Immunology (5 &6)
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| Which region of the immunoglobulin molecule can bind antigen? A. Fab B. CL C. CH D. Hinge region | show 🗑
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| show | IgM
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| Which is characteristic of IgG: A. First class of antibody to appear B. Found mainly in secretions C. The least abundant antibody in serum D. Provides immunity for the newborn | show 🗑
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| show | The recognition of antigens by naive B cells
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| Identify the correct pairing of an immunoglobulin and its property A. IgA: crosses the placenta B. IgG: most abundant in serum C. IgM: immunoglobulin produced by a T cell D. IgE: major immunoglobulin of secondary response | show 🗑
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| Which of the following is a characteristic of IgA? A. It is found in secretions B. It fixes complement C. It is a pentamer in serum D. It is the primary response antibody | show 🗑
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| show | VH + VL
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| show | IgM
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| Kappa or lambda light chains: A. are encoded on the same chromosome B. associate with only one type of heavy chain at a time C. can be expressed by the same B cell D. are expressed by a pre-B cell | show 🗑
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| show | Allotypes
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| The ability of an antibody to opsonize is located in which region? A. F(ab)2 B. Fc C. VL + VC D. Hypervariable | show 🗑
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| show | It is able to fix complement
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| show | The primary response has a long lag phase, the anamnestic response has a short lag phase.
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| show | Lambda and kappa
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| show | IgM
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| The region of an antibody molecule that exhibits the greatest variability from antibody to antibody is known as the: A. hypervariable region B. constant region C. Fc region | show 🗑
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| show | IgG is increased 100-fold to 1,000-fold
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| Immunoglobulins are grouped into classes on the basis of similarities in: A. light chains B. heavy chains C. antigen binding sites D. disulfide bonds | show 🗑
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| Which class makes up 70% to 80% of total serum immunoglobulins? A. IgA B. IgG C. IgM D. IgE | show 🗑
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| show | IgE
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| show | Albumin
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| In serum protein electrophoresis, which band contains the immunoglobulins? A. alpha-1 B. alpha-2 C. Beta D. gamma | show 🗑
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| show | The most efficient subclass for activating complement
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| Characteristics of cytokines include which of the following? A. They are directly cytotoxic to bacteria B. they are produced primarily by the liver C. they are chemical messengers that regulate the immune system D. They are plysaccharides | show 🗑
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| Cytokines exhibit pleitropy, which refers to: A. multiple cytokines affecting the same cell B. one cytokine inhibiting the activity of another cytokine C. one cytokine affecting multiple cells D. cytokines acting together to affect a cell | show 🗑
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| IL-2 is synthesized by: A. T cells B. B cells C. monocytes D. mast cells | show 🗑
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| show | hematopoiesis
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| A person steps on a rusty nail, which punctures her skin and activates resident macrophages to secrete IL-1 beta. The fever that develops is an example of what type of cytokine signaling? A. autocrine B. paracrine C. endocrine D. kallikrein | show 🗑
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| show | Th1 cells
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| show | IFN-gamma
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| The priamry function of colony-stimulating factors (CSFs) is to promote: A. apoptosis B. lysis C. diapedesis D. Hematopoiesis | show 🗑
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| What is the main function of chemokines? A. inhibit the immune response B. enhance synthesis of acute-phase reactants C. establish a concentration gradient to guide cell movement | show 🗑
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| show | IL-6
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| Erythropoietin regulates: A. T-cell function B. Bone marrow cell differentiation C. proinflammatory cytokine synthesis D. the acute-phase response | show 🗑
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| show | TNF
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| Fab stands for: | show 🗑
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| show | IgM
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| show | IgG
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| show | IgG
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| show | Primary
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| Found in secretions such as sAlivA and teArs: | show 🗑
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| Associated with allergies: | show 🗑
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| Most abundant is serum: | show 🗑
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| Activates the classical complement pathway and fixes complement: | show 🗑
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| Activates the classical complement pathway and fixes complement: | show 🗑
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| show | Allotypes
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| show | Idiotype
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| show | Isotype and allotype
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| show | - kappa and lambda
