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PANCE GI UMDNJ

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Question
Answer
Achalasia Radiology   Bird's beak or Parrot beak on barium swallow  
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Achalasia Gold Standard   Manometry  
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Esophageal varices   Most common complication of portal hypertension; results in UGIB  
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Achalasia manifestation   1. Regurge of undigested food; 2. Substernal chest pain; 3. Gradual dysphagia of liquid and solids  
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Esophageal Motor Disorders   Achalasia; Esophageal spasm; Scleroderma  
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Achalasia Treatment   nifedipine 10 mg SL; pneumatic dilatation  
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Achalasia and Esophageal Spasm   auerbach's plexus degeneration  
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Esophageal spasm diagnosis   1. dysphagia; 2. Corkscrew on Barium Swallow  
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CREST Syndrome   1. calcinosis cutis; 2. Raynaud phenomenon; 3. esophageal dysmotility; 4. clerodactyly; 5. Telangiectasia  
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Schatzki's Ring   LE mucosal ring  
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Zenker's Diverticulum   1. Outpouching of the posterior hypopharynx; 2. Loss of UES elasticity  
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Zenker's Diverticulum Manifestation   1. Regurgitation of undigested food; 2. halitosis; 3. dysphagia  
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Mallory Weiss Tear   1.Gastroesophageal Junction; 2. Retching and forceful vomitting; 3. Binge Drinking  
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Esophageal Cancer   1. Smoking - SCC; 2. ETOH - SCC; 3. Barrett's - Adenocarcinoma  
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Esophgeal Cancer Manifestation   1. solid dysphagia; 2. weight loss; 3. lymphadenopathy/hepatomegaly - metastasis  
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Erosive Gastritis   most common cause of gastritis  
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Gastritis Protective Factors   1. mucus; 2. alkaline state; 3. bicarbonate; 4. hydrophbic layer; 5. mucosal blood flow; 6. epithelial renewal; 7. Prostaglandins  
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H. pylori   1. gram negative spiral bacillus; 2. gastric adenocarcinoma  
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H. pylori test   1. Endoscopic Rapid Urease Test - test of choice; 2. Urea breath test; 3. H. pylori antibodies; 4. fecal antigen serology  
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H. pylori treatment   1. triple therapy: PPI + amoxicillin (may sub metronidazole 500mg) + clarithromycin; 2. quadruple therapy: PPI + Bismuth + metronidazole 250mg + tetracycline 500mg  
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GERD Diagnosis   Barium Swallow  
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GERD Treatment   1. antacids: acute relief; 2. H2 blocker: mild first line; 3. PPI: mod - server or H2-blocker-failed  
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Barrett's Esophagus   1. Distal esophagus; 2. squamous epithelium cells becomes metaplastic epithelium cells; 3. Usually from chronic GERD; 4. predisposes to adenocarcinoma of the esophagus  
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PUD Characteristics   1. H. pylori; 2. Gastric ulcer - older - worsens with food; 3. Duodenal (more common) - 30 - 55 - improves with food  
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PUD Diagnosis   1. Upper endoscopy - procedure of choice; 2. Rapid urease via endoscope - test of choice for H. pylori  
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PUD Induced Ulcer perforation   1. Sudden  
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Gastric outlet obstruction   1. Early satiety; 2. "succession splash"; 3. vomit of partially digested food; 4. weight loss; 5. NG Tube produces >200ml foul smelling liquid  
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Zollinger-Ellison Syndrome diagnosis and treatment   Diagnosis; 1. fasting gastrin level > 150pg/ml; 2. Secretin test; Treatment:1. PPI; 2. surgery if possible  
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Gastric adenocarcinoma   strong connection with H. pylori and smoking  
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Sister Mary Joseph Nodule   1. Umbilical nodule; 2. Gastric malignancy; 3. Pancreatic cancer  
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Gastric Adenocarcinoma   H. pylori; resection first; radiation and chemo to follow; 5 year survival < 15%  
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Charcot's Triad   1. Charcot's triad 1: multiple sclerosis (nystagmus  
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Early intestinal obstruction   hyperactive bowel sound (high pitched); rushes  
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Gastric adenocarcinoma diagnosis   1. iron deficiency anemia; 2. increased LFT test; 3. CT determines disease extent  
