Neuropharmacology, S1KW
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| Effective Dose (ED) | % of people for whom a particular dose will cause the desired effects. (If ED50 for Fluoxetine is 150mg, 50% of population will be effected.)
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| Lethal Dose (LD) | % of fatalities at a drug dose.
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| Safety Margin | Difference between ED50 and LD1
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| Potency | The strength of binding between a drug (ligand) and the target (receptor).
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| Efficacy | The biological effect exerted by the binding.
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| Bioavailability | This is how well the drug gets into the brain and to its site of action.
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| Agonist | Drug binds to receptor and mimics the neurotransmitter.
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| Antagonist | Drug binds to receptor but produces no biologic effect.
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| Inverse Agonist | Produces an effect which is opposite the effect of the agonist.
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| Saturability | Saturation occurs when all receptors are occupied.
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| Selectivity | Receptors are selective for specific drugs.
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| Reversability | Binding is usually reversible.
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| Synapse | Space between bouton and receptor site.
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| Mitochondria | Essentially the energy source of a neuron.
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| Blood-Brain Barrier | A protective network of blood vessels and cells that filters blood flowing to the brain.
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| Depolarization | Pushing membrane toward 0.
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| Hyperpolarization | Pushing membrane away from 0.
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| Transmembrane Potential | -70 mV (-70 x 100 billion neurons). Maintained by active processes such as membrane ion pumps.
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| Transduction | translating one form of energy into another
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| Exocytosis | When vesicles which contain neurotransmitters go to the surface of the membrane and release into the synapse.
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| Synapse | must have vesicles and membrane thickening
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| Microglia | (Glial cell) tiny, move through brain easily, perform phagocytosis
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| Phagocytosis | eating of dead tissue
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| Nodes of Ranvier | The gaps formed between myelin sheath cells along the axons.
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| Myelin | fatty sheaths that coat axons to promote faster conduction.
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| Temporal Summation | Administering another stimulus before the action potential of previous stimulus begins to recede.
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