FA complete review part 4 Pharmacology
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| show | Reversible inhibitors of H1 histamine receptors.
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| What are some First generation H1-blockers? | show 🗑
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| What are the clinical uses for H1-blockers? | show 🗑
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| show | Sedation, antimuscarinic, anti-alpha-adrenergic.
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| What are some examples of Second generation H1-blockers? | show 🗑
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| What is the main use for H1-blockers of second generation? | show 🗑
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| show | Less entry into CNS
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| show | Guaifenesin
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| What is N-acetylcysteine? | show 🗑
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| N-acetylcysteine is used for antidote for ____________________ overdose. | show 🗑
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| show | Antitussive; antagonizes NMDA glutamate receptors; Synthetic codeine analog.
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| How can Dextromethorphan overdose treated? | show 🗑
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| show | Serotonin syndrome if combined with other serotonergic agents.
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| show | a-adrenergic agonists, used as nasal decongestants
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| show | 1. Reduce hyperemia, edema, and nasal congestion
2. Open obstructed eustachian tubes
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| What are the most significant adverse effects of Pseudoephedrine and phenylephrine? | show 🗑
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| What drug categories are used in the treatment of Pulmonary hypertension? | show 🗑
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| What is the MOA of Endothelin receptor antagonists? | show 🗑
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| Which endothelin receptor is blocked by Endothelin-receptor blockers? | show 🗑
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| What is the most common example of an Endothelin-receptor antagonist? | show 🗑
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| show | Endothelin-receptor antagonists
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| What is the associated adverse effect of Bosentan? | show 🗑
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| What is the MOA of PDE-2 inhibitors? | show 🗑
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| show | Erectile dysfunction
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| What drugs/compounds are contraindicated in a patient on PDE-5 inhibitors? | show 🗑
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| show | Sildenafil
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| show | Epoprostenol, iloprost
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| MOA of Prostacyclin analogs | show 🗑
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| What are the most common side effects of Prostacyclin analogues? | show 🗑
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| show | 1. Inflammatory processes
2. Parasympathetic tone
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| Short acting B2 agonist | show 🗑
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| What are 3 common B2-agonists used in Asthma treatment? | show 🗑
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| What is the common B2-agonist used in acute exacerbation of asthma? | show 🗑
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| What is MOA of Albuterol? | show 🗑
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| show | Salmeterol and Formoterol
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| What are common adverse effects of Salmeterol? | show 🗑
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| Examples of common inhaled corticosteroids? | show 🗑
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| What Asthma drugs are known to inhibit the synthesis of virtually all cytokines? | show 🗑
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| What drug(s) are the first line of treatment for chronic asthma ? | show 🗑
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| show | Inactivate NF-KB
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| show | Transcription factor that induces production of TNF-alpha and other inflammatory agents
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| What transcription factor is inactivated by inhaled corticosteroids, such as Fluticasone? | show 🗑
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| show | Use a spacer or rinse mouth after use
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| show | Tiotropium and Ipratropium
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| What is the MOA of Muscarinic antagonist? | show 🗑
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| show | Muscarinic antagonists
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| Which muscarinic antagonist is used in treatment of asthma and is known to be long-acting? | show 🗑
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| 3 common antileukotrienes: | show 🗑
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| Which antileukotrienes block leukotriene receptors CysLT1? | show 🗑
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| What are the recommended asthma drugs for Aspirin-induced asthma and Exercise-induced asthma? | show 🗑
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| Montelukast and Zafirlukast are _______________________-. | show 🗑
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| 5-lipoxygenase pathway inhibitor. | show 🗑
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| What is blocked by the use of Zileuton? | show 🗑
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| Which antileukotriene is known to be hepatotoxic? | show 🗑
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| What is Omalizumab? | show 🗑
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| show | Binds unbound serum IgE and blocks binding to FcERI
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| What type of asthma is the one that most commonly uses Omalizumab as part of drug therapy? | show 🗑
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| show | Omalizumab
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| show | Methylxanthine
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| show | By inhibiting phosphodiesterase --> elevated cAMP levels due to decreased cAMP hydrolysis
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| Why is the use of Theophylline limited? | show 🗑
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| show | Adenosine
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| Theophylline is metabolized by the ________________________. | show 🗑
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| show | Cromolyn and nedocromil
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| show | Prevent release of inflammatory mediators from mast cells
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| What is the main use for mast cell stabilizers? | show 🗑
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| show | 1. B-agonists
2. Theophylline
3. Muscarinic antagonists
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| show | Studies and Antileukotrienes
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| What is the early response of asthma process? | show 🗑
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| show | Inflammation --> bronchial hyperreactivity.
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