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Gastric adenocarcinoma manifestation   1. refractory dyspepsia; 2. virchow's nodes; 3. Sister Mary Joseph's nodule; 4. Krukenberg tumor  
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Young adult with bullous myringitis   1. Mycoplasmal pneumonia ; 2. Erythromycin  
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VIPoma   1. rare pancreatic cancer; 2. excess growth hormone; 3. diarrhea  
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VIP   vasoactive intestinal peptide  
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Malabsorption disorders   1. celiac; 2. whipple's  
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Celiac disease Characteristics   1. DM 1; 2. autoimmune thyroid disorder; 3. First degree relatives; 4. HLA-DQ2; 5. Dermatitis Herpetiformis  
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Pellagra   3Ds; 1. Diarrhea; 2. Dermatitis; 3. Dementia  
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Celiac Confirmation and treatment   1. Mucosal biopsy; 2. removal glutenous foods; 3. nutrition supplements: Vit. B12  
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Whipple's Charactericts   1. Infection by Tropheryma whippelii; 2. 'white male 40 - 60 y/o; 3. Wt loss; 4. anemia  
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Whipple's treatment   1. Antibiotics: cephtriaxone IV 2g/day x 2 weeks; then Bactrim/doxy if sulfar allergy PO bid. x 1 year  
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Pt over 50 with new onset constipation   evaluate for colorectal cancer  
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Constipation Treatment   1. increase fiber; 2. increase fluid; 3. exercise; Pharmacological treatment: 1. osmotic laxatives; 2. stimulant laxatives; 3. stool softeners  
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Fecal Impaction Predisposing Risks   1. Opioids use; 2. Severe Psychiatric disease; 3. Prolonged bed rest; 4. Neurogenic colonic disorders; 5. spinal cord disorders  
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Diarrhea Types   1. viral infection; 2. bacterial toxins - E. coli; 3. C. diff; 4. viral gastroenteritis  
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Inflammatory/non-inflammatory Diarrhea   1. Inflammatory: Fever  
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Fecal impaction treatment   1. manual disimpaction; 2. enemas; 3. long term stool softeners; 4. Regular BM's  
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Appendicitis Diagnosis   Contrast CT  
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Most common chronic/recurrent abdominal pain in the US   1. Irritable Bowel Syndrome; 2. Pain relieved by defacation; 3. Hyperresonance on percussion; 4. Treatment by high fiber diet and bulking agents; 5. 5-HT3 antagonist has limited success  
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Pseudomembranous Colitis Manifestatoin   1. Green foul-smelling watery diarrhea; 2. Lower abdominal cramp; 3. Mucous stool; 4. No stool pathogen; 5. Establish diagnosis by Cytotoxic Assay Toxin B; 6. Biopsy: volcano exudate  
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Pseudomembranous Colitis Characteristics   1. Antibiotic associated colitis - clindamycin  
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Crohn's Disease Overview   1. with some genetic predisposition; 2. Most with perirectal involvement; 3. Barium enema/CT - cobblestone pattern/skip lesions; 4. Diagnostic: colonscopy  
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Crohn's Disease Treatment   1. Sulfasalazine; 2. short-term steroids; 3. Immunomodulary agents: azathioprine  
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Ulcerative Colitis Manifestations   1. bloody diarrhea; 2. weight loss; 3. fever; 4. malaise; 5. often develop into toxic megacolon  
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Toxic Megacolon Hallmarks   1. Nonobstructive dilatation x 6cm; 2. Signs of systemic toxicity  
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Diverticular Disease Overview   1. Mostly in distal/sigmoid colon; 2. mostly in pt over 80 y/o; 3. Mostly in western country due to low-fiber intake  
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Disverticular disease diagnosis   1. occult blood; 2. leukocytosis; 3. Contrast CT  
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Diverticulitis treatment   1. low residue diet/outpatient; 2. broad spectrum abx: metronidazole/quinolones; 3. Moderate to severe: admit with IV abx  
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Small Bowel Obstruction   1. NPO; 2. Bowel rest; 3. Antiemetic: metoclopramide (Reglan)  
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Superior mesenteric ischemia overview   1. accounts for over 50% of the mesenteric ischemia; 2. BRBPR if right sided ischemia; 3. Thumbprint on x-ray; 4. gold standard - angiography  
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Ischemic colitis   1. Most common ischemic injury to the GI tract; 2. Mostly over 60 y/o; 3. risk factors: sickel cell  
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Chronic Hepatitis Causes   1. Hepatitis B & C; 2. Autoimmune; 3. ETOH Abuse; 4. isoniazide or macrobid  
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