clinical neuro 3
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| hypertensive emergencies | trimethaphan
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| dissecting aortic aneurysm | trimethaphan
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| adjunct to nicotine patch | mecamylamine
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| CNS adverse effects | tremor, chorea, mental disturbances
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| CNS effects esp common with | mecamylamine
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| Eye adverse effects | cycloplegia, blurred vision
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| CV adverse effects | dec BV tone, severe orthostatic hypotension, tachycardia
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| GI adverse effects | dec motility, constipation
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| GU adverse effects (in men) | urinary retention, ED, impaired ejaculation
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| effects on sweating | decreased
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| depolarizer | succinylcholine
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| short-acting non-depolarizer | nivacurium
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| long-acting non-depolarizer | pancuronium, doxacurium
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| intermediate-acting non-depolarizer | atracurium, cisatracurium, rocuronium, vecuronium
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| effect of advanced age on non-depolarizers | prolongs duration of action by decreasing clearance
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| cisatracurium | non-depolarizer, isoquinoline family
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| MOA of non-depolarizers in small doses | compete w/Ach at nicotinic receptor
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| MOA of non-depolarizers in large doses | enter pore of channel and dec sensitivity to neostigmine/edrophonium
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| GI absorption of non-depolarizers | poor
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| non-depolarizers & BBB | can't cross
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| increased response to non-depolarizers when also taking | inhaled anesthetics, aminoglycoside antibiotics, tetracyclines, Ca++ channel blockers
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| atracurium metabolism | hydrolyzed by plasma esterase
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| cisatracurium | isomer of atracurium; undergoes hoffman degradation
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| DOC for pts w/impaired renal/hepatic functions | cisatracurium
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| releases histamine at high doses | atracurium
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| minimal CV/resp effects | intermediate-acting non-depolarizers
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| MOA of sugammadex | reverses actions of steroid blockers by forming water-soluble complexes with drug and removing it from NMJ
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| initial fasciulations with subsequent paralysis | depolarizers
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| no antidote, irreversible effect | depolarizers
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| could produce apnea | depolarizers
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| contraindications of succinylcholine | unhealed skeletal m injury (ie - severe burn/trauma)
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| less commonly used in peds due to hyperkalemia risk | succinylcholine
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| may cause post-op myalgia | succinylcholine
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| risk of malignant hyperthermia | succinylcholine
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| can be reversed by anticholinesterase agents | non-depolarizers
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| increase tetanic fade | non-depolarizers
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drhermy
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