Nervous System (CNS)
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<pre> BZD Rx Only clonazepam Generic Name </pre> | <pre>
Treat seizure/panic disorder Rx Only
Klonopin
CNS depressant / GABA agonist Benzodiazepine
</pre>
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<pre> Muscle relaxant Rx Only cyclobenzaprine Generic Name </pre> | <pre>
Treat muscle spasms Rx Only
Flexeril
Blocks nerve impulses Antispasmodic
</pre>
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<pre> Rx Only Cyanocobalamin Generic Name </pre> | <pre>
Treat Pernicious Anemia
Dosage Form: Injection, Solution
Increase Vitamin B12 absorption Vitamer B12 Family
</pre>
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<pre> Miscellaneous AED Rx Only Carbamazepine Cranial Nerve - V Generic Name </pre> | <pre>
Treat seizures / Trigeminal Neuralgia aka tic douloureux cn-V
Tegretol
Blocks Na+ channels AED/Analgesic
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<pre> Historical Sedative/Hypnotic C-IV chloral hydrate Generic Name </pre> | <pre>
Treat sleep disorders/insomnia C-IV
"knock-out drops"/"Mickey Finn" in ETOH
CNS depressant Historical Sedative/Hypnotic
</pre>
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<pre> Historical Sedative/Hypnotic C-IV meprobamate Generic Name </pre> | <pre>
Treat insomnia (REM) C-IV
Miltown
CNS depressant Historical Sedative/Hypnotic
</pre>
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<pre> Historical Sedative/Hypnotic C-IV carisoprodol Generic Name </pre> | <pre>
Treat insomnia (REM) C-IV
Soma (prodrug of meprobamate)
Caution: High addiction risk (euphoria)
CNS depressant Historical Sedative/Hypnotic
</pre>
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<pre> Historical Sedative/Hypnotic C-IV thiopental Generic Name </pre> | <pre>
Treat insomnia/general anesthesia C-IV
Pentothal (ultrashort)
IV dose form
GABA agonist Barbiturate
</pre>
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<pre> Historical Sedative/Hypnotic C-IV methohexital Generic Name </pre> | <pre>
Treat insomnia/general anesthesia C-IV
Brevital (ultrashort)
IV dose form
GABA agonist Barbiturate
</pre>
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<pre> Historical Sedative/Hypnotic C-II pentobarbital Generic Name </pre> | <pre>
Treat insomnia/general anesthesia C-II
Nembutal (short-acting)
GABA agonist Barbiturate
</pre>
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<pre> Historical Sedative/Hypnotic C-II secobarbital Generic Name </pre> | <pre>
Treat insomnia/general anesthesia C-II
Seconal (short-acting)
GABA agonist Barbiturate
</pre>
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<pre> Historical Sedative/Hypnotic C-II amobarbital Generic Name </pre> | <pre>
Treat insomnia/general anesthesia C-II
Amytal (intermediate-acting)
GABA agonist Barbiturate
</pre>
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<pre> Historical Sedative/Hypnotic C-II secobarbital + amobarbital Generic Name </pre> | <pre>
Treat insomnia/general anesthesia C-II
Tuinal
GABA agonist Barbiturate
</pre>
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<pre> Historical Sedative/Hypnotic C-III butabarbital Generic Name </pre> | <pre>
Treat insomnia/general anesthesia C-III
Butisol (intermediate-acting)
GABA agonist Barbiturate
</pre>
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<pre> Historical Sedative/Hypnotic C-IV (PB) phenobarbital Generic Name </pre> | <pre>
Treat insomnia/epilepsy/anxiety C-IV
Tramadol (long-acting)
GABA agonist Barbiturate/AED
</pre>
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<pre> Historical Sedative/Hypnotic C-II to C-IV barbituates Generic Name </pre> | <pre>Cautions:
1) Tolerance develops rapidly (due to liver enzyme induction)
2) Many drug interactions, Addiction is quick, Withdrawal is severe
3) Increases metabolism, Rebound nightmares, Suppresses REM sleep
</pre>
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<pre> Historical Sedative/Hypnotic C-II to C-IV barbituates Generic Name </pre> | <pre>Cautions:
4) Drug-Automatism, Causes "hangover", Emotional depression
5) Rebound insomnia
</pre>
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<pre> BZD C-IV GABA (gamma-aminobutyric acid) benzodiazepines GABA: Chief inhibitory neurotransmitter in CNS Generic Name </pre> | <pre>
Advantages: All C-IV
1) Little REM suppression or hangover
2) Slower tolerance and addiction
3) No liver enzyme induction
4) Therapeutic Index is wide
Caution:
1) May see disinhibition
CNS depressant/GABA agonist azepam, azolam
<
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<pre> BZD C-IV GABA (gamma-aminobutyric acid) flurazepam GABA: Chief inhibitory neurotransmitter in CNS Generic Name </pre> | <pre>
Treat anxiety / insomnia C-IV
Dalmane
Long onset/duration; "active metabolites"
Not recommended in elderly or renal DZ
Active metabolites accumulate w/use
CNS depressant/GABA agonist benzodiazepine
</pre>
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<pre> BZD C-IV GABA (gamma-aminobutyric acid) triazolam GABA: Chief inhibitory neurotransmitter in CNS Generic Name </pre> | <pre>
Treat anxiety / insomnia C-IV
Halcion
Short onset/duration
Rebound insomnia can occur the same night
Faster tolerance due to short half-life
CNS depressant/GABA agonist benzodiazepine
</pre>
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<pre> BZD C-IV GABA (gamma-aminobutyric acid) lorazepam GABA: Chief inhibitory neurotransmitter in CNS Generic Name </pre> | <pre>
Treat anxiety / insomnia C-IV
Ativan
Intermediate half-life
CNS depressant/GABA agonist benzodiazepine
</pre>
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<pre> BZD C-IV GABA (gamma-aminobutyric acid) temazepam GABA: Chief inhibitory neurotransmitter in CNS Generic Name </pre> | <pre> Restoril
Intermediate half-life
Moderate accumulation, produces less daytime impairment
Best suited for sleep-maintenance difficulties
"Best" hypnotic for late-life insomnia
CNS depressant/GABA agonist benzodiazepine
</pre>
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<pre> BZD C-IV GABA (gamma-aminobutyric acid) quazepam GABA: Chief inhibitory neurotransmitter in CNS Generic Name </pre> | <pre>
Treat anxiety / insomnia C-IV
Doral
"BZ-1 selective" (newer drug)
Decreased effects on cognition/memory
Longer half-life minimizes rebound insomnia
CNS depressant/GABA agonist benzodiazepine
</pre>
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<pre> BZD C-IV GABA (gamma-aminobutyric acid) estazolam GABA: Chief inhibitory neurotransmitter in CNS Generic Name </pre> | <pre>
Treat anxiety / insomnia C-IV
ProSom
Intermediate half-life
Newer drug
Rapid onset
CNS depressant/GABA agonist benzodiazepine
</pre>
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<pre> Non-benzo GABA agonist C-IV Non-benzo GABA agonist Generic Name </pre> | <pre>
Advantages: C-IV
Less tolerance/dependence than BZD
BZ-1 selective; not chemically related to BZD
More sleep specific GABA agonists
GABA agonist Non-benzo GABA agonist
</pre>
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<pre> Non-benzo GABA agonist C-IV zolpidem Generic Name </pre> | <pre>
Treat short-term insomnia C-IV
Ambien, Ambien CR
Stay asleep longer: 7-8 hour duration
Ambien FDA approved for short-term use only
Ambien CR FDA pproved for chronic sleep
GABA agonist Non-benzodiazepine Hypnotic
</pre>
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<pre> Non-benzo GABA agonist C-IV eszopiclone Generic Name </pre> | <pre>
Treat chronic sleep C-IV
Lunesta
Stay asleep longer: 7-8 hour duration
FDA approved for chronic sleep