- k and (upside down) y
- associate with one type of H chain at a time
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| show | Fc
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| Immunoglobulin classes are determined by: | show 🗑
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| Which group migrates the slowest? | show 🗑
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| Antibodies are located in which region? | show 🗑
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| show | IgG3
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| Cytokines characteristics: | show 🗑
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| show | True
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| show | - CSF
- IL-3 and EPO
- IL-5
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| show | systemic
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| show | affecting the same cell that secreted it
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| Paracrine: | show 🗑
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| show | Chemokines
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| show | - Tumore Necrosis Factor
- Induces lysis of tumor cells
- Is secreted in response to gram negative bacterial infections
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| show | Pleiotropy - one cytokine has many actions
redundancy - different cytokines have the same function
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| show | Primary response
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| show | They occur on both the H and L chains
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| All of the following are true of IgM except that it: a. can cross the placenta b. fixes complement c. has a J chain d. is a priamry response | show 🗑
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| How does the structure of IgE differ from that of IgG | show 🗑
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| show | 10
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| show | L chains
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| A Fab fragment consists of: | show 🗑
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| show | IgA
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| show | IgGlm3 and IgGlm17
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| show | 2 L and 2H chains
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| Which of the following are L chains of antibody molecules? A. Kappa B. Gamma C. Mu D. Alpha | show 🗑
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| If the results of serum protein electrophoresis show a significant decrease in the gamma band, which of the following is a likely possibility? | show 🗑
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| show | The arrangement of disulfide bonds
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| Which best describes the role of the secretory component of IgA? | show 🗑
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| Which represents the main function of IgD? | show 🗑
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| show | IgM
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| show | B cells are preprogrammed for specific antibody synthesis
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| show | heat stable
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| Which best describes coding for immunoglobulin molecules? | show 🗑
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| show | Restricting the growth of myeloma cells
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| Papain digestion of an IgG molecule results in which of the following? A. 2 Fab' and 1 Fc' fragment B. F(ab')2 and 1 Fc' fragment C. 2 FAb and 2 Fc fragments 2 FAb and 1 Fc fragment | show 🗑
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| Which antibody provides protection to the growing fetus because it is able to cross the placenta? A. IgG B. IgA C. IgM D. IgD | show 🗑
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| show | There is a a large increase in IgG but not IgM
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| The ability of a single cytokine to alter the expression of several genes is called: | show 🗑
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| Which of the following effects can be attributed to IL-1? A. mediation of the innate immune response B. differentitation of stem cells C. halted growth of virally infected cells D. stimulation of mast cells | show 🗑
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| show | All of the above
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| A lack of Il-4 may result in: | show 🗑
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| Which of the following cytokines is also known as the T-cell growth factor? A. IFN-y B. IL-12 C. IL-2 D. IL-10 | show 🗑
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| show | increased IL-2 receptor expression by the Th cell producing it
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| IFN-a and IFN-B differ in which way from IFN-gamma? | show 🗑
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| show | TNF
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| IL-10 acts as an antagonist to what cytokine? | show 🗑
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| Which would be the best assay to measure a specific cytokine? A. blast formation B. T-cell proliferation C. measurement of leukocyte chemotaxis D. ELISA testing | show 🗑
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| Selective destruction of Th cells by the human immunodeficiency virus contributes to immune suppression by which means? | show 🗑
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| Why might a colony stimulating factor (CSF) be given to a cancer patient? | show 🗑
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| show | Decreased ability to fight gram-negative bacterial infections
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| Which cytokone acts to promote differentiation of T cells to the Th1 subclass? A. IL-4 B. IFN-a C. IL-12 D. IL-10 | show 🗑
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| show | Suppression of the immune response by inducing IL-10
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| Th17 cells affect the innate immune response by inducing production of which cytokines? A. IFN-y and IL-2 B. IL-4 and IL-10 C. IL-2 and IL-4 D. TNF-a and IL-6 | show 🗑
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