Radiation Protection
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Radiobiology | show 🗑
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Adverse effects of ionizing radiation effect? | show 🗑
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What are the attributes of ionizing radiations? | show 🗑
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What is used to Determine the extent different radiation modalities transfer energy into biologic tissues? | show 🗑
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show | The average energy deposited per unit path length of “track” as it traverses a material medium.
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What is an important factor in assessing potential tissue and organ damage from ionizing radiation? | show 🗑
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x & gamma radiation, no charge, Sparsely ionizing and interacts randomly along it’s trak, & cause damage through Indirect Action is know as what type of LET? | show 🗑
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Ionizing radiation with mass and charge, Densely Ionizing along track, Alpha Particles, Heavy Nuclei Ions, Charged Particles, Neutrons are know as what type of LET? | show 🗑
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What is the formula for Linear Energy Transfer (LET)? | show 🗑
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What is the size of DNA? | show 🗑
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Electron vs. Alpha | show 🗑
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Relative Biological Effectiveness (RBE) | show 🗑
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what is the formula for RBE? | show 🗑
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show | Many chemicals can change the response of cells to radiation. the one that has a very big effect and is important in Radiobiology is oxygen.
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show | oxygen
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show | Oxygen is most effective when administered simultaneously with the radiation.
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show | OER= Hypoxic/ Oxygenated
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Effects of Ionizing Radiation where observed in what 3 levels? | show 🗑
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Any induced injuries on living systems by radiation is a consequence of damage at what level? | show 🗑
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Direct Action | show 🗑
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Indirect Action | show 🗑
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How are free radicals produced? | show 🗑
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show | Free Radicals
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Single Strand Breaks | show 🗑
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show | Single Strand Breaks
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Double Strand Break | show 🗑
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What break is common with High LET radiation & damage to Nitrogenous bases? | show 🗑
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show | High LET
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show | Metaphase and Anaphase
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What is the irreplaceable master molecule in cell? | show 🗑
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show | 1000Gy received secs to mins will disrupt the cell and cause death.
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show | 1- 10Gy Cells does not die , but loses reproductive abilities
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Apoptosis | show 🗑
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Mitotic Death | show 🗑
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show | 0.01 Gy at beginning of division can cause mitotic delay
No known cause.
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show | Cell irradiation during mitosis can lead to chromosomal breakage.
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show | Relates sensitivity of a particular type of cell to ionizing radiation.
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show | Radiation has a more damaging effect on cells that are:
-Rapidly dividing
-Have Long Mitotic Cycle
-Immature stage in development
Undifferentiated cells
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Most Sensitive | show 🗑
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Least sensitive | show 🗑
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show | Established that Radiosensitivity is a function of the metabolic state of cell while irradiating Germ cell studies
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Radiosensitivity | show 🗑
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Hematologic Depression | show 🗑
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Immature Blood Cells | show 🗑
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show | BM cells can repopulate if low dose received
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show | stems cells
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What is the Lethal Dose of radiation in animals? | show 🗑
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show | LD 50/60
*3-4 Gy
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show | *“Scavenger” WBC
*Increase in number in response to irradiation
*Then decrease rapidly, then decrease slowly
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show | *Blood clotting and prevent Hemorrhaging
*Lifespan of 30 days
*50 rads (0.5Gy)
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Cell Survival Curves | show 🗑
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show | *Implanted
*Ingested
*Injected
*Inhaled
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show | 1. Chromosomal aberrations
2. Chromatid aberrations
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