GABA agonist Non-benzodiazepine Hypnotic
</pre>
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<pre> Non-benzo GABA agonist C-IV zaleplon Generic Name </pre> | <pre>
Treat short-term insomnia C-IV
Sonata
Fall asleep faster: 4 hour duration
Best for patients who have difficulty falling asleep
GABA agonist Non-benzodiazepine Hypnotic
</pre>
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<pre> Pineal gland secretion OTC melatonin Generic Name </pre> | <pre>
Treat "Jet Lag" OTC
Adjusts sleep cycle
Available as OTC dietary supplement
Melatonin receptor agonist Oral Hypnotic
</pre>
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<pre> Pineal gland secretion Rx Only ramelteon Generic Name </pre> | <pre>
Treat insomnia/trouble falling asleep Rx Only
Rozerem
Fall asleep faster
Does not help stay asleep
Not limited to short-term use
Melatonin receptor agonist Oral Hypnotic
</pre>
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<pre> Miscellaneous Hypnotic OTC diphenhydramine Generic Name </pre> | <pre>
Treat allergy symptoms/Parkinson's DZ/cause sedation/N/V OTC
Benadryl
Drugs that cause drowsiness as a side effect
Blocks H1/H2 receptors Antihistamine
</pre>
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<pre> Miscellaneous Hypnotic OTC Doxylamine Active ingredients found in cough/cold medicine Eg: Nyquil Generic Name </pre> | <pre>
Treat allergy symptoms/insomnia/cause sedation OTC
Unisom
Blocks H1/H2 receptors Antihistamine
</pre>
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<pre> Miscellaneous Hypnotic/TCA Rx Only doxepin 1st FDA approved anti-depressant for sleep Generic Name </pre> | <pre>
Treat depression/anxiety/insomnia Rx Only
Silenor
Sinequan contains same ingredients but older drug
Not FDA approved for sleep
Blocks H1/H2 receptor antagonist Antidepressant
</pre>
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<pre> Miscellaneous Hypnotic/TCA Rx Only amitriptyline Generic Name </pre> | <pre>
Treat depression/anxiety/chronic pain/insomnia Rx Only
Elavil
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> Miscellaneous Hypnotic Rx Only trazodone Generic Name </pre> | <pre>
Treat depression/panic attacks/insomnia Rx Only
Desyrel
Off label use only
Non-TCA, less anticholinergic action
Fewer CV effects than TCA's
SNRI reuptake inhibitor Non-TCA Hynotic
</pre>
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<pre> Neurotransmitter-Specific Effects: Potential consequences of enhancing activity of different neurotransmitters Serotonergic side effects </pre> | <pre>
1) Sexual dysfunction
2) Weight gain w/long-term enhancement
3) Suppression of dopamine neurotransmission; decreased ability to experience pleasure, apathy, motivation, attention, cognitive slowing
</pre>
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<pre> Neurotransmitter-Specific Effects: Potential consequences of enhancing activity of different neurotransmitters Serotonergic side effects (cont) </pre> | <pre>
4) GI upset
5) Sleep disturbance
</pre>
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<pre> Neurotransmitter-Specific Effects: Potential consequences of enhancing activity of different neurotransmitters NorAdrenergic side effects </pre> | <pre>
1) Tremor
2) Tachycardia
3) Dry mouth
4) Insomnia
</pre>
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<pre> Neurotransmitter-Specific Effects: Potential consequences of enhancing activity of different neurotransmitters Dopaminergic side effects </pre> | <pre>
1) Psychomotor activation
2) Aggravation of psychosis
</pre>
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<pre> Dopamine effects </pre> | <pre>
1) Decreased ability to experience pleasure
2) Decreased motivation
3) Decreased attention
4) Slowing of Cognitive ability
</pre>
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<pre> Norepinephrine effects </pre> | <pre>
1) Low energy
2) Lethargy
3) Decreased alertness
</pre>
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<pre> Serotonin effects </pre> | <pre>
1) Obsessive Compulsive Disorder
2) OCD
</pre>
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<pre> Serotonin neurotransmitter regulates: </pre> | <pre>
1) Obsessions
2) Compulsions
</pre>
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<pre> Dopamine neurotransmitter regulates: </pre> | <pre>
1) Attention
2) Motivation
3) Pleasure
4) Reward
</pre>
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<pre> Norepinephrine neurotransmitter regulates: </pre> | <pre>
1) Alertness
2) Energy
</pre>
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<pre> MAOI Rx Only Mono-Amino Oxidase (MAO) Inhibitors 1) Blocks MAO 2) Less destruction of serotonin and NE 3) More serotonin and NE in the synapse 4) Last choice for major depression Generic Name </pre> | <pre>
Caution: Rx Only
1) Do not mix w/other sympathomimetics (eg: pseudoephedrine)
2) Avoid Tyramine-containing foods (eg: cheeses, wines, fava beans)
3) Increased NE leads to HTN crisis, tachycardia, convulsions, stroke, death
</pre>
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<pre> TCA Rx Only Tricyclic Antidepressants 1) Chemically related to phenothiazines 2) Similar side effects: sedation, anticholinergic, dry mouth, increased HR Generic Name </pre> | <pre>
MOA: Rx Only
1) Block reuptake: Increases NE, 5-HT (serotonin) at receptors
2) Increase production/release: Increases NE, 5-HT (serotonin) at receptors
3) Sensitize receptors: Takes 3+ weeks to occur
</pre>
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<pre> TCA Rx Only Tricyclic Antidepressants (Kinetics) 1) Chemically related to phenothiazines 2) Similar side effects: sedation, anticholinergic, dry mouth, increased HR Generic Name </pre> | <pre>
Kinetics: Rx Only
1) PO drugs are Rx Only
2) Give routinely not PRN
3) Onset: several days to 3-4 weeks
4) Dose most TCA's at HS due to sedation
</pre>
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<pre> TCA Rx Only Tricyclic Antidepressants (Cautions) 1) Chemically related to phenothiazines 2) Similar side effects: sedation, anticholinergic, dry mouth, increased HR Generic Name </pre> | <pre>
Cautions: Rx Only
1) Decreases seizure threshold
2) Photosensitivity
3) Postural hypotension
4) Narrow TI: CV toxicity
</pre>
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<pre> TCA Rx Only amitriptyline Generic Name </pre> | <pre>
Treat depression/chronic pain/insomnia Rx Only
Elavil
Tertiary amine
Most sedating; 1st generation
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> TCA Rx Only amitriptyline / perphenazine Generic Name </pre> | <pre>
Treat depression/chronic pain/insomnia Rx Only
Triavil, Etrafon
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> TCA Rx Only nortriptyline Generic Name </pre> | <pre>
Treat depression/chronic pain/insomnia Rx Only
Aventyl, Pamelor
Secondary amine
Less sedation, 2nd generation
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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TCA Rx Only imipramine Generic Name </pre> | <pre>
Treat depression/chronic pain/insomnia Rx Only
Tofranil
Tertiary amine
Also used to treat enuresis (bed-wetting)
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> TCA Rx Only desipramine Generic Name </pre> | <pre>
Treat depression/chronic pain/insomnia Rx Only
Norpramin
Secondary amine
Also used to treat enuresis (bed-wetting)
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> TCA-like Rx Only doxepin Generic Name </pre> | <pre>
Treat depression/insomnia Rx Only
Sinequan
Good anxiolytic activity
