Radiation Protection
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| Radiobiology | show 🗑
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| show | *Cell structure
*Cell composition
*Cell function
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| What are the attributes of ionizing radiations? | show 🗑
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| show | *Linear Energy Transfer (LET)
*Relative Biological Effectiveness (RBE)
*Oxygen Enhancement Ratio (OER)
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| Linear Energy Transfer (LET) | show 🗑
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| show | Linear Energy Transfer (LET)
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| x & gamma radiation, no charge, Sparsely ionizing and interacts randomly along it’s trak, & cause damage through Indirect Action is know as what type of LET? | show 🗑
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| show | High LET
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| show | LET is inversely proportional to the square of the velocity and is directly proportional to the square of the charge
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| What is the size of DNA? | show 🗑
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| show | *e- represents Compton or Photoelectric effect in Diagnostic Beam
*Alpha represents particles ejected from radioactive decay (Radon)
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| show | A term relating the ability of radiations with different LET's to produce a specific biologic response
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| what is the formula for RBE? | show 🗑
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| Oxygen Enhancement Ratio (OER) | show 🗑
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| show | oxygen
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| show | Oxygen is most effective when administered simultaneously with the radiation.
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| show | OER= Hypoxic/ Oxygenated
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| show | *Molecular
*Cellular
*Organic
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| show | The molecular level
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| Direct Action | show 🗑
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| show | Effects produced by reactive free radicals
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| How are free radicals produced? | show 🗑
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| What are extremely reactive and can undergo a number of reactions? | show 🗑
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| show | *Point Mutation
*Radiation can rupture chemical bonds
*Can sever Sugar Phosphate (Strand) chain
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| show | Single Strand Breaks
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| show | *Further exposure to radiation results in additional breaks on *Sugar Phosphate chain
DSB on same chain are not easily repaired
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| What break is common with High LET radiation & damage to Nitrogenous bases? | show 🗑
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| show | High LET
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| Damage is only seen at what phase of Mitosis? | show 🗑
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| What is the irreplaceable master molecule in cell? | show 🗑
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| show | 1000Gy received secs to mins will disrupt the cell and cause death.
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| show | 1- 10Gy Cells does not die , but loses reproductive abilities
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| Apoptosis | show 🗑
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| show | Retards the mitotic process and adversely affects cellular division
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| Mitotic Delay | show 🗑
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| show | Cell irradiation during mitosis can lead to chromosomal breakage.
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| show | Relates sensitivity of a particular type of cell to ionizing radiation.
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| show | Radiation has a more damaging effect on cells that are:
-Rapidly dividing
-Have Long Mitotic Cycle
-Immature stage in development
Undifferentiated cells
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| Most Sensitive | show 🗑
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| show | S phase of cell cycle.
*GI phase
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| show | Established that Radiosensitivity is a function of the metabolic state of cell while irradiating Germ cell studies
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| show | *Directly proportional to reproductive activity
*Inversely proportional to degree of differentiation
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| Hematologic Depression | show 🗑
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| show | Irradiated Bone Marrow(BM) lead to depressed stem or precursor cells.
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| Repopulation | show 🗑
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| show | stems cells
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| What is the Lethal Dose of radiation in animals? | show 🗑
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| show | LD 50/60
*3-4 Gy
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| Granulocytes | show 🗑
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| Thrombocytes (Platelets) | show 🗑
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| show | *With Low LET radiation, a shoulder to the curve at lower doses indicates the cells ability to repair some damage at low doses.
*High-LET radiation typically has no shoulder, indicating that little or no repair takes place.
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| show | *Implanted
*Ingested
*Injected
*Inhaled
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| What are the two types of Chromosomal Anomalies observed at metaphase? | show 🗑
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Created by:
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