Wade
🗑
|
||||
| If short-term memory and long-term memory are spared, but new learning is impaired, what is the location of the lesion? | Medial temporal lobe lesion
🗑
|
||||
| What is the term for return to an earlier stage of development? | Regression
🗑
|
||||
| What is the defense mechanism in which the person perceives his or her unacceptable feelings, thoughts, or impulses as belonging to another person? | Projection
🗑
|
||||
| What four characteristics define the sick role? | 1. Exempt from normal responsibilities 2. Not to blame for the illness 3. Obligated to get well 4. Obligated to seek help
🗑
|
||||
| What is the defense mechanism in which a patient projects his or her thoughts, feelings, or wishes onto the physician or therapist? | Transference
🗑
|
||||
| What is the term for the state of being arrested in a stage of development? | Fixation
🗑
|
||||
| According to Freud, what facet of the psyche represents the internalized ideals and values of one's parents? | Superego
🗑
|
||||
| What term refers to acting out the reverse of an unacceptable behavior? | Undoing
🗑
|
||||
| What is the defense mechanism which involves "unconscious forgetting"? | Repression
🗑
|
||||
| In psychoanalytic theory, which mature defense mechanism uses comedy to express feelings and thoughts without causing personal discomfort? | Humor
🗑
|
||||
| Per Freud, with what part of the unconscious are sex and aggression (instincts) associated? | Id
🗑
|
||||
| What is the term for: Wasting away due to malnutrition? | Cachexia
🗑
|
||||
| What is the term for: Sexual energy? | Cathexis
🗑
|
||||
| What is the term for: A purging of emotions? | Catharsis
🗑
|
||||
| Which defense mechanism involves preparation for future events? | Anticipation
🗑
|
||||
| What term describes conscious forgetting? | Suppression
🗑
|
||||
| What is the term for the mature defense mechanism whereby one helps others with no apparent expectation of help in return? | Altruism
🗑
|
||||
| What five qualities in an object attract a newborn's attention? | 1. Largeness 2. Brightness 3. Contrasts 4. Curves 5. Complex design
🗑
|
||||
| What type of depression can occur in an infant if there is prolonged separation from the primary caregiver? | Anaclitic depression
🗑
|
||||
| School phobia can result from failure to resolve what? | Separation anxiety
🗑
|
||||
| At what stage of sleep do you see sleep spindles and K complexes on EEG? | Stage 2
🗑
|
||||
| What hormone level increases in the first 3 hours of sleep? | Prolactin
🗑
|
||||
| Which stages of sleep decrease in length when a person grows older? | REM, non-REM, and total sleep time
🗑
|
||||
| What hormone increases at nighttime and is associated with seasonal affective disorder? | Melatonin
🗑
|
||||
| What are the five Kiibler-Ross stages of adjustment to dying? | 1. Denial 2. Anger 3. Bargaining 4. Depression 5. Acceptance
🗑
|
||||
| What five things are checked in the APGAR test? | 1. Sldn color 2. Heart rate 3. Reflexes 4. Muscle tone 5. Respiratory rate APGAR Appearance, Pulse, Grimace, Activity, Respiration
🗑
|
||||
| A baby's smile at birth is known as what? | Endogenous smile
🗑
|
||||
| What is the term for a baby's fear of unfamiliar people that begins at about 6 months of age, peaks at about 8 months, and is usually gone at 12 months? | Stranger anxiety
🗑
|
||||
| What stage of sleep is assodated with theta waves and the disappearance of alpha waves? | Stage 1
🗑
|
||||
| At what stage of sleep is human chorionic gonadotropin (hCG) output elevated? | Stage 4
🗑
|
||||
| What is the most prevalent sexual disorder in men? | Secondary impotence
🗑
|
||||
| What is the term used when someone has sexual orientation distress? | Ego-dystonic sexual orientation
🗑
|
||||
| What is the name of the painful involuntary muscle contraction of the outer one third of the vagina? | Vaginismus
🗑
|
||||
| What is the term for inability to have an orgasm? | Anorgasmia (occurs in 35% of women)
🗑
|
||||
| What is the term for recurrent and persistent pain during intercourse? | Dyspareunia
🗑
|
||||
| What neurotransmitter produces arousal and wakefulness? | Dopamine
🗑
|
||||
| What hormone initiates sleep? | Serotonin
🗑
|
||||
| What hormone increases during REM sleep? | Acetylcholine (ACh)
🗑
|
||||
| What is the term for the lack of respiration during sleep? | Sleep apnea
🗑
|
||||
| What hormone decreases during REM sleep? | Norepinephrine (NE)
🗑
|
||||
| What are the four pathognomonic signs of narcolepsy? | 1. Cataplexy 2. Sleep attacks 3. Sleep paralysis 4. Hypnagogic and hypnopompic hallucinations (disorders of REM)
🗑
|
||||
| At what stage of sleep does bruxism (grinding of the teeth) occur? | Stage 2
🗑
|
||||
| What is an irrational fear called? | A phobia
🗑
|
||||
| What three laboratory tests are used to test for probable depression? | 1. Test for decreased levels of 3-methoxy-4-hydroxyphenlyglycol (MHPG), which is an NE metabolite 2. TRH stimulation test 3. Dexamethasone suppression test
🗑
|
||||
| What is the most common psychiatric illness in women, which presents as a vague feeling of apprehension or worrying accompanied by one or more body sensations? | Generalized anxiety disorder
🗑
|
||||
| An adult with a 2-year history of depressed mood, low energy, feelings of hopelessness, and low selfesteem, but with no major depressive episodes or manic episodes has what disorder? | Dysthymic disorder
🗑
|
||||
| What is the disorder in which the patient has concurrent symptoms of schizophrenia and depression or mania? | Schizoaffective disorder
🗑
|
||||
| In statistics, what form of bias is at work when the experimenter's expectation induces results? | Pygmalion effect
🗑
|
||||
| Someone who is excessively shy, has a fear of rejection, and is socially isolated has what type of personality disorder? | Avoidant personality disorder
🗑
|
||||
| Name the personality disorders described below: A person who has a longstanding feeling of mistrust or suspicion, no hallucinations, no delusions, and no antisocial behavior? | Paranoid personality disorder
🗑
|
||||
| Name the personality disorders described below: A person who is uncomfortable not being the center of attention, is an attention seeker, and has seductive behavior that is colorful, dramatic, and extroverted? | Histrionic personality disorder
🗑
|
||||
| Name the personality disorders described below: A person who gets others to assume responsibility, has difficulty expressing disagreement, and often has an abusive spouse? | Dependent personality disorder
🗑
|
||||
| What type of seizure is associated with young children and involves a brief loss of consciousness with minor motor activity? | Petit mal (absence) seizure
🗑
|
||||
| What is the drug of choice for treatment of Petit Mal seizures? | Ethosuximide
🗑
|
||||
| What neurotransmitter is responsible for allergic conditions, and regulates emotions and acid secretions in the stomach? | Histamine
🗑
|
||||
| What is the primary excitatory neurotransmitter of the brain? | Glutamic acid
🗑
|
||||
| What is the major neurotransmitter of sensory neurons for pain? | Substance P
🗑
|
||||
| Increased levels of what neurotransmitter, released from the raphe nuclei of the brain stem, is used to treat depression and also to regulate homeostasis? | Serotonin
🗑
|
||||
| What naturally occurring substances mimic the effects of opiates? | Enkephalins
🗑
|
||||
| What neurodegenerative disorder is associated with frontal and temporal lobe atrophy and is manifested primarily as dementia? | Pick's disease
🗑
|
||||
| What disease causes ceruloplasmin deficiency, hepatolenticular degeneration, and Kayser-Fleischer rings? | Wilson's disease
🗑
|
||||
| What is the main inhibitory neurotransmitter to the spinal cord and the brain stem? | Glycine
🗑
|
||||
| The effect on a person's behavior caused by the act of being studied is called what? | Hawthorns effect
🗑
|
||||
| What type of bias is involved when you ask leading questions? | Sampling bias
🗑
|
||||
| What level of retardation is involved if a person has an IQ of 20 to 34 and cannot be trained but can learn basic habits? | Severe
🗑
|
||||
| What is the half-way point on the x-axis of a gaussian curve? | Median
🗑
|
||||
| As prevalence increases, what happens to: Sensitivity? | No change
🗑
|
||||
| As prevalence increases, what happens to: Specificity? | No change
🗑
|
||||
| As prevalence increases, what happens to: Positive predictive value? | Increases
🗑
|
||||
| As prevalence increases, what happens to: Negative predictive value? | Decreases
🗑
|
||||
| In medical screening, what is the term for: The proportion of individ uals with a positive test result for the disease that the test is intended to reveal? | Sensitivity
🗑
|
||||
| In medical screening, what is the term for: The total percentage of correctly identified subjects for what you are testing? | Accuracy
🗑
|
||||
| What rate is represented by the total number of cases divided by the population at risk? | Prevalence rate
🗑
|
||||
| What is the name for the type of study in which neither the investigator nor the subjects know which participants are receiving the placebo (i.e., the control group) and which are receiving the test drug? | Double-blind study
🗑
|
||||
| What is the term for the form of bias in which preconception leads to a biased interpretation? | Prejudice
🗑
|
||||
| What is the most scientifically rigorous study in which subjects in a population are randomly allocated into groups? | Randomized controlled study
🗑
|
||||
| In what form of trial is it unethical to withhold treatment from any specific group? | Crossover trial (e.g., azidothymidine [AZT] trials)
🗑
|
||||
| In what type of skew is the tail to the left, and the median greater than the mean? | Negative skew
🗑
|
||||
| In what form of drug trial do researchers administer regimens to humans to evaluate the efficacy and safety of a drug? | Clinical trial
🗑
|
||||
| What term describes the average on a normal curve? | Mean
🗑
|
||||
| In reference to the tail on a curve, what is the greatest value-the mean, median, or mode? | The mean (mean > median > mode)
🗑
|
||||
| What type of scale has a true zero point and orders items with equal intervals? | Ratio scale
🗑
|
||||
| What statement is the opposite of what the experimenter hopes to prove? | Null hypothesis
🗑
|
||||
| What is the degree to whichtwo measures are related? | Correlation coefficient (does not employ causality)
🗑
|
||||
| What term denotes the probability that the null hypothesis will be rejected if it is indeed false? | Power
🗑
|
||||
| What is used to predict one variable from another with interval data only? | Regression
🗑
|
||||
| What type of error is made when you fail to reject the null hypothesis when it is indeed false? | Type II error (beta error)
🗑
|
||||
| What do you do with the null hypothesis if the P-value is greater than .05? | Do not reject the null hypothesis.
🗑
|
||||
| If the confidence interval contains 1.0, what would this indicate? | There is no significant effect.
🗑
|
||||
| What test is used to compare two interval scales? | Pearson correlation
🗑
|
||||
| What type of scale ranks with an equal distance between groups? | Interval scale
🗑
|
||||
| What type of scale ranks without distance or set spaces between the groups? | Ordinal scale
🗑
|
||||
| What percentage of a normal curve falls between ± 1 standard deviation? | 68%
🗑
|
||||
| A 95% confidence score means the z score is equal to what? | 2
🗑
|
||||
| What is the term for the hypothesis that the experimenter hopes to prove true? | Alternative hypothesis
🗑
|
||||
| What test compares two ordinal levels? | Spearman correlation
🗑
|
||||
| What does a one-tailed null hypothesis state? | That one group is better or worse than the other (depending on what is asked); it is directional
🗑
|
||||
| What does a two-tailed null hypothesis state? | That two groups are not the same; they are nondirectional
🗑
|
||||
| What test is used when one interval scale and two nominal data sets are available? | Two-way analysis of variance (ANOVA)
🗑
|
||||
| On a normal curve, what percentage of the curve falls between ± 2 standard deviations? | 95.50%
🗑
|
||||
| What is the most common cancer in men? | Prostate
🗑
|
||||
| What is the most common cancer in women? | Breast
🗑
|
||||
| What is the most commonly reported STD? | Gonorrhea
🗑
|
||||
| What is the most commonly made diagnosis in men? | Hypertension
🗑
|
||||
| What is the most commonly made diagnosis in women? | Pregnancy
🗑
|
||||
| What is the most common cause of: Hospital admissions? | GI disturbances
🗑
|
||||
| What is the most common cause of: Hospital days? | Cardiovascular disease
🗑
|
||||
| What is the most common cause of: Days lost from work? | Upper respiratory tract infection
🗑
|
||||
| What is the most common cause of: Ambulatory clinic visits? | Back pain
🗑
|
||||
| What is the most common cause of: Work-related injury? | Musculoskeletal problem
🗑
|
||||
| What are the CAGE questions of alcoholism? | 1. Cut down 2. Annoyed about criticism 3. Guilty 4. Eye opener
🗑
|
||||
| What type of learning is described as an old response to a new behavior? | Classical conditioning
🗑
|
||||
| What type of learning is described as a new response to an old behavior? | Operant conditioning
🗑
|
||||
| What is the tendency to respond to related stimuli with the same response or a similar response? | Stimulus generalization
🗑
|
||||
| What term describes any stimulus that will increase the probability of a response? | Reinforcement
🗑
|
||||
| In classical conditioning, what is the cause of the original response? | Unconditioned stimulus
🗑
|
||||
| What response occurs when a conditioned stimulus is added to an unconditioned stimulus? | Conditioned response
🗑
|
||||
| What is used to stop stimulus generalization and discontinue a reinforcement that is maintaining an operant? | Extinction
🗑
|
||||
| What sort of ratio is on a fixed time and has a continuous schedule? | Fixed interval ratio
🗑
|
||||
| In this form of reinforcement, not every response is reinforced, and the response is hard to extinguish and slow to be learned? | Intermittent reinforcement
🗑
|
||||
| What technique uses successive reinforcements to establish a behavior? | Shaping (funneling)
🗑
|
||||
| What treatment used to treat anxiety and phobias is slow, stepwise, and based on counterconditioning? | Systemic desensitization
🗑
|
||||
| What is the term for a stimulus which is introduced: To encourage a particular behavior? | Positive reinforcement
🗑
|
||||
| What is the term for a stimulus which is introduced: To stop a behavior? | Punishment
🗑
|
||||
| What is it called when a stimulus unconsciously controls a behavior? | Stimulus control
🗑
|
||||
| What type of learning provides the organism with information about internal functioning via monitoring of autonomic function? | Biofeedback
🗑
|
||||
| What method of learning involves a faced number of responses to obtain reinforcement? | Fixed ratio
🗑
|
||||
| According to Rotter's social learning theory, people who feel that they are in control of their own lives, and who believe that effort, care, and persistence pays off have what locus of control? | Internal locus of control
🗑
|
||||
| What IQ test is used for persons aged 6 to 17? | Wechsler Intelligence Scale for Children-Revised (WISC-R)
🗑
|
||||
| What method of learning involves a varying number of responses to give reinforcement? | Variable ratio schedule
🗑
|
||||
| What is the range of the average IQ? | 90-109
🗑
|
||||
| Which IQ test is used for persons 17 years of age and older? | Wechsler Adult Intelligence Scale-Revised (WAIS-R)
🗑
|
||||
| Below what IQ level is a person perceived as being mentally retarded? | Below 69
🗑
|
||||
| What method of learning delivers the reinforcement after an unpredictable period of time? | Variable interval ratio
🗑
|
||||
| What are the three advanced directives? | 1. Oral directive 2. Living will 3. Healthy power of attorney
🗑
|
||||
| What defense mechanism involves temporary inhibition of thoughts or impulses, in which the person is aware that he is "forgetting"? | Blocking
🗑
|
||||
| What defense mechanism involves defining things as either "bad" or "good"? | Splitting
🗑
|
||||
| The qualities of an object are internalized, obliterating the distinction between subject and object, in what defense mechanism? | Introjection
🗑
|
||||
| What defense mechanism is operating when a person avoids becoming aware of some painful aspect of reality? | Denial
🗑
|
||||
| What term describes the accuracy of a test? | Validity (You need reliability for validity.)
🗑
|
||||
| What court case upheld the parents' decision to forgo potentially lifesaving surgery for their infant with Down syndrome and tracheoesophageal fistula (known as the "letting nature take its course" case)? | The Infant Doe case
🗑
|
||||
| What are the three surrogate criteria? | 1. What did the patient want, 2. What would the patient say, 3. What is in the patient's best interests
🗑
|
||||
| What court case established that the right of decision belongs to the incompetent patient by virtue of the right of autonomy and privacy, and that a surrogate can draw a conclusion about the wants and needs of the incompetent person, based on knowing the | Karen Ann Quinlan case
🗑
|
||||
| What are the four most common defense mechanisms used by obsessive-compulsive persons? | Isolation of affect, Undoing, Reaction formation, Intellectualization
🗑
|
||||
| What defense mechanism shifts an emotion or drive from one idea or object to another? | Displacement
🗑
|
||||
| What defense mechanism involves the separation of oneself from one's experiences? | Dissociation
🗑
|
||||
| What mature defense mechanism substitutes socially acceptable intentions for those that are unacceptable, allowing instincts to be refocused rather than blocked? | Sublimation
🗑
|
||||
| The indirect expression of hostility is known as what? | Passive-aggressive behavior
🗑
|
||||
| What defense mechanism consists of an emotional or behavioral outburst to cover up an underlying feeling or idea? | Acting out
🗑
|
||||
| What is the defense methanism in which the person uses a self-serving explanation for a belief or behavior in order to avoid the stress of admitting his or her true motivation? | Rationalization
🗑
|
||||
| What defense mechanism involves the separation of ideas from the feelings origiinally associated with them? | Isolation
🗑
|
||||
| What type of smile appears at 8 weeks of age in reaction to faces? | Exogenous smile
🗑
|
||||
| What defense mechanism involves excessive thinking to avoid affective expression? | Intellectualization
🗑
|
||||
| In what stages of sleep, known as "deep sleep," are delta waves seen on EEG? | Stages 3 and 4
🗑
|
||||
| In what stage of sleep, comprising 25% of total sleep time, are saw-tooth waves seen on EEG? | REM stage
🗑
|
||||
| What type of smile occurs when a 14-month-old baby smiles at her mother? | Preferential smile
🗑
|
||||
| What are the three characteristics of attention deficit hyperactive disorder (ADHD)? | 1. Short attention span 2. Impulsivity 3. Hyperactivity
🗑
|
||||
| What is the drug of choice for treating ADHD? | Methylphenidate (Ritalin)
🗑
|
||||
| Describe the normal bereavement period? | The person identifies with the deceased. The person has low suicidal tendencies. The period lasts for less than 6 months.
🗑
|
||||
| What percentage of stage 4, REM, and total sleep time is "made up" after sleep deprivation? | Stage 4-80% REM-50% Total sleep-33%
🗑
|
||||
| Name the reaction that appears in babies when they are temporarily deprived of their usual caretaker. (This reaction usually begins around 6 months of age, peaks around 8 months, and decreases at 12 months.)? | Separation anxiety
🗑
|
||||
| What are the characteristics of pathologic grief (depression)? | Greater than I year in duration, Abnormal identification with the deceased, Suicidal tendencies
🗑
|
||||
| What is the term used to describe ejaculation before or just after beginning a sexual encounter? | Premature ejaculation
🗑
|
||||
| What disorder is defined by the following criteria: occurs during stages 3 and 4 of sleep; can't be diagnosed until 5 years of age; occurs more often in boys; occurs at least 2x a week for at least 3 consecutive months; and causes distress or impairment i | Enuresis (bedwetting)
🗑
|
||||
| In what lobe of the cerebral cortex is the visual center located? | Occipital lobe
🗑
|
||||
| What disorder seen in late adolescence is characterized by normal weight, cavities, calluses on the back of hands, enlarged parotid glands, esophageal scars, and electrolyte imbalances? | Bulimia
🗑
|
||||
| Name the level of retardation in which the person has an IQ of 35 to 49 and is considered "trainable"? | Moderate
🗑
|
||||
| What is the level of retardation of a person with an IQ of less than 20 who requires total care? | Profound
🗑
|
||||
| What are the pharmacologic effects seen sexually with: alpha-Blockers? | Impaired ejaculation
🗑
|
||||
| What are the pharmacologic effects seen sexually with: Serotonin? | Inhibited orgasm
🗑
|
||||
| What are the pharmacologic effects seen sexually with: beta-Blockers? | Impotence
🗑
|
||||
| What are the pharmacologic effects seen sexually with: Trazodone? | Priapism
🗑
|
||||
| What are the pharmacologic effects seen sexually with: Dopamine agonists? | Increased erection and libido
🗑
|
||||
| What are the pharmacologic effects seen sexually with: Neuroleptics? | Erectile dysfunction
🗑
|
||||
| What is the level of retardation of a person with an IQ of 50 to 70 who is self-supportive with help (This category includes approximately 85% of all mentally retarded persons.)? | Mild
🗑
|
||||
| What is the diagnosis of a child who is oblivious to the external world; has delayed language development and pronoun reversal; participates in head-banging; inflicts self-injury; and has no separation anxiety? | Autism
🗑
|
||||
| What is the probable diagnosis of a person who has a depressed mood and hypomania for more than 2 years (not caused by substance abuse)? | Cyclothymic (non-psychotic bipolar) disorder
🗑
|
||||
| What four factors are indicators of a good prognosis for a person with schizophrenia? | 1. Late onset 2. Acute onset 3. Presence of positive symptoms 4. Paranoid type
🗑
|
||||
| What form of schizophrenia has no prominent psychotic symptoms at evaluation? | Residual or treated
🗑
|
||||
| What disorder that carries a high mortality rate is most often associated with girls in their mid-teens who weigh less than 85% of ideal body weight, have primary or secondary amenorrhea and presence of lanugo? | Anorexia nervosa
🗑
|
||||
| What disorder is described by the following characteristics: 41-year-old woman of low socioeconomic status; decreased levels of dopamine, thyroid-stimulating hormone, and norepinephrine; depressed mood most of the time; diminished interest and pleasure; f | Major depression (unipolar)
🗑
|
||||
| What is the disorder associated with an abnormally and persistently elevated, expansive, or irritable mood (manic episode) that alternates with depression? | Bipolar disorder
🗑
|
||||
| What lobe of the cerebral cortex is responsible for emotion, memory, and language? | Temporal lobe
🗑
|
||||
| What neurotransmitter plays a significant role in Alzheimer's disease and memory function, and is also responsible for erections in men? | Acetylcholine (ACh)
🗑
|
||||
| What lobe of the cerebral cortex is responsible for speech, personality, memory, abstract thoughts, and high-order functions? | Frontal lobe
🗑
|
||||
| What is the term for bilateral occlusion of the posterior cerebral arteries resulting in cortical blindness, where the patient denies he or she is blind? | Anton's syndrome (Visual hallucinations are common in relation to occipital epileptic foci.)
🗑
|
||||
| What lobe of the cerebral cortex is associated with motivation, memory, emotion, violent behaviors, and social-sexual behaviors? | Limbic lobe
🗑
|
||||
| What hemisphere is used for language and (for most people) is the dominant hemisphere? | Left hemisphere (Left = Language.)
🗑
|
||||
| What lobe is responsible for intellectual processing of sensory information for visual-spatial tasks? | The nondominant parietal lobe (usually the right)
🗑
|
||||
| What is the name of a report made from the outcome of a single clinical subject? | Case report
🗑
|
||||
| What is the main inhibitory neurotransmitter of the brain that is associated with anxiety? | Gamma-aminobutyric acid (GABA)
🗑
|
||||
| Movement disorders are associated with what dopamine pathway (what part of the brain)? | Nigrostriatal pathways (basal ganglia)
🗑
|
||||
| What neurotransmitter is low in depression and high in mania, is found in the locus ceruleus, and is the neurotransmitter of the sympathetic nervous system? | Norepinephrine (NE)
🗑
|
||||
| In which syndrome does a person present with intentionally produced physical ailments with the intent to assume the "sick role"? | Munchausen's syndrome (factitious disorder)
🗑
|
||||
| What dopamine pathway is associated with the "positive" symptoms of psychosis? | Mesolimbic-cortical pathway
🗑
|
||||
| The tuberoinfundibular system is associated with what two hormones? | 1. Dopamine (prolactin inhibitory protein [PIP])-inhibits release of prolactin 2. Prolactin
🗑
|
||||
| In medical screening, what is the term for the proportion of truly disease-free individuals who are correctly identified as not having the disease? | Specificity
🗑
|
||||
| Of the number of people who are tested as being negative, the percentage that is truly negative is known as what? | Negative predictive value
🗑
|
||||
| What type of study looks forward in time (the subjects are followed into the future) and takes a long time to complete? | Prospective study
🗑
|
||||
| What type of study examines the relationship between diseases and other variables at one particular time, but not causality? | Cross-sectional study
🗑
|
||||
| What study reports on the outcome of a group of clinical subjects? | Case series reports
🗑
|
||||
| What type of study looks back in time to provide some indication of past circumstances? | Retrospective study
🗑
|
||||
| Of the people who tested positive, what is the term for the percentage that is actually positive for the disease? | Positive predictive value
🗑
|
||||
| What test is used when you have one interval data, one set of nominal data, and only two groups? | T-test
🗑
|
||||
| In a classic gaussian curve, what percentage of the curve is between: ± 3 standard deviations (SDs)? | 99.70%
🗑
|
||||
| In a classic gaussian curve, what percentage of the curve is between: The mean and ± 1 SD? | 34%
🗑
|
||||
| In a classic gaussian curve, what percentage of the curve is between: ± 1 SD and ± 2 SDs? | 13.50%
🗑
|
||||
| In a classic gaussian curve, what percentage of the curve is between: ± 2 SDs and ± 3 SDs? | 2.40%
🗑
|
||||
| In a classic gaussian curve, what percentage of the curve is between: ± 3 SDs? | 0.15%
🗑
|
||||
| What is the range for a high-average IQ? | 110 to 119
🗑
|
||||
| What test is used when you have one set of interval data and one set of nominal data with more than two groups? | One-way analysis of variance (ANOVA)
🗑
|
||||
| What test measures spatial construction and drawing tasks? | Benton visual retention test
🗑
|
||||
| What type of personality is impatient, competitive, preoccupied with deadlines, highly involved with work, and has a high prevalence and incidence of coronary attacks? | Type A personality
🗑
|
||||
| What test uses nominal data only and has more than 25 subjects associated with the study? | Chi square
🗑
|
||||
| What test uses nominal data only, uses a 2 X 2 table, and has fewer than 25 subjects? | Fischer exact test
🗑
|
||||
| In what two areas of learning do boys often excel? | Mathematics and visual-spatial tasks
🗑
|
||||
| What is the range of superior IQ? | 120 to 129
🗑
|
||||
| What form of test shows one or more persons in ambiguous situations and then requires the patient to tell a story about what is going on in the picture? | Thematic apperception test (TAT)
🗑
|
||||
| Name the disorder described by the following symptoms: delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, affective flattening, social dysfunction; persistence for at least 6 months? | Schizophrenia
🗑
|
||||
| Name the type of schizophrenia in which the person is preoccupied with delusions of persecution, frequently has auditory hallucinations, and shows little or no impairment in cognitive testing? | Paranoid schizophrenia
🗑
|
||||
| In what form of schizophrenia is the person child-like, primitively active but aimless, and most regressed? | Disorganized schizophrenia
🗑
|
||||
| Name the form of schizophrenia in which the person presents in complete stupor, has a rigid posture with violent/destructive outbursts, is mute, and has psychomotor disturbances? | Catatonic schizophrenia
🗑
|
||||
| What personality disorder does an estimated 75% of the total prison population have? | Antisocial personality disorder
🗑
|
||||
| What is the probable diagnosis of a person who suddenly and unexpectedly leaves home, cannot recall his past, and is confused about his identity? | Dissociative fugue
🗑
|
||||
| What form of amnesia is usually retrograde, with the patient unable to remember facts about himself? | Psychogenic amnesia (Amnesia associated with head trauma is usually antegrade.)
🗑
|
||||
| What is the probable personality disorder of: A person who is shy and who has always been eccentric and content to be alone? | Schizoid personality disorder
🗑
|
||||
| What is the probable personality disorder of: A person who seems a little odd and who has magical thinking, ideas of reference, and illusions? | Schizotypal personality disorder
🗑
|
||||
| How does 1-tryptophan affect sleep? | It increases REM and total sleep time.