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> TCA-like Rx Only doxepin (insomnia) Generic Name </pre> | <pre>
Treat depression/insomnia Rx Only
Silenor
Low dose doxepin
3 or 6mg tablets
FDA approved to treat chronic/transient insomnia
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> TCA-like Rx Only doxepin (pruritus) Generic Name </pre> | <pre>
Treat depression/insomnia Rx Only
Zonalon
Cream
FDA approved to treat pruritis
SNRI reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> SSRI Rx Only Selective Serotonin Reuptake Inhibitors Generic Name </pre> | <pre>
MOA: Rx Only
1) Blocks reuptake of serotonin
2) Increases stimulation of receptors
3) Little effect on norepinephrine levels
</pre>
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<pre> SSRI Rx Only Selective Serotonin Reuptake Inhibitors (Indications) Generic Name </pre> | <pre>
Indications of Use: Rx Only
1) Endogenous depression
2) OCD
3) Panic disorders, Social anxiety disorder
4) Eating disorders, obesity, bulimia
</pre>
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<pre> SSRI Rx Only Selective Serotonin Reuptake Inhibitors (Cautions) Generic Name </pre> | <pre>
Cautions/Side-Effects: Rx Only
1) Very little sedation (dose in AM except paroxetine taken at HS sedation)
2) Very little anticholinergic effect
3) No orthostatic hypotension but causes sexual dysfunction, gynecomastia
</pre>
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<pre> SSRI Rx Only fluoxetine Generic Name </pre> | <pre>
Treat depression/OCD/PMDD/Bulimia Rx Only
Prozac
SSRI reuptake inhibitor Antidepressant
</pre>
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<pre> SSRI Rx Only fluoxetine (PMDD) Generic Name </pre> | <pre>
Treat depression/OCD/PMDD/Bulimia Rx Only
Serafem
Treat PMDD (Premenstrual Dysphoric Disorder)
SSRI reuptake inhibitor Antidepressant
</pre>
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<pre> SSRI Rx Only fluoxetine w/ olanzapine Generic Name </pre> | <pre>
Treat depression/OCD/PMDD/Bulimia Rx Only
Symbyax
Treat Bipolar Depression
Less risk of switching to mania phase
SSRI reuptake inhibitor Antidepressant
</pre>
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<pre> SSRI Rx Only paroxetine Generic Name </pre> | <pre>
Treat depression/OCD/PMDD/Bulimia Rx Only
Paxil, Paxil CR, Pexeva
Dose at HS due to sedation
SSRI reuptake inhibitor Antidepressant
</pre>
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<pre> SSRI Rx Only sertraline Generic Name </pre> | <pre>
Treat depression/OCD/PMDD/Bulimia Rx Only
Zoloft
SSRI reuptake inhibitor Antidepressant
</pre>
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<pre> SSRI Rx Only citalopram Generic Name </pre> | <pre>
Treat depression/OCD/PMDD/Bulimia Rx Only
Celexa
SSRI reuptake inhibitor Antidepressant
</pre>
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<pre> SSRI Rx Only escitalopram Generic Name </pre> | <pre>
Treat depression/OCD/PMDD/Bulimia Rx Only
Lexapro
Isomer of Celexa
SSRI reuptake inhibitor Antidepressant
</pre>
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<pre> SNRI Rx Only Serotonin-Norepinephrine Reuptake Inhibitors Generic Name </pre> | <pre>
MOA: Rx Only
1) Blocks reuptake of both serotonin and NE
2) Like TCA's but w/fewer side effects
</pre>
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<pre> SNRI Rx Only venlafaxine Generic Name </pre> | <pre>
Treat depression/anxiety/panic disorder/ADHD Rx Only
Effexor, Effexor XR
SNRI reuptake inhibitor Antidepressant
</pre>
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<pre> SNRI Rx Only desvenlafaxine Generic Name </pre> | <pre>
Treat depression/anxiety/panic disorder Rx Only
Pristiq
SNRI reuptake inhibitor Antidepressant
</pre>
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<pre> SNRI Rx Only duloxetine Generic Name </pre> | <pre>
Treat depression/anxiety/panic disorder Rx Only
Cymbalta
Also FDA approved to Tx diabetic neuropathic pain
SNRI reuptake inhibitor Antidepressant
</pre>
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<pre> a-2 Receptor Antagonist Rx Only mirtazapine Tetracyclic agent, net effect increases NE, 5-HT1a activity Ideal for patients w/depression accompanied w/ insomnia / weight loss Generic Name </pre> | <pre>Treat depression Rx Only
Remeron
Also acts as a potent antihistamine due to sedation
Off-Label use for sleep and appetite simulant in elderly
a-2 Receptor Antagonist Antidepressant
</pre>
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<pre> Dopamine Reuptake Blockers Rx Only bupropion Generic Name </pre> | <pre>
Treat depression/SAD/ADHD Rx Only
Wellbutrin
Seizure risk: Dose related: dose TID
May cause agitation/insomnia; take last does no later than 4-5 pm
May cause weight loss
Dopamine Reuptake Blockers Antidepressant
</pre>
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<pre> Dopamine Reuptake Blockers Rx Only bupropion (smoking cessation) Generic Name </pre> | <pre>
Treat depression/SAD/smoking cessation Rx Only
Zyban
Smoking cessation
Dopamine Reuptake Blockers Antidepressant
</pre>
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<pre> Dopamine Reuptake Blockers Rx Only bupropion (Caution) Generic Name </pre> | <pre>
Treat depression/SAD/smoking cessation Rx Only
Zyban
Wellbutrin SR: dose BID
Wellbutrin XL: dose QD
Dopamine Reuptake Blockers Antidepressant
</pre>
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<pre> Miscellaneous Antidepressants Rx Only trazodone Dividose: 150mg tablet can be broken into 50mg or 75mg doses Allows titration of dose w/o using multiple strengths Give HS dose w/food Generic Name </pre> | <pre>
Treat depression Rx Only
Desyrel
More commonly: Off-Label to Tx insomnia due to sedation
Drug-induced priapism (painful erection > 6 hrs)
Serotonin reuptake inhibitor Antidepressant
</pre>
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<pre> Miscellaneous Antidepressants Rx Only trazodone (XR) Generic Name </pre> | <pre>
Treat depression Rx Only
Oleptro
Extended Release trazodone, QD daily dosing
Both rapid/sustained release maintaining blood levels w/therapeutic range 24 hrs
Serotonin reuptake inhibitor Antidepressant
</pre>
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<pre> Miscellaneous Antidepressants Rx Only nefazodone Generic Name </pre> | <pre>
Treat depression Rx Only
Serzone
Trade no longer available
Black Box Warning: hepatotoxic
Serotonin reuptake inhibitor Antidepressant
</pre>
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<pre> TCA Rx Only clomipramine Generic Name </pre> | <pre>
Treat depression/OCD Rx Only
Anafranil
Increases serotonin
Serotonin reuptake inhibitor Tricyclic Antidepressant
</pre>
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<pre> SSRI Rx Only fluvoxamine Generic Name </pre> | <pre>
Treat depression/OCD Rx Only
Luvox, Luvox ER
Increases serotonin
Selective-Serotonin reuptake inhibitor Antidepressant
</pre>
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<pre> SSRI Rx Only fluvoxamine (other indications) Also used: Prozac, Paxil, other SSRI's Generic Name </pre> | <pre>
Treat depression/OCD Rx Only
Luvox, Luvox ER
"atypical" anti-psychotics (eg: olanzapine, quetiapine, risperdone)
Useful as adjuncts to SSRI in treatment resistant OCD
Selective-Serotonin reuptake inhibitor Antidepressant
</p
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<pre> Chemical compound lithium, carbon, oxygen Rx Only Lithium carbonate Narrow TI: side effects relate to blood levels Toxicity increases when Na+ levels decrease OD: arrhythmia leads to CV collapse > death Generic Name </pre> | <pre>
Treat mania/bipolar Rx Only
Eskalith, Lithobid
