Test 1
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
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| What is the synthetic, plant, and animal form of vitamin k? | Menadione, phylloquinone, menaquinone
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| What pathway should you follow for absorption of vitamin k? | Absorption of lipids.
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| What vitamin can interfere with vitamin k absorption? | Vitamin A because it is fat soluble and may have similar transporters
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| Phylloquinone's absorption has what kind of transporter and where is it absorbed? | regulated transporter that requires energy, and absorbed in jejunum
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| menaquinone and menadione are absorbed where and by what means? | absorbed in the distal small intestines (ileum) and the colon by passive diffusion
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| How is vitamin K transported? | mainly in VLDL
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| Once absorbed how is phyllaquinone found in the body? | in circulation
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| Once absorbed how is menaquinone found in the body? | mainly in the liver: however very little stays in the liver it is in highest concentrations in the adrenal glands, lymph nodes, bone marrow, kidneys and lungs
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| Explain in detail the absorption of vitamin K the form of menaquinone | Bile acids breaking fat into micelles, passive diffusion in ileum or colon for menaquinone
Packaged into chylomicrons sent to liver as chylomicron remnants, packaged into VLDL's
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| Explain in detail the absorption of vitamin K in the form of phylloquinone | Bile acids breaking fat into micelles,absorption via transporters in jejunum for phylloquinone. Packaged into chylomicrons sent to liver as chylomicron remnants, packaged into VLDL's
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| Explain in detail the absorption of vitamin K in the form of menadione | Bile acids breaking fat into micelles, passive diffusion in ileum or colon for menadione. Packaged into chylomicrons sent to liver as chylomicron remnants, alkylated (side chains added), packaged into VLDL's
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| When is vitamin K done being metabolized and is excreted? | When it is glucuronidated
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| How is vitamin k excreted? | conjugated mainly in feces also excreted in urine
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| List all the functions of vitamin k in the body | blood clotting, bone mineralization, vascular calcification
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| Explain vitamin K's role in blood clotting/coagulation | vitamin k is necessary for the post-translational carboxylation of specific glutamate residues (modified glutamate residues called GLA) which enable protein to bind calcium
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| What form must vitamin k be in for activity in the vitamin k cycle to form Gla residues | the reduced hydroquinone form with OH's on it
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| Explain the enzyme that helps with post translational carboxylation of glutamate residues | Vitamin K dependent carboxylase enzyme adds a carboxyl group to a glutamic acid residue that attracts and binds calcium really avidly
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| Can vitamin K be recycled? | Yes through the activity of the epoxide reductase enzymes
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| General features of coagulation cascade | Zymogens converted to enzymes
“Complex formation” requiring calcium, phospholipid surface, cofactors
Thrombin converts fibrinogen to fibrin monomer
Fibrin monomer crosslinked to fibrin Forms "glue" for platelet plug
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| Which factors of are vitamin K dependent | II, VII, IX, X
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| What are the four components of hemostasis for prevention of blood loss | Vasculature
Platelets: ATP, Ca ions(making calcium available at the site of injury)
Coagulation proteins/factors
Fibrinolytic system
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| What starts the coagulation cascade? | Beginning of cascade can be due the presence of collagen, which is normally contained in endothelium
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| Explain the importance of calcium in coagulation | The heads of the gla proteins all bind Ca avidly which grabs onto the phospholipid bilayer (because of the charge attraction) and creates a bridge that brings all the clotting factors within proximity of each other
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| Who is at risk for vitamin K deficiency | Newborns, malabsorption diseases, liver disease, people who take high doses of vitamin A and E for long periods, injured
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| What are some easy assessments of vitamin K deficiency | Blood clotting time longer than normal, plasma prothrombin levels are HIGHLOW? high undercarboxylated osteocalcin
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| where is osteocalcin made and by what cells? | bone, osteoblasts
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| what is the purpose of osteocalcin? | it inhibits mineralization of bones,
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| What would happen if you didn't have Ca present in clotting cascade? | The coagulation factors would not be allowed to assemble in proximity to each other. Calcium is the bridge, without calcium these would never meet, its like match.com
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| In the clotting cascade thrombin converts ________ to ______. | fibrinogen to fibrin
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| What happens in general following tissue injury? | Vasoconstriction
Platelet aggregation
fibrin (the glue) formation
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| what is fibrin? | fibrin is the end result of the clotting cascade and this protein forms a clot over a wound site
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Created by:
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