🗑
|
||||
| What disorder is described by the following: associated with great apprehension and fear; the person has three or more attacks in a 3-week period; the attacks can happen "out of the blue" and can be induced; the drug of choice is alprazolam (Xanax)? | Panic disorder
🗑
|
||||
| In what personality disorder may a person be frequently suicidal, impulsive, have intense, unstable relationships, engage in risky behaviors, have fear of abandonment, and even self-mutilate? | Borderline personality disorder
🗑
|
||||
| The typical person with this disorder is an obsessive-compulsive 7-year-old boy with an elevated dopamine level, ADHD, and multiple motor/vocal tics for longer than 1 year? | Tourette's syndrome
🗑
|
||||
| What medications are used to treat this disorder? | Haloperidol (Haldol), pimozide, and clonidine
🗑
|
||||
| What type of seizure involves no loss of consciousness, altered sensory perception, and an EEG focal spike or a spike with a slow wave pattern? | Simple partial seizure
🗑
|
||||
| What is the probable diagnosis of a person with fragile self-esteem who is prone to depression, has a grandiose sense of self-importance, and needs constant attention? | Narcissistic personality disorder
🗑
|
||||
| What type of seizure is characterized by major motor activity, loss of consciousness, and no true aura? | Grand mal seizure
🗑
|
||||
| Name the type of seizure in which the person smells "burning rubber," has hallucinations and illusions, demonstrates automatism after aura, experiences focal sensory perceptions, and loses consciousness? | Complex partial seizure
🗑
|
||||
| What acute and reversible disease involving a thiamine deficiency is characterized by ataxia, nystagmus, and ophthalmoplegia? | Wernicke's encephalopathy
🗑
|
||||
| What disorder involving a lesion of the frontal lobe (Brodmann's area 44) is characterized by the following: there is no problem with comprehension; the person has trouble repeating statements; speech is broken, telegraphic, and ungrammatical; the person | Broca's aphasia
🗑
|
||||
| Where is the lesion if the person refuses to accept that there is a problem, neglects the left side, and has constructional apraxia? | Right parietal lobe
🗑
|
||||
| What disease involves a lesion of the superior temporal gyros (Brodmann's area 22), impaired comprehension, fluent but incoherent and rapid speech, and hyperactivity, but no muscle weakness? | Wernicke's aphasia
🗑
|
||||
| What is the most common dementia in persons older than 65 years of age that is more common in women, and that involves diffuse atrophy, flattened cortical sulci, senile plaques, enlarged cerebral ventricles, neuro6brillary tangles, granulovascular changes | Alzheimer's disease
🗑
|
||||
| A lesion in what lobe of the cerebral cortex would present with euphoria, auditory hallucinations, delusions, and thought disorders? | Dominant temporal lobe lesion
🗑
|
||||
| What form of dementia is found in hypertensive patients, usually affects men between the ages of 60 and 70 years, is characterized by decremental or patchy deterioration in cognitive function owing to the cardiovascular disease, is of sudden onset, and ha | Multi-infarct dementia (vascular)
🗑
|
||||
| With what lesion do you see irritability and a decreased visual and music ability? | Lesion in right temporal lobe
🗑
|
||||
| Where is the lesion if the patient has apathy, aggression, and memory problems? | Limbic system
🗑
|
||||
| Where is the lesion if the patient presents with apathy, decreased drive, poor grooming, decreased attention span, and a poor ability to abstract? | Dorsal prefrontal cortex lesion
🗑
|
||||
| In what disease does the patient present with a history of insidious onset, worsening cognition, a normal level of consciousness, and often "sundowning"? | Dementia
🗑
|
||||
| What reversible disease is characterized by a rapid onset in days to weeks, fluctuating levels of consciousness, impaired memory, and visual hallucinations? | Delirium
🗑
|
||||
| Where is the lesion if the patient presents with fearfulness, explosive moods, decreased inhibition, withdrawal, and violent outbursts? | Orbitomedial frontal cortex lesion
🗑
|
||||
| What syndrome is characterized by the following: bilateral medial temporal lobe lesion, placidity, hyperorality, hypersexuality, hyperreactivity to visual stimuli, and visual agnosia? | Kliiver-Bucy syndrome
🗑
|
||||
| If there is a lesion in the lateral hypothalamus, how does the patient present? | With anorexia and starvation
🗑
|
||||
| In what chronic and irreversible disease does the patient present with thiamine deficiency, confusion, confabulations, and amnesia? | Korsakoff's syndrome (alcohol induced amnestic syndrome)
🗑
|
||||
| Where is the lesion if short-term memory is spared, while long-term memory and new learning are impaired? | Hippocampus
🗑
|
||||
| Where is the lesion if the patient presents with hyperphagia and obesity? | Ventromedial hypothalamus
🗑
|
||||
| How is sleep affected in a person with alcohol intoxication? | Decreased REM sleep and REM rebound during withdrawal
🗑
|
||||
| What happens to REM, REM latency, and stage 4 sleep during major depression? | Increased REM sleep, decreased REM latency, and decreased stage 4 sleep, leading to early morning awakening
🗑
|
||||
| What aspects of sleep are affected during benzodiazepine use? | They decrease REM and stage 4 sleep
🗑
|
||||
| How do barbiturates affect sleep? | Rebound insomnia, Decrease in REM sleep
🗑
|
||||
| What is the rate-limiting step of: Glycolysis? | PFK-1
🗑
|
||||
| What is the rate-limiting step of: Gluconeogenesis? | Pyruvate carboxylase
🗑
|
||||
| What is the rate-limiting step of: TCA (Krebs) cycle? | Isocitrate dehydrogenase
🗑
|
||||
| What is the rate-limiting step of: Glycogenesis (glycogen synthesis)? | Glycogen synthase
🗑
|
||||
| What is the rate-limiting step of: Glycogenolysis? | Glycogen phosphorylase
🗑
|
||||
| What is the rate-limiting step of: Hexose monophosphate (HMP) shunt? | Glucose-6-phosphate dehydrogenase (G-6-PD)
🗑
|
||||
| What is the rate-limiting step of: Fatty acid synthesis? | Acetyl CoA carboxylase
🗑
|
||||
| What is the rate-limiting step of: ß-Oxidation? | Carnithine acyltransferase I
🗑
|
||||
| What is the rate-limiting step of: Ketogenolysis? | HMG CoA synthase
🗑
|
||||
| What is the rate-limiting step of: Cholesterol synthesis? | HMG CoA reductase
🗑
|
||||
| What is the rate-limiting step of: Urea cycle? | Carbamoyl phosphate synthetase I
🗑
|
||||
| What is the rate-limiting step of: Heme synthesis? | Delta-Aminolevulinic acid (ALA) synthase
🗑
|
||||
| What is the rate-limiting step of: Pyrimidine synthesis? | Aspartate transcarbomylase
🗑
|
||||
| What is the rate-limiting step of: Purine synthesis? | Phosphoribosyl pyrophosphate (PRPP) glutamyl amido transferase
🗑
|
||||
| What is the only fatty acid that is gluconeogenic? | Propionic acid
🗑
|
||||
| Aldose reductase converts galactose to what? | Galactitol
🗑
|
||||
| How many ATPs are generated from glycolysis? | 8
🗑
|
||||
| In the mitochondria, what complex is needed in order for pyruvate carboxylase to catalyze the reaction from pyruvate to OAA? | Biotin, ATP, and COZ
🗑
|
||||
| What is the enzyme for the oxidative reaction in glycolysis? | Glyceraldehyde dehydrogenase
🗑
|
||||
| What three substrates control the enzyme phosphoenolpyruvate carboxykinase (PEPCK) for the conversion of OAA to pyruvate in the cytoplasm? | 1. Cortisol (stimulates PEPCK) 2. Glucagon 3. Guanine triphosphate (GTP)
🗑
|
||||
| What is released from the reaction of phosphoenolpyruvate carboxykinase (PEPCK) for the conversion of OAA to pyruvate? | C02
🗑
|
||||
| What enzyme deficiency causes cataracts, galactosemia, and galactosuria? | Galactokinase deficiency
🗑
|
||||
| The addition of D-2,3-bisphosphoglycerate (D-2,3-BPG) to HbA does what to the 02 saturation curve? | Shifts it to the right
🗑
|
||||
| In what benign condition do you see excretion of large amounts of fructose after ingestion? | Essential fructosuria (fructokinase deficiency)
🗑
|
||||
| What is the glycolysis enzyme found only in the liver? | Glucokinase
🗑
|
||||
| How many ATPs are generated per acetyl CoA? | 12 (Not 15-that would be the answer if you included the pyruvate to acetyl CoA step.)
🗑
|
||||
| What enzyme is associated with the substrate-level phosphorylation in the TCA cycle? | Succinate thiokinase
🗑
|
||||
| The availability of OAA and acetyl CoA regulates what pathway? | TCA cycle
🗑
|
||||
| What complex of the electron transport chain (ETC) is inhibited by malonate? | Complex II
🗑
|
||||
| What drug blocks the FO portion of the adenosine triphosphatase (ATPase) system of the electron transport chain (ETC)? | Oligomycin
🗑
|
||||
| In what two places is glycogen made and stored? | 1. Liver 2. Muscle: Liver stores are for blood glucose; muscle stores are for energy reserves.
🗑
|
||||
| What drug blocks the ETC by attaching itself to K+ for passage through the membrane, negating the charge gradient? | Valinomycin
🗑
|
||||
| At what step of the TCA cycle is FADH2 generated? | Succinate dehydrogenase (inhibited by malonate)
🗑
|
||||
| What inhibits complex III of the ETC? | Antimycin A
🗑
|
||||
| What inhibits the ATP/ADP translocase of the ETC? | Atractyloside
🗑
|
||||
| Thiamine pyrophosphate (TPP) is associated with what three enzymes? | 1. a-ketoglutarate dehydrogenase 2. Pynivate dehydrogenase 3. Transketolase
🗑
|
||||
| What hormone stimulates glycogen synthesis? | Insulin
🗑
|
||||
| Deficiency in what enzyme leads to insoluble glycogen formation? | A-1,6 transferase
🗑
|
||||
| The reduced nicotinamide adenine dinucleotide phosphate (NADPH) generated from the G-6-PD reaction is used exclusively for what? | Fatty acid synthesis
🗑
|
||||
| What enzyme requires selenium (Se) to function? | Glutathione peroxidase
🗑
|
||||
| What are the two essential fatty acids? | 1. Linoleic acid 2. Linolenic acid
🗑
|
||||
| What intermediate of the HMP pathway is used to generate nucleotides? | Ribose-5-phosphate
🗑
|
||||
| A deficiency in what enzyme causes a decrease in oxidoreductase activity in neutrophils? | G-6-PD
🗑
|
||||
| What are the nonoxidative enzymes of the HMP shunt? | Transketolase and transaldolase
🗑
|
||||
| Are the reactions they catalyze reversible or irreversible? | Reversible
🗑
|
||||
| A patient who presents with cardiomegaly and hepatomegaly has what glycogen storage disease? | Pompe's disease (lysosomal glucosidase deficiency)
🗑
|
||||
| Very low density lipoprotein (VLDL) remnants are known as what? | Intermediate-density lipoproteins (IDLs)
🗑
|
||||
| What carries triacylglycerols (TAGS) and cholesterol from the diet? | Chylomicrons
🗑
|
||||
| What protein is required for the uptake of low-density lipoproteins (LDLs) in the peripheral tissue? | Apoprotein B-100
🗑
|
||||
| What 3 apoproteins are on the surface of chylomicrons? | Apoprotein B-48, C-II, and E
🗑
|
||||
| What protein carries free fatty acids to the liver? | Albumin
🗑
|
||||
| What hormone is activated in adipose tissue when blood glucose levels decrease? | Hormone-sensitive lipase
🗑
|
||||
| In the P-oxidation pathway, what enzyme generates the FADH2? | Acyl CoA dehydrogenase
🗑
|
||||
| How many ATPs are generated per acetyl CoA in [3-oxidation? | 5
🗑
|
||||
| How many ATPs are generated per acetyl CoA from [3-oxidation if it is run through the TCA cycle? | 12
🗑
|
||||
| What is the only organ in the body that can produce ketone bodies? | The liver (in the mitochondria)
🗑
|
||||
| What two tissues prefer ketone bodies over glucose? | 1. Heart muscle 2. Renal cortex
🗑
|
||||
| What enzyme is absent in the liver so that ketogenolysis cannot occur? | Thiophorase
🗑
|
||||
| What pathway utilizes HMG-CoA synthetase in the cytoplasm? | Cholesterol biosynthesis
🗑
|
||||
| What two vitamins are inactivated when they come in contact with acetaldehyde? | 1. Thiamine 2. Folate
🗑
|
||||
| What is the precursor of all sphingolipids? | Ceramide
🗑
|
||||
| What two sugars can be used to produce cerebrosides? | 1. Glucose 2. Galactose
🗑
|
||||
| Where does the energy for the urea cycle come from? | Fat metabolism
🗑
|
||||
| What are the two major carriers of nitrogen from tissues? | 1. Glutamine (most tissues) 2. Alanine (muscle)
🗑
|
||||
| What are the ketogenic amino acids? | Leucine and lysine
🗑
|
||||
| What is the storage form of folate? | N-methyl folate
🗑
|
||||
| What disease is produced by a deficiency in the enzyme tyrosinase? | Albinism (Tyrosine is converted to melanin by the enzyme tyrosinase.)
🗑
|
||||
| What two enzymes are blocked by lead? | 1. ALA dehydratase 2. Ferrochelatase
🗑
|
||||
| Where in the body is heme converted to bilirubin? | Reticular endothelial system (RES)
🗑
|
||||
| What type of bilirubin is found in neonatal jaundice? | Indirect or unconjugated
🗑
|
||||
| What is the primary end product of pyrimidine synthesis? | Uridine monophosphate (UMP)
🗑
|
||||
| All amino acids have titration plateaus at what pH values? | PH of 2 and 9
🗑
|
||||
| What amino acid is a good buffer at a pH of 7? | Histidine
🗑
|
||||
| What is the only way to increase maximum velocity (VmaY)? | Increase enzyme concentrations
🗑
|
||||
| What happens to affinity if you increase K„? | Affinity decreases (they are inversely proportional)
🗑
|
||||
| What two amino acids disrupt an a-helix? | 1. Glycine 2. Proline
🗑
|
||||
| What amino acid is a phenol? | Tyrosine
🗑
|
||||
| What enzyme requires molybdenum (Mo) as a cofactor? | Xanthine oxidase
🗑
|
||||
| What determines the rate of a reaction? | The energy of activation (Ea)
🗑
|
||||
| What substrate concentration is required to produce 1/2 Vmax? | Km
🗑
|
||||
| What enzyme is blocked by allopurinol? | Xanthine oxidase ("suicide inhibitor")
🗑
|
||||
| What enzyme is stimulated by PTH to produce 1,25 vitamin D3? | 1-a-Hydroxylase
🗑
|
||||
| What three organs are used to produce vitamin D? | 1. Skin 2. Liver 3. Kidney
🗑
|
||||
| What vitamin is an important component of rhodopsin? | Vitamin A
🗑
|
||||
| What G protein is stimulated by activated rhodopsin? | Gt (transducin), which decreases cyclic guanosine monophosphate (cGMP) and closes the Na+ channels, causing nerve transmission
🗑
|
||||
| What are the vitamin K-dependent clotting factors? | 2, 7, 9, and 10
🗑
|
||||
| What vitamin is connected to selenium (Se) metabolism? | Vitamin E
🗑
|
||||
| What is the activated form of vitamin E? | Alpha-tocopherol
🗑
|
||||
| What elements make up a nucleoside? | A base and a sugar
🗑
|
||||
| What is the most common methylated base? | Cytosine
🗑
|
||||
| DNA is replicated at what phase of the cell cycle? | S phase
🗑
|
||||
| At which end of DNA are new bases added? | 3' end
🗑
|
||||
| What keeps single-strand DNA (ssDNA) from re-annealing during DNA replication? | Single-strand (ss) binding protein
🗑
|
||||
| What enzyme is responsible for producing a single-strand (ss) cut in the DNA to relieve the coil tension? | Topoisomerase I (relaxase)
🗑
|
||||
| What two amino acids are found in high concentrations in the nucleosome? | 1. Arginine 2. Lysine
🗑
|
||||
| What three bases are pyrimidines? | 1. Cytosine 2. Uracil (only in RNA) 3. Thymidine
🗑
|
||||
| What enzyme creates a short sequence of RNA to start DNA replication? | Primase
🗑
|
||||
| What type of enzyme is reverse transcriptase? | RNA-dependent DNA polymerise
🗑
|
||||
| What is the direction of transcription? | 5' to 3' direction
🗑
|
||||
| Where is the TATA box in located eukaryotes? | 25 bases downstream (-25)(promoter)
🗑
|
||||
| What causes transcription to stop in eukaryotes? | The poly(A) site on the DNA
🗑
|
||||
| What protein binds to the promoter region in eukaryotes to initiate transcription? | TF II D (transcription factor)
🗑
|
||||
| What part of the 30S ribosome binds to the Shine-Dalgarno sequence? | 16S subunit
🗑
|
||||
| What is the start codon for translation? | AUG
🗑
|
||||
| What is the enzyme that activates the amino acids for the tRNA? | Aminoacyl-tRNA synthetase
🗑
|
||||
| What is needed to direct enzymes to a lysosome? | Phosphorylation of mannose residues
🗑
|
||||
| What cofactor is needed for lysyl oxidase? | Cu2+
🗑
|
||||
| What part of the 50S and 60S ribosomal subunit is needed for elongation? | Peptidyl transferase
🗑
|
||||
| In the lac operon: At which site is the repressor gene encoded? | I gene
🗑
|
||||
| To which site does the repressor protein bind in order to inhibit transcription? | Operator
🗑
|
||||
| What amplification technique is used to generate a larger amount of DNA? | Polymerase chain reaction (PCR)
🗑
|
||||
| What test is used to determine whether a gene is expressed? | Northern blotting
🗑
|
||||
| At what organ in the body is urea produced? | Liver
🗑
|
||||
| What regulatory proteins work during fetal development to ensure that cells become a specific cell type (If there is a defect here, there can be profound structural mutations.)? | Homeobox genes
🗑
|
||||
| What is the mode of inheritance in which a trait is seen in every generation and is passed on only by females? | Mitochondrial inheritance
🗑
|
||||
| What is the name for the process of going from mRNA to proteins? | Translation
🗑
|
||||
| What are the components of a nucleotide? | A base, a sugar, and a phosphate
🗑
|
||||
| What enzymes hydrolyze 3'-5' phosphodiesterase bonds from the outside of the strand in? | Exonucleases
🗑
|
||||
| What type of organisms have monocistronic mRNA? | Eukaryotes
🗑
|
||||
| In collagen, every third amino acid is this amino acid. | Glycine
🗑
|
||||
| What form of continuous DNA, used in cloning, has no introns or regulatory elements? | c-DNA, when it is made from mRNA
🗑
|
||||
| What proteins stimulate a cell to enter the S phase? | Growth factors
🗑
|
||||
| At what pH is there no net charge on the structure? | pI (isoelectric point)
🗑
|
||||
| What complex of the ETC contains Cue+? | Complex 4
🗑
|
||||
| What two shuttles are needed to keep NAD+ in the reduced state? | Malate/aspartate and glycerol-3-phosphate shuttles
🗑
|
||||
| What vitamin is required for y-carboxylation of many Cat+-binding proteins? | Vitamin K
🗑
|
||||
| From where is the energy for gluconeogenesis derived? | ß-Oxidation of fatty acids
🗑
|
||||
| What amino acid is broken down into N20, causing an increase in eGMP of smooth muscle resulting in vasodilatation? | Arginine
🗑
|
||||
| What hormone phosphorylates enzymes to decrease their activity? | Glucagon
🗑
|
||||
| Lack of what enzyme can lead to Wernicke-Korsakoff syndrome through lack of activity in the HMP shunt? | Thiamine pyrophospate (TPP)
🗑
|
||||
| What enzyme found in the liver catalyzes glycerol to glycerol-3-phosphate? | Glycerol kinase
🗑
|
||||
| Which shuttle is used to bring fatty acyl CoA from the cytoplasm for ketogenesis? | Carnitine acyl CoA transferase II
🗑
|
||||
| Which enzyme is deficient in phenylketonuria (PKU)? | Phenylalanine hydroxylase
🗑
|
||||
| After approximately how many days of a prolonged fast does death occur in humans? | 60 days
🗑
|
||||
| What is the cause of death? | The breakdown of the essential proteins of the heart and brain
🗑
|
||||
| All the carbons in a fatty acid are derived from what source? | Cytoplasmic acetyl CoA that left the mitochondria as citrate
🗑
|
||||
| What enzyme is deficient in alcaptonuria? | Homogentisic acid
🗑
|
||||
| In a diabetic patient, glucose is converted by aldose reductase to what? | Sorbitol (resulting in cataracts)
🗑
|
||||
| What glycolytic intermediate can be used to synthesize triglycerides and phospholipids? | DHAP
🗑
|
||||
| What glycolytic enzyme has a high Vmax high Km and low affinity for glucose? | Glucokinase
🗑
|
||||
| What is the main inhibitor of pyrnvate dehydrogenase? | Acetyl CoA (pyruvate to acetyl CoA)
🗑
|
||||
| What are the two substrate-level phosphorylations in glycolysis? | 1. Pyruvate kinase 2. Phosphoglycerate kinase
🗑
|
||||
| What are the eight liver-specific enzymes? | 1. Fructokinase 2. Glucokinase 3. Glycerol kinase 4. PEPCK 5. Pyruvate carboxylase 6. Galactokinase 7. Fructose-1,6-biphosphate 8. Glucose-6-phosphate
🗑
|
||||
| In what cycle does glucose go to the muscle, where it is converted to pyruvate and then into alanine before being taken back to the liver? | Alanine cycle
🗑
|
||||
| In what cycle does glucose go to the muscle, where it is converted to lactate, and then returned to the liver? | Cori cycle
🗑
|
||||
| What four substances increase the rate of gluconeogenesis? | 1. Glucagon 2. NADH 3. Acetyl CoA 4. ATP
🗑
|
||||
| What enzyme is deficient in a patient who presents with: Liver damage and severe hypoglycemia? | Aldolase B (hereditary fructose intolerance)
🗑
|
||||
| Jaundice, vomiting, lethargy, cat, galactosemia, and galactosuria? | Galactose 1-phosphate uridyltransferase
🗑
|
||||
| What three substances stimulate glycogenolysis? | 1. Cat+:calmodulin ratio 2. Epinephrine 3. Glucagon
🗑
|
||||
| What are the two inhibitors of complex I of the ETC? | 1. Rotenone 2. Amytai (barbiturates)
🗑
|
||||
| What are the five factors that constitute the pyruvate dehydrogenase complex? | 1. TPP 2. Lipoic acid 3. CoASH 4. FAD 5. NAD
🗑
|
||||
| What attaches to protons and allows them to enter into the mitochondria without going through the ATP-generating system? | 24-Dinitrophenol
🗑
|
||||
| What are the two decarboxylation steps of the TCA cycle? | 1. Isocitrate dehydrogenase 2. a-Ketoglutarate dehydrogenase
🗑
|
||||
| What are the three inhibitors of complex IV of the ETC? | 1. Cyanide 2. CO 3. Azide
🗑
|
||||
| What three steps of the TCA cycle generate NADH? | 1. Malate dehydrogenase 2. Isocitrate dehydrogenase 3. a-Ketoglutarate dehydrogenase
🗑
|
||||
| What disease presents with weakness and cramps on exercise without an increase in blood lactate levels? | McArdle's disease (muscle glycogen phosphorylase deficiency)
🗑
|
||||
| NADPH generated from the HMP shunt is used for what? | Fatty acid synthesis, nucleotide synthesis, and glutathione reductase
🗑
|
||||
| Is linolenic acid an omega-3 or -6 fatty acid? | Omega-3; linoleic is omega-6
🗑
|
||||
| Is the oxidative reaction of the HMP shunt reversible or irreversible? | Irreversible (G-6-PD and 6-phosphogluconate dehydrogenase)
🗑
|
||||
| What disease presents with an enlarged liver and kidneys, dwarfism, hypoglycemia, acidosis, and hyperlipidemia? | Von Gierke's disease (glucose 6-phosphatase deficiency)
🗑
|
||||
| At what three sites can the HMP shunt enter into glycolysis? | 1. Fructose-6-phosphate 2. Glucose-6-phosphate 3. Glyceraldehyde-3-phosphate 1
🗑
|
||||
| Deficiency in the liver glycogen phosphorylase enzyme is known as what? | Hers disease
🗑
|
||||
| What causes the lysis of red blood cells by oxidizing agents in a glucose-6- phosphate dehydrogenase deficiency? | The lack of glutathione peroxidase activity results in a decrease in NADPH production, leaving glutathione in the reduced state.
🗑
|
||||
| What disease presents with hepatomegaly and a normal EKG? | Glycogen storage disease, type III (Forbes disease, Cori disease)
🗑
|
||||
| What apoprotein is on the surface of LDL? | Apoprotein B-100
🗑
|
||||
| What carries cholesterol from the tissues back to the liver? | HDLs
🗑
|
||||
| What apoprotein mediates the uptake of remnants by the liver? | Apoprotein E
🗑
|
||||
| What is the complex needed for acetyl CoA carboxylase? | Biotin, ATP, and G02 (acetyl CoA to malonyl CoA)
🗑
|
||||
| What are the three tissues where TAGS are produced? | 1. Liver 2. Muscle 3. Adipose tissue
🗑
|
||||
| What delivers cholesterol to the tissues? | LDLs
🗑
|
||||
| What apoprotein is produced by the intestinal epithelium? | Apoprotein B-48
🗑
|
||||
| What carries TAGS to the peripheral tissues? | VLDLs
🗑
|
||||
| How many NADPHs are used per addition of each of acetyl CoA into a fatty acid chain? | 2 NADPHs/acetyl CoA
🗑
|
||||
| What apoprotein activates lipoprotein lipase in the capillary epithelium to hydrolyze TAGS? | Apoprotein C-II
🗑
|
||||
| What apoproteins are on the surface of IDL? | Apoproteins B-100 and E
🗑
|
||||
| From which two substances are phospholipids made? | 1. DAGs 2. Phosphatidic acid
🗑
|
||||
| What apoproteins are on the surface of HDL? | Apoprotein A-I, C-II, and E
🗑
|
||||
| What is needed to produce a double bond in a fatty acid chain in the endoplasmic reticulum? | NADPH, O2, and cytochrome b5
🗑
|
||||
| What apoprotein activates lecithin cholesterol acyl transferase to esterify cholesterol from tissue? | Apoprotein A-I
🗑
|
||||
| What apoproteins are on the surface of VLDL? | Apoproteins B-100, C-II, and E
🗑
|
||||
| At the end of each round of ß-oxidation, what is released? | Acetyl CoA, FADH, and NADH
🗑
|
||||
| What two enzymes are vitamin B12 dependent? | 1. Homocysteine methyl transferase 2. Methylmalonyl CoA transferase
🗑
|
||||
| What enzyme is blocked by disulfiram? | Aldehyde dehydrogenase
🗑
|
||||
| What hormone hydrolyzes TAGS to free fatty acids and glycerol? | Hormone-sensitive lipase
🗑
|
||||
| What enzyme is deficient in a patient 2 years of age or younger who presents with vomiting, lethargy, coma, hypoketosis, and hypoglycemia following a fast of more than 12 hours? | Medium-chain acyl dehydrogenase
🗑
|
||||
| What form of alcohol did the patient drink if he became blind as a result? | Methanol (wood alcohol)
🗑
|
||||
| What regulates the rate of ketone body formation? | The rate of ß-oxidation
🗑
|
||||
| What intermediate enables propionyl CoA to enter into the TCA cycle? | Succinyl CoA
🗑
|
||||
| What sphingolipid is formed by the union of serine and palmitoyl CoA? | Sphingosine
🗑
|
||||
| What intermediate of cholesterol synthesis anchors proteins in the membranes and forms CoQ? | Farnesyl pyrophosphate (FPP)
🗑
|
||||
| What is the complex needed for propionyl CoA carboxylase? | Biotin, ATP, and C02
🗑
|
||||
| What are the three ketone bodies? | 1. Acetoacetate 2. Acetone 3. ß-hydroxybutyrate
🗑
|
||||
| What type of damage to the kidneys is caused by drinking ethylene glycol (antifreeze)? | Nephrotoxic oxylate stones
🗑
|
||||
| What is the only sphingolipid that contains choline and p04? | Sphingomyelin (lecithin also, but it is not a sphingolipid)
🗑
|
||||
| What is the order of fuel utilization in a prolonged fast? | 1. Glucose from liver glycogen 2. Glucose from gluconeogenesis 3. Body protein 4. Body fat
🗑
|
||||
| Sialic acid and amino sugars are needed to produce what sphingolipid? | Ganglioside
🗑
|
||||
| What vitamin is needed as a cofactor for decarboxylation and transaminase reactions? | Vitamin B6
🗑
|
||||
| What are the two ways that nitrogen can enter into the urea cycle? | 1. Aspartate 2. Carbomoyl PO4
🗑
|
||||
| What is the only enzyme in the body that uses N5 methyl folate? | Homocysteine methyl transferase
🗑
|
||||
| What enzyme deficiency will result in an increase in blood ammonia and an increase in uracil and orotate concentrations in both the blood and urine? | Ornithine transcarbamoylase (OTC) deficiency-also called ornithine carbamoyltransverase (OCT) deficiency
🗑
|
||||
| What amino acid is a precursor of the following substances: Serotonin? | Tryptophan
🗑
|
||||
| What amino acid is a precursor of the following substances: GABA? | Glutamate
🗑
|
||||
| What amino acid is a precursor of the following substances: Histamine? | Histidine
🗑
|
||||
| What amino acid is a precursor of the following substances: Creatine? | Glycine/arginine
🗑
|
||||
| What amino acid is a precursor of the following substances: NAD? | Tryptophan
🗑
|
||||
| What amino acid is a precursor of the following substances: N20? | Arginine
🗑
|
||||
| What enzyme deficiency will result in an increase in blood ammonia, but no increase in uracil concentrations? | Carbamoyl-phosphate synthetase
🗑
|
||||
| What are the glucogenic and ketogenic amino acids? | Phenylalanine, Tyrosine, Tryptophan, Isoleucine, Threonine
🗑
|
||||
| What are the three diseases of sphingolipids? | 1. Niemann-Pick disease 2. Gaucher's disease 3. Tay-Sachs disease
🗑
|
||||
| What type of jaundice is seen in Rotor's syndrome? | Conjugated (direct) hyperbilirubinemia
🗑
|
||||
| What is the pyrimidine intermediate that joins PRPP? | Orotic acid
🗑
|
||||
| What three amino acids are used to synthesize the purine ring? | 1. Glycine 2. Aspartate 3. Glutamine
🗑
|
||||
| What enzyme is blocked by hydroxyurea? | Ribonucleotide reductase
🗑
|
||||
| What is the primary end product of purine synthesis? | IMP
🗑
|
||||
| What enzyme is deficient in hereditary protoporphyria? | Ferrochelatase
🗑
|
||||
| What are the two precursors of heme? | 1. Glycine 2. Succinyl-CoA
🗑
|
||||
| What enzyme is blocked by 5-FU? | Thymidylate synthetase
🗑
|
||||
| What disease has a genetically low level of UDPglucuronate transferase, resulting in elevated free unconjugated bilirubin? | Gilbert's syndrome
🗑
|
||||
| What form of bilirubin can cross the blood-brain barrier? | Unconjugated free bilirubin
🗑
|
||||
| What substrates are needed to produce carbamoyl P04 (de novo pyrimidine synthesis)? | Glutamine, CO2, and ATP via carbamoyl PO4 synthetase II
🗑
|
||||
| What enzyme is blocked by methotrexate/trimethoprim? | Dihydrofolate reductase
🗑
|
||||
| What type of jaundice is seen in Dubin-Johnson syndrome? | Conjugated (direct) hyperbilirubinemia (It is a transport defect.)
🗑
|
||||
| What form of bilirubin is carried on albumin? | Unconjugated (indirect)
🗑
|
||||
| In what disease is there a genetic absence of UDPglucuronate transferase, resulting in an increase in free unconjugated bilirubin? | Crigler-Najjar syndrome
🗑
|
||||
| What enzyme is deficient in acute intermittent porphyria? | Uroporphyrinogen I synthetase
🗑
|
||||
| What enzyme is deficient in congenital erythropoietic porphyria? | Uroporphyrinogen III cosynthase
🗑
|
||||
| What amino acid has a pKa of 13? | Arginine
🗑
|
||||
| What two amino acids have a pKa of 10? | 1. Lysine 2. Tyrosine
🗑
|
||||
| What two amino acids have a pKa of 4? | 1. Aspartic acid 2. Glutamic acid
🗑
|
||||
| What disease has a genetic deficiency in adenosine deaminase? | Severe combined immunodeficiency (SCID)
🗑
|
||||
| What type of charge does the molecule have if the pH is greater than the pI (isoelectric point)? | A net negative charge
🗑
|
||||
| In what disease is there a deficiency in hypoxanthine guanine phosphoribosyl transferase (HGPRT)? | Lesch-Nyhan syndrome
🗑
|
||||
| What is the end product of purine catabolism? | Uric acid
🗑
|
||||
| What enzyme is deficient in selective T cell immunodeficiency? | Purine nucleoside phosphorylase
🗑
|
||||
| What substrate builds up in Tay-Sachs disease? | Ganglioside GM2
🗑
|
||||
| On a Lineweaver-Burke plot, what type of binding has both plots crossing the y-axis in the same spot? | Competitive, reversible inhibition (Vmax is the same, increase Km)
🗑
|
||||
| What toxin ADP-ribosylates via GS protein to increase CAMP? | Cholera toxin
🗑
|
||||
| What vitamin derivatives are used for growth and differentiation of epithelium for reproductive and embryonic development? | Vitamin A
🗑
|
||||
| Light causes isomerization of what in the eyes? | 11-cis-retinal to traps-retinal (activated rhodopsin)
🗑
|
||||
| What are the two actions of calcitonin? | 1. Increases Ca2+ excretion from the kidney 2. Increases bone mineralization
🗑
|
||||
| What causes an increase in bone mineralization and Cat+, as well as P04 absorption from the GI tract and kidney tubules? | Vitamin D
🗑
|
||||
| On the Lineweaver-Burke plot, what type of binding has both plots crossing the x-axis in the same spot? | Noncompetitive, reversible binding (decrease in Vmax; Km is same)
🗑
|
||||
| What is the maximum rate possible with a given amount of enzyme? | Vmax
🗑
|
||||
| To what are intracellular glucose levels inversely related? | cAMP levels
🗑
|
||||
| Does a saturated fatty acid have double bonds? | No; unsaturated fatty acids have double bonds
🗑
|
||||
| What two factors cause PTH to be secreted? | 1. A decrease in blood Ca2+ 2. A decrease in PO4 concentrations
🗑
|
||||
| What in the human genome differs in each individual that can serve as an identification marker? | RFLP-restriction fragment length polymorphism
🗑
|
||||
| What test is used to identify HIV-positive patients? | ELISA-enzyme-linked immunosorbent assay
🗑
|
||||
| What toxin ADP-ribosylates via G to increase cAMP? | Pertussis toxin
🗑
|
||||
| What vitamin is essential for normal Ca2+ and P04 metabolism? | Vitamin D
🗑
|
||||
| What vitamin is deficient in a person who has impaired taste, night blindness, and increased risk for having an abortion? | Vitamin A
🗑
|
||||
| What bond does an endonuclease cleave? | 3', 5' internal phosphodiesterase bond
🗑
|
||||
| What protein separates base pairs and unwinds the DNA at the replication fork? | Helicase (It is an ATP-dependent enzyme.)