Inhibits nerve conduction by substituting for Na+
Decreases NE release, Increased NE reuptake
Nerve conduction (Na+) inhibitor Antipsychotic
</pre>
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<pre> Chemical compound lithium, carbon, oxygen Rx Only Lithium carbonate (Cautions) Narrow TI: side effects relate to blood levels Toxicity increases when Na+ levels decrease OD: arrhythmia leads to CV collapse > death Generic Name | <pre>
Treat mania/bipolar Rx Only
1) Do not restrict Na (salt intake)
2) Do not drink excessive water (forces salt out of system)
Nerve conduction (Na+) inhibitor Antipsychotic
</pre>
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<pre> Alternate drugs for Mania Rx Only divalproex sodium aka valproic acid Generic Name </pre> | <pre>
Treat seizures/mania Rx Only
Depakote
GABA antagonist Antiepileptic
</pre>
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<pre> Alternate drugs for Mania Rx Only carbamazepine Generic Name </pre> | <pre>
Treat seizures/Trigeminal Neuralgia/mania Rx Only
Tegretol, Equetro
Na+ channel inhibitor Antiepileptic
</pre>
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<pre> Alternate drugs for Mania Rx Only lamotrigine Generic Name </pre> | <pre>
Treat seizures/mania Rx Only
Lamictal
Caution: potentially life-threatening rash (Steven's Johnson Syndrome)
Cell death causes dermis to separate from epidermis
Na+ channel inhibitor Antiepileptic
</pre>
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<pre> Alternate drugs for Mania Rx Only olanzapine Generic Name </pre> | <pre>
Treat schizophrenia/bipolar disorder/mania Rx Only
Zyprexa
Na+ channel inhibitor Atypical Antipsychotics
</pre>
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<pre> Alternate drugs for Mania Rx Only risperidone Generic Name </pre> | <pre>
Treat schizophrenia/bipolar disorder/mania Rx Only
Risperdal
Na+ channel inhibitor Atypical Antipsychotics
</pre>
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<pre> Alternate drugs for Mania Rx Only ziprasidone Generic Name </pre> | <pre>
Treat schizophrenia/bipolar disorder/mania Rx Only
Geodon
Na+ channel inhibitor Atypical Antipsychotics
</pre>
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<pre> Alternate drugs for Mania Rx Only aripiprazole Generic Name </pre> | <pre>
Treat schizophrenia/bipolar disorder/mania Rx Only
Abilify
Na+ channel inhibitor Atypical Antipsychotics
</pre>
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<pre> Alternate drugs for Mania Rx Only asenapine Generic Name </pre> | <pre>
Treat schizophrenia/bipolar disorder/mania Rx Only
Saphris
Na+ channel inhibitor Atypical Antipsychotics
</pre>
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<pre> Major tranquilizer Rx Only antipsychotics (MOA) aka Major Tranquilizers Generic Name </pre> | <pre>
MOA: Rx Only
1) Antidopaminergic: blocks or reduces dopamine
2) Acts in the limbic system (feelings, emotions)
</pre>
🗑
|
||||
<pre> Major tranquilizer Rx Only antipsychotics (Therapeutic Effects) aka Major Tranquilizers Controls severe agitation Needs "informed consent" to use in SNF's Generic Name </pre> | <pre>
Therapeutic Effects: Rx Only
1) Calms patient w/o hynotic effect, does not put to sleep
2) Decreases irrational thought precesses
3) Allows patient to resume a "normal" life
</pre>
🗑
|
||||
<pre> Major tranquilizer Rx Only antipsychotics (Side Effects) aka Major Tranquilizers Lack of secretion, dry eyes, mouth, Constipation, Retention Urination Generic Name </pre> | <pre>
Side Effects: Rx Only
1) Tardive dyskinesia "zombie" from decreased dopamine
2) Apathy: loss of feeling
3) EPS: dystonia (involuntary muscle movement), akathisia (inner restlessness)
4) Postural Hypotension
</pre>
🗑
|
||||
<pre> Major tranquilizer Rx Only antipsychotics (Side Effects) cont aka Major Tranquilizers Lack of secretion, dry eyes, mouth, Constipation, Retention Urination Generic Name </pre> | <pre>
Side Effects: Rx Only
5) Anticholinergic
6) Dysphoria: low "feeling" unhappy
7) Decreased seizure threshold > convulsions
8) No addiction
</pre>
🗑
|
||||
<pre> Phenothiazine Rx Only fluphenazine decanoate Generic Name </pre> | <pre>
Treat schizophrenia Rx Only
Prolixin
Q4+week
Blocks D1/D2 receptors antipsychotic
</pre>
🗑
|
||||
<pre> atypical antipsychotic Rx Only risperidone Generic Name </pre> | <pre>
Treat schizophrenia/bipolar mania/autism Rx Only
Risperdal Consta
Q2 week
Blocks D2/S2/a2 receptors atypical antipsychotic
</pre>
🗑
|
||||
<pre> Phenothiazines/AED/anxiolytic Rx Only chlorpromazine Generic Name </pre> | <pre>
Treat schizophrenia/N/V/severe pain/anxiety Rx Only
Thorazine
Blocks D2/S2/a2 receptors antipsychotic
</pre>
🗑
|
||||
<pre> Phenothiazines/AED/anxiolytic Rx Only thioridazine Generic Name </pre> | <pre>
Treat schizophrenia/N/V/severe pain/anxiety Rx Only
Mellaril
Least risk of EPS
Blocks D2/S2/a2 receptors antipsychotic
</pre>
🗑
|
||||
<pre> Phenothiazines/AED/anxiolytic Rx Only fluphenazine Generic Name </pre> | <pre>
Treat schizophrenia/N/V/severe pain/anxiety Rx Only
Prolixin
Blocks D2/S2/a2 receptors antipsychotic
</pre>
🗑
|
||||
<pre> Phenothiazines/AED/anxiolytic Rx Only trifluoperazine Generic Name </pre> | <pre>
Treat schizophrenia/N/V/severe pain/anxiety Rx Only
Stelazine
Blocks D2/S2/a2 receptors antipsychotic
</pre>
🗑
|
||||
<pre> Phenothiazines/AED/anxiolytic Rx Only perphenazine Generic Name </pre> | <pre>
Treat schizophrenia/N/V/severe pain/anxiety Rx Only
Trilafon (in amytriptiline=Triavil)
Blocks D2/S2/a2 receptors antipsychotic
</pre>
🗑
|
||||
<pre> antipsychotic/AED/anxiolytic Rx Only phenothiazines Generic Name </pre> | <pre>
Cross-allergenicity: Rx Only
1) Allergic to 1 drug in phenothiazine class, then allergic to all
2) Screen for same chemical class/group
</pre>
🗑
|
||||
<pre> antipsychotic/AED/anxiolytic Rx Only phenothiazines (Cautions) Generic Name </pre> | <pre>
Caution: Rx Only
1) Photo-sensitivity (sun sensitivity) > skin turns violet, dark grey
2) Use SPF sun tan lotion/sunscreen
3) Hypothermia: always cold (negative side-effect)
</pre>
🗑
|
||||
<pre> antipsychotic/AED/anxiolytic Rx Only Non-penothiazine antipsychotics (MOA) Generic Name </pre> | <pre>
MOA: Rx Only
1) Antidopaminergic
2) Risk of EPS (like Parkinson's DZ)
</pre>
🗑
|
||||
<pre> antipsychotic/AED/anxiolytic Rx Only heloperidol Generic Name </pre> | <pre>
Treat schizophrenia/symptoms of Tourette's disorder Rx Only
Haldol (older drug)
Blocks D2/S2/a2 receptors Non-phenothiazine antipsychotic
</pre>
🗑
|
||||
<pre> antipsychotic/AED/anxiolytic Rx Only thiothixene Generic Name </pre> | <pre>
Treat schizophrenia/symptoms of Tourette's disorder Rx Only
Navane
Blocks D2/S2/a2 receptors Non-phenothiazine antipsychotic
</pre>
🗑
|
||||
<pre> antipsychotic/AED/anxiolytic Rx Only loxapine Generic Name </pre> | <pre>
Treat schizophrenia/symptoms of Tourette's disorder Rx Only
Loxitane
Blocks D2/S2/a2 receptors Non-phenothiazine antipsychotic
</pre>
🗑
|
||||
<pre> antipsychotic/AED/anxiolytic Rx Only pimozide Generic Name </pre> | <pre>
Treat schizophrenia/symptoms of Tourette's disorder Rx Only
Orap (DOC for Tourette's Syndrome)
Blocks D2/S2/a2 receptors Non-phenothiazine antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotics (MOA) Rx Only Increases risk of metabolic complications: 1) obesity 2) diabetes: increased bs > hyperglycemia > increased A1c 3) dyslipidemias: increased blood cholesterol > increased lipid/fat </pre> | <pre>
MOA: Rx Only
1) Blocks both dopamine and serotonin receptors
2) Decreases risk of EPS: fewer movement disorders
