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psychopharmacology

Neuropharmacology, S1KW

QuestionAnswer
Effective Dose (ED) % of people for whom a particular dose will cause the desired effects. (If ED50 for Fluoxetine is 150mg, 50% of population will be effected.)
Lethal Dose (LD) % of fatalities at a drug dose.
Safety Margin Difference between ED50 and LD1
Potency The strength of binding between a drug (ligand) and the target (receptor).
Efficacy The biological effect exerted by the binding.
Bioavailability This is how well the drug gets into the brain and to its site of action.
Agonist Drug binds to receptor and mimics the neurotransmitter.
Antagonist Drug binds to receptor but produces no biologic effect.
Inverse Agonist Produces an effect which is opposite the effect of the agonist.
Saturability Saturation occurs when all receptors are occupied.
Selectivity Receptors are selective for specific drugs.
Reversability Binding is usually reversible.
Synapse Space between bouton and receptor site.
Mitochondria Essentially the energy source of a neuron.
Blood-Brain Barrier A protective network of blood vessels and cells that filters blood flowing to the brain.
Depolarization Pushing membrane toward 0.
Hyperpolarization Pushing membrane away from 0.
Transmembrane Potential -70 mV (-70 x 100 billion neurons). Maintained by active processes such as membrane ion pumps.
Transduction translating one form of energy into another
Exocytosis When vesicles which contain neurotransmitters go to the surface of the membrane and release into the synapse.
Synapse must have vesicles and membrane thickening
Microglia (Glial cell) tiny, move through brain easily, perform phagocytosis
Phagocytosis eating of dead tissue
Nodes of Ranvier The gaps formed between myelin sheath cells along the axons.
Myelin fatty sheaths that coat axons to promote faster conduction.
Temporal Summation Administering another stimulus before the action potential of previous stimulus begins to recede.
Created by: EmptySpaces
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