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322 Anticoagulants and Antilipidemics

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Term
Definition
anticoagulants   prevent new clots from forming  
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side effects of anticoagulants   bleeding, petechiae, weakness, epistaxis  
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antiplatelets   prevent platelet aggregation, prevent thrombosis in artery  
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clopidogrel (plavix)   used after MI or stroke to prevent recurrence; prevents ADP from binding with platelet receptor  
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thrombolytics   attack and dissolve already formed blood clots; bind to fibrin promoting plasminogen to plasmin  
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adverse effects of thrombolytics   anaphylaxis, laryngeal edema, angioedema, cerebral edema, seizures  
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anticoagulants interventions   monitor PT and INR, use soft toothbrush  
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bile acid sequestrants   reduce LDL cholesterol levels by binding with bile acids in the intestine - helps excrete lipids through the GI tract  
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fibrates (fibric acid)   reduce triglycerides and VLDL, do not take with anticoagulants  
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nicotnic acid   reduces VLDL and LDL, large doses required; niacin  
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cholesterol absorption inhibitor   decreases cholesterol from dietary absorption, reducing serum cholesterol, triglycerides and apoB levels; ezetimibe  
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HMG - COA, statins   inhibit the enzyme HMG CoA reductase in cholesterol biosynthesis, decreasing LDLs, VLDL and triglycerides, increases HDLs slightly  
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adverse reactions of statins   muscle cramps and weakness, cataracts, liver impairment, myalgia, rhabdomyolysis  
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rhabdomyolysis   breakdown of muscle tissue that releases a damaging protein into the bloodstream  
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heparin   accelerates anticoagulation cascade, prolongs clotting time; monitor PTT (normal 60 to 70), aPTT  
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bleeding precautions   aware of epistaxis, hematoma, avoid large amounts of leafy greens, do not take a lot of aspirin  
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low molecular weight heparin   more stable, less lab monitoring, less risk for bleeding; enoxeparin  
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direct thrombin inhibitors   treatment of DVT and PE; argathroban  
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side effects of direct thrombin inhibitors   chest pain, dyspnea, hematoma, hypotension, cardiac arrest  
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oral warfarin   inhibits synthesis of vitamin K, monitor PT (prothrombin time), INR (international normalized ratio)  
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PT   time it takes to form a clot  
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selective factor xa inhibitor   selectively blocks clotting factor xa, does not require close monitoring  
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side effects of warfarin   petechiae, priapism, alopecia, fever  
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anti platelet example   aspirin  
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HDL   good cholesterol  
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LDL   bad cholesterol  
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statin teaching   avoid grapefruit juice, take before bed  
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niacin side effects   flushing, headache, hyperglycemia, hyperuricemia; take with aspirin  
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