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotics (Caution) Rx Only Increases risk of metabolic complications: 1) obesity 2) diabetes: increased bs > hyperglycemia > increased A1c 3) dyslipidemias: increased blood cholesterol > increased lipid/fat </pre> | <pre>
Black Box Warning: Rx Only
1) May increase risk of stroke (CVI)
2) Caution in elderly dementia patients
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only risperidone Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Risperdal
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only risperidone (depo form) Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Risperdal Consta
Depo form: longer-acting
IM q2 weeks
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only risperidone (ODT form) Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Risperdal M-tab
ODT (orally dissolving)
To promote compliance
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only paliperidone Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Invega
Extended Release PO
Active metabolite of risperidone
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only olanzapine Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Zyprexa
PO form and IM form
Also used for CINV (chemo induced)
Blocks dopamine/5-HT3 to Tx bipolar mania
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only Olanzapine w/ fluoxetine Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Symbyax
fluoxetine=Prozac: SSRI to Tx depression
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only quetiapine Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Seroquel
PO form only
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only ziprasidone Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Geodon
PO form and IM form
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only aripiprazole Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Abilify
Not a PPI inhibitor
"dopamine system stabilizer"
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only asenapine Generic Name </pre> | <pre>
Treat schizophrenia/bipolar/autism Rx Only
Saphris
Sublingual form
NPO 10 minutes post dose
Blocks D2/S2/a2 receptors "Atypical" antipsychotic
</pre>
🗑
|
||||
<pre> "Atypical" antipsychotic Rx Only clozapine Black Box Warning: Causes Agranulocytosis: Drop in white blood cell count Week supply at a time until stabilized (7-14 days maximum Rx order) Generic Name </pre> | <pre>
Treat schizophrenia Rx Only
Clozaril
Patient must be registered in drug program
Patient needs CBC test done every week
Labs must be documented (WBC/ANC) w/each fill
Blocks D2/S2/a2 receptor "Atypical" antipsychotic
🗑
|
||||
<pre> Increase Ach in CNS Rx Only tacrine Generic Name </pre> | <pre>
Treat mild to moderate AD Rx Only
Cognex ("cognition")
QID ac
Black Box Warning: hepatotoxic
cholinesterase inhibitors anticholinergic
</pre>
🗑
|
||||
<pre> Increase Ach in CNS Rx Only tacrine=Cognex (side effects) Generic Name </pre> | <pre>
Treat mild to moderate AD Rx Only
Side Effects:
1) diarrhea: increased preistalsis
2) drooling: increased salivation
3) pee more: increased urinary urgency
4) bronchiospasms
cholinesterase inhibitors anticholinergic
</pre>
🗑
|
||||
<pre> Increase Ach in CNS Rx Only donepezil Generic Name </pre> | <pre>
Treat mild to moderate AD Rx Only
Aricept, Aricept ODT
QD at HS
More selctive for CNS, works in brain not in tissue
Many drug interactions
cholinesterase inhibitors anticholinergic
</pre>
🗑
|
||||
<pre> Increase Ach in CNS Rx Only glantamine Generic Name </pre> | <pre>
Treat mild to moderate AD Rx Only
Razadyne
BID c food
cholinesterase inhibitors anticholinergic
</pre>
🗑
|
||||
<pre> Increase Ach in CNS Rx Only Glantamine (Extended Release) Generic Name </pre> | <pre>
Treat mild to moderate AD Rx Only
Razadyne ER (formerly Reminyl)
QD (longer-lasting)
cholinesterase inhibitors anticholinergic
</pre>
🗑
|
||||
<pre> Increase Ach in CNS Rx Only rivastigmine Generic Name </pre> | <pre>
Treat mild to moderate AD Rx Only
Exelon
BID c food
Most severe N/V: titrate dose up
New form: Transdermal Patch QD less N/V
cholinesterase inhibitors anticholinergic
</pre>
🗑
|
||||
<pre> Increase Ach in CNS Rx Only memantine Generic Name </pre> | <pre>
Treat moderate to severe AD Rx Only
Namenda
Reduces nerve damage
Combo therapy
Fewer side effects
NMDA blocker anticholinergic
</pre>
🗑
|
||||
<pre> CNS stimulants (MOA) Rx Only Physiologic Effects: 1) Increased physiological processes (HR, BP, etc.) 2) Increased metabolism (weight loss) 3) Alertness (may cause insomnia) 4) Anorexia (loss of appetite) </pre> | <pre>
MOA: Rx Only
1) Block reuptake of NE / dopamine
Cautions:
1) Do not combine CNS simulants
2) Do not take w/other sympathomimetics (eg: Sudafed)
</pre>
🗑
|
||||
<pre> CNS stimulants (Therapeutic Uses) Rx Only Physiologic Effects: 1) Increased physiological processes (HR, BP, etc.) 2) Increased metabolism (weight loss) 3) Alertness (may cause insomnia) 4) Anorexia (loss of appetite) </pre> | <pre>
Therapeutic Uses: Rx Only
1) Narcolepsy: cannot stay awake (lethargic, sleepy)
2) ADHD (Attention Deficit Hyperactivity Disorder)
3) NE regulates attention, impulsivity, activity
4) Adult ADHD has less hyperactivity
</pre>
🗑
|
||||
<pre> CNS stimulants (Off-Label Uses) Rx Only Physiologic Effects: 1) Increased physiological processes (HR, BP, etc.) 2) Increased metabolism (weight loss) 3) Alertness (may cause insomnia) 4) Anorexia (loss of appetite) </pre> | <pre>
Off-Label Uses: Rx Only
1) Increase BMR
2) obesity
3) depression (from lack of energy, motivation)
4) "Lifestyle" drugs: "High", studying, partying
</pre>
🗑
|
||||
<pre> CNS stimulant C-II dextroamphetamine Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-II
Dexedrine
Block NE/dopamine reuptake amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant C-II methamphetamine Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-II
Desoxyn
Block NE/dopamine reuptake amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant C-II Amphetamine/dextroamphetamine Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-II
Adderall
Adderall XR: extended release QD
BID dosing: Need it only during school, AM and noon, M-F
Drug holidays recommended for summer
Block NE/dopamine reuptake amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant C-II lisdexamphetamine Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-II
Vyvanse (prodrug)
Block NE/dopamine reuptake amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulants C-II amphetamines (Side Effects) May produce extreme tolerance and addiction Highest scheduled drug Generic Name </pre> | <pre>
Side Effects: C-II
1) Hypertension, tachycardia, angina
2) CV problems
3) Weight loss, anorexia
</pre>
🗑
|
||||
<pre> CNS stimulants C-II amphetamines (Acute Toxicity) May produce extreme tolerance and addiction Highest scheduled drug Generic Name </pre> | <pre>
Acute Toxicity: C-II
1) Death, CVA (stroke), MI (heart attack)
2) Arrhythmia
</pre>
🗑
|
||||
<pre> CNS stimulant C-II methylphenidate Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-II
Ritalin, Concerta
Block NE/dopamine reuptake Non-amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant C-II methylphenidate (patch) Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-II
Daytrana Patch
Wear for 9 hours QD during schooltime
Block NE/dopamine reuptake Non-amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant C-II dexmethylphenidate Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-II
Focalin
Focalin XR: isomer
Block NE/dopamine reuptake Non-amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant C-IV modafinil Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-IV