🗑
|
||||
| What vitamin deficiency would cause liver necrosis and red blood cell fragility? | Vitamin E deficiency
🗑
|
||||
| What protein catalyzes the formation of the last phosphodiester bond (PDE) between the Okazaki fragments to produce a continuous strand? | DNA ligase
🗑
|
||||
| What is the hypochromic effect? | Increased absorption as DNA goes from double stranded to single stranded
🗑
|
||||
| What technique uses DNA for analysis? | Southern blotting
🗑
|
||||
| In what direction is a new DNA strand made? | 5' to 3'
🗑
|
||||
| What enzyme has a 5' to 3' synthesis activity and a 3' exonuclease activity? | DNA polymerase III
🗑
|
||||
| What enzyme makes a double-stranded cut through DNA, needs ATP, and introduces negative supercoiling? | Topoisomerase II
🗑
|
||||
| What eukaryotic DNA polymerase is used for: DNA replication? | a- and delta-polymerase
🗑
|
||||
| What eukaryotic DNA polymerase is used for: Replication in mitochondria? | gamma-Polymerase
🗑
|
||||
| What eukaryotic DNA polymerase is used for: DNA repair? | ß-Polymerase
🗑
|
||||
| What is the orientation of the gene sequence strand? | 5' to 3' (same as RNA)
🗑
|
||||
| What is the location of the TATA box in procaryotes? | 10 bases downstream
🗑
|
||||
| What binds to the promoter region in procaryotes? | Sigma factor
🗑
|
||||
| What enzyme has a 5' to 3' synthesis of the Okazaki fragments, 3' exonuclease activity, and 5' exonuclease activity? | DNA polymerase I
🗑
|
||||
| What type of mutation has the same amino acid coded for, but with a different codonsequence? | Silent mutation
🗑
|
||||
| At what position of the anticodon does the "wobble" hypothesis occur? | Position 1 of the anticodon (the 5' end)- which is the same as position 3 of the codon (the 3' end)
🗑
|
||||
| What are the three "stop" codons? | 1. UAA 2. UAG 3. UGA
🗑
|
||||
| What stops transcription in procaryotes? | Rho factor or a hairpin loop
🗑
|
||||
| What are the three post-transcriptional modifications? | 1. 7-methyl guanine cap on the 5' end 2. Addition of the poly(A) tail to the 3' end 3. Removal of introns
🗑
|
||||
| In what type of mutation is a different codon added, resulting in formation of a different amino acid? | Missense mutation
🗑
|
||||
| What amino acid is attached to the 3' end of the tRNA in eukaryotes? | Methionine
🗑
|
||||
| What enzyme makes tRNA and the SsRNA? | RNA polymerase III
🗑
|
||||
| What structure of a protein describes the interaction among subunits? | Quaternary structure
🗑
|
||||
| What two amino acids require vitamin C for hydroxylation? | 1. Proline 2. Lysine
🗑
|
||||
| What is determined by the secondary structure of an amino acid? | The folding of an amino acid chain
🗑
|
||||
| Which mutation has a stop codon put in place of the previous codon? | Nonsense mutation
🗑
|
||||
| What amino acid is attached to the 3' end of the tRNA in prokaryotes? | f-Methionine
🗑
|
||||
| What enzyme makes rRNA (barring the 5s subunit)? | RNA polymerase I
🗑
|
||||
| What is the site of action of cycloheximide? | Peptidyl transferase (60S)
🗑
|
||||
| What translation factor is blocked by erythromycin? | Elongation factore G (EF-G)
🗑
|
||||
| What is the charge of the molecule if the pH is less than the pI (isoelectric point)? | A net positive charge
🗑
|
||||
| What technique uses the separation of proteins on a gel electrophoresis? | Western blot
🗑
|
||||
| Lack of what vitamin causes multiple carboxylase deficiency? | Biotin
🗑
|
||||
| What enzyme makes hnRNA/mRNA? | RNA polymerase II
🗑
|
||||
| What enzyme is deficient in cystathioninuria? | Cystathionase
🗑
|
||||
| What enzyme is deficient in maple syrup urine disease? | Branched-chain keto acid dehydrogenase
🗑
|
||||
| What type of mutation has the addition or deletion of a base? | Frameshift
🗑
|
||||
| What is the site of action of puromycin? | Aminoacyl tRNA (A site)
🗑
|
||||
| What translational factor is blocked by both diphtheria and Pseudomonas toxins? | Elongation factor 2 (EF-2)
🗑
|
||||
| What substrate gets built up in Gaucher's disease? | Glucosyl cerebroside
🗑
|
||||
| What enzyme is deficient in homocystinuria? | Homocysteine methyl transferase or cystathionine synthetase
🗑
|
||||
| What substrate is built up in Niemann-Pick disease? | Tyrosine kinase
🗑
|
||||
| What is the second messenger system used by growth factors? | Sphingomyelin
🗑
|
||||
| What is the name of the sequence on mRNA that precedes the start codon in prokaryotes? | Shine-Dalgarno sequence
🗑
|
||||
| What amino acid undergoes N-glycosylation? | Asparagine
🗑
|
||||
| What translational factor is blocked by tetracycline? | Elongation factor Tu (EF-Tu)
🗑
|
||||
| What translational factor is blocked by streptomycin? | IF-2
🗑
|
||||
| Which organisms have polycistronic mRNA? | Prokaryotes: Polycistonic and prokaryotes both start with P.
🗑
|
||||
| In what disease are lysosomal enzymes released into the extracellular space where an accumulation of inclusion bodies compromises the cell's function? | I-cell disease
🗑
|
||||
| What is the site of action of chloramphenicol? | Peptidyl transferase (50s)
🗑
|
||||
| What is needed to initiate translation? | IF and GTP (OF for eukaryotes)
🗑
|
||||
| What is the name of the process of going from DNA to mRNA? | Transcription
🗑
|
||||
| Is the hydroxyl (-OH) end of DNA and RNA at the 3' or the 5' end? | 3' end. Phosphate (P04) is at the 5' end.
🗑
|
||||
| What is the only factor of enzyme kinetics that the enzyme affects? | Ea (activation energy)
🗑
|
||||
| What tumor suppressor gene prevents a cell from entering S phase when no growth factors are present? | Rb gene
🗑
|
||||
| What tumor suppressor gene prevents a cell with damaged DNA from entering the S phase? | p53 gene
🗑
|
||||
| What factors are needed for elongation in prokaryotes? | EF-Tu or EF-is and GTP
🗑
|
||||
| What factors are needed for translocation in eukaryotes? | EF-2 and GTP
🗑
|
||||
| What type of inheritance involves carriers, affects only males, and skips generations? | X-linked recessive
🗑
|
||||
| What type of separation technique uses RNA on an electrophoresis? | Northern blotting
🗑
|
||||
| What factors are needed for elongation in eukaryotes? | EF-1 and GTP
🗑
|
||||
| What factors are needed for translation in prokaryotes? | EF-G and GTP
🗑
|
||||
| What type of inheritance has no male-to-male transmission, and every daughter is affected from the father in every generation? | X-linked recessive
🗑
|
||||
| What virus is associated with intranuclear inclusions known as "owl's eye" inclusions? | Cytomegalovirus (CMV)
🗑
|
||||
| What virus is associated with Negri bodies? | Rabies virus
🗑
|
||||
| What virus is associated with Guarnieri bodies? | Variola virus -7-ox vtrcs
🗑
|
||||
| What virus causes small, pink, benign wart-like tumors and is associated with HIV-positive patients? | Molluscum contagiosum
🗑
|
||||
| What viruses are associated with cervical carcinoma? | Human papilloma viruses (HPVs) 16 and 18
🗑
|
||||
| What virus is associated with erythema infectiosum or fifth disease? | Parvovirus B-19
🗑
|
||||
| What virus binds to: CD4? | Human immunodeficiency virus (HIV)
🗑
|
||||
| What virus binds to: ß2-Microglobulin? | Cytomegalovirus (CMV)
🗑
|
||||
| What virus binds to: Complement factor C3? | Epstein-Barr virus (EBV) - Qp7_1
🗑
|
||||
| What virus binds to: ACh receptors? | Rabies virus
🗑
|
||||
| What is the only dsRNA virus? | Reovirus
🗑
|
||||
| What are the three non-enveloped RNA viruses? | 1. Picornavirns 2. Calicivirns 3. Reovirns (PCR)
🗑
|
||||
| What viruses are associated with Cowdry type A intranuclear inclusions? | Herpes virus I and II
🗑
|
||||
| What virus is associated with the Norwalk agent? | Calicivirns
🗑
|
||||
| What virus affects the motor neurons in the anterior horn? | Poliovirus
🗑
|
||||
| What is the most common cause of diarrhea in children? | Adenovirns /Ro.S.mftg
🗑
|
||||
| What virus lies dormant in the: Trigeminal ganglia? | Herpes I
🗑
|
||||
| What virus lies dormant in the: Dorsal root ganglia? | Varicella
🗑
|
||||
| What virus lies dormant in the: Sensory ganglia of S2 and S3? | Herpes II
🗑
|
||||
| With what virus are Downey type II cells associated? | EBV
🗑
|
||||
| What are the four segmented RNA viruses? | 1. Bunyavirns 2. Orthomyxovirus 3. Reovirns 4. Arenavirus (BORA)
🗑
|
||||
| Koilocytic cells on a Papanicolaou (Pap) smear are indicative of what virus? | HPV
🗑
|
||||
| What bacteria constitute the most common cause of nosocomial infections in burn patients and in patients with cystic fibrosis? | Pseudomonas
🗑
|
||||
| What organism is associated with pneumonia acquired from air conditioners? | Legionella
🗑
|
||||
| What species of bacteria is associated with whooping cough? | Bordetella pertus,sis
🗑
|
||||
| What two bacteria are associated with drinking unpasteurized milk? | 1. Brucella 2. Listeria (has tumbling motility)
🗑
|
||||
| What organism is associated with gastritis and ulcers? | Helicobacter pylori
🗑
|
||||
| What species of bacteria is associated with traveler's diarrhea? | Escherichia coli (enterotoxic)
🗑
|
||||
| With what organism is "currant jelly" sputum associated? | Klebsiella pneumoniae
🗑
|
||||
| What is the most common cause of enterocolitis? | Salmonella enteritidis
🗑
|
||||
| What organism is so infective that it takes only 1 to 10 organisms to cause an infection? | Shigella
🗑
|
||||
| What organism stains bipolar and causes buboes? | Yersinia pesos
🗑
|
||||
| Rice water stools are indicative of what organism? | Vibrio cholerae
🗑
|
||||
| With what organism are intracellular gram-negative inclusions in neutrophils associated? | Neisseria gonorrhoeae
🗑
|
||||
| What organism is most likely to cause an infection if you are bitten by a dog or a cat? | Pasteurella
🗑
|
||||
| What organism needs factor X and NAD in order to grow on growth medium? | Haemophilu.s influenzae type B
🗑
|
||||
| What organism is associated with a rigid belly and rose spots on the belly? | Salnwnella typhi
🗑
|
||||
| What organism will cause an infection if undercooked or raw seafood is eaten? | Vibrio parahaemolyticus
🗑
|
||||
| What organism is likely to infect you if you get cut by a shell at the beach? | Vibrio vulnificus
🗑
|
||||
| What infective bacteria are found in undercooked hamburgers? | Escherichia coli strain 0157:H7ss
🗑
|
||||
| What organism is said to have a "spaghetti and meatball" arrangement under a microscope? | Malassezia furfur
🗑
|
||||
| What fungus is associated with rose gardener's disease? | Sporothrix schenckii
🗑
|
||||
| What fungus is seen as colored cauliflower lesions? | Chromomycosis
🗑
|
||||
| What fungus is found in soil with bird or bat feces? | Histoplasma cap.sulatum
🗑
|
||||
| Which organism causes San Joaquin fever? | Coccidioides immitis
🗑
|
||||
| What fungus causes endocarditis in IV drug users? | Candida albicans
🗑
|
||||
| What fungus is found in pigeon droppings? | Cryptococcus neoformans
🗑
|
||||
| What fungus is seen as a yeast with broad-based buds and a double refractile cell wall? | Blastomyces dermatitidis
🗑
|
||||
| What fungus is stained positive with India ink? | Cryptococcus neoforrnans
🗑
|
||||
| What virus is the most common causative agent of the common cold in the summer and the fall? | Rhiuovirus
🗑
|
||||
| To what family of viruses do dengue, St. Louis, and yellow fever belong? | Flavivirus
🗑
|
||||
| What is the name of the bullet-shaped virus? | Rhabdovirus
🗑
|
||||
| What virus is responsible for causing the croup and also the common cold in the young and the old? | Paraiuflueuza virus
🗑
|
||||
| What is the causative agent of orchitis, parotids, and pancreatitis? | Mumps virus
🗑
|
||||
| What virus causes hoof-and-mouth disease? | Vesicular stomatitis virus
🗑
|
||||
| What is the most common cause of pneumonia in children 1 year old or younger? | Respiratory syncytial virus (RSV)
🗑
|
||||
| What virus is the most common cause of the common cold in the winter and early spring? | Coronavinzs
🗑
|
||||
| What yeast is urease positive? | Cryptococcus neoformans
🗑
|
||||
| What fungus is a facultative intracellular parasite of the reticular endothelial system? | Histoplasma capsulatum
🗑
|
||||
| What virus is helical and has HN and F glycoprotein spikes? | Paramyxovirus
🗑
|
||||
| What is the most common cause of pneumonia in persons with underlying health problems? | Klebsiella pneumoniae
🗑
|
||||
| What is the most common cause of pneumonia in young children? | Mycoplasma
🗑
|
||||
| What virus causes epidemic keratoconjunetivitis? | Adenovirus
🗑
|
||||
| What is the most common cold virus? | Rhinovirus
🗑
|
||||
| What two viruses have neuraminidase activity? | 1. Influenza 2. Mumps
🗑
|
||||
| What is the most common cause of diarrhea in infants? | Rotavirus
🗑
|
||||
| What is the reservoir for the togavirus? | Birds
🗑
|
||||
| What two viruses cause pancreatitis? | 1. Mumps 2. Coxsackie B40
🗑
|
||||
| With what two viruses are Reye's syndrome associated? | 1. Varicella virus 2. Influenza virus
🗑
|
||||
| What is the most common cause of meningitis in: Children younger than 3 months of age? | Streptococcus agalactiae or Escherichia Coli
🗑
|
||||
| What is the most common cause of meningitis in: Non-immunized children 12 months to 6 years old? | Haemophilus influenzae type b
🗑
|
||||
| What is the most common cause of meningitis in: Immunized children 12 months to 6 years old? | Streptococcus pneumoniae
🗑
|
||||
| What is the most common cause of meningitis in: Military recruits? | Neisseria meningitidis
🗑
|
||||
| What is the most common cause of meningitis in: HIV+/immunocompromised persons? | Cryptococcus neoformans
🗑
|
||||
| What is the most common cause of meningitis in: Adults? | Streptococcus pneunwniae
🗑
|
||||
| What is the most common cause of bronchiolitis in children? | RSV
🗑
|
||||
| What is the most common cause of urinary tract infections? | Escherichia coli
🗑
|
||||
| Which three organisms cause heterophilic negative mononucleosis? | 1. CMV 2. Toxoplasma gondii 3. Listeria
🗑
|
||||
| What two genera are spore formers? | 1. Clostridia 2. Bacillus
🗑
|
||||
| What bacteria are responsi- ble for woolsorters' disease? | Bacillus anthracis
🗑
|
||||
| What is the most common cause of bacterial pneumonia? | Streptococcus pneumoniae
🗑
|
||||
| What bacteria cause subacute endocarditis and dental caries? | Streptococcus viridans
🗑
|
||||
| Which two organisms can cause sulfur granules in the pus? | 1. Actinomyces 2. Nocardia
🗑
|
||||
| What species of bacteria is responsible for causing endocarditis in IV drug users? | Staphylococcus epidermidis
🗑
|
||||
| What bacteria are responsible for food poisoning from rice, fried rice, and reheated foods? | Bacillus cereus
🗑
|
||||
| Which bacteria present as a common cause of meningitis in renal transplant patients? | Listeria
🗑
|
||||
| What bacteria get inoculated into the body by a puncture wound in the skin and also inhibit glycine and GABA? | Clostridium tetani
🗑
|
||||
| What bacteria are found in poorly preserved canned food and cause flaccid paralysis? | Clostridium botulinum
🗑
|
||||
| What bacteria cause myonecrosis? | Clostridium perfringens
🗑
|
||||
| What bacteria cause pseudomembranous colitis? | Clostridium difficile
🗑
|
||||
| What bacteria are associated with food poisoning from ham, potato salad, and custards? | Staphylococcus aureus
🗑
|
||||
| What three bacteria are quellung reactive test positive? | 1. Neisseria meningitidis 2. Haemophilus influenzae 3. Streptococcus pneumoniae
🗑
|
||||
| Which organism causes a painful chancre? | Haemophilus ducreyi
🗑
|
||||
| What is the most common cause of viral pneumonia? | RSV
🗑
|
||||
| What is the predominant anaerobe in the colon? | Bacillus fragilis
🗑
|
||||
| Which organism causes trench mouth? | Fusobacterium
🗑
|
||||
| Which organism causes Lyme disease? | Borrelia burgdorferi
🗑
|
||||
| Which organism causes Weil's disease? | Leptospira
🗑
|
||||
| What organism causes Q fever? | Coxiella burnetii
🗑
|
||||
| Which agent causes pneumonia in college students and military recruits? | Mycoplasma pneumoniae
🗑
|
||||
| What is the tetrad of Jarisch-Herxheimer reaction? | Rigors, leukopenia, decrease in blood pressure, and increase in temperature
🗑
|
||||
| Which spirochete causes Rocky Mountain spotted fever? | Rickettsia rickettsii (wrist to trunk rash)
🗑
|
||||
| Which organism causes trench fever? | Rochalimaea quintana
🗑
|
||||
| Which organism causes epidemic typhus? | Rickettsia prowazekii (trunk to periphery rash)
🗑
|
||||
| Which organism causes pneumonia in bird owners? | Chlamydia psittaci
🗑
|
||||
| Which organism causes multiple infections by antigen switching? | Borrelia recurrentis
🗑
|
||||
| Which organism has protein A for an anti-opsonization defense? | Staphylococcus aureus
🗑
|
||||
| Which organism releases endotoxins PRIOR to cell death? | Neisseria meningitidis
🗑
|
||||
| What is the only ssDNA virus? | Parvovirus
🗑
|
||||
| What is the only DNA virus to replicate in the cytoplasm? | Poxvirus
🗑
|
||||
| What are the three naked DNA viruses? | 1. Parvovirus 2. Adenovirus 3. Papovavirus (PAP)
🗑
|
||||
| What is the only DNA virus that has the reverse transcriptase enzyme? | Hepadnavirus
🗑
|
||||
| Which hepatitis virus is an RNA viroid-like virus that needs hepatitis B to be infective? | Hepatitis D
🗑
|
||||
| Which hepatitis virus is an enveloped RNA flavivirus, which is known for postinfusional hepatitis? | Hepatitis C
🗑
|
||||
| What antigen is needed to diagnose an infectious patient with hepatitis B? | Hepatitis Be antigen
🗑
|
||||
| Which type of hepatitis can cause hepatocellular carcinoma? | Hepatitis B 4- C
🗑
|
||||
| Which type of hepatitis is a calicivirus? | Hepatitis E (enteric)
🗑
|
||||
| Which type of hepatitis is a picornavirus? | Hepatitis A (infectious)
🗑
|
||||
| What two antigens need to be positive for a patient to have chronic active hepatitis? | 1. Hepatitis Bs 2. Hepatitis A antigen
🗑
|
||||
| In the window phase of a hepatitis B infection, which antibodies do you see? | Hepatitis Be and c antibodies; You see the antibodies c and e.
🗑
|
||||
| Which virus is found in the urine of rodents? | Arenavirus
🗑
|
||||
| Which virus is associated with hairy T cell leukemia? | HTLV-I and HTLV-II
🗑
|
||||
| What are the components of the rubella triad? | 1. Patent ductus arteriosus (PDA) 2. Cataracts 3. Mental retardation
🗑
|
||||
| What is the drug of choice to treat: HSV encephalitis? | Vidarabine
🗑
|
||||
| What is the drug of choice to treat: RSV pneumonia? | Ribavirin
🗑
|
||||
| What is the drug of choice to treat: CMV retinitis/infection? | Ganciclovir
🗑
|
||||
| What is the drug of choice to treat: Influenza A? | Amantadine
🗑
|
||||
| What is the drug of choice to treat: HSV? | Acyclovir
🗑
|
||||
| What is the drug of choice to treat: HPV? | Interferon alpha
🗑
|
||||
| What does Candida albicana do that distinguishes it from other fungi? | It forms a germinal tube at 37°C.
🗑
|
||||
| Which organism, transmitted by sexual contact, is almost diagnostic by the foul-smelling, green discharge from the vagina and its associated itch? | Trichomonas vaginalis
🗑
|
||||
| Which organism is associated with a diffuse bilateral interstitial pneumonia and with HIV-positive patients with CD4 counts of 200 or lower? | Pneumocysti.s carinii
🗑
|
||||
| What three organs can be affected by Trypanoaoma cruzi? | 1. Heart 2. Esophagus 3. Colon Remember-you get "megas:" 1. Cardiomegaly 2. Megaesophagus 3. Megacolon
🗑
|
||||
| What organism causes kala-azar, which is associated with hyperpigmentation of the skin, enlargement of the spleen, and decreased bone marrow activity? | Leishmania donovani
🗑
|
||||
| Which type of malaria is associated with dark urine? | Plasmodium falciparum (malignant)
🗑
|
||||
| What people are "protected" from malaria? | People with heterogenous sickle cell trait
🗑
|
||||
| What type of Plasmodium is banana or crescent shaped when stained with Giemsa stain? | Plasmodium falciparum
🗑
|
||||
| What is the only Plasmodium that is quartan? | Plasmodium malarize; the others are tertian.
🗑
|
||||
| What types of Plasmodium produce latent hypnozoites in the liver, which can cause a relapse? | Plasmodium vivax and Plasmodium ovale
🗑
|
||||
| What organism is associated with liver abscess, t ulcers, and perforated diaphragms? | Entamoeba histolytica
🗑
|
||||
| What type of Plasmodium affects: Only mature RBCs? | Plasmodium malariae
🗑
|
||||
| What type of Plasmodium affects: Only redculocytes? | Plasmodium vivax
🗑
|
||||
| What type of Plasmodium affects: RBCs of all ages? | Plasmodium falciparum
🗑
|
||||
| What three carcinomas are associated with EBV? | 1. Burkitt's lymphoma 2. Nasopharvngeal 3. Thymic
🗑
|
||||
| What is the direction of the strand if a virus has infectious +RNA? | 5' to 3' RNA
🗑
|
||||
| What two viruses do not get their envelope from budding but actually from coding? | HIV and poxvirus
🗑
|
||||
| What glycoprotein in the HIV virus is used for fusion? | GP41
🗑
|
||||
| What glycoprotein in the HIV virus attaches to CD4? | GP120
🗑
|
||||
| What protein of the HIV virus is used to detect if a patient is HIV-positive by ELISA? | P24
🗑
|
||||
| What two viruses cause progressive multifocal encephalitis? | 1. Simian (SV40) virus 2. JC virus
🗑
|
||||
| With what virus do you see Koplik's spots and Worthin- Finkeldy cells, and possibly subacute sclerosing panencephalitis? | Rubeola (measles)
🗑
|
||||
| What are known as jumping genes? | Transposons
🗑
|
||||
| What is the most common viral cause of myocarditis? | Coxsackie B
🗑
|
||||
| What virus is associated with heterophil-positive mononucleosis? | EBV
🗑
|
||||
| What is the only virus to be eradicated? | Smallpox virus
🗑
|
||||
| What virus, which creates painful vesicular lesions, is a cause of aseptic meningitis? | Herpes simplex II
🗑
|
||||
| What virus attaches to fibroblastic growth factor? | Herpes simplex I
🗑
|
||||
| What is the most prevalent coral infection in the USA? | Varicella-zoster virus
🗑
|
||||
| What is the only herpes virus to cross the placenta? | CMV
🗑
|
||||
| Of what virus are Guarnieri bodies diagnostic? | Smallpox
🗑
|
||||
| What cells are atypical on a peripheral blood smear in a heterophil-positive mononucleosis? | T cells not the B cells
🗑
|
||||
| What type of hepatitis has the highest mortality rate among pregnant women? | Hepatitis E
🗑
|
||||
| What does hepatitis D virus need from hepatitis B virus to be infective? | Hepatitis Bs antigen as its envelope
🗑
|
||||
| What are the two hepatitis viruses that can be chronic and can lead eventually to hepatocellular carcinoma? | 1. Hepatitis B 2. Hepatitis C
🗑
|
||||
| What are the only two viruses where naked dsDNA is NOT infectious? | 1. Poxvirus 2. Hepatitis B virus
🗑
|
||||
| What is the only diploid virus? | Retrovirus
🗑
|
||||
| What types) of immune response is the body capable of making when presented with a live vaccine? | Humoral and cell mediated
🗑
|
||||
| What IIPV is the causative agent of anogenital warts? | HPV 6 and 11
🗑
|
||||
| What types) of immune response is the body capable of making when presented with a killed vaccine? | Humoral only
🗑
|
||||
| Who are the "typical" women who present with endometrial carcinoma? | Older, non-sexually active women (whereas young, sexually active women present with cervical carcinoma)
🗑
|
||||
| What type of vaccine is the MMR vaccine? | Live, attenuated vaccine
🗑
|
||||
| With what virus is postauricular lymphadenopathy associated? | Measles (rubella) virus
🗑
|
||||
| In what trimester is the fetus most vulnerable to congenital rubella syndrome? | The first trimester
🗑
|
||||
| What is the order of the antibodies, from first to last, in an infected patient with hepatitis? | Hepatitis Be, e, s
🗑
|
||||
| What is the first antigen seen in an individual with hepatitis? | Hepatitis Bs antigen (incubation period)
🗑
|
||||
| What antibody is an indication of low transmissibility for hepatitis? | Hepatitis Be antibody
🗑
|
||||
| What antibody is an indication of recurrent disease for hepatitis? | Hepatitis Be antibody
🗑
|
||||
| Antibodies to what hepatitis B antigen provide immunity? | Antibodies to hepatitis Bs antigen
🗑
|
||||
| What are the three C's of measles? | 1. Cough 2. Coryza 3. Conjunctivitis
🗑
|
||||
| What vector is associated with malaria? | Anopheles mosquito
🗑
|
||||
| What is the vector for yellow fever? | Aedes mosquito
🗑
|
||||
| What are the only two picornaviruses that do NOT lead to aseptic meningitis? | 1. Rhinovirus 2. Hepatitis A virus
🗑
|
||||
| Are antibiotics helpful in treating a disease caused by a prion? | No. Prions are infectious proteins; thus, antibiotics are useless.
🗑
|
||||
| What is the only part of the virus that is "detectable" during the eclipse period of the viral growth cycle? | The viral nucleic acid .
🗑
|
||||
| What is the only virus to carry its own ribosomes? | Arenavirus
🗑
|
||||
| What is the term for the period from the onset of an infection to the appearance of the virus extracellularly? | Latent period
🗑
|
||||
| What is the leading cause of diarrhea in the USA? | Campylobacter jejuni
🗑
|
||||
| What organism would cause a patient to present with constant diarrhea after drinking mountain stream water on a camping trip? | Giardia lamblia
🗑
|
||||
| What parasite can cause vitamin B12 deficiencies? | Diphyllobothrium latum
🗑
|
||||
| What viral infection is associated with black vomit? | Yellow Fever (flavivirus)
🗑
|
||||
| What are the two nonspecific chemical defenses of the body? | Acidic pH and lysozymes
🗑
|
||||
| What are the two nonspecific physical defenses of the body? | Skin and mucus
🗑
|
||||
| What immunoglobulin is the first antibody in an immune response? | IgM
🗑
|
||||
| What is the major antibody of external secretions? | IgA
🗑
|
||||
| What is the major antibody of internal secretions (blood, CSF, lymph)? | IgG
🗑
|
||||
| What is the valence of an immunoglobulin molecule equal to? | The number of antigens that the antibody can bind
🗑
|
||||
| What immunoglobulin is a marker for mature B cells and is the antigen receptor for B cells? | IgD
🗑
|
||||
| What is the only IgG that cannot bind to Staphylococcus protein A? | IgG3
🗑
|
||||
| By which process do antibodies make microorganisms more easily ingested via phagocytosis? | Opsonization
🗑
|
||||
| Which immunoglobulin is found as a pentamer and activates complement? | IgM
🗑
|
||||
| What is synthesized by epithelial cells, protects IgA from degradation, and transports IgA across epithelial barriers? | Secretory component of IgA
🗑
|
||||
| Which IgG cannot activate complement? | IgG4
🗑
|
||||
| What cell surface marker is used to distinguish different stages in the maturation of T cells? | CD3
🗑
|
||||
| What form of graft involves tissue or organ transplantation between genetically identical twins? | Isograft (isogenic graft, syngraft)
🗑
|
||||
| True or false: antigen. antibody binding is irreversible? | False; it is reversible because the antigens and antibodies are not linked covalently.
