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Immunosuppressants

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Question
Answer
cyclosporin   binds to cyclophilin forming a complex that binds to calcenurin  
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sirolimus   binds to mTOR interfering with signal 3  
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tacrolimus   binds to FKBP-12  
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azathioprine   forms 6-MP then thioinosinic acid  
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mycophenolate mofetil   forms MPA, which inhibits IMP  
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mycophenolate sodium   created to minimize the GI effects associated with MMF  
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alemtuzumab   directed CD52  
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antithymocyte globulins   Ab against thymocytes  
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basiliximab   binds to CD25  
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daclizumab   binds to CD25 but more potent  
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muromonab-CD3   binds to CD3  
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methylprednisolone   corticosteroid used for transplantation  
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prednisolone   corticosteroid used for autoimmune conditions  
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prednisone   corticosteroid used for transplantation or autoimmune conditions  
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