Provigil, Sparlon
Tx: narcolepsy
Block NE/dopamine reuptake Non-amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant C-IV armodafinil Generic Name </pre> | <pre>
Treat ADHD/narcolepsy C-IV
Nuvigil
Isomer used to Tx: narcolepsy
Block NE/dopamine reuptake Non-amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant C-II cocaine Generic Name </pre> | <pre>
Used as Vasoconstrictor/local anesthetic C-II
FDA approval for use only in hospitals
C-I has not medicinal use, white powder, street drug
Block NE/dopamine reuptake Non-amphetamines
</pre>
🗑
|
||||
<pre> CNS stimulant OTC caffeine Generic Name </pre> | <pre>
Used as Vasoconstrictor/local anesthetic OTC
xanthine
Found in cola and tea
Also in form: caffeine tablets
Block NE/dopamine reuptake Non-amphetamines
</pre>
🗑
|
||||
<pre> Non-stimulants for ADHD Rx Only amotoxetine Generic Name </pre> | <pre>
Treat ADHD Rx Only
Strattera
Not a controlled substance
May increase BP and HR
Less addiction potential than scheduled CNS stimulants
SNRI inhibitor/blocker SNRI non-stimulant
</pre>
🗑
|
||||
<pre> Non-stimulants for ADHD Rx Only guanfacine Extended-Release Controls attention Controls impulsivity Generic Name </pre> | <pre>
Treat ADHD Rx Only
Intuniv
Not a controlled substance
Centrally acting
A2-receptor agonist Adrenergic non-stimulant
</pre>
🗑
|
||||
<pre> Non-stimulants for ADHD Rx Only guanfacine Generic Name </pre> | <pre>
Treat hypertension HTN Rx Only
Tenex
Do not take w/grapefruit juice
Do not abruptly stop medication > due to HTN rebound
A2 adrenergic receptor agonist Antihypertensive
</pre>
🗑
|
||||
<pre> CNS depressants/anticonvulsants Rx Only Antiepileptic AED (MOA) epilepsy / seizure Generic Name </pre> | <pre>
MOA: Rx Only
1) Supresses electricity in the brain
2) Decreases excitability of brain cells
3) Decreases spread of abnormal brain waves
4) Decreases risk of seizures
</pre>
🗑
|
||||
<pre> CNS depressants/anticonvulsants Rx Only Antiepileptic AED (Side Effects) epilepsy / seizure Generic Name </pre> | <pre>
Side Effects: Rx Only
1) drowsiness
2) ataxia: lack or coordination, order
</pre>
🗑
|
||||
<pre> CNS depressants/anticonvulsants Rx Only Antiepileptic AED (Caution) epilepsy / seizure Generic Name </pre> | <pre>
Caution: Rx Only
1) Check for FDA approved AB-Rated drugs, same TI
2) Often use adjunctive therapy
</pre>
🗑
|
||||
<pre> Barbiturate/CNS depressant/anticonvulsant C-IV phenobarbital PB long-acting Generic Name </pre> | <pre>
Treat or prevent seizures C-IV
Luminal
PO prophylaxis (eclampsia: hypertension during pregnancy)
IV Tx: Status Epilepticus: seizures >= 30 minutes
GABA agonist Antiepileptic AED
</pre>
🗑
|
||||
<pre> Barbiturate/CNS depressant/anticonvulsant C-IV mephenobarbital long-acting Generic Name </pre> | <pre>
Treat or prevent seizures C-IV
Mebaral
Barbiturate derivative
Off-label use for tremors
GABA agonist Antiepileptic AED
</pre>
🗑
|
||||
<pre> Barbiturate/CNS depressant/anticonvulsant C-IV primidone Generic Name </pre> | <pre>
Treat or prevent seizures C-IV
Mysoline
Barbiturate derivative
GABA agonist Antiepileptic AED
</pre>
🗑
|
||||
<pre> Hydantoins/CNS depressant/anticonvulsant Rx Only phenytoin Generic Name </pre> | <pre>
Treat tonic-clonic(grand mal)/partial seizures Rx Only
Dilantin DPH
PO drug
Na+ channel blocker Antiepileptic AED
</pre>
🗑
|
||||
<pre> Hydantoins/CNS depressant/anticonvulsant Rx Only fosphenytoin (IV form) Generic Name </pre> | <pre>
Treat tonic-clonic(grand mal)/partial seizures Rx Only
Cerebyx
IV form, prodrug: converted to phenytoin after metabolism
Injectable only
Na+ channel blocker Antiepileptic AED
</pre>
🗑
|
||||
<pre> AED/CNS depressants/anticonvulsants Rx Only hydantoins (Side Effects) epilepsy / seizure Generic Name </pre> | <pre>
Side Effects: Rx Only
1) Little sedation
2) Gingival Hyperplasia
</pre>
🗑
|
||||
<pre> AED/CNS depressants/anticonvulsants Rx Only hydantoins (Toxic Effects) epilepsy / seizure Generic Name </pre> | <pre>
Toxic Effects: Rx Only
1) Ataxia: Lack of coordination
2) Nystagmus: Jittering of eyes, eyes move back and forth
</pre>
🗑
|
||||
<pre> AED/CNS depressants/anticonvulsants Rx Only hydantoins (Dosing) epilepsy / seizure Generic Name </pre> | pre>
phenytoin Dosing: Rx Only
1) Based on bioavailability (rate / extent of absorption)
2) Different forms: "prompt" TID and "extended" QD
</pre>
🗑
|
||||
<pre> succinimides/anticonvulsant Rx Only ethosuximide (DOC) Generic Name </pre> | <pre>
Treat and prevent absence spells/petit mal seizures Rx Only
Zarontin
motor cortex blocker Antiepileptic AED
</pre>
🗑
|
||||
<pre> succinimides/anticonvulsant Rx Only methsuximide Generic Name </pre> | <pre>
Treat and prevent absence spells/petit mal seizures Rx Only
Celontin
motor cortex blocker Antiepileptic AED
</pre>
🗑
|
||||
<pre> BZD/CNS depressant C-IV clonazepam Generic Name </pre> | <pre>
Treat seizures/panic disorders C-IV
Klonopin
GABA agonist benzodiazepine/AED
</pre>
🗑
|
||||
<pre> BZD/CNS depressant C-IV lorazepam Generic Name </pre> | <pre>
Treat seizures/panic disorders C-IV
Ativan
Injectable form: store in refridgerator
In ER, DOC to Tx Status Epilepticus
GABA agonist benzodiazepine/AED
</pre>
🗑
|
||||
<pre> BZD/CNS depressant C-IV diazepam Generic Name </pre> | <pre>
Treat seizures/panic disorders C-IV
Valium
In ambulance, DOC to Tx Status Epilepticus
GABA agonist benzodiazepine/AED
</pre>
🗑
|
||||
<pre> BZD/CNS depressant C-IV clorazepate Generic Name </pre> | <pre>
Treat seizures/panic disorders C-IV
Tranxene
GABA agonist benzodiazepine/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only Carbamazepine Cranial Nerve - V Generic Name </pre> | <pre>
Treat seizures/Trigeminal Neuralgia Rx Only
Tegretol
Side Effects: bone marrow suppression (Aplastic Anemia)
May see increase in moood and alertness or mental disturbance
Na+ channel blocker AED/analgesic
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only carbamazepine (ER) Cranial Nerve - V Generic Name </pre> | <pre>
Treat seizures/Trigeminal Neuralgia/acute bipolar mania Rx Only
Equetro
Extended Release carbamazepine
Also to Tx Acute Bipolar Mania
Na+ channel blocker AED/analgesic
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only oxcarbazepine Generic Name </pre> | <pre>
Treat seizures/Trigeminal Neuralgia/acute bipolar mania Rx Only
Trileptal
Newer form of Tegretol
Lesser side effects
Na+ channel blocker AED/analgesic
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only valproic acid Generic Name </pre> | <pre>
Treat seizure disorders Rx Only
Depakene, Depacon IV
Delayed form: Stavzor
GABA inhibitor anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only divalproex sodium Generic Name </pre> | <pre>
Treat seizure disorders/prevent migraine HA/bipolar Rx Only
Depakote, Depakote ER (migraine HA)
Caution: hepatotoxic > monitor LFT's
Take w/food to decrease GI distress > prevent nausea
GABA agonist anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only gabapentin Generic Name </pre> | <pre>
Treat seizure/nerve pain (herpes zoster infection) Rx Only
Neurontin
Dose TID (max interval - q 12 h)
Also used to Tx neuropathic pain
GABA agonist anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only lamotrigine Generic Name </pre> | <pre>
Treat seizure/bipolar Rx Only
Lamictal
May cause Steven's Johnson (severe rash) > eats into tissue > necrosis
Also used to Tx bipolar disorder
Na+ channel blocker anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only topiramate Generic Name </pre> | <pre>
Treat seizure/migraine prophylaxis Rx Only
Topamax
May cause loss of appetite
Also used to Tx migraine w/low dose
Prevent migraine headaches