🗑
|
||||
| What is the term for a single isolated antigenic determinant? | Hapten (not immunogenic)
🗑
|
||||
| Which chromosome is associated with major histocompatibility complex (MHC) genes? | Chromosome 6
🗑
|
||||
| Which region of the variable domain comprises the antigen-binding site of the antibody? | Hypervariable region (three per light chain; three per heavy chain)
🗑
|
||||
| What form of transplantation crosses the species barrier? | Xenograft
🗑
|
||||
| What subdivision of MHC is found on all nucleated cells? | MHC class I (three subtypes: -A,-B,-C)
🗑
|
||||
| What protein is used to differentiate MHC class I from MHC class II, and on what chromosome is it found? | ß2-Microglobulin, on chromosome 15
🗑
|
||||
| What cell type recognizes MHC class I? | Cytotoxic T cell (CD8)
🗑
|
||||
| What is the predominant antibody of a secondary immune response in the mucosal route? | IgA
🗑
|
||||
| What substance is secreted by activated helper T cells to induce T and B cell division? | IL-2
🗑
|
||||
| What type of antigen do B cells recognize? | Free, unprocessed antigen
🗑
|
||||
| What type of antigen do T cells recognize? | Processed antigenic peptides bound in the groove of the MHC molecule
🗑
|
||||
| Which protein prevents internal binding of self proteins within an MHC class II cell? | Invariant chain
🗑
|
||||
| In a binding of helper T cells and an antigen-presenting cell (APC), which is the first cell to secrete activating signals? | Helper T cells (cytokines to activate the APCs)
🗑
|
||||
| Which type of cell is responsible for immunologic memory? | Memory B cell
🗑
|
||||
| What region of the immunoglobulin does not change with class switching? | Hypervariable region
🗑
|
||||
| What type of cell does an antigen-stimulated B cell turn into if there is a continuous supply of antigen? | Plasma cell
🗑
|
||||
| What three cells are essential for T cell differentiation in the thymus? | 1. Dendritic cells 2. Macrophages 3. Thymic epithelial cells
🗑
|
||||
| What type of T cell leaves the bone marrow? | Pre-T cell (unable to recognize antigen)
🗑
|
||||
| What cytokine stimulates stem cell differentiation? | IL-3
🗑
|
||||
| What form of T cell binds to mature B cells? | Activated helper T cell
🗑
|
||||
| What co-stimulatory molecules are necessary for effective T cell and B cell signaling? | B7 and CD28 (stimulatory signal for the T cell)
🗑
|
||||
| At which site of the lymph node are B cells found? | The germinal centers (follicles)
🗑
|
||||
| What are the two primary lymphoid organs? | 1. Bone marrow 2. Thymus
🗑
|
||||
| What cytokine, produced by stromal cells of the bone marrow, is important in myeloid development? | IL-3 A " 3" on its side looks like an m for myeloid
🗑
|
||||
| What immunoglobulins are found in an infant at birth? | Maternal IgG and fetal IgM
🗑
|
||||
| What cell surface marker is found on blood B cells? | CD19
🗑
|
||||
| What cell surface marker do all T cells have? | CD3
🗑
|
||||
| What is the major antigen-trapping site in the immune system? | The lymph node
🗑
|
||||
| What cells are the first to come into contact with soluble antigen in the lymph node? | Macrophages or dendritic cells
🗑
|
||||
| In which region of the lymph node do plasma cells spend their lives secreting antibodies? | Medulla
🗑
|
||||
| What cell surface marker is found on activated helper T cells? | CD40
🗑
|
||||
| In which region of the lymph node are T cells found? | Paracortex
🗑
|
||||
| Myeloperoxidase uses H202 and what to generate additional oxidants? | Halide cofactor (Cl-, I-)
🗑
|
||||
| What is the main cell type of chronic inflammation? | Macrophages
🗑
|
||||
| What aspect of the complement system is deficient if there are repeated gonococcal infections and recurrent episodes of meningococcal meningitis? | C5, 6 ,7, or 8
🗑
|
||||
| A deficiency in C1 esterase (C1-INH) results in what disease? | Hereditary angioedema
🗑
|
||||
| What form of immunity kills the host cell in order to recover from intracellular infections? | Cell-mediated immunity
🗑
|
||||
| With what area of the spleen are the T cells associated? | Periarteriolar Lymphatic Sheath (PALS)
🗑
|
||||
| What are the three secondary lymphoid tissues? | 1. Lymph nodes 2. Spleen 3. Mucosal-Associated Lymphoid Tissue (MALT)
🗑
|
||||
| What type of cell can never leave the lymph node? | Plasma cell
🗑
|
||||
| What is the B cell-dependent area of the spleen? | The marginal zone
🗑
|
||||
| Which major cell type is found in the red pulp of the spleen? | RBCs-that is why it is called red pulp.
🗑
|
||||
| At what stage of the immune response do you see an increase in serum specific antibody levels? | Log phase
🗑
|
||||
| What cytokines do APCs secrete to activate helper T cells? | IL-1, IL-6, TNF-a
🗑
|
||||
| What immunoglobulin is responsible for antibody- dependent cell-mediated cytotoxicity (ADCC) of parasites, has a high-affinity Fc receptor on mast cells and basophils, and is responsible for the allergic response? | IgE
🗑
|
||||
| What immunoglobulin is responsible for activation of complement, opsonization, and ADCC, and is actively transported across the placenta? | IgG
🗑
|
||||
| What immunoglobulin activates the alternate pathway, neutralizes bacterial endotoxins and viruses, and prevents bacterial adherence? | IgA
🗑
|
||||
| What are defined by antigen-binding specificity? | Idiotypes
🗑
|
||||
| What are the genetic variants of a molecule within members of the same species? | Allotypes
🗑
|
||||
| What are different classes and subclasses of the same gene products known as? | Isotypes
🗑
|
||||
| What are the four phases of immune system defense? | 1. Recognition 2. Amplification 3. Regulation 4. Elimination-Rare
🗑
|
||||
| What is the term for a molecule that will trigger an immune response? | Immunogen (It must be foreign and have at least two antigenic determinants.)
🗑
|
||||
| What MHC class does not participate in immune cell communication by direct contact? | MHC class III
🗑
|
||||
| What types of T cell receptors (TCRs) comprise 95% of all TCRs? | Alpha and beta chains
🗑
|
||||
| Which TCRs are found on the skin and mucosal surfaces? | Gamma and delta TCRs
🗑
|
||||
| What type of graft transplants from one individual to another with a different genetic makeup (within the same species)? | Allograft
🗑
|
||||
| What type of graft transplants from one site to another on the same person? | Autograft
🗑
|
||||
| What is the term for the strength of association between multiple antibody-binding sites and multiple antigenic determinants? | Avidity (greater than one binding site)
🗑
|
||||
| How is IgA found in secretions? | As a dimer; it is a monomer in the blood.
🗑
|
||||
| What is the limited portion of a large antigen that will actually be recognized and bound to an antibody and contains approximately five to six amino acids or four to five hexose units? | Antigenic determinant (epitope) (Idiotypes bind to epitopes.)
🗑
|
||||
| What would be the result if an antibody were cleaved with papain? | There would be two Fab and Fc regions.
🗑
|
||||
| What would be the result if an antibody were cleaved with pepsin? | There would be a Fab' region; thus, it would still be able to participate in precipitation and agglutination.
🗑
|
||||
| What type of binding is involved when there is binding of one Fab or one idiotype of IgG? | Affinity
🗑
|
||||
| What cytokines are secreted by helper T cells to activate the APC? | INF-y and IL-4
🗑
|
||||
| What acts as a target for elimination of abnormal host cells? | MHC class I
🗑
|
||||
| At what stage of an immune response do we see stable levels of antibody in the serum? | Plateau phase
🗑
|
||||
| At what stage of an immune response do we see catabolism without synthesis of antibody, causing a decline in the levels? | Antigen processing
🗑
|
||||
| What stage of the immune response is involved from the time when we are first presented with an antigen to the first time that there are detectable levels of antibody in the serum? | Lag phase
🗑
|
||||
| What response involves elevated levels of antibody and a short lag phase, and requires low levels of antigen to precipitate? | Secondary response
🗑
|
||||
| Whose function is it to present exogenous peptides to helper T cells? | MHC class II
🗑
|
||||
| What process is involved when an antigen is in the endocytic vacuole and there is fusion with lysosomes, which contain proteases that cleave the protein antigens into peptide fragments? | Antigen processing
🗑
|
||||
| Which four helper T cell cytokines are involved in differentiation? | I. IL-4 2. IL-5 3. IL-6 4. IL-10
🗑
|
||||
| Which co-stimulatory molecules are necessary for B cell differentiation (class switching)? | CD40 and CD40L (gp39)
🗑
|
||||
| Which cytokine is chemotactic for neutrophils? | IL-8
🗑
|
||||
| Which nondividing cells synthesize immunoglobulins in great amounts? | Plasma cells
🗑
|
||||
| Which process is involved in rearranging the DNA that encodes for the constant region of the heavy chain? | Class switching
🗑
|
||||
| What are the two functions of the thymus in T cell differentiation? | 1. Hormone secretion for T cell differentiation 2. T cell education to recognize self from nonself
🗑
|
||||
| Which process is involved in rearranging one heavy chain gene to produce a functional gene product, while it shuts off the rearrangement and expression of the other alleles to ensure that one antibody type is made? | Allelic exclusion
🗑
|
||||
| What are the three rules of clonal selection? | 1. One cell type 2. One antibody type 3. Random selection of hypervariable regions, and only cells with bound antigen undergo clonal expansion
🗑
|
||||
| When is the last time that maternal IgG is seen in circulation? | Between 9 and 15 months
🗑
|
||||
| What cytokine, produced by stromal cells of the bone marrow, is important in lymphoid development? | IL-7 A "7" upside down looks like an "L" (L for Lymphoid).
🗑
|
||||
| Which region of the thymus contains the mature T cells? | The medulla (They mature in the cortex.)
🗑
|
||||
| What are the cell surface markers of helper T cells? | CD28 and CD4
🗑
|
||||
| What are the cell surface markers of cytotoxic T cells? | CD28 and CD8
🗑
|
||||
| Which complement fragments cause lysis of cells? | C5b-9
🗑
|
||||
| Which complement fragment is deficient if a patient presents with repeated infections, fever, rash, and arthralgia? | C3
🗑
|
||||
| What three factors cause opsonization? | IgG, C3b, and mannose binding protein
🗑
|
||||
| Which cell surface marker binds to C3d fragments? | CD21
🗑
|
||||
| What disease is associated with an inherited deficiency in NADPH oxidase, in which the individual is likely to develop infections with catalase-positive organisms? | Chronic granulomatous disease
🗑
|
||||
| What cells are antigen-specific and have MHC restricted killing? | Cytotoxic T cells
🗑
|
||||
| What large granular lymphocytes have CD16 and CD56 as cell surface markers, do not secrete immunoglobulins, and are not antigen specific? | NK cells
🗑
|
||||
| What three complement fragments are also anaphylatoxins? | 1. C3a 2. C4a 3. C5a
🗑
|
||||
| What pathology is associated with low levels of immunoglobulin that persist in children for up to 2 years? | Transient hypogammaglobulinemia of childhood
🗑
|
||||
| What cell surface marker is found on pre-T cells? | Tdt
🗑
|
||||
| What cell surface marker is required for class switching? | CD40
🗑
|
||||
| What large granular lymphocytes are stimulated by IL-2 and INF-y and are activated by natural killer (NK) cells? | Lymphokine-activated killer (LAK) cells
🗑
|
||||
| Which cells recognize the Fc region of IgG and carry out ADCC? | Killer cells
🗑
|
||||
| What are the four chemotactic agents? | 1. C5a 2. Leukotriene B4 3. IL-8 4. Bacterial peptides
🗑
|
||||
| What are the five main oxidizing reactions that are used to kill ingested organisms? | 1. H202 2. Superoxide 3. Hydroxyl radical 4. Myeloperoxidase 5. Hypochlorous acid
🗑
|
||||
| True or false-it is perfectly normal to have low levels of IgG from 3 to 12 months of age? | True; it is called physiologic hypogammaglobulinemia of infancy.
🗑
|
||||
| What valve of the heart is most commonly affected in IV drug abusers? | Tricuspid valve
🗑
|
||||
| What is the first sign of reversible cellular damage? | Ballooning or hydropic changes secondary to mitochondrial injury
🗑
|
||||
| What is another name for isolated right-sided heartfailure? | Cor pulmonale
🗑
|
||||
| What region of the aorta is affected in syphilitic (luetic) aneurysms? | Ascending arch or the root
🗑
|
||||
| What organism is associated with hyaline membrane formation and cold agglutinins? | Mycoplasma
🗑
|
||||
| What cell type is commonly elevated in asthma? | Eosinophils
🗑
|
||||
| What enzyme level is commonly elevated in sarcoidosis? | Angiotensin converting enzyme (ACE)
🗑
|
||||
| What form of lung cancer is commonly associated with asbestosis? | Malignant mesothelioma
🗑
|
||||
| With what protein-losing enteropathy do you see hypertrophied gastric rugal folds? | Menetrier's syndrome
🗑
|
||||
| What region of the GI tract does Giardia lamblia most commonly affect? | Duodenum
🗑
|
||||
| What organism is associated with "flask-shaped" ulcers? | Entamoeba histolytica
🗑
|
||||
| What hepatic pathology is associated with ingestion of oral contraceptives? | Liver adenoma
🗑
|
||||
| True or false alpha-1-antitrypsin deficiency can lead to cirrhosis of the liver? | True; it is most commonly associated with panacinar emphysema of the lower lobes.
🗑
|
||||
| What organism is associated with cholangiocarcinoma? | Clonorchis sinensis
🗑
|
||||
| True or false-polycythemia is associated with renal cell carcinoma? | True, because there is an increase in erythropoietin
🗑
|
||||
| What cancer of the male genitourinary system is associated with osteoblastic bony metastasis? | Prostatic carcinoma
🗑
|
||||
| What organism is commonly associated with IUD infections? | Actinomyces
🗑
|
||||
| What female genitourinary pathology is associated with elevated levels of human chorionic gonadotropin (hCG) and has a "snowstorm" appearance on an ultrasound? | Hydatidiform mole
🗑
|
||||
| What subset of leukemia involves gingival hypertrophy? | Acute myelocytic leukemia (AML)-M5, also called acute myelogenous leukemia
🗑
|
||||
| What chemical pathogen is associated with squamous cell carcinoma of the skin? | Arsenic
🗑
|
||||
| With what form of cancer is diethylstilbestrol (DES) associated? | Vaginal clear cell adenoma
🗑
|
||||
| What form of cancer is most commonly associated with nitrosamines? | Gastric cancer
🗑
|
||||
| What cellular process defines irreversible cellular injury? | Vacuolation of the mitochondria
🗑
|
||||
| Antinuclear antibodies (ANA), anti-dSDNA, and smooth muscle antigen (Sm ag) are all used to diagnose what disease? | Systemic lupus erythematosus (SLE)
🗑
|
||||
| SS-A(Ro), SS-B(La), and R-ANA are diagnostic markers of what disease? | Sjogren's disease
🗑
|
||||
| What disease is characterized by decreased bone resorption due to defective osteoclast function? | Osteopetrosis (Albers- Schonberg disease)
🗑
|
||||
| What metaplastic cellular change (from what cell type to what cell type) occurs in Barren's esophagus? | Squamous to columnar cell (adenocarcinoma)
🗑
|
||||
| Antinuclear antibodies (ANAs) and anti-SCL-70 antibodies are diagnostic of what disease? | Scleroderma
🗑
|
||||
| What T cell defect is found in Graves' disease? | Defect in antigen-specific suppressor T cells
🗑
|
||||
| A gastric mucosal erosion caused by extensive burns to the body surface is known as what? | Curling's ulcer (Burns = hot = curling iron) VXP
🗑
|
||||
| A superficial gastric mucosal erosion causing an excessive secretion of pepsin, due to an increase in intracranial pressure from trauma or surgical injury to the CNS, is known as what? | Cushing's ulcer
🗑
|
||||
| What two antibodies are used to diagnose Hashimoto's thyroiditis? | Antithyroglobulin and antimicrosomal antibodies
🗑
|
||||
| What is the term for the copper corneal deposits found in Wilson's disease? | Kayser-Fleischer rings
🗑
|
||||
| What is the triad of Meig's syndrome? | 1. Right-sided hydrothorax 2. Ascites 3. Ovarian fibroma
🗑
|
||||
| What is the triad of Plummer-Vinson syndrome? | 1. Atrophic glossitis 2. Esophageal webs 3. Iron-deficiency anemia
🗑
|
||||
| In multiple myeloma, what are the immunoglobulin protein droplets within plasma cells called? | Russell bodies
🗑
|
||||
| Obstetric hemorrhage or shock to the anterior pituitary leads to what syndrome? | Sheehan's syndrome (approximately 90% destruction of the pituitary)
🗑
|
||||
| What is the term for a twisting of a loop of bowel leading to an obstruction? | Volvulus
🗑
|
||||
| In what condition is a strawberry gallbladder seen? | Cholesterolosis
🗑
|
||||
| What is the term for a palpable left supraclavicular lymph node? | Virchow's node (due to metastatic gastric carcinoma)
🗑
|
||||
| What pathology is associated with Budd-Chiari syndrome? | Hepatic venous thrombus
🗑
|
||||
| Cell fragments of hemolysis are known as what? | Helmet cells (schistocytes)
🗑
|
||||
| What is the name given to the red blood cell that contains a peripheral rim of hemoglobin along with a dark central area containing hemoglobin? | Target cell
🗑
|
||||
| What are the three causes of a microvesicular fatty change in the liver? | 1. Tetracycline toxicity 2. Reye's syndrome 3. Fatty liver of pregnancy
🗑
|
||||
| Abnormal, unstable RNA within a developing RBC is known as what? | Basophilic stippling
🗑
|
||||
| What is the term for an RBC with inorganic iron-containing granules? | Siderocyte
🗑
|
||||
| A patient presenting with dark urine, pale stools, and itchy skin has what form of jaundice? | Obstructive (direct) jaundice
🗑
|
||||
| ... | With what form of hepatitis do you see elevated levels of AST (SGOT) and GGT liver enzymes?
🗑
|
||||
| In both alcoholic 2nd viral hepatitis, AST and ALT are elevated. SGOT > SGPT in alcoholic hepatitis, and SGPT > SGOT in viral hepatitis. | What region of the liver is affected during shock?
🗑
|
||||
| Pericentral (necrotic) region | What drug can cause amyloidosis and focal segmental glomerulosclerosis in the kidney?
🗑
|
||||
| Heroin | What type of metal poisoning causes basophilic stippling?
🗑
|
||||
| Lead | What drug causes a six- fold increase in schizophrenia, can impair motor activity, and can cause lung problems?
🗑
|
||||
| Marijuana | ...
🗑
|
||||
| With what disease do you see dust-containing macrophages within a reticulin mesh? | Coal workers' pneumoconiosis
🗑
|
||||
| With what two pathologies is a honeycomb lung associated? | 1. Asbestosis 2. Silicosis
🗑
|
||||
| What is Caplan's syndrome? | Rheumatoid arthritis with silicosis
🗑
|
||||
| What chemical can be potentially dangerous if you work in the aerospace industry or in nuclear plants? | Beryllium
🗑
|
||||
| What are the three causes of angiosarcoma of the liver? | 1. Vinyl chloride 2. Thorium dioxide 3. Arsenic
🗑
|
||||
| What causes acellular fibrosis in the upper zone of the lung? | Silicosis
🗑
|
||||
| What dye is a major cause of transitional cell carcinoma of the urinary bladder? | Naphthalene
🗑
|
||||
| Interstitial fibrosis of the lower lobe is pathognomonic of what? | Asbestosis
🗑
|
||||
| With what is cherry red intoxication associated? | Acute carbon monoxide poisoning
🗑
|
||||
| With what disease do you see Brushfield's spots? | Down syndrome
🗑
|
||||
| What is the causative organism associated with: Acute infectious endocarditis? | Staphylococcus aureus; Aureus begins with an "a" just like acute.
🗑
|
||||
| Subacute infectious endocarditis? | Streptococcus viridans
🗑
|
||||
| What percentage of a vessel is stenosed in order to cause sudden cardiac death? | Greater than 75% of the vessel
🗑
|
||||
| What foci of fibrinoid necrosis are surrounded by lymphocytes and macrophages throughout all the layers of the heart? | Aschoff's bodies of rheumatic fever
🗑
|
||||
| What cardiac pathology are children with pharyngeal infections more likely to develop? | Rheumatic heart disease
🗑
|
||||
| Where is the embolism site for a right-sided heart lesion? | The lungs
🗑
|
||||
| What is the term for white retinal spots surrounded by hemorrhage? | Roth's spots
🗑
|
||||
| In what condition are they seen? | In bacterial endocarditis
🗑
|
||||
| The painless hemorrhagic areas on the palms and soles in a patient with bacterial endocarditis are known as what? | Janeway lesions
🗑
|
||||
| What pathology involves a diastolic blood pressure greater than 90 mmHg or a systolic blood pressure greater than 140 mmHg? | Hypertension
🗑
|
||||
| What are the four cardiac abnormalities associated with tetralogy of Fallot? | 1. Shifting of the aorta 2. Hypertrophy of the right ventricle 3. Interventricular septal defect 4. Pulmonary stenosis 3X (SHIP)
🗑
|
||||
| What term applies when a single vessel receives blood from both ventricles? | Truncus arteriosus
🗑
|
||||
| How do you diagnose a patient who presents with an underdeveloped right ventricle, atrial septal defect, and no tricuspid valve? | Tricuspid atresia
🗑
|
||||
| What are the three left-to-right shunts? | 1. Ventricular septa] defect (VSD) 2. Atrial septal defect (ASD) 3. Patent ductus arteriosus (PDA)
🗑
|
||||
| What type of coarctation of the aorta is associated with Turner's syndrome? | Preductal (infantile) type
🗑
|
||||
| Which leaflet is most commonly affected in mitral valve prolapse? | Posterior leaflet due to the long chordae tendineae
🗑
|
||||
| What disease affects medium to small arteries, occurs most commonly in men, is associated with elevated perinuclear anti-neutrophilic cytoplasmic antibody (P-ANCA) levels to myeloperoxidase, and involves 30% of patients with hepatitis Bs antigen? | Polyarteritis nodosa (PAN) Remember by P in P-ANCA and P in PAN.
🗑
|
||||
| With what disease do you see IgA deposits in small vessels of the skin and the kidneys? | Henoch-Schonlein purpura
🗑
|
||||
| What type of vasculitis presents with headache, facial pain, and sometimes loss of vision? | Temporal arteritis (usually in women older than 80 years of age)
🗑
|
||||
| What type of vasculitis affects children, has conjunctival involvement associated with skin rash and lymphadenopathy, and involves 70% of persons with coronary artery aneurysms? | Kawasaki disease; Think kids, koronary, konjunctiva-Kawasaki
🗑
|
||||
| What is the difference between a true aneurysm and a false aneurysm? | A true aneurysm is the bulging of an arterial wall that is intact, whereas a false aneurysm is a rupture where a sac is formed by the tissue adjacent to the artery.
🗑
|
||||
| With what lung pathology do you see a collapsed leathery lung? | Acute respiratory distress syndrome CARDS)
🗑
|
||||
| In which region of the lung are 75% of the pulmonary infarcts seen? | Lower lobes
🗑
|
||||
| What is it called when the cervical lymph node is involved in Tb? | Scrofula
🗑
|
||||
| What is the difference between Raynaud's disease and Raynaud's phenomenon? | Disease occurs when there is vasospasm in a small artery without any underlying pathology, whereas a phenomenon has some underlying pathology associated with it.
🗑
|
||||
| What is the difference between a Ghon focus and a Ghon complex? | A Ghon focus is a TB tubercle, whereas a Ghon complex is a focus with hilar lymph node involvement.
🗑
|
||||
| What is the term for laminated concretions of Ca2+ and protein found in granulomas, especially sarcoidosis? | Schaumann's bodies
🗑
|
||||
| What condition is manifested by bilateral sarcoidosis of the parotid glands, submaxillary gland, and submandibular gland with posterior uveal tract involvement? | Mikulicz's syndrome
🗑
|
||||
| In what autosomal recessive (AR) disease do you see a decrease in adenine triphosphatase (ATPase) activity of dynein arms in cilia, also known as immotile cilia syndrome? | Kartagener's syndrome
🗑
|
||||
| What disease involves a decrease in al-antitrypsin activity, causing all the alveoli to be affected? | Panacinar emphysema
🗑
|
||||
| What lung pathology involves columnar to squamous cell metaplasia and cannot be diagnosed unless the patient has 3 months of productive sputum for 2 years or more? | Chronic bronchitis
🗑
|
||||
| What bronchogenic carcinoma: Is found in the peripheral aspect of the lung and is known as the "scar" carcinoma? | Adenocarcinoma
🗑
|
||||
| Has a poor prognosis because 50% of the cases have metastasized to the brain by diagnosis? | Undifferentiated cell carcinoma
🗑
|
||||
| What hematoma involves lucid intervals and affects the middle meningeal artery? | Epidural hematoma
🗑
|
||||
| What renal pathology involves uniform thickening of the glomerular capillary wall, "granular" appearance under the microscope, and effacement of foot processes? | Membranous glomerulonephritis (MGN)
🗑
|
||||
| What syndrome has massive proteinuria, hypoalbuminemia, hyperlipidemia, and anasarca as its components? | Nephrotic syndrome
🗑
|
||||
| What renal pathology is associated with an alteration of the basement membrane and mesangial cell proliferation, along with a tram-track appearance under the microscope? | Membranoproliferative glomerulonephritis (MPGN)
🗑
|
||||
| What is the triad of renal cell carcinoma? | 1. Hematuria 2. Costovertebral pain 3. A palpable mass
🗑
|
||||
| What is the most common type of kidney stone? | Calcium oxalate
🗑
|
||||
| In what condition do you see "dimpling" on the kidney's surface? | Pyelonephritis
🗑
|
||||
| What are the four most common metastatic sites for renal cell carcinoma? | 1. Lung 2. Liver 3. Brain 4. Bone
🗑
|
||||
| What is the causative organism involved in squamous cell carcinoma of the bladder? | Schistosomiasis haematobia
🗑
|
||||
| Is cigarette smoking associated with transitional cell carcinoma of the bladder? | Yes. It is also a cause of cancers of the lung, esophagus, ureter, and kidney, just to name a few.
🗑
|
||||
| What type of peptic ulcers is associated with elevated gastric secretions and blood group O and responds well to cimetidine? | Duodenal ulcer, whereas gastric ulcers are associated with blood group A and low gastric secretions
🗑
|
||||
| What GI pathology can be caused by a patient taking clindamycin or lincomycin or by Clostridium diffcile, ischemia, Staphylococcus, Shigella, or Candida infections? | Pseudomembranous colitis
🗑
|
||||
| How is Pseudomembranous colitis treated? | With vancomycin or metronidazole
🗑
|
||||
| What regions of the GI tract are the most common sites of peptic ulcers? | The lesser curvature of the stomach and the first part of the duodenum
🗑
|
||||
| What three criteria allow you to differentiate an ulcer from an erosion or carcinoma? | 1. Less than 3 cm 2. Clean base 3. Level with the surrounding mucosa
🗑
|
||||
| What is the watershed area of the GI tract? | It is the most common site of ischemic bowel disease (splenic flexure of large bowel).
🗑
|
||||
| What is the term for hypoperfusion of an area involving only the inner layers? | Mural infarct
🗑
|
||||
| Failure of neural crest cells to migrate to the rectum and sigmoid colon is known as what? | Hirschsprung's disease (congenital megacolon)
🗑
|
||||
| What is the term for the irregular linear lacerations in the long axis of the esophagus seen in chronic alcoholics? | Mallory-Weiss tears
🗑
|
||||
| What is the condition in which progressive dysphagia and regurgitation occur owing to failure of the lower esophageal sphincter to relax when swallowing is initiated? | Achalasia (can also be seen in Chagas' disease)
🗑
|
||||
| With what autosomal dominant disease do you see polyps in the GI tract that can be large and pedunculated, along with melanin pigmentation of the oral mucosa, lips, and palms? | Peutz-Jeghers syndrome (rarely predisposes to colon cancer)
🗑
|
||||
| What is the most common hemolytic anemia that has an elevated reticulocyte count and a positive result on a Coombs' test? | Autoimmune/immune hemolytic anemia
🗑
|
||||
| What is the first sign of megaloblasdc anemia on a blood smear? | Hypersegmented polymorphonucleocytes (more than five lobes)
🗑
|
||||
| With what autosomal dominant disease do you see osteomas in the mandible and maxilla, epidermoid cysts, and edematous polyps in the GI tract? | Gardner's syndrome
🗑
|
||||
| In what autosomal recessive disease do you see a decrease in ceruloplasmin, micronodular cirrhosis, and Kayser-Fleischer rings? | Wilson's disease
🗑
|
||||
| What is the term for the smooth, round fragments of nuclear chromatin seen in RBCs? | Howell-Jolly bodies
🗑
|
||||
| What form of hepatitis involves Kupffer's cell hyperplasia, ballooning hepatocytes, councilman bodies, and an increase in ALT? | Viral hepatitis
🗑
|
||||
| What X-linked recessive disease involves a decrease in hypoxanthine guanine phosphoribosyl transferase (HGPRT), mental retardation, self-mutilation, choreoathetosis, and spasticity and an increase in uricemia? | Lesch-Nyhan syndrome
🗑
|
||||
| In what X-linked recessive disease is there a decrease in the hexose monophosphate (HMP) shunt, along with Heinz body formation? | G-6-PD deficiency (glucose-6-phosphate dehydrogenase deficiency)
🗑
|
||||
| What illegal drug can cause rhabdomyolysis, myocardial infarction, cerebral infarct, and lethal cardiac arrhythmias? | Cocaine
🗑
|
||||
| What type of metal poisoning causes mental retardation, somnolence, convulsions, and encephalopathy? | Lead
🗑
|
||||
| What type of acute metal poisoning involves stomach and colon erosion and acute tubular necrosis? | Mercury
🗑
|
||||
| What enzyme level increases in hours and falls 24 to 48 hours after a myocardial infarction? | Creatinine phospholanase (CPK)
🗑
|
||||
| What form of infectious endocarditis is most likely to metastasize? | Acute infectious endocarditis
🗑
|
||||
| What is the terminology for the secondary disease of benign hypertension in the kidney? | Benign nephrosclerosis
🗑
|
||||
| What is the term for the appearance of the kidney in malignant hypertension (it has petechiae on its surface)? | Flea-bitten kidney (can also be seen in pyelonephritis)
🗑
|
||||
| What is the term for fibrinoid necrosis of the arterioles in the kidney secondary to malignant hypertension? | Onion skinning
🗑
|
||||
| What are the three most common sites for left-sided heart embolisms to metastasize? | 1. Brain 2. Spleen 3. Kidney
🗑
|
||||
| What enzyme levels increase in 6 to 8 hours, peak in 24 to 48 hours, and fall 4 to 8 days after an MI? | SGOT
🗑
|
||||
| What are the four right-to-left shunts? | 1. Tricuspid atresia 2. Truncus arteriosus 3. Transposition of the great vessels 4. Tetralogy of Fallot; All of the Ts
🗑
|
||||
| What form of angina pectoris is classically brought on by exercise or by an elevated heart rate? | Stable angina (S-T depressions are seen on EKG.)
🗑
|
||||
| What form of angina pectoris is the most serious and is referred to as "preinfarction angina"? | Unstable angina
🗑
|
||||
| What marker increases in 12 hours, peaks in 48 to 72 hours, and falls in 1 to 2 weeks after an MI? | Lactate dehydrogenase (LDH)-1 > 2
🗑
|
||||
| What form of angina pectoris is caused by coronary artery vasospasms? | Prinzmetal's angina (variant). S-T elevations are seen on EKG.
🗑
|
||||
| What is the condition that involves focal accumulations of basophilic, mutinous extracellular substance in the media of the aorta? | Cystic medial necrosis
🗑
|
||||
| When do you see an elevated blood pressure in the upper extremities with hypotension in the lower extremities? | Coarctation of the aorta (postductal), adult type
🗑
|
||||
| What is the characteristic radiographic finding in postductal coarctation of the aorta? | Notching of the ribs due to dilated internal mammary arteries
🗑
|
||||
| What test uses p24 protein when diagnosing HIV? | ELISA test (enzyme-linked immunosorbent assay test)
🗑
|
||||
| What type of vasculitis occurs in male heavy smokers, typically younger than 35 years of age, that can cause gangrene in the lower extremities? | Buerger's disease
🗑
|
||||
| Low to absent levels of pulmonary surfactant along with hyaline membrane formation is the hallmark of what? | NRDS (neonatal respiratory distress syndrome)
🗑
|
||||
| What form of emphysema affects the upper lobes, increases in smokers, and has carbon deposits distal to the affected areas? | Centriacinar emphysema
🗑
|
||||
| Is right ventricular hypertrophy (RVH) in utero a sign of coaretation of the aorta? | Yes, if you are referring to preductal or infantile coarctation of the aorta; congestive heart failure is also a sign of the infantile form.