Na+ channel blocker/GABA agonist anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only tiagabine Generic Name </pre> | <pre>
Treat partial seizure Rx Only
Gabitril
Tx for patients 12 years or older for partial seizures
May cause new seizures
Selective GABA reuptake inhibitor anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only levetiracetam Generic Name </pre> | <pre>
Treat partial-onset seizure Rx Only
Keppra
Minimum drug interactions
Selective GABA reuptake inhibitor anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only zonisamide Generic Name </pre> | <pre>
Treat partial seizure Rx Only
Zonegran
Caution: Sulfa drug: causes Oligohidrosis
Oligohidrosis: Condition of few/little sweating
Na+ channel blocker Sulfonamide/anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED C-V pregabalin Generic Name </pre> | <pre>
Treat partial seizure/anxiety/nerve pain C-V
Lyrica
"Son of Gabapentin" may cause euphoria > addiction
Tx neuralgia/neurpathic pain
GABA agonist anticonvulsant/AED
</pre>
🗑
|
||||
<pre> Miscellaneous AED Rx Only felbamate FDA: D/C unless benefit >>> than risks Last DOC > only if other AED did not work Generic Name </pre> | <pre>
Treat partial seizure Rx Only
Felbatol
Black Box Warning: significant risk of the following:
Aplastic Anemia: bone marrow suppression > abnormal white blood cells
Acute liver failure
NMDA antagonist anticonvulsant/AED
🗑
|
||||
<pre> AED/CNS depressants/anticonvulsants Rx Only Antiepileptic (other Indication) 1) intractable pain, diabetic neuropathy 2) Shingles (post hepatic neuralgia) 3) Insomnia epilepsy / seizure Generic Name </pre> | <pre>
Other Indication of Uses: Rx Only
1) Migraine HA (headaches) prophylaxis (prevention)
2) Bipolar disorder (mania)
3) Neuropathic pain
4) Trigeminal Neuralgia (Bell's Palsy -cn-V)
</pre>
🗑
|
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<pre> Migraine HA Rx Only Analgesic/Migraine Prophylaxis (Sx) Migraine headache/"vascular" headache Generic Name </pre> | <pre>
Symptoms: Rx Only
1) Cerebral vasoconstriction > aura: sensation, sights, smells
2) Rebound > cerebral vasodilation > throbbing pain
3) N/V, sensitivity/intolerance to light/noise
4) Irritable
</pre>
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|
||||
<pre> Migraine Headache Rx Only Ergot alkaloid Rarely used currently Strong vasoconstrictors > hypertension Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Ergomar (SL)
Sublingual form
Must take drug holiday
a1 selective adrenergic agonist Vasoconstrictor/analgesic/sympatholytic
</pre>
🗑
|
||||
<pre> Migraine Headache Rx Only ergot alkaloid (injection) Rarely used currently Strong vasoconstrictors > hypertension Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
DHE-45 (injection)
Injection form
Must take drug holiday
a1 selective adrenergic agonist Vasoconstrictor/analgesic/sympatholytic
</pre>
🗑
|
||||
<pre> Migraine Headache Rx Only ergot alkaloid (nasal spray) Rarely used currently Strong vasoconstrictors > hypertension Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Migranal (nasal spray)
Nasal Spray form
Must take drug holiday
a1 selective adrenergic agonist Vasoconstrictor/analgesic/sympatholytic
</pre>
🗑
|
||||
<pre> Migraine Headache C-IV isometheptene/dichloraphenazone/APAP vasoconstrictor/sedative/analgesic Generic Name </pre> | <pre>
Treat Acute Migraine Headache C-IV
Midrin
a1 selective adrenergic agonist Vasoconstrictor/analgesic/sympatholytic
</pre>
🗑
|
||||
<pre> Migraine Headache OTC ASA / APAP / caffeine Generic Name </pre> | <pre>
Treat Acute Migraine Headache OTC
Excedrin Migraine
Dose: 2 tabs q 24 h
Dose Excedrin Regular: 2 tabs q 6 h
Vasoconstrictor: increases BP, HR, etc.
a1 selective adrenergic agonist Vasoconstrictor/analgesic/sympatholytic
🗑
|
||||
<pre> Acute Migraine HA Rx Only serotonin 5-HT1 agonists (dose) Cautions: May increase BP Angina (chest pain) MI / CVA risk Migraine headache/"vascular" headache Generic Name </pre> | <pre>
Dosing: Rx Only
1) PO
2) ODT (Orally Dissolving Tablet) for N/V
3) Injectable (auto-injector): self-administration
4) Nasal spray: self-administration
</pre>
🗑
|
||||
<pre> Acute Migraine Headache Rx Only sumatriptan Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Imitrex, Sumavel
Sumavel: oldest drug
Prevent vasodilation/induce vasoconstriction serotonin 5-HT1 agonists
</pre>
🗑
|
||||
<pre> Acute Migraine Headache Rx Only zolmitriptan Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Zomig
Prevent vasodilation/induce vasoconstriction serotonin 5-HT1 agonists
</pre>
🗑
|
||||
<pre> Acute Migraine Headache Rx Only rizatriptan Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Maxalt
Prevent vasodilation/induce vasoconstriction serotonin 5-HT1 agonists
</pre>
🗑
|
||||
<pre> Acute Migraine Headache Rx Only naratriptan Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Amerge
Prevent vasodilation/induce vasoconstriction serotonin 5-HT1 agonists
</pre>
🗑
|
||||
<pre> Acute Migraine Headache Rx Only almotriptan Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Axert
Prevent vasodilation/induce vasoconstriction serotonin 5-HT1 agonists
</pre>
🗑
|
||||
<pre> Acute Migraine Headache Rx Only frovatriptan Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Frova
Prevent vasodilation/induce vasoconstriction serotonin 5-HT1 agonists
</pre>
🗑
|
||||
<pre> Acute Migraine Headache Rx Only eletriptan Generic Name </pre> | <pre>
Treat Acute Migraine Headache Rx Only
Relpax
Prevent vasodilation/induce vasoconstriction serotonin 5-HT1 agonists
</pre>
🗑
|
||||
<pre> Migraine Prophylaxis Rx Only propranolol Take routingely Identify > eliminate "triggers" (eg: chocolate, sun) Generic Name </pre> | <pre>
Prevent Migraine Prophylaxis/treat hypertension/angina Rx Only
Inderal
Longer-acting
Beta blockers vasodilator/antihypertensive/adrenergic
</pre>
🗑
|
||||
<pre> Migraine Prophylaxis Rx Only nadolol Take routingely Identify > eliminate "triggers" (eg: chocolate, sun) Generic Name </pre> | <pre>
Prevent Migraine Prophylaxis/treat hypertension/angina Rx Only
Corgard
Beta blockers vasodilator/antihypertensive/adrenergic
</pre>
🗑
|
||||
<pre> Migraine Prophylaxis Rx Only timolol Take routingely Identify > eliminate "triggers" (eg: chocolate, sun) Generic Name </pre> | <pre>
Prevent Migraine Prophylaxis/treat hypertension/angina Rx Only
Blocadren
Beta blockers vasodilator/antihypertensive/adrenergic
</pre>
🗑
|
||||
<pre> Migraine Prophylaxis Rx Only lisinopril Take routingely Identify > eliminate "triggers" (eg: chocolate, sun) Generic Name </pre> | <pre>
Prevent Migraine Prophylaxis/treat hypertension/angina Rx Only
Prinivil, Zestril
Ace inhibitor cardiotonic/antihypertensive/adrenergic
</pre>
🗑
|
||||
<pre> Migraine Prophylaxis/AED Rx Only Divalproex sodium Take routingely Identify > eliminate "triggers" (eg: chocolate, sun) Generic Name </pre> | <pre>
Prevent Migraine Prophylaxis/seizure/mania Rx Only
Depakote ER
Extended Release: QD dosing
Not generically equivalent to Depakote
Na+ channel blocker/GABA agonist antiepileptic/anticonvulsant/adrenergic
</pre
🗑
|
||||
<pre> antidopaminergic drugs/antiemetics Rx Only drug-induced EPS (Parkinson's DZ) EPS (Extra-Pyramidal Symptoms) Generic Name </pre> | <pre>
antidopaminergic drugs: Rx Only
1) Phenothiazine (eg: Thorazine)
2) Other major tranquilizers (eg: Haldol)
3) Some antiemetics (eg: Reglan) > prokinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS Rx Only levodopa Disorder: dopamine < ACh L-dopa has limited span of activity > becomes ineffective Goal: Delay using L-dopa, use other drugs first Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