🗑
|
||||
| What tumor involves an increase in 5-hydroxyindoleacetic acid; is associated with skin flushing, cramps, diarrhea, and nausea; and affects the valves on the right side of the heart along with the endocardium? | Carcinoid tumor of the heart
🗑
|
||||
| What is the consolidation around the small bronchi known as? | Bronchopneumonia
🗑
|
||||
| What disease usually occurs in men in their 40s who present with persistent pneumonia, chronic sinusitis, renal disease, and mucosal alterations, and show an increase in cytoplasmic antineutrophilic cytoplasmic antibodies (C-ANCAs)? | Wegener's granulomatosis
🗑
|
||||
| What disease involves a weakened pulse and hypotension in the upper extremities, visual problems, and dizzy spells and occurs in Asian females who are 15 to 45 years of age? | Takayasu's arteritis (pulseless disease)
🗑
|
||||
| What bronchogenic carcinoma occurs most commonly in men and smokers; is found centrally; and can have eetopic production of adrenocorticotrophic hormone (ACTH) or antidiuretic hormone (ADH)? | Small-cell carcinoma (oat cell)
🗑
|
||||
| What bronchogenic carcinoma is commonly associated with Addison's disease? | Squamous cell carcinoma
🗑
|
||||
| What disease, diagnosed by exclusion, involves bilateral hilar lymphadenopathy and noncaseating granulomas in many organs and is most commonly seen in black women? | Sarcoidosis
🗑
|
||||
| What causes a nutmeg liver? | Right-sided heart failure
🗑
|
||||
| What bronchogenic carcinoma is associated with an elevated level of Cat+, involves keratin pearls, occurs in men more than women, is associated with smoking, occurs in the major bronchi, and is seen in the central areas of the lung? | Squamous cell carcinoma
🗑
|
||||
| What GI pathology involves a loss of villi and a decrease in the absorptive area due to gluten sensitivity? | Celiac disease
🗑
|
||||
| What tumor spreads via the lymphatic system into the peritoneum, rectal shelf, and both ovaries, secondary to metastatic gastric carcinoma? | Krukenberg's tumor
🗑
|
||||
| What is necrosis and distortion of liver architecture with nodular regeneration and fibrosis known as? | Cirrhosis
🗑
|
||||
| What disease is due to increased iron deposits causing congestive heart failure (CHF), bronze diabetes, and micronodular cirrhosis? | Hemochromatosis
🗑
|
||||
| What autosomal dominant syndrome involves 1000 or more edematous polyps, most commonly affects the colorectal area, and is associated with chromosome 5q21? | Familial poly posis coli
🗑
|
||||
| What autosomal dominant disease involves hyperkeratosis of the palms and soles in association with esophageal carcinoma? | Tylosis
🗑
|
||||
| What primary carcinoma is associated with signet ring cells? | Gastric carcinoma
🗑
|
||||
| What liver pathology involves an increase in AST, GGT, Mallory bodies, fatty change, and micronodular cirrhosis? | Chronic alcoholism
🗑
|
||||
| What is the term for a reversible change in which one adult cell type is replaced by another adult cell type? | Metaplasia
🗑
|
||||
| What is a decrease in the size of cells because of the loss of structural components known as? | Atrophy
🗑
|
||||
| What hemoglobin-derived pigment contains iron? | Hemosiderin
🗑
|
||||
| What brown-black pigment is derived from the oxidation of tyrosine? | Melanin
🗑
|
||||
| What form of necrosis is seen in the lower extremity or the bowel due to vascular occlusion? | Gangrenous necrosis
🗑
|
||||
| What is the term for depositions of Ca2+ in normal tissue due to hypercalcemia? | Metastatic calcifications
🗑
|
||||
| What is the most common type of necrosis? | Coagulative necrosis
🗑
|
||||
| What is the increase in the number of cells known as? | Hyperplasia
🗑
|
||||
| What form of necrosis is caused by the actions of lipases on adipose tissue, seen in acute hemorrhagic pancreatitis? | Fat necrosis
🗑
|
||||
| What is the term for cells that have undergone proliferation and atypical cytologic alterations involving all sizes, shapes, and orientations? | Dysplasia
🗑
|
||||
| What pigment, called the "aging pigment," is due to free radical injury and lipid peroxidation and is seen in brown atrophy? | Lipofuscin
🗑
|
||||
| The increase in the size of cells due to synthesis, causing an increase in the size of the organ, is known as what? | Hypertrophy
🗑
|
||||
| What is the term for a collection of epithelioid cells surrounded by a rim of lymphocytes? | Granuloma
🗑
|
||||
| What form of necrosis is caused by immune-mediated vascular damage? | Fibrinoid necrosis
🗑
|
||||
| What is the term for excess amounts of granulation tissue that can block re-epithelialization and wound healing? | Proud flesh
🗑
|
||||
| In what rare autosomal recessive disorder do you see neutropenia, defective degranulation, and delayed microbial killing due to a problem in chemotaxis and migration? | Chediak-Higashi syndrome
🗑
|
||||
| What is the main cell type of chronic inflammation? | Macrophages (from blood monocytes)
🗑
|
||||
| What are the two main components of granulation tissue? | 1. Fibroblasts 2. Neovascularization
🗑
|
||||
| What causes platelets to bind to the collagen of the basement membrane? | von Willebrand's factor (factor VIII)
🗑
|
||||
| What is the term for ischemia to the CNS causing dissolution of the tissue due to the actions of hydrolytic enzymes? | Liquefactive necrosis
🗑
|
||||
| What is a sudden loss of oxygen to tissue, causing death of the cells because of a cessation of blood flowing to a particular area, known as? | Coagulative necrosis (most common in heart and kidneys)
🗑
|
||||
| What is the term for depositions of Ca2+ in nonviable or dying tissue, when the calcium level in the blood is normal? | Dystrophic calcifications
🗑
|
||||
| What type of necrosis is seen as a part of granulomatous inflammation? | Gaseous necrosis
🗑
|
||||
| What are the three causes of transudate? | 1. CHF 2. Cirrhosis 3. Nephrosis
🗑
|
||||
| What is the type of healing that occurs in a clean surgical incision? | Primary intention
🗑
|
||||
| What protein causes clot retraction? | Thrombosthenin
🗑
|
||||
| What protein acts as a binding factor in wound healing and embryogenesis? | Fibronectin
🗑
|
||||
| What IgE-mediated cell secretes major basic protein and has elevated levels in the blood during asthma and parasitic infections? | Eosinophils
🗑
|
||||
| What are the three platelet aggregating factors? | 1. Adenosine diphosphate (ADP) 2. Prostaglandin 3. Thromboxane A2 (TXA2)
🗑
|
||||
| What is the triad of fat embolism? | 1. Petechiae 2. Hyperactive mental status 3. Occurs within 24 to 48 hours of the initial insult (e.g., long bone fracture)
🗑
|
||||
| An intense inflammatory reaction, an increase in the amounts of granulation tissue and wound contraction by myofibroblasts are the characteristics of what? | Healing by secondary intention
🗑
|
||||
| What are the two most common origins of pulmonary embolism? | 1. Deep veins of the legs 2. The prostatic plexus of veins in the pelvis
🗑
|
||||
| What is a localized area of necrosis caused by circulatory insufficiency known as? | Infarction
🗑
|
||||
| What is the term for an abnormal amount of collagen type III that produces a large bulging scar, seen primarily in blacks? | Keloid
🗑
|
||||
| What component of the basement membrane binds to collagen type IV and heparin sulfate and is a cell surface receptor? | Laminin
🗑
|
||||
| What is the term for an excessive production of collagen that flattens out and does not extend beyond the site of the injury? | Hypertrophic scar
🗑
|
||||
| What are the three Bs of adult polycystic kidneys? | 1. Big 2. Bilateral 3. Berry aneurysm
🗑
|
||||
| What pathway in the coagulation cascade is activated after tissue injury? | Extrinsic pathway
🗑
|
||||
| What is an intravascular mass that is carried from its point of origin to a distant site known as? | Embolism
🗑
|
||||
| In what disease do you see horseshoe kidneys, rockerbottom feet, low-set ears, micrognathia, and mental retardation? | Edward's syndrome (trisomy 18)
🗑
|
||||
| What genetic disease has an increased risk for developing carcinoma of the breast? | Klinefelter's syndrome
🗑
|
||||
| What is the predominant cell type of humoral immunity? | B lymphocytes
🗑
|
||||
| What protein causes fibrinolysis? | Plasmin
🗑
|
||||
| What factors in the coagulation cascade need Ca2+ to be activated? | Factors II and X
🗑
|
||||
| What tumor comprises 40% of all testicular tumors in children? | Teratoma
🗑
|
||||
| What most common germ cell tumor can be detected by elevated hCG levels and metastasizes to the bone, lung, and liver? | Choriocarcinoma
🗑
|
||||
| What pathway in the coagulation cascade is activated by making contact with foreign substances? | Intrinsic pathway
🗑
|
||||
| What protein is a common activator of the coagulation, 6brinolytic, and inflammatory systems? | Hageman factor (XII)
🗑
|
||||
| What factors in the coagulation cascade need factor Ila (activated) to become activated? | Factors V and VIII
🗑
|
||||
| What lobe of the brain is most commonly affected by herpes virus? | Temporal lobe
🗑
|
||||
| What disease involves microcephaly, mental retardation, cleft lip or palate, and dextrocardia? | Patau's syndrome (trisomy 13)
🗑
|
||||
| What disease, caused by decompression sickness, leads to multiple foci of ischemic necrosis that affect the head of the femur, humerus, and tibia? | Caisson's disease
🗑
|
||||
| What type of hemostasis occurs in an intravascular space and consists of fibrin, platelets, and red and white blood cells? | Thrombus
🗑
|
||||
| What disease involves mental retardation, flat face, muscle hypotonia, and a "double-bubble" sign on an x-ray and poses an increased risk of Alzheimer's disease and acute lymphocytic leukemia (ALL)? | Down syndrome (trisomy 21)
🗑
|
||||
| What are the three components of amyloid? | 1. Fibrillary protein 2. Amyloid protein 3. Glycosaminoglycans
🗑
|
||||
| What type of hypersensitivity is mediated by IgE? | Type I hypersensitivity
🗑
|
||||
| What type of hypersensitivity involves the antigen-antibody complex and activates complement, leading to tissue injury? | Type III hypersensitivity
🗑
|
||||
| What type of hypersensitivity involves serum sickness, SLE, Arthus reaction, and acute glomerulonephritis? | Type III hypersensitivity
🗑
|
||||
| What test uses gp120 protein when diagnosing HIV? | Western blot test
🗑
|
||||
| What disease involves a patient with dry eyes and dry mouth; is associated with other collagen vascular diseases and B cell dysfunction; occurs in women more than men; and poses an increased risk of the patient developing a high-grade B cell lymphoma? | Sjogren's disease
🗑
|
||||
| What is the most common fungal infection in HIV? | Candida
🗑
|
||||
| What is the most common infectious agent in HIV? | Pneumocystis carinii
🗑
|
||||
| What are the two most common viral infections in HIV? | 1. CMV retinitis 2. HSV-2
🗑
|
||||
| What is the most common opportunistic infection of the CNS in HIV? | Toxoplasmosis
🗑
|
||||
| What is the term for a hospital-acquired infection? | Nosocomial infection
🗑
|
||||
| What are the four DNA oncogenic viruses? | 1. HPV (human papilloma virus) 2. EBV (Epstein-Barr virus) 3. Hepatitis B 4. Kaposi's sarcoma- HSI/?
🗑
|
||||
| What disease is X-linked recessive, presents with eczema thrombocytopenia and an increased chance of developing recurrent infections, involves a decrease in serum IgM and in the T cell-dependent paracortical areas of the lymph nodes, and means that the pa | Wiskott-Aldrich syndrome
🗑
|
||||
| What is the most common pathway for carcinomas to spread? | Via lymphatics
🗑
|
||||
| With what are the following microscopic changes associated: loss of polarity, anaplasia, pleomorphism, discohesiveness, increase in the nuclear:cytoplasmic ratio, hyperchromasia, and increase in the rate of mitosis? | Malignancy
🗑
|
||||
| What is the most common pathway for sarcoma to spread? | Hematogenous pathway
🗑
|
||||
| What is the most common complement deficiency? | C2 deficiency
🗑
|
||||
| What type of erythema do you see in: Ulcerative colitis? | Erythema nodosum
🗑
|
||||
| Rheumatic fever? | Erythema marginatum
🗑
|
||||
| Stevens-Johnson syndrome? | Erythema multiforme
🗑
|
||||
| What is the triad of meningitis? | 1. Fever 2. Headache 3. Stiff neck (Nausea, photophobia, and irritability are also commonly seen in patients with meningitis.)
🗑
|
||||
| What carcinoma in the thyroid involves stromal amyloidosis and an excessive release of calcitonin? | Medullary carcinoma
🗑
|
||||
| What is the name for an adenoma in the adrenal glands that causes elevated levels of aldosterone? | Conn's syndrome-page230
🗑
|
||||
| What does prepubertal hypersecretion of growth hormone lead to? | Gigantism
🗑
|
||||
| What is an ACTH-secreting tumor in the pituitary gland known as? | Cushing's disease
🗑
|
||||
| What is a beta cell tumor that secretes an excess of gastrin, which causes multiple peptic ulcers in aberrant locations, known as? | Zollinger-Ellison syndrome
🗑
|
||||
| What type of pancreatic tumor has the following common signs: hypoglycemia, hunger, sweating, tremors, seizures, and coma? | Insulinoma
🗑
|
||||
| The most common causes of osteomyelitis: Overall? | Staphylococcus aureus
🗑
|
||||
| In neonates? | Streptococcus agalactiae
🗑
|
||||
| In patients with sickle cell disease? | Staphylococcus aureu.s (but they are more prone to developing salmonella infections)
🗑
|
||||
| In drug addicts? | P.seudomonas
🗑
|
||||
| What renal disease in diabetic patients is seen as a halo of capillaries around the mesangial nodules? | Kimmelstiel-Wilson disease
🗑
|
||||
| With what pancreatic tumor do you see watery diarrhea, hypokalemia, and achlorhydria? | Vasoactive intestinal peptide (VIP) tumor of the pancreas
🗑
|
||||
| What are the four most common causes of femoral head necrosis? | 1. Steroids 2. Alcohol 3. Scuba diving 4. Sickle cell anemia
🗑
|
||||
| What bone pathology is associated with teenagers, occurrence in men more than women, hematogenous spread to the lungs, and Codman's triangle on an x-ray? | Osteosarcoma
🗑
|
||||
| What is the collapse of the vertebral body due to Tb known as? | Pott's disease
🗑
|
||||
| What pathology is associated with cartilage formation in the bone of the jaw, shoulder, and pelvic girdle and presents in middle age? | Chondrosarcoma
🗑
|
||||
| What disease is found in persons in the 20- to 40-year-old age range; affects women more than men; occurs at the epiphysis of the knee; and is seen as a "soap bubble" appearance on an x-ray? | Giant cell tumor of the bone
🗑
|
||||
| What disease is seen in the first or second generations; is associated with chromosome 11,22; affects men more than women; and has pseudorosettes and an onion- skin layering formation? | Ewing's sarcoma
🗑
|
||||
| What joint is affected causing Heberden's nodes in osteoarthritis? | Distal interphalangeal (DIP) joint (Bouchard's nodes are in the proximal interphalangeal [PIP] joint)
🗑
|
||||
| What vitamin D deficiency leads to a softening of the bone causing demineralization? | Osteomalacia
🗑
|
||||
| Podagra, tophi in the ear, and polymorphonucleocytes (PMNs) with monosodium urate crystals are associated with what pathology? | Gout
🗑
|
||||
| With what pathology are bamboo spine on an x-ray and the haplotype HLA-B27 associated? | Ankylosis spondylitis
🗑
|
||||
| With what pathology is deposition of calcium pyrophosphate in patients older than 50 years of age associated? | Pseudogout
🗑
|
||||
| What childhood pathology involves anterior bowing of the tibia, epiphyseal enlargements, and costochondral widening with the endochondral bones being affected? | Rickets
🗑
|
||||
| What is the triad of Reiter's syndrome? | 1. Peripheral arthritis 2. Conjunctivitis 3. Nongonococcal urethritis
🗑
|
||||
| What are the five chemotactic mediators? | 1. LB4, 2. IL-8, 3. C5a, 4. TNF-a, 5. N-formyl-methionine
🗑
|
||||
| What are the three opsonins? | 1. C3b 2. Fc region of IgG 3. Mannose-binding protein
🗑
|
||||
| What enzyme is lacking in the autosomal recessive type of severe combined immunodeficiency? | Adenosine deaminase
🗑
|
||||
| What two components of the complement cascade are anaphylatoxins? | 1. C3a 2. C5a (causes mast cells to secrete histamine)
🗑
|
||||
| What causes vasodilatation, pain, and smooth muscle contraction? | Bradykinins
🗑
|
||||
| What is the most potent vasoconstrictor and can cause platelet aggregation? | TXA2
🗑
|
||||
| What prostaglandin is associated with vasodilatation (edema) iand nhibits platelet aggregation? | Prostaglandin I2, (PGI2)
🗑
|
||||
| What prostaglandin is associated with vasodilatation, fever, and pain? | PGE2
🗑
|
||||
| What are the three characteristics in Virchow's triad of thrombosis? | 1. Injury to the endothelium 2. Change in laminar flow 3. Hypercoagulation
🗑
|
||||
| What is collagen and fibrin surrounded by macrophages in rheumatic fever known as? | Aschoff bodies
🗑
|
||||
| What leukotriene is a major chemotactic factor that causes WBCs to adhere to the endothelium? | LB4
🗑
|
||||
| What two substances, produced by the body, cause fever? | 1. Interleukin 1 (IL-1) 2. Tumor necrosis factor (TNF)
🗑
|
||||
| What three leukotrienes are associated with bronchospasms and an increase in vessel permeability and vasoconstriction? | LC4, LD4, and LE4,
🗑
|
||||
| What substance, derived from IgE-sensitized basophils, causes increased vascular permeability, leukocyte adhesion, chemotaxis, and aggregation along with being one of the most potent platelet stimulators? | Platelet-activating factor (PAF)
🗑
|
||||
| What is the most common organ involved in amyloidosis? | Kidney
🗑
|
||||
| What is the term that describes when treatment for one disease leads to another disease presenting itself? | Iatrogenic infection
🗑
|
||||
| What disease involves a failure of the third and fourth pharyngeal pouches to develop, with a lack of T cell immunity causing a poor defense response to certain fungal and viral infections and tetany? | DiGeorge's syndrome
🗑
|
||||
| What disease involves a lack of both T cell-mediated and Immoral immune responses that can be either X-linked or autosomal recessive? | Severe combined immunodeficiency
🗑
|
||||
| What pathology involves excessive fibrosis throughout the body via increased fibro- blast activity, occurs in women more than men, and is most commonly seen in the third to the fifth decade? | Scleroderma
🗑
|
||||
| What type of hypersensitivity involves autoimmune hemolytic anemia, erythroblastosis fetalis, Goodpasture's syndrome, parasitic killing, Graves' disease, and myasthenia gravis? | Type II hypersensitivity
🗑
|
||||
| What type of hypersensitivity involves systemic anaphylaxis and skin and food allergies? | Type I hypersensitivity
🗑
|
||||
| What joints in the hand are most commonly affected by rheumatoid arthritis? | Proximal interphalangeal and metacarpal phalangeal joints
🗑
|
||||
| What disease is seen in the 20- to 40-year-old age group, is more prevalent in women than men, involves diarrhea with or without bloody stools, starts in the rectum and ascends without skipping areas, includes pseudopolyps, and has a thickness of the bowe | Ulcerative colitis
🗑
|
||||
| What disease arises from the adrenal medulla, displaces and crosses the midline, metastasizes early, is the most common solid tumor, and is seen in the 2- to 4-year-old age group? | Neuroblastoma
🗑
|
||||
| In which disease do you find a decrease in the bone density and thickness of the cortex, occurring most commonly in postmenopausal women but can be induced by steroids, old age, or idiopathic causes? | Osteoporosis
🗑
|
||||
| What is cortical hypersecretion of the adrenal gland known as? | Cushing's syndrome
🗑
|
||||
| What does postpubertal hypersecretion of growth hormone cause? | Acromegaly
🗑
|
||||
| What tumor is seen in the 2- to 4-year-old age group; does not cross the midline; has immature glomeruli, tubules, and stroma; and metastasizes late to the lungs? | Wilms' tumor
🗑
|
||||
| What GI pathology is associated with the following: a positive string sign, an increase in the number of bloody stools, RLQ pain, skip lesions, terminal ileum most commonly affected, occurrence in women more than men, and an increased thickness of the bow | Crohn's disease
🗑
|
||||
| What is associated with deposition of an extracellular amorphous substance in the blood vessel walls and connective tissue and green birefringence under polarized light? | Amvloidosis
🗑
|
||||
| What disease is characterized by a mosaic pattern of bone marrow replacement; involves high-output cardiac failure; and occurs in women more than men and in people older than 40 years of age? | Paget's disease of the bone
🗑
|
||||
| What type of hypersensitivity involves a Tb test, viral infections, graft rejections, and tumor-associated antigen? | Type IV hypersensitivity
🗑
|
||||
| What form of hypersensitivity involves T cell-mediated cytotoxicity? | Type IV hypersensitivity
🗑
|
||||
| What disease has the following characteristics: occurrence in women more than men; involvement of the second or third generation; positive ANAs; joint pain; skin rash in a malar distribution; diffuse proliferate GN; Libman- Sacks endocarditis; and neurolo | SLE : MD SOAP N HAIR (malar rash; discoid lesion; serologic; oligoarthritis; ANA positive; pleuritis/pericarditis; neurologic complications; hematologic [leukopenia/thrombocytopenia]; anticardiolipin antibodies; 3 & immunologic; and renal)
🗑
|
||||
| What form of hypersensitivity includes IgG- or IgM-activating phagocytosis, complement, or antibody-dependent cell-mediated cytotoxicity (ADCC)? | Type II hypersensitivity
🗑
|
||||
| What X-linked recessive disease involves failure of maturation of pre-B cells with no surface immunoglobulins, leading to recurrent pyogenic infections in infants? | X-linked agammaglobulinemia
🗑
|
||||
| What syndrome comprises small-cell carcinoma of the lung and myasthenia gravis? | Lambert-Eaton syndrome
🗑
|
||||
| What pathologic process and pattern of involvement in the brain consist of necrosis, fibrosis, edema, and gliosis going from the center out? | Abscess of the brain on a CT scan
🗑
|
||||
| What is the most common site of a contrecoup contusion? | Orbital surface of the frontal lobe
🗑
|
||||
| What artery is the most common site of infarctions in the cerebral circulation? | Middle cerebral artery
🗑
|
||||
| What is the most common cause of a cerebral infarct? | Atherosclerosis/arteriosclerosis
🗑
|
||||
| What event involves the following precipitating factors: hypertension, diabetes, aneurysms, atherosclerosis, and occurrence in blacks more than in whites? | Intracerebral hemorrhage
🗑
|
||||
| What artery is affected in a subarachnoid hematoma? | Middle cerebral artery
🗑
|
||||
| What is the most common cause of meningitis in: Neonates? | Escherichia coli or group B streptococci
🗑
|
||||
| What is the most common cause of meningitis in: Immunized children? | Streptococcus pneumoniae
🗑
|
||||
| What is the most common cause of meningitis in: Non-immunized children? | Haemophilus influenzae
🗑
|
||||
| What is the most common cause of meningitis in: Young adults? | Neisseria meningitidis
🗑
|
||||
| What is the most common cause of meningitis in: The base of the brain? | Haemophilus influenzae
🗑
|
||||
| What AR disease involves a lack of phenylalanine hydroxylase? | Phenylketonuria (PKU)
🗑
|
||||
| What type of head trauma is characteristic of a fractured temporal or parietal bone, lucid intervals, headache, and confusion? | Epidural hematoma
🗑
|
||||
| What disease is seen in children younger than 5 years of age; X-linked recessive, cardiac myopathies; calf pseudohypertrophy; lordosis; protuberant bellies; an increase then a decrease in CPK; and death in the second generation of life? | Duchenne's muscular dystrophy
🗑
|
||||
| What breast pathology involves malignant cells with "halos" invading the epidermis of the skin? | Paget's disease of the breast
🗑
|
||||
| What tumor comprises 40% of all testicular tumors in children? | Teratoma
🗑
|
||||
| What disease has the following characteristics: has autoantibodies to IgG; occurs in women more than men; and includes exophthalmos, pretibial myxedema, nervousness, heart palpitations, and fatigue? | Graves' disease
🗑
|
||||
| What germ cell tumor is seen in the 15- to 35-year-old age group, peaks when the person is 35 years of age, and is a bulky mass that spreads via the lymphatic system? | Seminoma
🗑
|
||||
| What sex cell tumor causes precocious puberty, masculinization, gynecomastia in adults, and crystalloids of Reinke? | Leydig cell tumor
🗑
|
||||
| What thyroid pathology causes dwarfism, retarded bone maturation, myxedema, mental retardation, and decreased T4 with increased thyroid-stimulating hormone (TSH) levels? | Cretinism
🗑
|
||||
| What are the following risk factors characteristic of: late menopause, early menarche, obesity, nulliparity, excessive estrogen, genetic factor p53, and brc-abl? | Breast cancer
🗑
|
||||
| What adenocarcinoma presents with elevated levels of acid phosphatase, dihydrotestosterone, prostate-specific antigen (PSA), and bone pain? | Prostatic carcinoma
🗑
|
||||
| What myopathy, due to autoantibodies to ACh receptors, can present with thymic abnormalities, red cell aplasia, and muscle weakness? | Myasthenia gravis
🗑
|
||||
| What two factors of the complement cascade are deficient in the person with SLE? | C2 and C4
🗑
|
||||
| What aspect of the complement cascade is defective if a patient constantly presents with recurrent infections with Neisseria gonorrhoeae or N. meningitidis? | Membrane attack complex-MAC (C5 to C9)
🗑
|
||||
| What disease involves "cold" skin abscesses due to a defect in neutrophil chemotaxis and a serum IgE level higher than 2000? | Job's syndrome
🗑
|
||||
| What X-linked recessive disease, deficient in NADPH oxidase, presents with catalase- positive infections? | Chronic granulomatous disease (30% are AR)
🗑
|
||||
| When does fetal IgM first appear in the fetal circulation? | Third trimester (6 to 9 months)
🗑
|
||||
| Hereditary angioneurotic edema (AD) presents with local edema in which organs? | GI, skin, respiratory tract
🗑
|
||||
| What enzyme deficiency causes increased capillary permeability due to a release of vasoactive peptides? | C1 esterase inhibitor (C1INH)
🗑
|
||||
| What AR disease contains the most common neutrophil defect? | Myeloperoxidase deficiency
🗑
|
||||
| How can a deficiency in adenosine deaminase be a bone marrow suppressor? | It causes a buildup of dATP, which inhibits ribonucleotide reductase and leads to a decrease in deoxynucleoside triphosphate (a precursor of DNA), resulting in overall bone marrow suppression.
🗑
|
||||
| What disease involves an adenosine deaminase deficiency, B and T cell deficiency, and defective IL-2 receptors? | Severe combined immunodeficiency (SCID)
🗑
|
||||
| What AR disease presents with B and T cell deficiencies, lymphopenia, an IgA deficiency, cerebellar problems, and spider angiomas? | Ataxia-telangiectasia
🗑
|
||||
| What immunoglobulins are present on the surface of mature B cells? | IgM and IgD
🗑
|
||||
| What is the only immunoglobulin found in the fetal circulation in the second trimester? | Maternal IgG
🗑
|
||||
| How does maternal immunoglobulin cross the placenta to get into fetal circulation? | Fc receptor on the heavy chain of the immunoglobulin via active transport
🗑
|
||||
| What disease involves a deficiency in IgM; elevated IgA; normal IgG; and recurrent pyogenic infections, especially from pneumococci; and thrombocytopenia? | Wiskott-Aldrich syndrome
🗑
|
||||
| What syndrome in children involves hypofunction of the adrenal glands due to bilateral hemorrhagic infarctions, which are most commonly associated with meningococcemia? | Waterhouse- Friderichsen syndrome
🗑
|
||||
| What thyroid carcinoma presents with psammoma bodies? | Papillary carcinoma of die thyroid
🗑
|
||||
| In what disease do you see a large, hard, fibrous proliferation of the connective tissue of the thyroid? | Riedel's thyroiditis
🗑
|
||||
| What thyroid pathology presents with a "cold," solitary, discrete nodule? | Adenoma of the thyroid
🗑
|
||||
| What cell type involves Immoral immunity? | B lymphocytes
🗑
|
||||
| What disease involves a goiter, hypothyroidism, and autoimmunity due to ag-specific suppressor T cells and occurs in women more commonly than in men? | Hashimoto's thyroiditis
🗑
|
||||
| How is gonadal sex determined? | The gonads' histologic characteristics
🗑
|
||||
| How is ductal sex determined? | Presence of mullerian or wolffian ducts
🗑
|
||||
| How is phenotypic sex determined? | Appearance of external genitalia
🗑
|
||||
| What disease presents with severe mental retardation, VSD, asymmetric face, microcephaly, and chromosome 5p deletion? | Cri du chat
🗑
|
||||
| What is primary hyperparathyroidism most commonly due to? | Chief cell adenoma (80%)
🗑
|
||||
| What are low levels of Ca2+ and P04 along with neuromuscular irritability signs of? | Hypoparathyroidism
🗑
|
||||
| What pathology has the following signs: severe headache, palpitations with or without tachycardia, diaphoresis, anxiety, nervousness, and hypertensive episodes? | Pheochromocytoma
🗑
|
||||
| What pathology has the following signs: elevated levels of Cat+, cardiac arrhythmias, bone resorption, kidney stones, and metastatic calcifications? | Primary hyperparathyroidism
🗑
|
||||
| What adrenal pathology presents with hypotension, hyponatremia, hypoglycemia, and hyperkalemia along with skin pigmentation? | Addison's disease
🗑
|
||||
| What disease, with familial mental retardation, presents with large everted ears and macroorchidism? | Fragile X syndrome
🗑
|
||||
| What ovarian pathology involves psammoma bodies? | Serocystadenocarcinoma
🗑
|
||||
| What cystic swelling of the chorionic villi is the most common precursor of choriocarcinoma? | Hydatidiform mole
🗑
|
||||
| What estrogen- or progesterone-producing tumor is associated with Call-Exner bodies? | Granulosa cell tumor
🗑
|
||||
| What ovarian pathology is associated with Turner's syndrome or malformation of the genitals and comprises 50% of all malignant germ cell tumors? | Dysgerminoma
🗑
|
||||
| What ovarian pathology involves ectoderm, endoderm, and mesoderm in a histologic section and is most commonly seen in the early reproductive years? | Dermoid cyst (teratoma)
🗑
|
||||
| What AR disease involves a deficiency in glucocerebrosidase,a huge spleen, and engorged phagocytic cells and is associated with chromosome 1? | Gaucher's disease
🗑
|
||||
| What disease, with an abnormality in collagen type I, presents with "blue sclera"? | Osteogenesis imperfecta
🗑
|
||||
| What small, subareolar, solitary tumor that affects the lactiferous ducts presents with bloody discharge from the nipple? | Intraductal papilloma
🗑
|
||||
| What cell consists of a binucleate giant cell with eosinophilic inclusions? | Reed-Sternberg cells
🗑
|
||||
| What disease involves bilateral, enlarged, pale ovaries and presents with infertility, hirsutism, obesity, secondary amenorrhea with elevated levels of LH, testosterone, and low levels of FSH? | Polycystic ovaries
🗑
|
||||
| What benign tumor of the breast, seen in the young, is well demarcated and has a very low risk of cancer? | Fibroadenoma
🗑
|
||||
| What breast pathology commonly occurs bilaterally in the upper outer quadrants, and includes microcalcifications, hypertrophy of the ducts, apocrine metaplasia, sclerosing adenoma, and blue-domed cysts? | Fibrocystic change of the breast
🗑
|
||||
| What AR disease involves a deficiency in tyrosinase, poses an increased risk of developing basal cell or squamous cell carcinoma, and is associated with chromosome llp? | Albinism
🗑
|
||||
| What is the most common fatal recessive disease in whites? | Cystic fibrosis
🗑
|
||||
| What AR disease has a deficiency in homogentisic oxidase that causes brittle, fibrillated articular cartilage, blue-black pigmentation of collagen, and urine that turns black upon standing? | Alkaptonuria
🗑
|
||||
| What AR disease involves a decreased amount of sphingomyelinase, massive organomegaly, zebra bodies, and foamy histiocytes microscopically and is associated with chromosome llp? | Niemann-Pick disease
🗑
|
||||
| What disease has multiple schwannomas, cafe au lait spots on the skin, and Lisch nodules and is associated with chromosome 17q? | Neurofibromatosis I (chromosome 22q is with neurofibromatosis II and no Lisch nodules either)
🗑
|
||||
| Name the AD disease associated with chromosome 15 in which the patient has long extremities, lax joints, pigeon chest, and posterior mural leaflet prolapse, and is prone to developing dissecting aortic aneurysm? | Marfan's syndrome
🗑
|
||||
| What AR disease involves a defect in amino acid 508 on chromosome 7, causing a defect in Cl- transportation that leads to recurrent pulmonary infections and an increase in viscid mucoid secretions along with pancreatic insufficiencies? | Cystic fibrosis (Parents are usually the first to find out because the baby tastes salty.)
🗑
|
||||
| What AD disease, associated with chromosome 19, involves a defect in the LDL receptors, leading to skin and tendon xanthomas? | Familial hypercholesterolemia
🗑
|
||||
| In what syndrome does the patient have angiomatosis; renal cell carcinomas; pheochromocytomas; retinal, cerebellar, medulla, or spinal cord hemangioblastomas; and epidermal cysts? | von Hippel-Lindau syndrome
🗑
|
||||
| What AD disease is associated with chromosome 4p; does not present until the person is in his or her 30s; and involves atrophy of the caudate nucleus, dilatation of the lateral and third ventricles, and signs of extrapyramidal lesions? | Huntington's disease
🗑
|
||||
| What is the most common cause of death in this disease? | Suicide
🗑
|
||||
| In utero death, caused by a complete lack of an alpha chain, is known as what? | Hydrops fetalis
🗑
|
||||
| What AR disease involves a substitution of valine for glutamic acid at position 6 on the beta chain? | Sickle cell anemia
🗑
|
||||
| What AD disease involves a defect in spectrin and leads to jaundice, splenomegaly, and cholecystitis? | Hereditary spherocytosis
🗑
|
||||
| What spinal cord pathology is caused by a degeneration of the cortical spinals, leading to weakness, fasciculations, hyperreflexia, and spasticity? | Amyotrophic lateral sclerosis (ALS)-Lou Gehrig's disease
🗑
|
||||
| What are the two reasons for megaloblastic anemia with elevated mean corpuscular volume (MCV)? | 1. Vitamin B12 deficiency 2. Folate deficiency
🗑
|
||||
| What are the five reasons for normochromic normocytic anemia with a normal MCV and an elevated reticulocyte count? | 1. Autoimmune hypersplenism 2. Trauma 3. Anemia 4. Spherocytosis 5. Sickle cell anemia
🗑
|
||||
| What are the four reasons for hypochromic microcytic anemia with a low MCV? | 1. Sideroblastic anemias (i.e., porphyrin and heme synthesis disorders) 2. Thalassemia 3. Iron deficiency 4. Lead poisoning
🗑
|
||||
| What are the three causes for normochromic normocytic anemia with a normal MCV and a low reticulocyte count? | 1. Marrow failure 2. Cancer 3. Leukemia
🗑
|
||||
| How is iron-deficiency anemia differentiated from the other forms of hypochromic microcytic anemia? | RDW value greater than 15 (indicative of iron-deficiency anemia)
🗑
|
||||
| What CNS tumor is seen in persons between 40 and 50 years of age; occurs in men more than women; affects the cerebral brain stem; is GFAP-positive; has a poor prognosis; and microscopically displays pseudopalisades,increased cellularity, pleomorphism, neo | Glioblastoma multiforme
🗑
|
||||
| In what CNS tumor, arising from arachnoid cells, do you see psammoma bodies? | Meningioma occurs in (women more often than in men).
🗑
|
||||
| What CNS pathology has a protracted history of seizures, occurs in the 30- to 40-year-age range, and microscopically involves "fried egg" cells? | Oligodendroglioma
🗑
|
||||
| In what disease do you see atrophy of the frontal and temporal lobes ("walnut brain")? | Pick's disease
🗑
|
||||
| What disease affects the basal ganglia and the substantia nigra, produces cogwheel rigidity, mask-like faces, and resting tremors; and reveals Lewy bodies microscopically? | Parkinson's disease
🗑
|
||||
| What pathology has bilateral periventricular plaques, perivascular inflammation, and demyelination and is thought to be autoimmune or brought on by a viral infection? | Multiple sclerosis
🗑
|
||||
| What type of vascular pathology, involving damage to the bridging veins that drain into the superior sagittal sinus, is due to blunt trauma and is seen most commonly in old people? | Subdural hematoma
🗑
|
||||
| What pathology is associated with a bloody lumbar puncture, which is caused most commonly by a ruptured berry aneurysm that produces the worst headache that the person has ever experienced? | Subarachnoid hemorrhage
🗑
|
||||
| What is the most common intramedullary spinal cord tumor? | Ependymoma
🗑
|
||||
| What is the most common cause of dementia; occurs in women more than men in the 60- to 90-year-old age group; and is associated with (32 amyloid, senile plaques, and neuroflbrillary tangles? | Alzheimer's disease
🗑
|
||||
| What common cause of hypogonadism in men involves testicular atrophy, azoospermia, gynecomastia, and Barr bodies? | Klinefelter's syndrome
🗑
|
||||
| What is the main type of cell involved in cellular immunity? | T lymphocyte
🗑
|
||||
| What is the syndrome associated with women of short stature with a web neck, a low posterior hairline, streaky ovaries, and preductal coarctation of the aorta? | Turner's syndrome
🗑
|
||||
| What is the term for a person with ambiguous external genitalia who has both ovarian and testicular tissue (Note: 66% of such persons are 46 XX.)? | True hermaphrodite (due to an X,Y translocation)
🗑
|
||||
| What type of Ehlers-Danlos syndrome is X-linked recessive and is caused by a defect in copper metabolism, causing a problem with cross-linking collagen and elastin fibers? | Type IX
🗑
|
||||
| What type of Ehlers-Danlos syndrome involves decreased activity of lysyl hydroxylase and affects collagen types I and III the most? | Type VI (AR)
🗑
|
||||
| What type of Ehlers-Danlos syndrome involves a deficiency in procollagen- N-peptidase? | Type VII (AR)
🗑
|
||||
| What type of person has testicular tissue with female genitalia and both the Y chromosome and testis present? | Male pseudohermaphrodite 3 & "Dude looks like a lady!"
🗑
|
||||
| What type of person presents with male external genitalia and is 46XX owing to excess exposure to androgenic steroids during the early stage of gestation? | Female pseudohermaphrodite
🗑
|
||||
| What syndrome has the following components: hypertension, proteinuria, hematuria, azotemia, and oliguria? | Nephritic syndrome
🗑
|
||||
| What type of glomerular nephritis (GN) occurs most commonly in children after a pharyngeal or skin infection; is immune complex mediated; and is seen as "lumpy-bumpy" subepithelial deposits? | Postinfectious glomerular nephritis
🗑
|
||||
| In what type of GN, seen in the 2- to 6-year-old age group, is there albuminuria and effacement of the visceral epithelial foot process with no deposits? | Minimal change disease (lipoid nephrosis)
🗑
|
||||
| What type of GN, associated with celiac disease and dermatitis herpetiformis, has mesangial deposits of IgA, C3, properdin, IgG, and IgM? | Berger's disease (IgA nephropathy)
🗑
|
||||
| What pathology has pulmonary and renal basement membrane involvement and crescent formation and involves type II hypersensitivity? | Goodpasture's syndrome
🗑
|
||||
| In what AD pathology is there a derangement of the epiphyseal cartilage growth, causing a large skull and a normal-sized vertebral column? | Achondroplasia
🗑
|
||||
| What gynecologic pathology occurs in the third and fourth decades, is the cause of 18 to 25% of all gynecologic laparoscopic procedures, and presents with chocolate cysts? | Endometriosis
🗑
|
||||
| What form of GN is characteristically associated with crescent formation? | Rapidly progressive glomerulonephritis (RPGN)
🗑
|
||||
| What type of GN has C3, IgG, C1q, C4 along with subendothelial deposits? | MPGN type I (two thirds of the MPGN cases)
🗑
|
||||
| What type of skin carcinoma occurs on sun-exposed sites, has a low level of metastasis, and involves keratin pearls? | Squamous cell carcinoma
🗑
|
||||
| A herniation of the brain through a defect in the skull is known as what? | Fungus cerebri
🗑
|
||||
| What type of skin pathology, located on the central face and on sun-damaged skin, is a precursor to squamous cell carcinoma? | Keratoacanthoma
🗑
|
||||
| True or false-Hodgkin's lymphoma affects Waldeyer's ring? | False; non-Hodgkin's disease affects Waldeyer's ring and the periaortic nodes
🗑
|
||||
| What pathology is due to increased resorption or impaired synthesis of bone, resulting in decreased bone mass, and is associated with postmenopause, inactivity, hyperthyroidism, hyperadrenocorticism, and Ca2+ deficiency? | Osteoporosis
🗑
|
||||
| What is a circumscribed, flat, nonpalpable pigmented change up to 1 cm? | Macule (e.g., a freckle)
🗑
|
||||
| What is a palpable, elevated solid mass up to 0.5 cm? | Papule
🗑
|
||||
| What is the most common tumor on sun-exposed sites that rarely metastasizes but is locally aggressive and has palisade arrangements of the nuclei? | Basal cell carcinoma
🗑
|
||||
| What is an elevated, fluid-filled cavity between skin layers up to 0.5 cm? | Vesicle (e.g., poison ivy)
🗑
|
||||
| What is an elevated, fluid-filled cavity between the layers greater than 0.5 cm? | Bulla
🗑
|
||||
| What melanocytic tumor has a neural filament tumor marker and vertical or radial growth? | Malignant melanoma
🗑
|
||||
| What benign neoplasm has the total lesion above the level of the skin with a "pasted on appearance"? | Seborrheic keratosis
🗑
|
||||
| What are the gray-black patches of verrucous hyperkeratosis, usually found in the axillary folds, that can be a sign of an underlying malignancy? | Acanthosis nigricans (It is commonly seen in obese patients.)
🗑
|
||||
| What is it called when the posterior cerebellar mass pushes the tonsils through the foramen magnum? | Tonsillar herniation
🗑
|
||||
| What form of lymphoma is diffuse in the lymph node, has an IgM spike, slowly evolves to chronic lymphocytic leukemia (CLL), is seen in the old, and also has liver, spleen, and bone marrow involvement? | Small-cell lymphoma
🗑
|
||||
| What lymphoma is a diffusely mixed, diffusely large cell that grows rapidly and consists mainly of B cells along with "null" cells? | Diffuse aggressive lymphoma
🗑
|
||||
| What lymphoma forms 30% of childhood lymphomas, is linked to EBV, is associated with chromosome 8,14q translocation, and has a "starry sky" pattern of involvement on a histologic section? | Burldtt's lymphoma
🗑
|
||||
| What lymphoma arises from germinal follicles and is associated with proto- oncogene bcl-2 due to translocation of chromosome 14,18? | Follicular lymphoma
🗑
|
||||
| What variant of small lymphocytic lymphoma has a slow course and elevated levels of IgM that lead to hyperviscosity syndrome and blindness? | Waldenstrom's macroglobulinemia
🗑
|
||||
| What lymphoma is seen in male adolescents, is associated with a thymic mass, and progresses to ALL? | Lymphoblastic lymphoma {verify this}
🗑
|
||||
| What is the term for the condition in which the brain is pushed under the falx cerebri by a one-sided mass lesion? | Subfalcial herniation
🗑
|
||||
| What CNS tumor arises from Rathke's pouch? | Craniopharyngioma
🗑
|
||||
| What variant of Hodgkin's lymphoma occurs least frequently, is seen in people younger than 35 years of age, is localized, has an excellent prognosis, and involves mainly lymphocytes and a few Reed-Sternberg cells? | Lymphocyte predominant
🗑
|
||||
| What variant of Hodgkin's lymphoma is the most common type; involves women more than men; occurs in adolescence more than in old age; affects the lower cervical, supraclavicular, and mediastinal lymph nodes with broad bands of fibrous tissue and "lacunar" | Nodular sclerosis
🗑
|
||||
| What variant of Hodgkin's lymphoma is widespread with extensive fibrosis and necrosis, occurs in older patients, involves many Reed-Sternberg cells, and has a poor prognosis? | Lymphocyte depletion
🗑
|
||||
| What variant of Hodgkin's lymphoma can be localized or widespread and has an intermediate prognosis with lymphocytes, eosinophils, plasma cells, histiocytes, and Reed-Sternberg cells? | Mixed cellularity
🗑
|
||||
| What AR disease involves a deficiency in hexosaminidase A and cherry red spots on the retina; is seen more commonly in Jewish people; and is associated with chromosome 15q? | Tay-Sachs disease
🗑
|
||||
| Name the condition described by the following: Adenomas of the thyroid, parathyroid, and adrenal cortex along with Zollinger-Ellison syndrome? | Multiple endocrine neoplasia, type I (MEN I)-Wermer's syndrome
🗑
|
||||
| Pheochromocytoma, medullary carcinoma of the thyroid, and adenoma of the parathyroid? | MEN Ila-Sipple's syndrome
🗑
|
||||
| What cranial nerve is most commonly affected in a schwannoma? | CN VIII
🗑
|
||||
| What leukemia is associated with a chromosome 9,22 translocation; constitutes 80% of childhood leukemias; and has blasts with PAS-positive material and terminal deoxy-transferase (TdT) marker present? | Acute lymphocytic leukemia (ALL)
🗑
|
||||
| What leukemia is seen in the 15- to 39-year-old age group, has blasts with myeloperoxidase-positive granules, tends to invade tissues, and is associated with a poor prognosis? | Acute myelocytic leukemia (AML)
🗑
|
||||
| What leukemia is seen in the 25- to 60-year-old age group and is associated with chromosome 9,22 translocation, bcr-abl oncogene, and blast crisis? | Chronic myeloid leukemia (CML)
🗑
|
||||
| What leukemia is the most indolent of all leukemias; affects persons older than 55 years of age; and is associated with trisomy 12 (Hint: 95% are B cell neoplasms.)? | Chronic lymphocytic leukemia (CLL)
🗑
|
||||
| What type of GN has C3 MPGN type II deposits in irregular granular/linear foci and intramembranous deposits of unknown material? | MPGN Type II
🗑
|
||||
| What is the term for a News benign melanocytic tumor? | Nevus
🗑
|
||||
| Which muscarinic receptor uses a decrease in adenyl cyclase as its second messenger? | M2
🗑
|
||||
| What drug is used to differentiate a cholinergic crisis from myasthenia gravis? | Edrophonium
🗑
|
||||
| What drug causes a gradual loss of choline from the presynaptic nerve terminal by blocking its reuptake? | Hemicholium
🗑
|
||||
| What is the only site in the body that uses Ml receptors? | The stomach
🗑
|
||||
| What drug is an Ml-specific antispasmodic? | Pirenzepine
🗑
|
||||
| What is the most potent neuromuscular junction Mocker (NMJB), and also has no cardiovascular side effects? | Doxacurium
🗑
|
||||
| What antimuscarinic is used as an inhalant for asthma? | Ipratropium
🗑
|
||||
| What is the antidote for organophosphate ingestion? | Atropine and 2-PAM (pralidoxime)
🗑
|
||||
| What is the drug of choice for atropine or tricyclic antidepressant (TCA) overdose? | Physostigmine
🗑
|
||||
| What is the rate-limiting step for norepinephrine synthesis? | Tyrosine hydroxylase
🗑
|
||||
| What two enzymes are blocked by disulfiram? | Aldehyde dehydrogenase and dopamine ß-hydroxylase
🗑
|
||||
| What is the monoamine oxidase B (MAOB) inhibitor? | Selegiline
🗑
|
||||
| What two drugs inhibit the release of neurotransmitters from storage granules? | 1. Guanethidine 2. Bretylium
🗑
|
||||
| What drug blocks intragranular uptake of norepinephrine (NE)? | Reserpine
🗑
|
||||
| What two drugs, when mixed, can lead to malignant hyperthermia? | 1. Succinylcholine 2. Halothane (Treatment is with dantrolene.)
🗑
|
||||
| In what phase of noncompetitive depolarization does no further depolarization occur, producing a desensitized block? | Phase 2
🗑
|
||||
| What adrenergic receptors use inositol triphosphate (IP3) and diacylglycerol (DAG) for their second messenger system? | a1-Receptors
🗑
|
||||
| What a1-agonist is used to treat paroxysmal atrial tachycardia with hypotension? | Metaraminol (a1, ß1)
🗑
|
||||
| What a1-agonist, not inactivated by catechol-O- methyl transferase (COMT), is used as a decongestant and also for treatment of paroxysmal atrial tachycardia? | Phenylephrine
🗑
|
||||
| What ß2-agonist is used in the prophylactic treatment of asthma? | Salmeterol
🗑
|
||||
| What two ß2-agonists cause myometrial relaxation? | 1. Ritodrine 2. Terbutaline
🗑
|
||||
| A hypertensive crisis can be caused by the addition of an MAO inhibitor and what? | Tyramine
🗑
|
||||
| What group of drugs is known as the "antihypertensive" group? | a1-Antagonists
🗑
|
||||
| Why? | Because they decrease total peripheral resistance (TPR) and preload with no change in heart rate or cardiac output
🗑
|
||||
| What mixed a-antagonists are used for patients with pheochromocytoma? | Phentolamine and phenoxybenzamine
🗑
|
||||
| What a2-antagonist is used to treat impotence and postural hypotension? | Yohimbine
🗑
|
||||
| What drug that penetrates the blood-brain barrier is found in asthma preparations and used as a nasal decongestant? | Ephedrine
🗑
|
||||
| What two ß2-agonists are used to produce bronchodilatation? | 1. Metaproterenol 2. Albuterol
🗑
|
||||
| What ß-blocker is also an a-blocker? | Labetalol
🗑
|
||||
| What are the four cardioselective ß-blockers? | 1. Bisoprolol 2. Atenolol 3. Metoprolol 4. Acebutolol (BAMA)
🗑
|
||||
| What ß-blocker is also a membrane stabilizer? | Propranolol
🗑
|
||||
| In what three areas of the body are sympathetics the predominant tone? | 1. Sweat glands 2. Arterioles 3. Veins
🗑
|
||||
| What three ß-blockers are used in the treatment of glaucoma? | 1. Propranolol 2. Timolol 3. Carteolol
🗑
|
||||
| What two ß-blockers decrease serum lipids? | 1. Pindolol 2. Acebutolol
🗑
|
||||
| In what area of the brain can an excess of dopamine lead to psychotic symptoms? | Mesocortical area
🗑
|
||||
| What area of the brain is linked to emotion and movement? | Mesolimbic system
🗑
|
||||
| What two drugs block dopa-decarboxylase in the periphery to decrease the conversion of L-dopa to dopamine? | 1. Carbidopa 2. Benserazide
🗑
|
||||
| What is the drug of choice for early Parkinson's disease? | Selegiline
🗑
|
||||
| What antiviral agent is used in the treatment of drug-induced Parkinson's disease? | Amantadine
🗑
|
||||
| What drug which causes Ca2+ independent release of dopamine is used to treat attention deficit hyperactive disorder (ADHD) and narcolepsy? | Methylphenidate
🗑
|
||||
| What dopamine-2 (D2) agonist is used to treat neuroleptic malignant syndrome? | Bromocriptine
🗑
|
||||
| What cofactor of dopa- decarboxylase decreases the efficacy of L-dopa? | Vitamin B6
🗑
|
||||
| What three drugs can cause gingival hyperplasia? | 1. Phenytoin 2. Cyclosporine 3. Nifedipine
🗑
|
||||
| What antiepileptic agent has syndrome of inappropriate antidiuretic hormone (SIADH) as a side effect? | Carbamazepine
🗑
|
||||
| What drug is used for partial seizures and Lennox-Gastaut syndrome in children? | Felbamate
🗑
|
||||
| What is the drug of choice for trigeminal neuralgia? | Carbamazepine
🗑
|
||||
| What are the first signs of overdose from Phenobarbitals? | Nystagmus and ataxia
🗑
|
||||
| What drug, used for partial seizures, inhibits the release of glutamate and causes rashes in 45% of patients taking it? | Lamotrigine
🗑
|
||||
| What benzodiazepine is used to treat absent mal seizures? | Clonazepam
🗑
|
||||
| What are the two drugs of choice for simple partial seizures? | 1. Carbamazepine 2. Phenytoin
🗑
|
||||
| What is the only neuroleptic agent that does not cause hyperprolactemia? | Clozapine
🗑
|
||||
| What is the drug of choice for status epilepticus? | Diazepam
🗑
|
||||
| What two neuroleptic agents are associated with tardive dyslunesia? | 1. Haldol 2. Fluphenazine
🗑
|
||||
| What neuroleptic agent causes retinal deposits, hypotension, and torsades de pointes? | Thioridazine
🗑
|
||||
| What neuroleptic has amoxapine as a metabolite? | Loxapine
🗑
|
||||
| What is the only neuroleptic that does not cause an increase in weight or appetite? | Molindone
🗑
|
||||
| What TCA causes sudden cardiac death in children? | Desipramine
🗑
|
||||
| What TCA is used to treat enuresis? | Imipramine
🗑
|
||||
| What class of antidepressants are associated with insomnia? | Serotonin selective reuptake inhibitors (SSRIs)
🗑
|
||||
| What monoamine oxidase inhibitor (MAOI) does not cause a hypertensive crisis? | Selegiline
🗑
|
||||
| What occurs if you mix an MAOI and a sympathomimetic? | Severe hypertension, which can lead to subarachnoid hemorrhage
🗑
|
||||
| What two TCAs are considered to be heavily sedative? | 1. Amitriptyline 2. Trazodone
🗑
|
||||
| What neuroleptic agent is also considered to be an antihistamine? | Risperidone
🗑
|
||||
| What TCA is used to treat obsessive-compulsive disorder and is said to cause aggressive behavior? | Clomipramine
🗑
|
||||
| What neuroleptic agent causes agranulocytosis and also has no tardive dyslcinesia as a side effect? | Clozapine
🗑
|
||||
| What drug decreases mood swings and is used for the manic phase of a bipolar illness? | Lithium
🗑
|
||||
| What group of drugs potentiate the activity of gamma-aminobutyric acid (GABA)? | Benzodiazepines
🗑
|
||||
| What benzodiazepine is used for: Anxiety/panic attacks? | Alprazolam
🗑
|
||||
| Absence seizures and as an anticonvulsant? | Clonazepam
🗑
|
||||
| Alcohol withdrawal and as an anticonvulsant? | Clorazepate
🗑
|
||||
| Status epilepticus, as a preoperative medication? | Diazepam
🗑
|
||||
| Preoperative medication? | Lorazepam
🗑
|
||||
| What benzodiazepines are activated outside of the liver? | Oxazepam, temazepam, and lorazepam (OTL = "outside the liver")
🗑
|
||||
| What benzodiazepine antagonist is used for benzodiazepine overdose? | Flumazenil
🗑
|
||||
| What are the three signs of morphine overdose? | 1. Pinpoint pupils 2. Decreased respiratory rate 3. Coma
🗑
|
||||
| What is the neurotransmitter (NT) at the mu receptor? | ß-Endorphin
🗑
|
||||
| What is the NT at the delta receptor? | Enkephalin
🗑
|
||||
| What is the NT at the kappa receptor? | Dynorphin
🗑
|
||||
| Which type of receptor antagonist is the most clinically efficacious? | Competitive antagonist
🗑
|
||||
| Which type of antagonist acts on the same receptor as the agonist that it blocks? | Pharmacologic antagonist
🗑
|
||||
| How are water-soluble drugs eliminated primarily? | Via the kidneys
🗑
|
||||
| What class of pharmaceuticals are initially inactive but are then metabolized to their active products? | Prodrugs
🗑
|
||||
| How are drugs that are excreted via the biliary system resorbed by the GI tract? | Enterohepatic cycling
🗑
|
||||
| What body fluid preferentially breaks down esters? | Blood
🗑
|
||||
| Which type of antagonist takes out a drug by binding to it? | Chemical antagonist
🗑
|
||||
| Which type of antagonist directly reverses the action of a drug by working on a different receptor? | Physiologic antagonist
🗑
|
||||
| Quantal dose-response curves indicate what two things about a drug in a patient population? | 1. Margin of error 2. Relative safety
🗑
|
||||
| When an agonist drug binds to its receptor, what type of mechanism does it activate? | Effector mechanism
🗑
|
||||
| What are the four types of signaling mechanisms? | 1. Intracellular receptors 2. Membrane receptors 3. Enzymes 4. Intracellular effectors
🗑
|
||||
| What are the two factors that influence low oral bioavailability? | 1. First-pass metabolism 2. Acid lability
🗑
|
||||
| What do the following values stand for: EDS ? | Effective dose for 50% of drug takers (median effective dose)
🗑
|
||||
| TD50? | Toxic dose for 50% of drug takers (median toxic dose)
🗑
|
||||
| LD50? | Lethal dose for 50% of drug takers (median lethal dose )
🗑
|
||||
| What is the equation for a drug's ther-a e~utic index? | LD50 divided by ED50
🗑
|
||||
| What does the FDA regulate? | Efficacy and safety of drugs
🗑
|
||||
| Which phases of drug testing require an investigational new drug exemption? | Phases I, II, and III
🗑
|
||||
| How many years do preclinical animal studies last? | 2 to 5 years
🗑
|
||||
| How many phases of clinical testing are there? | Four phases
🗑
|
||||
| Before which phase of clinical testing is a new drug application applied for? | Phase IV
🗑
|
||||
| How many years does clinical testing last? | 4 to 5 years
🗑
|
||||
| What antineoplastic drug is a prodrug? | Flucytosine
🗑
|
||||
| What carbapenem is resistant to penase and is a partial cell wall inhibitor? | Imipenem
🗑
|
||||
| What monobactam is resistant to ß-lactamases of some bacteria? | Aztreonam
🗑
|
||||
| What are the drugs used in the triple treatment of Helicobacter pylori? | Pepto-Bismol, metronidazole, and erythromycin or amoxicillin
🗑
|
||||
| What is the commonly IV opioid used in surgery? | Fentanyl
🗑
|
||||
| Which IV agent has the lowest incidence of postoperative emesis and has the fastest rate of recovery? | Propofol
🗑
|
||||
| What is the major pulmonary side effect of mu-activators? | Respiratory depression
🗑
|
||||
| Which drug causes dissociative anesthesia and is used mainly in pediatric surgery? | Ketamine
🗑
|
||||
| Which short-acting benzodiazepine is often used for conscious sedation? | Midazolam
🗑
|
||||
| What is the most commonly used IV opioid in cardiovascular surgery? | Morphine sulfate
🗑
|
||||
| What toxicities are caused by the following agents: Occupational nitrous oxide exposure? | Anemia
🗑
|
||||
| MethoxyHurane? | Nephrotoxicity
🗑
|
||||
| Halothane? | Hepatitis, with or without necrosis
🗑
|
||||
| What is the only local anesthetic that does not cause vasodilatation? | Cocaine (It is vasoconstrictive.)
🗑
|
||||
| Do opioids increase or decrease uterine smooth muscle tone? | Decrease-but they increase ureter smooth muscle tone
🗑
|
||||
| What are the two side effects of opioids to which the user will not develop tolerance? | 1. Constipation 2. Miosis
🗑
|
||||
| What two classes of drugs can cause schizoid behavior? | 1. Clucocorticoids 2. Amphetamines
🗑
|
||||
| What is another name for prolactin inhibiting factor? | Dopamine
🗑
|
||||
| What is the mechanism behind tardive dyskenesia? | Dopamine receptor upregulation
🗑
|
||||
| What sedative-hypnotic is used for alcohol withdrawal? | Diazepam
🗑
|
||||
| To what is inhalational anesthesia potency proportional? | Lipid solubility
🗑
|
||||
| What is the only commonly used inhalant that is not a halogenated hydrocarbon? | Nitrous oxide
🗑
|
||||
| Which sedative-hypnotic is contraindicated in patients on warfarin therapy? | Chloral hydrate
🗑
|
||||
| What is the triad associated with "serotonin crisis"? | Myoclonus, hyperthermia, and rigidity
🗑
|
||||
| What form of antimicrobial therapy is better to treat an immunocompromised patient? | Bactericidal
🗑
|
||||
| What drug used to treat alcoholism has a long half-life and is given orally? | Naltrexone
🗑
|
||||
| What is the site of action for carbonic anhydrase inhibitors? | Proximal tubule
🗑
|
||||
| What is the site where local anesthetics bind? | Inactive Na+ channels
🗑
|
||||
| Which bactericidal agents interfere with cell wall synthesis by inhibiting transpeptidation? | Penicillins
🗑
|
||||
| What are the three ß-lactamase inhibitors? | 1. Clavulanic acid 2. Sulbactam 3. Tazobactam
🗑
|
||||
| What sulfonamide is the drug of choice in treating: UTIs? | Sulfisoxazole
🗑
|
||||
| Toxoplasmosis? | Sulfadiazine and pyrimethamine
🗑
|
||||
| Malaria prophylactically? | Sulfadoxine and pyrimethamine
🗑
|
||||
| Ophthalmic infections? | Sulfacetamide
🗑
|
||||
| Crohn's or ulcerative colitis? | Sulfasalazine
🗑
|
||||
| What drug blocks dihydrofolate reductase? | Trimethoprim (Sulfonamides block dihydropteroate synthase.)