L-dopa
Crosses blood-brain barrier > converted to dopamine
Side effect: N/V
Increase dopamine levels dopamine agent/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS Rx Only levodopa/carbidopa Disorder: dopamine < ACh L-dopa has limited span of activity > becomes ineffective Goal: Delay using L-dopa, use other drugs first Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Sinemet
Prevents peripheral conversion of levodopa
Less levodopa > less N/V
Increase dopamine levels dopamine agent/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS Rx Only carbidopa Disorder: dopamine < ACh L-dopa has limited span of activity > becomes ineffective Goal: Delay using L-dopa, use other drugs first Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Parcopa ODT
ODT form: carbidopa
Prevents peripheral conversion of levodopa
Less levodopa > less N/V
Increase dopamine levels dopamine agent/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS Rx Only pergolide Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Permax
Causes heart valve damage > taken off the market
mimic dopamine at receptors dopamine agonist/antidyskinetic
</pre>
🗑
|
||||
pre> Parkinson's DZ/EPS Rx Only amantadine Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS/viral infection Rx Only
Symmetrel
Also used to Tx viral infections
Also used to Tx influenza
mimic dopamine at receptors dopamine agonist/antiviral/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS Rx Only bromocriptine Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Parlodel
mimic dopamine at receptors dopamine agonist/antiviral/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS Rx Only pramipexole Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Mirapex
Second generation
mimic dopamine at receptors dopamine agonist/antiviral/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS Rx Only ropinirole Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Requip
Second generation
Also used to Tx RLS (Restless Leg Syndrome)
mimic dopamine at receptors dopamine agonist/antiviral/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS/CNS depressant Rx Only apomorphine Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS/severe pain Rx Only
Apokyn
Injectable "rescue" Tx
SQ prn up to 5 x d
mimic dopamine at receptors dopamine agonist/analgesic/narcotic/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS/MAOI (Manoamine Oxidase Inhibitors) Rx Only Selegiline aka Deprenyl (zelapar ODT) stimulant: metabolites are amphetamine-like > insomnia Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS/depression Rx Only
Eldepryl
BID dosing: AM and Noon
increase dopamine by preventing metabolism dopamine agonist/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS/MAOI (Manoamine Oxidase Inhibitors) Rx Only rasagiline stimulant: metabolites are amphetamine-like > insomnia Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS/depression Rx Only
Azilect
Many drug/food interactions w/ Manoamine Oxidase Inhibitors (MAOI)
May cause hypertensive crisis
increase dopamine by preventing metabolism dopamine agonist/antidyskinetic
🗑
|
||||
<pre> Parkinson's DZ/EPS/COMT inhibitor Rx Only tolcapone Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Tasmar
catechol-o-methyl transferase inhibitor (COMT)
COMT inhibitor antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS/COMT inhibitor Rx Only entacapone Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Comtan
catechol-o-methyl transferase inhibitor (COMT)
COMT inhibitor antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS/COMT inhibitor Rx Only entacapone/levodopa/carbidopa Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Stalevo
catechol-o-methyl transferase inhibitor (COMT)
COMT inhibitor antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS/Ach blocker Rx Only benztropine Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Cogentin
Less effective than dopamine
Used to Tx EPS
Synthetic, fewer side effects than antispasmodics (belladonna alkaloids)
ACh blocker anticholinergic/antidyskinetic
</pre>
🗑
|
||||
<pre> Parkinson's DZ/EPS/Ach blocker Rx Only trihexyphenidyl Generic Name </pre> | <pre>
Treat Parkinson's DZ/EPS Rx Only
Artane
Less effective than dopamine
Used to Tx EPS
Synthetic, fewer side effects than antispasmodics (belladonna alkaloids)
ACh blocker anticholinergic/antidyskinetic
</pre>
🗑
|
||||
<pre> benzodiazepine/anxiolytic C-IV diazepam Generic Name </pre> | <pre>
Treat anxiety/seizure/insomnia/ETOH withdrawal/muscle spasms C-IV
Valium
CNS depressant/GABA agonist anxiolytic/AED/sedative/antidyskinetic
</pre>
🗑
|
||||
<pre> benzodiazepine/anxiolytic C-IV chlordiazepoxide Generic Name </pre> | <pre>
Treat anxiety/seizure/insomnia/ETOH withdrawal/muscle spasms C-IV
Librium
CNS depressant/GABA agonist anxiolytic/AED/sedative/antidyskinetic
</pre>
🗑
|
||||
<pre> benzodiazepine/anxiolytic C-IV lorazepam Generic Name </pre> | <pre>
Treat anxiety/seizure/insomnia/ETOH withdrawal/muscle spasms C-IV
Ativan
CNS depressant/GABA agonist anxiolytic/AED/sedative/antidyskinetic
</pre>
🗑
|
||||
<pre> benzodiazepine/anxiolytic C-IV alprazolam Generic Name </pre> | <pre>
Treat anxiety/seizure/insomnia/ETOH withdrawal/muscle spasms C-IV
Xanax
CNS depressant/GABA agonist anxiolytic/AED/sedative/antidyskinetic
</pre>
🗑
|
||||
<pre> benzodiazepine/anxiolytic C-IV oxazepam Generic Name </pre> | <pre>
Treat anxiety/seizure/insomnia/ETOH withdrawal/muscle spasms C-IV
Serax
"Serax comedown" for ETOH withdrawal
CNS depressant/GABA agonist anxiolytic/AED/sedative/antidyskinetic
</pre>
🗑
|
||||
<pre> benzodiazepine/anxiolytic C-IV midazolam Generic Name </pre> | <pre>
Treat anxiety/seizure/insomnia/ETOH withdrawal/muscle spasms C-IV
Versed
Trade off market
Injectable + PO form to Tx peri-operative
CNS depressant/GABA agonist anxiolytic/AED/sedative/antidyskinetic
</pre>
🗑
|
||||
<pre> benzodiazepine/anxiolytic C-IV clorazepate Generic Name </pre> | <pre>
Treat anxiety/seizure/insomnia/ETOH withdrawal/muscle spasms C-IV
Tranxene
CNS depressant/GABA agonist anxiolytic/AED/sedative/antidyskinetic
</pre>
🗑
|
||||
<pre> benzodiazepine antagonist Rx Only flumazenil Generic Name </pre> | <pre>
Treat BZ overdose Rx Only
Romazicon
Side effect: increase HR/respirations will increase
Block "benzo" receptors antidotes/GABA modulator
</pre>
🗑
|
||||
<pre> non-benzodiazepine anxiolytic Rx Only buspirone Generic Name </pre> | <pre>
Treat anxiety Rx Only
Buspar
Very little sedation
No dependence
anxio-selective non-benzodiazepine anxiolytic
</pre>
🗑
|
||||
<pre> anxiolytic/antihistamines Rx Only hydroxyzine antihistamine cause mild sedation > relieve anxiety Generic Name </pre> | <pre>
Treat anxiety/allergy symptoms Rx Only
Atarax
PO only: Atarax
IM, PO: Vistaril
Caution: use "Z track" for IM to avoid skin irritation
anxio-selective anxiolytic/antipruritic/hypnotic/histamine H1 antagonist
</pre>
🗑
|
||||
<pre> anxiolytic/antihistamines Rx Only promethazine antihistamine cause mild sedation > relieve anxiety Generic Name </pre> | <pre>
Treat anxiety/allergy symptoms Rx Only
Phenergan
Chemically similar to phenothiazine > EPS risk (blocks dopamine)
Antiemetic, no antipsychotic activity
H1-antagonist anxiolytic/antipruritic/hypnotic/anticholenergic
<
🗑
|
||||
<pre> antihistamines Rx Only antihistamines (indication) histamine H1-antagonist Generic Name </pre> | <pre>
Indication of Use: Rx Only
1) Allergy symptoms, pruritis, N/V
2) Mild sedation > relieve anxiety
3) w/narcotics (synergism) for pain
4) may cause anticholinergic side effects
</pre>
🗑
|
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