🗑
|
||||
| What are the two "broad-spectrum" penicillins? | 1. Ampicillin 2. Amoxicillin
🗑
|
||||
| Which penicillin can cause interstitial nephritis? | Methicillin
🗑
|
||||
| What form of penicillin is stable in acid environments? | Penicillin-V
🗑
|
||||
| What form of penicillin is used in the treatment of life-threatening illnesses? | Penicillin-G (benzylpenicillin)
🗑
|
||||
| What is the drug of choice in the treatment of Pneumocystis carinii pneumonia? | Sulfonamide/trimethoprim
🗑
|
||||
| What are the five penicillinase-resistant penicillins? | 1. Cloxacillin 2. Oxacillin 3. Nafcillin 4. Dicloxacillin 5. Methicillin (CONDM)
🗑
|
||||
| Which antiviral agent is teratogenic? | Amantadine
🗑
|
||||
| Which broad-spectrum antibiotic inhibits the attachment of amino acyl tRNA by binding to the 30S ribosomal subunit? | Tetracycline
🗑
|
||||
| Which tetracycline is used in the treatment of SIADH? | Demeclocycline
🗑
|
||||
| Which tetracycline is used when there is a decrease in renal function? | Doxycycline
🗑
|
||||
| With which two tetracyclines is phototoxicity associated? | 1. Doxycycline 2. Minocycline
🗑
|
||||
| Which drug inhibits peptidyl transferase enzyme and binds to the 50S ribosomal subunit? | Chloramphenicol
🗑
|
||||
| What two tetracyclines have the highest plasma binding? | 1. Doxycycline 2. Minocycline
🗑
|
||||
| Renal tubular acidosis, nephrosis, and amino aciduria constitute the triad of what syndrome? | Fanconi-like syndrome
🗑
|
||||
| What is the cephalosporin of choice for Pseudomonas infections? | Ceftazidime
🗑
|
||||
| Which bacteriostatic drug inhibits translocation of protein synthesis by binding to the 50S ribosomal subunit and is a narrow-spectrum antibiotic used for pulmonary infections? | Erythromycin
🗑
|
||||
| Vestibular toxicity is associated with what tetracycline? | Minocycline
🗑
|
||||
| Hepatotoxicity is associated with what tetracycline? | Chlortetracycline
🗑
|
||||
| Which two cephalosporins cross the blood-brain barrier? | 1. Cefuroxime 2. Cefaclor
🗑
|
||||
| What three cephalosporins are eliminated via biliary mechanisms? | 1. Cefamandole 2. Cefoperazone 3. Ceftriaxone
🗑
|
||||
| What three cephalosporins can produce disul6ram-like reactions? | 1. Cefamandole 2. Cefoperazone 3. Moxalactam
🗑
|
||||
| What three cephalosporins inhibit vitamin K-dependent factors? | 1. Cefamandole 2. Cefoperazone 3. Moxalactam
🗑
|
||||
| What three cephalosporins have good penetration against Bacteroides fragilis? | 1. Cefotetan 2. Cefoxitin 3. Ceftizoxime
🗑
|
||||
| What cephalosporin-like drug has excellent coverage against gram-positive and gram-negative bacilli activity and is used in conjunction with the enzyme inhibitor cilastatin? | Imipenem
🗑
|
||||
| What is the drug of choice for penicillin-resistant gonococcalinfections? | Spectinomycin
🗑
|
||||
| Which drugs block the enzyme DNA gyrase? | Quinolones/nalidixic acid
🗑
|
||||
| What aminoglycoside is used before surgery to sterilize the bowel? | Neomycin
🗑
|
||||
| What aminoglycoside causes disruption of CN I? | Streptomycin
🗑
|
||||
| Which anti-Tb drug gives orange urine, saliva, and tears? | Rifampin
🗑
|
||||
| What is the drug of choice for amebic dysentery caused by Bacillus fragil%s? | Metronidazole
🗑
|
||||
| Which topical agent blocks the enzyme isoprenyl phosphate? | Bacitracin
🗑
|
||||
| What is the drug of choice for Legionella, Mycoplasma, and Campylobacter infections? | Erythromycin
🗑
|
||||
| What drug is used to treat Tb, tularemia, and the plague? | Streptomycin
🗑
|
||||
| What is the drug of choice for methicillin-resistant Staphylococcus aureus? | Vancomycin
🗑
|
||||
| Which drugs bind to the 30S ribosomal subunit and interfere with the initiation complex, causing a misreading of mRNA? | Aminoglycosides
🗑
|
||||
| What is the drug of choice for asymptomatic meningitis carriers? | Rifampin
🗑
|
||||
| Which three aminoglycosides have vestibular toxicity? | 1. Streptomycin 2. Gentamicin 3. Tobramycin
🗑
|
||||
| What are the two most important features in the diagnosis of malaria? | 1. Splenomegaly 2. Anemia (With a high index of suspicion)
🗑
|
||||
| Which antihelmintic increases membrane permeability to Ca2+ and is the drug of choice for schistosomiasis? | Praziquantel
🗑
|
||||
| What is the drug of choice in the treatment of the lepra reaction? | Clofazimine
🗑
|
||||
| What is the drug of choice for taeniasis which inhibits oxidative phosphorylation in cestodes? | Niclosamide
🗑
|
||||
| What is the drug of choice for threadworm, trichinosis, and larva migrans? | Thiabendazole
🗑
|
||||
| What inhibitor of microtubule synthesis is the drug of choice for whipworm and pinworm? | Mebendazole
🗑
|
||||
| Which bacteriostatic drug inhibits folic acid synthesis and a major side effect is the lepra reaction? | Dapsone
🗑
|
||||
| What mosquito is responsible for the transmission of malaria? | Anopheles mosquito
🗑
|
||||
| What is the drug of choice for filariasis and onchocerciasis? | Diethylcarbamazine
🗑
|
||||
| What drug of choice for ascaris causes neuromuscular blockade of the worm? | Pyrantel pamoate
🗑
|
||||
| What drug blocks glucose uptake, leading to decrease formation of adenosine 5' triphosphate (ATP) and resulting in immobilization of the parasite? | Albendazole
🗑
|
||||
| What drug is an irreversible inhibitor of the Na+/K+ pump? | Omeprazole
🗑
|
||||
| What is the drug of choice for: Herpes simplex virus (HSV) infections? | Acyclovir or trifluridine
🗑
|
||||
| What is the drug of choice for: Varicella-zoster? | Acyclovir
🗑
|
||||
| What is the drug of choice for: Cytomegalovirus (CMV) infections? | Ganciclovir
🗑
|
||||
| What is the drug of choice for: Human immunodeficiency virus (HIV) infections? | azidothymidine (AZT)
🗑
|
||||
| What is the drug of choice for: Influenza and rubella infections? | Amantadine
🗑
|
||||
| What is the drug of choice for: Respiratory syncytial virus (RSV) infections? | Ribavirin
🗑
|
||||
| What is the drug of choice for: Human papilloma virus (HPV) infections? | a-Interferon
🗑
|
||||
| What antihistamine is used in the treatment of serotonergic crisis? | Cyproheptadine
🗑
|
||||
| What are the three nonsedating antihistamines? | 1. Terfenadine 2. Astemizole 3. Loratadine
🗑
|
||||
| Skin necrosis is caused by a deficiency in what? | Transient protein C deficiency
🗑
|
||||
| What D2 receptor blocker is used as an antiemetic? | Chlorpromazine
🗑
|
||||
| What prostaglandin El (PGE1) analog is used in the treatment of ulcers caused by the excessive use of NSAIDs? | Misoprostol
🗑
|
||||
| What ß2-agonist is used as a prophylactic agent in the treatment of asthma? | Salmeterol
🗑
|
||||
| What is the only form of insulin that can be given IV? | Regular insulin
🗑
|
||||
| What drug, if given during pregnancy, would cause the uterus to exhibit signs of progesterone withdrawal and induce an abortion? | RU 486
🗑
|
||||
| What two forms of insulin, if mixed together, would result in precipitation of zinc? | 1. Lente insulin 2. NPH insulin or protamine zinc insulin (PZI)
🗑
|
||||
| What blood disorder is a side effect of metformin? | Megaloblastic anemia (decreased absorption of vitamin B12 and folic acid)
🗑
|
||||
| Which antineoplastic agents' site of inhibition is in: M phase of the cell cycle? | Vinblastine and vincristine
🗑
|
||||
| Gl phase of the cell cycle? | L-asparaginase and mitomycin
🗑
|
||||
| G2 phase of the cell cycle? | Bleomycin
🗑
|
||||
| Between GI and S phases of the cell cycle? | Hydroxyurea
🗑
|
||||
| Between S and G2 phases of the cell cycle? | Etoposide
🗑
|
||||
| S phase of the cell cycle? | Cytarabine, methotrexate, 6-mercaptopurine, and 6-thioguanine
🗑
|
||||
| What is the physiologic basis for the actions of birth control pills? | They block the midcycle surge of luteinizing hormone (LH)
🗑
|
||||
| True or false: Oral sulfonylureas increase the number of insulin receptors. | False-verify this answer.
🗑
|
||||
| What drugs combined together produce neuroleptanalgesia? | True. They also increase insulin release and decrease glucagon release.
🗑
|
||||
| What drugs combined together produce neurolepanalgesia? | Droperidol and fentanyl
🗑
|
||||
| What ultra-short-acting barbiturate induces hypnosis and is associated with cardiovascular and respiratory depression? | Thiopental
🗑
|
||||
| What is the most common pain killer used during pregnancy? | Meperidine
🗑
|
||||
| What antimicrobial agent's major side effect is: Gray baby syndrome? | Chloramphenicol
🗑
|
||||
| What antimicrobial agent's major side effect is: CN VIII damage (vestibulotoxic)? | Aminoglycosides
🗑
|
||||
| What antimicrobial agent's major side effect is: Teratogenicity? | Metronidazole
🗑
|
||||
| What antimicrobial agent's major side effect is: CholestaHc hepatitis? | Erythromycin
🗑
|
||||
| What antimicrobial agent's major side effect is: Hemolytic anemia? | Nitrofurantoin
🗑
|
||||
| What antimicrobial agent's major side effect is: Dental staining if used in the pediatric population? | Tetracycline
🗑
|
||||
| What antimicrobial agent's major side effect is: Altered folate metabolism? | Trimethoprim
🗑
|
||||
| What antimicrobial agent's major side effect is: Auditory toxicity? | Vancomycin
🗑
|
||||
| What antimicrobial agent's major side effect is: Cartilage abnormalities? | Quinolones
🗑
|
||||
| What are the five zero-order processes? | 1. Sustained release 2. IV drip 3. Phenytoin 4. Alcohol 5. Aspirin toxicity
🗑
|
||||
| What morphine derivative is used in patients with renal failure? | Hydromorphone
🗑
|
||||
| Which group of antihypertensive agents decreases left ventricular hypertrophy the best? | Thiazide diuretics
🗑
|
||||
| What is the site of action of: Osmotic diuretics? | The entire tubule barring the thick ascending limb
🗑
|
||||
| What is the site of action of: Loop diuretics? | Ascending limb
🗑
|
||||
| What is the site of action of: Thiazide diuretics? | Early distal tubule
🗑
|
||||
| What is the site of action of: K+-sparing diuretics? | Early collecting duct
🗑
|
||||
| What is the site of action of: Aldosterone antagonists? | Distal convoluted tubules
🗑
|
||||
| What is the only diuretic that works on the blood side of the nephron? | Spironolactone (binds to aldosterone receptors)
🗑
|
||||
| What is the active metabolite of spironolactone? | Canrenone
🗑
|
||||
| What drug is given transdermally for chronic pain but can cause chest wall rigidity if given IV? | Fentanyl
🗑
|
||||
| What is the lipid solubility and potency of a drug if the induction and recovery from the drug were both rapid? | Low lipid solubility and potency (They are inversely proportional.)
🗑
|
||||
| What is the drug of choice for hypertensive patients with a decreased renal function? | a-Methyldopa (Guanabenz or clonidine is also used.)
🗑
|
||||
| What hormone is released by the atria due to an increase in blood pressure to cause an increase in glomerular filtration rate (GFR), Na+ retention, and renin-angiotensin release? | Atrial natriuretic factor
🗑
|
||||
| What is the drug of choice in treatment for the late phaseof asthma? | Corticosteroids
🗑
|
||||
| Which antigenic thrombolytic agent causes a decreased level of circulating fibrinogen? | Streptokinase
🗑
|
||||
| What is the only class of diuretics to retain Cl- used in the short-term treatment of glaucoma and also in the treatment of acute mountain sickness? | Acetazolamide
🗑
|
||||
| What diuretic is used to decrease intraocular and intracranial pressures? | Mannitol
🗑
|
||||
| Which thrombolytic agent, activated in the presence of fibrin, is manufactured by recombinant DNA process? | Alteplase
🗑
|
||||
| Which diuretic causes irreversible ototoxicity and GI bleeding as its main side effects? | Ethacrynic acid
🗑
|
||||
| What IV agent is used to treat respiratory depression associated with withdrawal from alcohol usage? | Naloxone
🗑
|
||||
| What is the best form of treatment if an elevated blood pressure is due to: Elevated heart rate? | ß-Blockers
🗑
|
||||
| What is the best form of treatment if an elevated blood pressure is due to: Elevated force of contractions? | ß-Blockers
🗑
|
||||
| What is the best form of treatment if an elevated blood pressure is due to: Increase in fluid volume? | Diuretics or angiotensin converting enzyme (ACE) inhibitors
🗑
|
||||
| What is the best form of treatment if an elevated blood pressure is due to: Increase in TPR? | Centrally acting sympatholytics, a-antagonists, or Ca2+ channel bockers
🗑
|
||||
| Which class of diuretics blocks Na/Cl cotransport in the distal tubules? | Thiazide diuretics
🗑
|
||||
| Why should codeine be carefully administered acetaminophen or aminosalicylic acid? | Because it has an additive effect with with these agents
🗑
|
||||
| What muscle comprises the upper esophageal sphincter? | Cricopharyngeus
🗑
|
||||
| True or false: chewing is essential for digestion? | False; it just increases the surface area of the food.
🗑
|
||||
| In which region of the stomach are parietal and chief cells located? | Body or corpus
🗑
|
||||
| What hormone, released in response to low pH, inhibits gastric emptying by decreasing antral contractions, increases constriction of the pyloric sphincter, and also increases bicarbonate secretions from the pancreas? | Secretin
🗑
|
||||
| In which region of the stomach are G cells located? | Antrum (They secrete gastrin: G for gastrin.)
🗑
|
||||
| How long is the transit time through the large intestine? | 3 to 4 days
🗑
|
||||
| How long is the transit time through the small intestine? | 2 to 4 hours
🗑
|
||||
| What hormone causes contractions of smooth muscle, regulates interdigestive motility, and prepares the intestine for the next meal? | Motilin
🗑
|
||||
| What is the main function of HCl in the stomach? | Converts pepsinogen into pepsin
🗑
|
||||
| What hormone increases the intestinal secretions of electrolytes and H2O, relaxes smooth muscle, dilates peripheral blood vessels, and inhibits gastric secretions? | Vasoactive intestinal peptide (VIP)
🗑
|
||||
| What gland produces 20% of salivary secretions and contributes to almost all of the amylase secretions? | Parotid gland (serous secretions)
🗑
|
||||
| What hormone causes contractions of the gallbladder, augments the action of secretin to produce an alkaline pancreatic juice, inhibits gastric emptying, and increases constriction of the pyloric sphincter? | Cholecystoldnin (CCK)
🗑
|
||||
| What are the four functions of saliva? | 1. Provides antibacterial action 2. Lubricates 3. Begins carbohydrate digestion 4. Begins fat digestion
🗑
|
||||
| What is composed of skeletal muscle, innervated by the pudendal nerve, and in a voluntary constant state of contraction that relaxes for defecation? | External anal sphincter
🗑
|
||||
| What hormone is stimulated by glucose and fat in the duodenum, inhibits gastric secretions and motility, and stimulates insulin secretion? | Gastrin inhibitory peptide (GIP)
🗑
|
||||
| Which portion of the autonomic nervous system regulates salivary flow? | Parasympathetic portion
🗑
|
||||
| A pH of less than 4.5 stimulates the release of what hormone? | Secretin (It inhibits acid Secretion.)
🗑
|
||||
| What is composed of smooth muscle, innervated by pelvic splanchnics and hypogastric nerves, and involuntary? | Internal anal sphincter
🗑
|
||||
| What gland produces 70% of total salivary secretions? | Submandibular gland (produces both mucous and serous secretions)
🗑
|
||||
| What is the tonicity of pancreatic juice? | Isotonic
🗑
|
||||
| What organism is associated with gastric ulcers? | Helicobacter pylori
🗑
|
||||
| What is the only gastric secretion required to sustain life? | Intrinsic factor (IF)
🗑
|
||||
| What three structures increase the surface area of the GI tract? | 1. Plicae circularis 2. Villi 3. Microvilli
🗑
|
||||
| What hormone is the primary regulator of HCO3 secretion from the pancreas? | Secretin
🗑
|
||||
| What cells of the GI tract secrete mucus? | Goblet cells
🗑
|
||||
| What are the five F's associated with gallstones? | 1. Fat 2. Forty 3. Female 4. Familial 5. Fertile
🗑
|
||||
| Lactose intolerance is caused by a lack of what enzyme? | Lactase
🗑
|
||||
| What are the three end products of amylase digestion? | 1. Maltose 2. Maltotetrose 3. Alpha limit dextrans (a-1,6 binding)
🗑
|
||||
| What percentage of bile acids are excreted daily? | 5% (95% reabsorbed via enterohepatic circulation)
🗑
|
||||
| Which glands of the upper duodenum secrete a bicarbonaterich solution? | Brunner's glands
🗑
|
||||
| What is the major route for excretion of cholesterol? | Bile
🗑
|
||||
| What hormone potentiates the effect of secretin? | CCK
🗑
|
||||
| What is the major phospholipid in bile? | Lecithin
🗑
|
||||
| What is the rate-limiting step in the formation of bile acids? | 7-a-Hydroxylase
🗑
|
||||
| What two amino acids are conjugated to bile acids to increase H2O solubility? | 1. Glycine 2. Taurine
🗑
|
||||
| What is absorbed in the gallbladder to concentrate bile? | Water
🗑
|
||||
| If a substance is removed from circulation by an organ, is its arteriovenous (AV) difference positive or negative? | Positive AV difference
🗑
|
||||
| In laminar flow, which area has the fastest flow? | The center of the tube
🗑
|
||||
| What are four ways to get an increased pump function of the heart? | 1. Exercise 2. Increase heart rate 3. Increase in arterial pressure 4. Increase contractility
🗑
|
||||
| What system has an increased pressure, decreased resistance, increased flow, increased compliance, and blood volume that is proportional to flow? | Pulmonary circuit
🗑
|
||||
| What two organs have local metabolites as the main determinant of blood flow? | 1. Brain (cerebral circulation) 2. GI tract (after a meal) All other organs are under neural control.
🗑
|
||||
| What are the three sympathetic effects on the pacemaker cells of the heart? | 1. Increase the slope of prepotential 2. Take less time to reach threshold 3. Increase the rate of firing
🗑
|
||||
| What are the three parasympathetic effects on the pacemaker cells of the heart? | 1. Hyperpolarize the cells by increasing K+ conductance 2. Take longer to reach threshold 3. Decrease the rate of firing
🗑
|
||||
| What are the two major causes of arterial pressure? | 1. Contraction of the heart 2. Hydrostatic pressure
🗑
|
||||
| What causes an increase in cardiac performance with no increase in preload? | Contractility (inotropic)
🗑
|
||||
| Change in what intracellular ion causes a change in contractility? | Calcium
🗑
|
||||
| What are the two main circulations with extrinsic regulation that are most affected by nervous reflexes? | 1. Cutaneous circulation 2. Resting skeletal muscle
🗑
|
||||
| What is the third heart sound caused by? | Ventricular filling (heard during diastole)
🗑
|
||||
| What is the fourth heart sound caused by? | Atria] contraction (heard during diastole)
🗑
|
||||
| If a substance is put into circulation by an organ, is its arteriovenous difference positive or negative? | Negative
🗑
|
||||
| What is the baroreceptor response to an increase in blood pressure? | Increase afferent activity of CN IX and CN X to decrease heart rate (parasympathetic)
🗑
|
||||
| What is a perfusionlimited situation? | When alveolar and capillary blood equilibrate for a substance
🗑
|
||||
| Which region of the lungs has a low perfusion pressure and a high resistance so that there is little blood flow? | Apex
🗑
|
||||
| What fluid is monitored directly by central chemoreceptors? | Cerebrospinal fluid (H+;CO2)
🗑
|
||||
| On a pressure-volume loop, what is seen with: Aortic regurgitation? | Increase in stroke volume
🗑
|
||||
| On a pressure-volume loop, what is seen with:Aortic stenosis? | Increase in afterload, decrease in stroke volume, increase in peak tension
🗑
|
||||
| On a pressure-volume loop, what is seen with:Increased contractility? | Increase in stroke volume by decreasing the end-systolic volume
🗑
|
||||
| On a pressure-volume loop, what is seen with:Heart failure? | Increase in end-systolic volume, decrease in afterload, decrease in peak tension, increase in peak tension
🗑
|
||||
| What two compensatory mechanisms occur to reverse hypoxia at high altitudes? | 1. Increase in erythropoietin 2. Increase in 2,3-bisphosphoglycerate (2,3-BPG)
🗑
|
||||
| What would you give to neutralize the excess base in an alkalotic patient? | NH4Cl(strong acid can lyse RBCs)
🗑
|
||||
| What would you give to neutralize the excess acid in an acidotic patient? | NaCO2 (CO2 eliminated by lungs)
🗑
|
||||
| What is a diffusion-limited situation? | When alveolar gas and capillary blood attempt to equilibrate but do NOT (i.e., CO2)
🗑
|
||||
| What must occur in order for PaCO2 to remain constant when there is an increase in the body's metabolism? | Need to increase alveolar ventilation (if not hypercapnia would result)
🗑
|
||||
| What enzyme is needed for conversion of testosterone to estradiol? | Aromatase
🗑
|
||||
| What two anions compete with iodine for the iodine pump in the thyroid gland? | 1. Perchlorate 2. Thiocyanate
🗑
|
||||
| What enzyme is associated with osteoblastic activity? | Alkaline phosphatase
🗑
|
||||
| What form of plasma calcium is the physiologically active form and is regulated within narrow limits? | Free calcium (ionized)
🗑
|
||||
| Which three factors cause the release of epinephrine from the adrenal medulla? | 1. Exercise 2. Emergencies (stress) 3. Exposure to cold (The three Es)
🗑
|
||||
| What phase of the female cycle ALWAYS lasts for the same number of days (14 days in most women)? | Luteal phase
🗑
|
||||
| What serves as a marker for 24-hour growth hormone secretion? | Plasma insulin-like growth factor type 1 (IGF-1) levels
🗑
|
||||
| What three things inhibit the secretion of glucagon? | 1. Insulin 2. Somatostatin 3. Hyperglycemia
🗑
|
||||
| Which three organs or structures have gluconeogenic capabilities? | 1. Liver 2. Kidney 3. GI epithelium
🗑
|
||||
| Which type of diabetes is more likely to lead to ketoacidosis? | Type I (insulin-dependent diabetes mellitus [IDDM])
🗑
|
||||
| Excess bone demineralization and remodeling can be detected by checking urine levels of what substance? | Hydroxyproline (breakdown product of collagen)
🗑
|
||||
| What two things cause l-a-hydroxylase activity to increase? | 1. Parathyroid hormone (PTH) 2. A decrease in PO4 levels
🗑
|
||||
| What type of membrane is permeable to water and small solutes? | Selectively permeable membrane
🗑
|
||||
| What is the movement of ions in an electrical held known as? | Conductance
🗑
|
||||
| What two components of a body of water cannot be measured and need to be calculated? | 1. Intracellular fluid (ICF) (water minus extracellular fluid) 2. Interstitial fluid (ISF) (extracellular fluid minus plasma volume)
🗑
|
||||
| What phase of an action potential has the greatest rate of Na+ influx? | Phase 0
🗑
|
||||
| Which phase of an action potential requires energy? | Phase 4 (via the Na+/K+ pump)
🗑
|
||||
| What type of muscle is associated with one T tubule and two cisternae (triad)? | Skeletal muscle
🗑
|
||||
| What is the region of an axon where no myelin is found? | Nodes of Ranvier
🗑
|
||||
| What types) of muscle contain the thin filament troponin? | Skeletal and cardiac muscle
🗑
|
||||
| Where are antidiuretic hormone (ADH) and oxytocin produced? | The supraoptic and paraventricular nuclei of the hypothalamus
🗑
|
||||
| What is the only hormone to INCREASE with a DECREASE in pituitary function? | Prolactin
🗑
|
||||
| Which enzyme converts cholesterol to pregnenolone? | Desmolase-rate limiting step (RLS) in steroid hormone synthesis
🗑
|
||||
| What are the four "stress" hormones? | 1. Growth hormone (GH) 2. Glucagon 3. Cortisol 4. Epinephrine
🗑
|
||||
| Proopiomelanocortin (POMC) is cleaved into what two substances? | 1. Adrenocorticotrophic hormone (ACTH) 2. (alpha)-Lipotropins (melanotropins and endorphins)
🗑
|
||||
| What are the six substances that promote the secretion of insulin? | 1. Glucose 2. Amino acid (arginine) 3. Gastrin inhibitory peptide (GIP) 4. Glucagon 5. Alpha-Agonists 6. ACh
🗑
|
||||
| What is the thin filament that has the attachment site for the crossbridges and also activates adenosine triphosphatase (ATPase)? | Actin
🗑
|
||||
| What types of muscle have a sarcomere? | Skeletal and cardiac muscle
🗑
|
||||
| Where is the action potential generated on a neuron? | Axon hillock
🗑
|
||||
| What is the name for the load that the muscle is working against during stimulation? | Afterload
🗑
|
||||
| What type of contraction has an active tension when the length is shortened? | Isotonic contraction
🗑
|
||||
| What type of muscle has high creatinine phosphokinase (CPK), high ATPase activity, and no myoglobin; is anaerobic; and is for short-term use? | White muscle (fast)
🗑
|
||||
| What type of muscle uses calmodulin? | Smooth muscle
🗑
|
||||
| What thick filament has crossbridges and ATPase activity? | Myosin
🗑
|
||||
| What causes actin-myosin crossbridge dissociation? | Binding of ATP
🗑
|
||||
| What is used as an index of cortisol secretions? | Urine 17-OH steroids
🗑
|
||||
| What would be the two major consequences if the zona fasciculata and the zona reticularis were removed? | 1. Circulatory failure 2. Inability to mobilize energy stores
🗑
|
||||
| How many carbons do androgens have? | Androgens are 19-carbon steroids.
🗑
|
||||
| How many carbons do estrogens have? | Estrogens are 18-carbon steroids. (Removal of one carbon from an androgen = an estrogen.)
🗑
|
||||
| The level of what hormone tends to DECREASE with stress? | Insulin
🗑
|
||||
| On what two occasions are cortisol releasing hormone (CRH) secretions elevated? | 1. Early morning 2. During stress
🗑
|
||||
| What is an inhibitory interneuron known as? | Renshaw neuron
🗑
|
||||
| What is the summation of mechanical stimuli known as? | Tetany
🗑
|
||||
| What is the thin filament that binds to calcium? | Troponin C
🗑
|
||||
| What determines the maximum velocity of shortening muscle? | The muscle's ATPase activity
🗑
|
||||
| What type of muscle has end plates? | Skeletal muscle
🗑
|
||||
| What type of contraction has an active tension, but the overall length of the con traction does not change and no work is done? | Isometric contraction
🗑
|
||||
| What thin filament covers the attachment site in resting muscle so that the crossbridges are unavailable for binding? | Tropomyosin
🗑
|
||||
| What is the load on a muscle in the relaxed state known as? | Preload
🗑
|
||||
| Total tension - preload = what? | Active tension (contraction)
🗑
|
||||
| What types of muscle are uninuclear? | Cardiac and smooth muscle
🗑
|
||||
| In a contractile muscle, what is the source of the calcium? | Sarcoplasmic reticulum (The source is NOT extracellular.)
🗑
|
||||
| What is the maximum force of a contraction determined by? | The number of motor units activated during the contraction
🗑
|
||||
| What types) of muscle have T tubules associated with them? | Cardiac and skeletal muscle
🗑
|
||||
| What type of muscle has myoglobin, low CPK, and low ATPase activity; is aerobic; and is for long-term use? | Red muscle (slow-twitch muscle)
🗑
|
||||
| What event signifies the first day of the menstrual cycle? | The first day of bleeding
🗑
|
||||
| What hormone is essential for induction of ovulation and formation of the corpus luteum? | Luteinizing hormone (LH)
🗑
|
||||
| How many days before the first day of bleeding is ovulation? | 14 days in most women (Remember: The luteal phase is always constant.)
🗑
|
||||
| What is required to maintain lactation? | Suckling (stimulates oxytocin secretion)
🗑
|
||||
| What hormone, in high levels, blocks milk production? | Estrogen
🗑
|
||||
| What hormone is necessary for maintenance of the corpus luteum for the first 3 months of pregnancy? | Human chorionic gonadotropin (hCG)- from the trophoblast
🗑
|
||||
| Up to how many hours after ejaculation are sperm able to fertilize the egg? | 72 hours
🗑
|
||||
| What hormone induces myometrial contraction and causes milk letdown? | Oxytocin
🗑
|
||||
| What hormone is necessary for the maintenance of the uterine endometrium from the fourth month of pregnancy on? | Progesterone (Estrogen is needed for progesterone to be effective.)
🗑
|
||||
| How long after ovulation does fertilization occur? | 8 to 25 hours
🗑
|
||||
| What hormone thins cervical mucus, stimulates LH receptors on granulosa cells, elicits the LH surge, and increases proliferation of the uterine mucosal layers? | Estradiol
🗑
|
||||
| What hormone is secreted by the placenta late in pregnancy, stimulates mammary growth during pregnancy, mobilizes energy stores from the mother so that the fetus can utilize them, and has an amino acid sequence like GH? | Human chorionic somatomanunotropin (hCS) or human placental lactogen (hPL)
🗑
|
||||
| What hormone causes an increase in the production of milk? | Prolactin
🗑
|
||||
| What is the force necessary to collapse the lung known as? | Lung recoil
🗑
|
||||
| For what hormone do Leydig cells have receptors? | LH
🗑
|
||||
| What vitamin needs thyroid hormone for conversion to its active form? | Vitamin A
🗑
|
||||
| What is the tonicity of fluid that leaves the loop of Henle? | Hypotonic
🗑
|
||||
| What enzyme converts androgens to estrogens? | Aromatase
🗑
|
||||
| What does excess production of thyroid-stimulating hormone (TSH) cause? | A goiter
🗑
|
||||
| What type of cell reabsorbs bone? | Osteoclast; Blasts make; clasts take.
🗑
|
||||
| What is the major form of androgen secreted from the adrenal gland? | Dehydroepiandrosterone (DHEA)
🗑
|
||||
| What cells of the genitourinary system produce testosterone in males? | Leydig cells
🗑
|
||||
| What type of urine does ADH cause to be excreted? | Hypertonic urine (because of the water reabsorption in the collecting duct)
🗑
|
||||
| What is the term for the volume of plasma removed from a substance per unit time? | Clearance
🗑
|
||||
| What is the most potent male sex steroid? | Dihydrotestosterone - DHT
🗑
|
||||
| What two substances stimulate Sertoli cells? | Follicle stimulating hormone (FSH) and testosterone At which three sites in the body is T4 converted to T3?
🗑
|
||||
| 1. Liver 2. Kidney 3. Pituitary gland (via 5'-deiodinase enzyme) The fresh air being delivered to the respiratory zone per minute is known as what? | Alveolar ventilation (the first 150 ml is not included)
🗑
|
||||
| What region of the lungs gets very little ventilation? | Apex
🗑
|
||||
| Where does polyuric originate if the patient is dehydrated and has electrolyte deficiencies? | Before the collecting duct (There is no electrolyte disturbance in the collecting duct.)
🗑
|
||||
| What substance is free filtered but partially reabsorbed by passive mechanisms? | Urea
🗑
|
||||
| What hormone promotes mobilization of energy stores, enhances the capacity of glucagon and catecholamines, and increases the capacity to withstand stress? | Cortisol
🗑
|
||||
| What is used as an index of androgen secretion? | Urine 17-ketosteroids
🗑
|
||||
| What are the pituitary hormones associated with: Thyrotropin releasing hormone (TRH)? | Thyroid stimulating hormone (TSH)
🗑
|
||||
| What are the pituitary hormones associated with: Cortisol releasing hormone (CRH)? | Adrenocorticotrophic hormone (ACTH)
🗑
|
||||
| What are the pituitary hormones associated with: Gonadotropin releasing hormone (GnRH)? | Luteinizing hormone (LH) and follicle stimulating hormone (FSH)
🗑
|
||||
| What are the pituitary hormones associated with: Growth hormone releasing hormone (GHRH)? | Growth hormone (GH)
🗑
|
||||
| What are the pituitary hormones associated with: Somatostatin? | Inhibits GH secretion
🗑
|
||||
| What are the pituitary hormones associated with: Prolactin inhibiting factor (PIF) [dopamine]? | Inhibits prolactin secretion
🗑
|
||||
| Which hormones are released from the: Zona glomerulosa? | Aldosterone (salt)
🗑
|
||||
| Which hormones are released from the: Zona fasciculata? | Cortisol (sugar)
🗑
|
||||
| Which hormones are released from the: Zona reticularis? | Androgens (sex)
🗑
|
||||
| Which hormones are released from the: Medulla? | NE:Epi (1:4) If the zona glomerulosa were removed from the adrenal gland, what would be seen?
🗑
|
||||
| Decrease in Na+ causing a decrease in the ECF volume, leading to a decrease in BP, and eventually to circulatory shock and death | What does subatmospheric pressure (negative) do to the lungs?
🗑
|
||||
| It causes them to expand (because of the decrease in intrathoracic pressure) Where is the last conducting zone of the lungs? | Terminal bronchioles (No gas exchange occurs here.) Where is there summation, hyperpolarization of the postsynaptic membrane, an increase in Cl- conductance, and local gradation?
🗑
|
||||
| Inhibitory postsynaptic potential (IPSP) | Which extravascular chemoreceptor detects low NaCI concentrations?
🗑
|
||||
| Macula densa | What is the major stimulus for cell division in chondroblasts?
🗑
|
||||
| Insulin-like growth factor-1 (IGF-1) The total air in and out of the respiratory system per minute is known as what? | The total ventilation (minute volume or minute ventilation)
🗑
|
||||
| What is the major hormone secreted by the ovarian follicle? | 17 alpha-Estradiol
🗑
|
||||
| What two conditions cause ADH to be released? | 1. Low blood volume 2. Elevated plasma volume (high solute concentration)
🗑
|
||||
| What cell converts androgens to estrogens? | Granulosa cell
🗑
|
||||
| What hormone acts on this cell? | FSH
🗑
|
||||
| What three lung volumes cannot be measured with a spirometer? | 1. Residual volume 2. Total lung capacity 3. Functional residual capacity
🗑
|
||||
| What two conditions decrease the secretion of aldosterone? | 1. An increase in blood pressure 2. Weightlessness
🗑
|
||||
| What cell in the female genitourinary system is stimulated by LH and is the site where androgens are produced? | Thecal cell
🗑
|
||||
| What serves as a marker of endogenous insulin secretions? | C peptide
🗑
|
||||
| What do you have when there is depolarization of the postsynaptic membrane owing to an influx of Na+, resulting in summation and local gradation? | Excitatory postsynaptic potential (EPSP)
🗑
|
||||
| What are days 15 to 28 in the female cycle known as? | Luteal phase
🗑
|
||||
| What hormone is secreted by the Sertoli cells to decrease FSH production? | Inhibin
🗑
|
||||
| What hormone regulates osmolarity because it controls water excretion? | ADH (It causes water reabsorption.)
🗑
|
||||
| What is the term for the air in the system after maximal inspiration? | Total lung capacity (TLC)
🗑
|
||||
| What is a sign of a Sertoli cell tumor in a man? | Excess estradiol in the blood
🗑
|
||||
| What hormone is responsible for the negative feedback onto LH and FSH of the anterior pituitary and positive feedback onto the granulosa cells? | Estrogen
🗑
|
||||
| What is the term for the total dead space of the lungs? | Physiologic dead space The surge of what hormone induces ovulation?
🗑
|
||||
| LH | What does positive pressure do to the lungs?
🗑
|
||||
| It collapses them. | What is the term for the air that can be taken in after normal inspiration?
🗑
|
||||
| Inspiratory reserve volume (IRV) | What is the first zone of the lungs that is capable of O2 exchange?
🗑
|
||||
| Respiratory bronchioles (because they have alveoli) | What is the term for ventilation of underperfused alveoli?
🗑
|
||||
| Alveolar dead space | What is the temperature of the scrotum?
🗑
|
||||
| 4 degrees cooler than the body How is the lower temperature of the testes maintained? | By a countercurrent heat exchanger in the spermatic cord
🗑
|
||||
| What happens to sex steroids, LH, and FSH: If the gonads are removed? | Sex steroids decrease; LH increases; FSH increases.
🗑
|
||||
| What happens to sex steroids, LH, and FSH: In postmenopausal women? | Sex steroids decrease; LH increases; FSH increases.
🗑
|
||||
| What happens to sex steroids, LH, and FSH: After the administration of testosterone? | Sex steroids increase; LH decreases; nothing happens to FSH.
🗑
|
||||
| What happens to sex steroids, LH, and FSH: After the administration of inhibin? | Nothing happens to sex steroids; nothing happens to LH; FSH decreases.
🗑
|
||||
| What happens to sex steroids, LH, and FSH: With constant infusion of GnRH? | Sex steroids decrease; LH decreases; FSH decreases (needs to be given pulsatile).
🗑
|
||||
| What region of the lungs is incapable of gas exchange? | Anatomic dead space
🗑
|
||||
| What is the term for the amount of air that can never leave the lungs? | Residual volume
🗑
|
||||
| If you increase the depth of breathing, what ventilatory parameters can be increased? | Total ventilation and alveolar ventilation
🗑
|
||||
| If you increase the rate of breathing, what ventilatory parameters can be increased? | Total ventilation
🗑
|
||||
| What is the term for the air left in the lungs after normal expiration? | Functional residual capacity (FRC)
🗑
|
||||
| The lung volume from maximum inspiration to maximum expiration is known as what? | Vital capacity (VC)
🗑
|
||||
| Where is renin produced? | In the juxtaglomerular ( JG) cells of the kidney
🗑
|
||||
| What phase of the female cycle occurs during days 1 to 15? | Follicular phase
🗑
|
||||
| What hormone level peaks 1 day before the surge of LH and FSH in the female cycle? | Estradiol
🗑
|
||||
| What is the day after the LH surge in the female cycle known as? | Ovulation
🗑
|
||||
| By what mechanism does chronic constriction keep blood flow through the penis low during non-aroused states? | Alpha-Adrenergic mediated constriction
🗑
|
||||
| Days 1 to 7 of the female cycle are known as what? | Menses
🗑
|
||||
| The amount of air that enters or leaves the respiratory system in a single respiratory cycle is known as what? | Tidal volume
🗑
|
||||
| What part of the autonomic nervous system is responsible for the movement of semen through the vas deferens and related structures? | Sympathetic nervous system
🗑
|
||||
| Which pancreatic cells secrete glucagon? | Alpha cells
🗑
|
||||
| Which pancreatic cells secrete somatostatin? | Delta cells
🗑
|
||||
| What term describes how easily a vessel stretches? | Compliance (pulse pressure is inversely proportional to compliance)
🗑
|
||||
| What is the most compliant artery in the body? | Aorta
🗑
|
||||
| What is the best way to regulate mean arterial pressure? | Via total peripheral resistance (TPR)
🗑
|
||||
| What is the term for resistance to ventricular outflow? | Afterload
🗑
|
||||
| What is the main determinant of resistance? | The radius of the vessel (also the viscosity and length)
🗑
|
||||
| What is the relationship between Na+ reabsorption and O2 consumption? | An increase in Na+ causes Oz consumption to increase.
🗑
|
||||
| What vessels have the greatest cross-sectional area? | Capillaries
🗑
|
||||
| What is the nontitratable acid that buffers secreted H+ in the kidney buffered as? | NH4+ (ammonium). H2PO4 (dihydrogen phosphate) is the titratable acid that buffers secreted H+.
🗑
|
||||
| What are the five ways to promote turbulent flow? | 1. Increase velocity 2. Branching 3. Narrow orifice 4. Increase tube diameter 5. Decrease viscosity
🗑
|
||||
| What part of the cardiovascular system has the lowest drop in pressure? | Right atrium
🗑
|
||||
| What vessels are the resistance vessels and have the largest drop in pressure? | Arterioles
🗑
|
||||
| What part of the autonomic nervous system is the main controller of blood flow when a person is at rest? | Sympathetic nervous system (alpha constricts, beta-2 dialates.
🗑
|
||||
| What process occurs when hydrostatic pressure exceeds plasma oncotic pressure? | Filtration
🗑
|
||||
| What vessels have the greatest blood volume? | Systemic veins of the lower extremities
🗑
|
||||
| What vessels have the smallest total cross-sectional area? | The aorta, then the vena cava
🗑
|
||||
| What is the only way to increase O2 delivery to the myocardium? | Increase the blood flow
🗑
|
||||
| What happens to airway resistance during inspiration? | It decreases. Sympathetics decrease resistance; parasympathetics increase resistance.
🗑
|
||||
| What is the main drive for ventilation? | The PCO2 of systemic circulation
🗑
|
||||
| Where does depolarization in the heart begin? | From the apex to the base and from the endocardium to the epicardium
🗑
|
||||
| Where is the greatest venous PO2 in resting tissue? | Renal circulation
🗑
|
||||
| The load on the muscle in the relaxed state is known as what? | Preload (also the end-diastolic volume [EDV])
🗑
|
||||
| What cells of the heart have the highest rate of automaticity? | Sinoatrial (SA) nodal cells
🗑
|
||||
| What are the slowest conducting cells of the heart? | Atrioventricular (AV) nodal cells
🗑
|
||||
| What is the main control of flow in exercising muscle? | Vasodilator metabolites
🗑
|
||||
| During what phase of the cardiac cycle do coronary vessels receive their blood flow? | Diastole
🗑
|
||||
| On the venous pressure curve, what do the following waves represent -a wave, -c wave, -v wave? | Atrial contraction, Ventricular contraction, Atrial filling (venous filling) Atrial contraction, Venous
🗑
|
||||
| What causes the second heart sound? | Aortic closure
🗑
|
||||
| Where is the second heart sound on an EKG? | At the T wave
🗑
|
||||
| What causes the diastolic interval to decrease? | Increase in the heart rate
🗑
|
||||
| What happens to cerebral circulation during hypoventilation? | Blood flow increases because PCO2 is increased. (The opposite occurs during hyperventilation.)
🗑
|
||||
| What is the main factor affecting PaCO2? | Alveolar ventilation (Hyperventilation decreases PaCO2 and vice versa. Body metabolism also affects PaCO2')
🗑
|
||||
| What are the normal values for: PaO2? | 100 mmHg
🗑
|
||||
| What are the normal values for: PaCO2? | 40 mmHg
🗑
|
||||
| What are the normal values for: PvO2? | 40 mmHg
🗑
|
||||
| What are the normal values for: PvCO2? | 47 mmHg
🗑
|
||||
| What are the two ways to increase stroke volume? | 1. Increase preload (EDV) 2. Decrease end-systolic volume (ESV)
🗑
|
||||
| What is the main factor that determines the glomerular filtration rate (GFR)? | Hydrostatic pressure
🗑
|
||||
| What is the normal value for the GFR? | 120 ml/min
🗑
|
||||
| What happens to pulmonary blood flow under conditions of low alveolar PO2? | A decrease in blood flow secondary to vasoconstriction
🗑
|
||||
| What is the normal compensatory mechanism for a state of metabolic alkalosis? | Hypoventilation (respiratory acidosis)
🗑
|
||||
| What anion is excreted in large amounts in the urine in a patient with a compensated alkalosis? | Bicarbonate (alkaline urine)
🗑
|
||||
| Which hormone affects the osmolarity? | ADH
🗑
|
||||
| What are the sympathetic effects on the kidney? | A decrease in GFR and an increase in filtration fraction: FF = GFR/RPF. (There is a larger decrease in the RPF than the GFR, resulting in an increase in the filtration fraction.)
🗑
|
||||
| What are the effects of angiotensin II on the kidney? | Constriction of the efferent arterioles
🗑
|
||||
| What four changes occur with an increase in contractility? | 1. Increased slope of action potential 2. Increased peak left ventricular pressure 3. Increased rate of relaxation 4. Decreased systolic interval
🗑
|
||||
| What fibers of the heart have the lowest intrinsic rate of automaticity? | Purkinje fibers
🗑
|
||||
| What causes the first heart sound, and when does it occur on an EKG? | Mitral valve closure at the QRS complex
🗑
|
||||
| What is the main determining factor of filtration fraction? | Renal plasma flow (decreases flow; increases filtration fraction)
🗑
|
||||
| What is the normal osmolarity of the filtrate in the renal tubule? | 300 mOsm
🗑
|
||||
| What prohibits the filtering of protein anions into the renal tubule? | The negative charge on the filtration membrane
🗑
|
||||
| What are the fastest conducting fibers in the heart? | Purkinje fibers
🗑
|
||||
| From which point to which point does repolarization travel in the heart? | From the base to the apex and from the epicardium to the endocardium (opposite of depolarization)
🗑
|
||||
| What are the three characteristics of autoregulation? | 1. Flow independent of BP 2. Flow proportional to local metabolism 3. Flow independent of nervous reflexes
🗑
|
||||
| What is/are the major autoregulators of: Cerebral circulation? | Increase in PCO2
🗑
|
||||
| What is/are the major autoregulators of: Coronary circulation? | Decrease in PO2; increase in PCO2 and adenosine
🗑
|
||||
| What is/are the major autoregulators of: Exercising skeletal muscle? | Lactate
🗑
|
||||
| What process occurs if the capillary oncotic pressure is greater than the hydrostatic pressure? | Reabsorption
🗑
|
||||
| What area of the circulatory system houses the greatest blood velocity? | Aorta
🗑
|
||||
| What two things happen to cutaneous circulation when the sympathetic nervous system is stimulated? | 1. Constriction of arterioles to decrease blood flow 2. Constriction of the venous plexus to decrease the blood volume
🗑
|
||||
| Adenosine in the kidney, decreased PO2 in the lungs, and thromboxane A2 (TXA2) have what effect in the circulation? | Vasoconstriction
🗑
|
||||
| What is the period when higher than normal stimulation is required to induce a second action potential? | Relative refractory period
🗑
|
||||
| During an action potential, what is the stimulus for opening the Na+ channels? | Depolarization
🗑
|
||||
| What substance "affects" the action potential? | Na+ conductance
🗑
|
||||
| What substance "affects" the resting membrane potential? | K+ conductance
🗑
|
||||
| In which direction do osmotically active substances cause water to move? | Toward them
🗑
|
||||
| What are the three tracers for total body water? | 1. Urea 2. Thiourea 3. Titrated water
🗑
|
||||
| What are the three characteristics of an action potential? | 1. All or none 2. Propagated 3. No summation
🗑
|
||||
| In what system is the second greatest blood volume found? | Pulmonary system
🗑
|
||||
| What are the four ways to increase total peripheral resistance (TPR)? | 1. Decrease the radius 2. Increase the viscosity 3. Increase the length 4. Decrease the number of parallel channels
🗑
|
||||
| What type of system is a high resistance system with flow equal at all points and where total resistance is the SUM of the individual resistances? | Vessels connected in a series
🗑
|
||||
| What effect on a blood vessel does each of the following have: histamine, bradykinin, prostaglandins (A2, E2, I2), nitric oxide, adenosine, an increase in K+, H+, PCO2 and a decrease in PO2? | Vasodilatory effect
🗑
|
||||
| What are three characteristics of a subthreshold potential? | 1. Graded 2. Summation 3. Not propagated
🗑
|
||||
| What is the depolarization phase of an action potential caused by? | Na+ influx
🗑
|
||||
| If the ventilation-perfusion ratio is less than 1, what part of the lung is involved and what physiologic process is occurring? | The base, because flow exceeds delivery of O2
🗑
|
||||
| How do you compensate for metabolic acidosis? | Hyperventilate (respiratory alkalosis)
🗑
|
||||
| How many liters of water are there in: Total body water? | 42 L
🗑
|
||||
| How many liters of water are there in: ICF? | 28 L
🗑
|
||||
| How many liters of water are there in: ECF? | 14 L
🗑
|
||||
| How many liters of water are there in: ISF? | 10.5 L
🗑
|
||||
| How many liters of water are there in: Plasma volume? | 3.5 L
🗑
|
||||
| What hormone affects fluid volume? | Aldosterone (Na+ content determines the volume of the plasma.)
🗑
|
||||
| The repolarization phase of the action potential is caused by what? | K+ efflux (depolarization opens the gates)
🗑
|
||||
| What is the name of the period in which, no matter how strong the stimulus, a second action potential cannot be generated? | Absolute refractory period
🗑
|
||||
| What hormone is necessary to maintain normal thyroid hormone levels? | GH
🗑
|
||||
| What region of the lung has the greatest blood flow? | The base
🗑
|
||||
| During inspiration, which region of the lung receives the greatest level of ventilation: the apex or the base? | The base
🗑
|
||||
| What is the function of the stretch receptors in the lungs? | To prevent overdistention of the lungs (inhibits inspiration)
🗑
|
||||
| Where does the inherent rhythm for respiration originate? | In the medullary center of the medullary oblongata
🗑
|
||||
| Where is the deep breathing center located? | Apneustic center in the pons
🗑
|
||||
| What type of system is a low-resistance system in which the total resistance is always less than any individual resistance, and the reciprocal of the total resistance is the sum of the reciprocal resistances? | System connected in parallel
🗑
|
||||
| What is happening to the renal arteriole in each of the following situations: Increased GFR, increased glomerular pressure, decreased RPF, increased FF? | Constriction of efferent arteriole
🗑
|
||||
| What is happening to the renal arteriole in each of the following situations: Decreased GFR, increased RPF, decreased glomerular pressure, decreased FF? | Dilatation of the efferent arteriole
🗑
|
||||
| What is happening to the renal arteriole in each of the following situations: Decreased GFR, decreased RPF, decreased glomerular pressure? | Constriction of the afferent arteriole
🗑
|
||||
| What is happening to the renal arteriole in each of the following situations: Increased GFR, increased RPF, increased glomerular pressure? | Dilatation of the afferent arteriole
🗑
|
||||
| Which region in the lungs gives the best ventilation - perfusion ratio? | The hilum
🗑
|
||||
| What causes peripheral chemoreceptors to be stimulated? | A decrease in die arterial PO2, H+, and PCO2 of the normal drive for ventilation)
🗑
|
||||
| What is secreted by the parafollicular C cells of the thyroid? | Calcitonin
🗑
|
||||
| What is the titrated acid that the secreted H+ is buffered as? | H2PO4
🗑
|
||||
| What type of dehydration is associated with hemorrhage, burns, vomiting, and diarrhea? | Isotonic dehydration
🗑
|
||||
| What is the potential at which concentrations are equal and opposite to the electrical forces, and also at which there is no net flux of ions across the membrane? | Equilibrium potential (Nernst's equation)
🗑
|
||||
| What hydration state is caused by the ingestion of salt water? | Hypertonic overhydration
🗑
|
||||
| What is the free water clearance if the osmolarity of urine is greater than 300 mOsm? | Negative free water clearance (concentrated urine)
🗑
|
||||
| What is the term for the process of water traveling from a low solute to a high solute concentration? | Osmosis
🗑
|
||||
| What three factors increase simple diffusion? | 1. Increased solubility 2. Increased concentration gradient 3. Decreased thickness of the membrane
🗑
|
||||
| What type of dehydration is associated with Addison's disease? | Hypotonic dehydration
🗑
|
||||
| When is GH released? | At night and during puberty
🗑
|
||||
| What is protein-mediated transportation down a concentration gradient known as? | Facilitated transport
🗑
|
||||
| What determines the level of alveolar ventilation? | Central chemoreceptors (PCO2)
🗑
|
||||
| Which point in the lungs is involved if the ventilation - perfusion ratio is greater than 1? | Apex
🗑
|
||||
| Why is the V-P ratio in the apex of the lung greater than 1? | Delivery exceeds the flow
🗑
|
||||
| How is CO2 carried in the blood? | As plasma bicarbonate
🗑
|
||||
| To what hydrated state can excess ingestion of water or syndrome of inappropriate antidiuretic hormone (SIADH) lead? | Hypotonic overhydration
🗑
|
||||
| What are the four major anabolic hormones? | 1. Insulin 2. Thyroid hormone 3. GH 4. Sex steroids
🗑
|
||||
| What are the eight insulin INdependent tissues? | 1. CNS 2. RBCs 3. Renal tubules 4. Testis 5. Teeth 6. ß cells 7. Liver 8. Intestinal epithelium
🗑
|
||||
| What are the growth factors released from the liver called? | Somatomedins
🗑
|
||||
| What state of hydration would you be in if you had edema and if you ingested an excessive amount of salt? | Isotonic overhydration
🗑
|
||||
| What type of cell lays down bone? | Osteoblast Remember: Blasts make; clasts take.
🗑
|
||||
| What is the only condition in which giving enriched O2 will not significantly increase PaO2? | Pulmonary shunt
🗑
|
||||
| What is the biologically active form of thyroid hormone? | T3
🗑
|
||||
| For how many months can you store thyroid hormone? | 2 to 3 months
🗑
|
||||
| What is the ratio of T4 to T3? | 20:01
🗑
|
||||
| What type of cell is surrounded by mineralized bone? | Osteocvte
🗑
|
||||
| What type of dehydration is associated with excess sweating, decreased water intake, fever, alcoholism, lithium salts, excess evaporation, and diabetes insipidus? | Hypertonic dehydration
🗑
|
||||
| During what part of the cardiac cycle do you hear: Aortic stenosis? | Systole
🗑
|
||||
| During what part of the cardiac cycle do you hear: Mitral stenosis? | Diastole
🗑
|
||||
| During what part of the cardiac cycle do you hear: Mitral regurgitation? | Systole (pan)
🗑
|
||||
| During what part of the cardiac cycle do you hear: Aortic regurgitation? | Diastole
🗑
|
||||
| What four factors affect the rate of diffusion for any process? | 1. Surface area 2. Thickness of the membrane 3. Concentration gradient 4. Solubility (main factor)
🗑
|
||||
| What does a decrease in GH in adolescence lead to? | Dwarfism
🗑
|
||||
| What type of transportation requires ATP and is protein mediated against a concentration gradient? | Primary active transportation
🗑
|
||||
| What does an increase in GH in adolescence lead to? | Gigantism
🗑
|
||||
| What gas has a low driving force but high solubility? | CO2
🗑
|
||||
| What are two causes of diffusion impairment in the lungs? | 1. Decrease in surface area 2. Increase in membrane thickness (PAO2 > PaO2)
🗑
|
||||
| What is evident in the urinalysis of a compensated acidotic patient? | Low HCO3 - excretion (acidotic)
🗑
|
||||
| What does angiotensin II do to restore blood pressure? | It has a direct vasoconstrictive effect.
🗑
|
||||
| When is systemic venous blood delivered to the left side of the heart without O2 exchange in the alveoli? | In a pulmonary shunt
🗑
|
||||
| What gas has a high driving force and low solubility? | O2
🗑
|
||||
| In what type of shunt do you see an increase in right atrial, ventricular, and pulmonary arterial PO2, along with an increase in pulmonary blood flow? | Left-to-right shunt
🗑
|
||||
| What causes Ca+ and PO4 to be reabsorbed from the kidney and Ca+ and PO4 to be absorbed from the GI tract, and also promotes bone synthesis? | Vitamin D3
🗑
|
||||
| What does excess secretion of GH in an adult lead to? | Acromegaly
🗑
|
||||
| The rate at which a substance is filtered into Bowman's capsule is known as what? | Filtered load rate (GFR X plasma concentration)
🗑
|
||||
| What part of the nephron has the greatest osmolarity? | Tip of the loop of Henle (1200 mOsm)
🗑
|
||||
| At what region of the nephron does H+/HCO3 - exchange occur? | Distal tubule
🗑
|
||||
| During what type of heart block do the atria and the ventricles beat independently of each other? | Third-degree heart block
🗑
|
||||
| What is the length of systole on a pressure curve? | From the beginning of the isovolumic contraction (IVC) to the beginning of the isovolumic relaxation (IVR)
🗑
|
||||
| From which point to which point does it appear on an EKG? | From the QRS to the T wave (S1 to S2)
🗑
|
||||
| What are the four features of aortic stenosis? | 1. Increase in afterload 2. Increase in LV pressure 3. Increase in the pressure gradient between the LV and the aorta 4. Crescendo-decrescendo systolic ejection murmur (early systolic ejection click)
🗑
|
||||
| When is surface tension the greatest in a respiratory cycle? | At the end of inspiration
🗑
|
||||
| What type of transportation requires ATP, can be co- or countertransport, and is a protein-mediated transport with a concentration gradient? | Secondary active transportation
🗑
|
||||
| What lung pathology is associated with a decrease in FEV1/FVC? | COPD (obstructive)
🗑
|
||||
| What is the most important factor in describing lung recoil? | Surface tension (also fibers of tissue)
🗑
|
||||
| What is the free water clearance if the osmolarity of urine is less than 300 mOsm? | Positive free water clearance (dilute urine)
🗑
|
||||
| What four characteristics are common to all protein-mediated transportation? | 1. More rapid than diffusion 2. Zero-order kinetics 3. Chemical specificity 4. Competition for carriers
🗑
|
||||
| What causes an increase in Na+ and water loss from the kidney by increasing GFR, stimulated by stress and high Na+ concentrations? | Atrial natriuretic factor (ANF) released from the right atrium
🗑
|
||||
| What growth factors are chondrogenic, working on the epiphyseal end plates of bone? | Somatomedins (insulin-like growth factor type 1[IGF-1])
🗑
|
||||
| What causes an increase in Ca+ reabsorption from the distal tubule, a decrease in PO4 reabsorption from the kidney, and an increase in Ca+ and PO4 reabsorption from the GI tract? | Parathyroid hormone (PTH)
🗑
|
||||
| If a patient is irritated, excited, and emotionally unstable and has overall symptoms of ß-adrenergic stimulation, would you assume that this patient is hyperthyroidic or hypothyroidic? | Hyperthyroidic
🗑
|
||||
| What is needed for proper postnatal and perinatal mental growth and also for proper bone ossification and GH secretion? | Thyroid hormone
🗑
|
||||
| What type of heart block is associated with slowed conduction through the AV node and PR intervals greater than 0.21 second? | First-degree heart block
🗑
|
||||
| What two occurrences cause an increase in the force of contraction? | 1. Increase in preload 2. Increase in contractility by increased intracellular Ca+
🗑
|
||||
| What are three features of mural regurgitation? | 1. Increase in v wave 2. Increase in preload 3. Increase in atrial pressure and volume
🗑
|
||||
| What is the length of diastole on a pressure curve, and where is it on an EKG? | From the beginning of the IVR to the beginning of the IVC, and from the T wave to the QRS complex (S2 to Sl)
🗑
|
||||
| What are the three features of aortic regurgitation? | 1. Increase in preload 2. Increase in systolic pressure 3. Decrease in aortic diastolic pressure
🗑
|
||||
| What are the three features of mitral stenosis? | 1. Increase in a wave 2. Decrease in LV filling 3. Increase in atrioventricular pressure
🗑
|
||||
| What type of heart block is characterized by: Progressive lengthening of the P-R interval until there is failure of the impulse to be transmitted? | Second-degree heart block, Wenckebach (Mobitz type I)
🗑
|
||||
| What type of heart block is characterized by: Constant P-R interval but with an occasional failure of conduction, resulting in an atrial rate greater than the ventricular rate? | Second-degree heart block, non-Wenckebach (Mobitz type II)
🗑
|
||||
| What are the three functions of surfactant? | 1. Increased compliance 2. Decreased surface tension 3. Decreased probability of pulmonary edema formation
🗑
|
||||
| More negative intrathoracic pressure causes what to happen to systemic venous return and what to the pulmonary vessels? | Promotes systemic venous return into the chest and increases the caliber and volume of the pulmonary vessels
🗑
|
||||
| What four factors cause the oxygen-hemoglobin dissociation curve to shift to the right? | 1. Increased PCO2 2. Decreased pH 3. Increased 2,3-BPG 4. Increased temperature
🗑
|
||||
| What part of respiration, on a pressure volume curve, acts "like the chest wall"? | Inspiration (collapse is due to elastic recoil) "Secretion + filtration =
🗑
|
||||
| Excretion" is the transport maximum (Tm) for what substance? | Paraaminohippurate (PAH)
🗑
|
||||
| What has happened if the amount filtered and the amount excreted per unit time are the same? | Nothing; there has been no tubular modification.
🗑
|
||||
| What happens to the following parameters in an obstructive versus restrictive lung problem: Lung recoil? | Decrease (obstructive); increase (restrictive)
🗑
|
||||
| What happens to the following parameters in an obstructive versus restrictive lung problem: FRO? | Increase (obstructive); decrease (restrictive)
🗑
|
||||
| What happens to the following parameters in an obstructive versus restrictive lung problem: TLC? | Increase (obstructive); decrease (restrictive)
🗑
|
||||
| What happens to the following parameters in an obstructive versus restrictive lung problem: FVC? | Decrease (obstructive); decrease (restrictive)
🗑
|
||||
| What happens to the following parameters in an obstructive versus restrictive lung problem: FEVI? | Decrease (obstructive); decrease (restrictive)
🗑
|
||||
| What happens to the following parameters in an obstructive versus restrictive lung problem: Peak flow? | Decrease (obstructive); increase (restrictive)
🗑
|
||||
| What happens to the following parameters in an obstructive versus restrictive lung problem: RV? | Increase (obstructive); decrease (restrictive)
🗑
|
||||
| What hormone increases reabsorption of Na+ by the principal cells and promotes excretion of H+ and K+ by the intercalated cells of the kidney? | Aldosterone
🗑
|
||||
| What three situations cause the rennin-angiotensin-aldosterone axis to fire? | 1. A decrease in blood pressure in the afferent arteriole 2. Low Na+ levels at the macula densa 3. ß1-Sympathetic nervous system input
🗑
|
||||
| What pathology is associated with low ACTH levels and high levels of cortisol? | Cushing's syndrome (adrenal)
🗑
|
||||
| When do you see low urine flow, high urine osmolarity, high ECF volume, low ECF osmolarity (low Na+), high ICF volume, and low ICF osmolarity? | SIADH (water retention)
🗑
|
||||
| What is the term for the process in which excretion is less than the filtered load? | Net positive reabsorption (glucose, Na+, urea)
🗑
|
||||
| What has happened when everything that is filtered is reabsorbed until the carriers are saturated and the excess is excreted in the urine? | The transport maximum has been reached (Tm glucose = 375 mg/min).
🗑
|
||||
| What four factors cause aldosterone to be released? | 1. Conversion of angiotensin I to angiotensin II 2. Hyperkalemia 3. Hyponatremia 4. A decrease in blood volume
🗑
|
||||
| What disease state includes buffalo hump, moon fades, hyperglycemia, hyperlipidemia, hypertension, hypokalemia, osteoporosis, and thinning of the hair? | Cushing's disease
🗑
|
||||
| What condition involves high urine flow, low urine osmolarity, low ECF volume, high ECF osmolarity, low ICF volume, and high ICF osmolarity? | Diabetes insipidus (lose water)
🗑
|
||||
| Which condition involves elevated ACTH and cortisol levels? | Cushing's disease (pituitary tumor)
🗑
|
||||
| Which condition involves high ACTH, low cortisol, high ADH, elevated renin levels, hypotension, and low body hair? | Addison's disease (primary adrenal insufficiency)
🗑
|
||||
| What process has taken place in the kidney when excretion is greater than the filtered load? | Net negative secretion (PAH, creatinine)
🗑
|
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You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
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HY90X
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