B&B Final
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Psychiatric Disorders | show 🗑
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DSM-IV-TR | show 🗑
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show | splitting of psychic functions; breakdown of integration among emotion, thought, and action
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show | Schizophrenia characterized by long periods of immobility and waxy flexibility (
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Waxy flexibility | show 🗑
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show | recurrence of only 2 of these symptoms for one month is grounds for diagnosis of schizophrenia: Delusions, inappropriate affect, hallucinations, incoherent thought, odd behavior, catatonia, echolalia
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show | 1st Anti-schizophrenic drug.1st developed as an antihystamine. Agitates schizos were calmed and emotionally unresponsive activated. Reduced symptoms enough for discharge. Typical, phenothiazine. Antagonist at dopaminergic synapses. Caused more metabolites
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Reserpine | show 🗑
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Striatum | show 🗑
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show | theory that schizophrenia is caused by too much dopamine and that anti-schizophrenic drugs exert their effects by decreasing dopamine levels. Contradiction=schizos have same amt of dopamine in brain
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show | Most uncommon symptom of schizophrenia. one of the ways ppl are IDed as faking. Hallucinations of odor.
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show | 1reserpine known 2 deplete brain/dopamine &other monoamines by breakdown synap vesicles that store these neurotransmitters 2drugs like amphetamine & coke ^ extracell levels / dopamine &monoamines in brain & 2 cause schizophrenic breaks in normal subjects.
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show | molecules created when another molecule is broken down Extracell levels of metabolites are increased by chloropromazine
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Receptor blocker | show 🗑
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Haloperodol | show 🗑
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show | ie chlorpromazine,reserpine; all bind 2 D1 + D2 receptors. Heather took it in the movie. Will cause Parkinson like symptoms by destroying dopamine receptors
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show | Only bind 2 d2 dopamine receptors ie Haloperodol & spiroperidol
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Neuroleptics | show 🗑
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show | highest affinity4d2 receptors&most potent antischiz effect. Ex of the current theory that schizophrenia caused by activity @D2 receptors specifically.butyrophenone.
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show | 1st atypical neuroleptic4treatment / schiz. has affinity 4 d1 receptors, D4, & serotonin receptors,slight affinity 4 D2 receptors. Often effective in treating schizophrenics who have not responded to typical neuroleptics &doesnt->Parkinsony sidefx
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show | evidence that D2 receptors not sole mechanism /schiz Anti-schiz drugs not primarily D2 receptor blockers ieClozapine.
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Positive Schizophrenic Symptoms | show 🗑
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show | Not as responsive 2 treatment w/neuroleptics ie lack/affect, cognitive deficits, &poverty/speech, lack of affect, inability to think clearly, lack of perceptual filtering, social withdrawl, sleep problems;assumed to be caused by brain damage
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show | Affective disorder-anhedonia, 4 no apparent reason. Often imposs 2 meet essential requirements / their daily lives. Most common mental illness.
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show | loss of capacity to experience pleasure. Symptom of depression
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show | affective disorder;overconfidence, impulsivity, distractibility, high energy episodes=people r talkative, energetic, impulsive, positive, very confident
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Bipolar affective disorder (manic depression) | show 🗑
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show | Depressives who do not experience manic episodes
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show | symptom of Bipolar disorder. Transitional states between mania and depression associated with particularly high suicide rates
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Reactive depression | show 🗑
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Endogenous depression | show 🗑
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Seasonal Affective Disorder (SAD) | show 🗑
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Iproniazid | show 🗑
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show | Iproniazid blocks this. Enzyme that breaks down monoamine neurotransmitters in the cytoplasm of the neuron.
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show | include Iproniazid. Can cause the cheese effect
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show | Sidefct/MAO inhibitors tyramine (in cheese, wine,pickles)metabolized by MAO in liver.MAO inhibitors prevent this-people on these meds & consume tyramine-strokes from surge in BP. blocks norepinephrine and serotonin. Dangerous
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show | amine in wine, cheese, pickles. Not broken down w/o MAO (prevented by MAO inhibitors)> buildup cause BP surge + strokes→ cheese effect
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show | antidepressants w/structure made of 3 atom rings ie imipramine Block serotonin+norepinephrine reuptake>^levels in brain Safer alternatives 2 MAO inhibitors
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show | 1st tricyclic antidepressant
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Lithium | show 🗑
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Mood stabilizer | show 🗑
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Selective serotonin-reuptake inhibitors (SSRIS) | show 🗑
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Fluoxetine | show 🗑
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Prozac | show 🗑
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show | another effective form of antidepressants
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show | Theory of depression,depression<under activity /serotinergic &noradrenergic synapses. basis=monoamine oxidase inhibitors, tricyclic antidepressants, SSRIS, &selective norepinephrine-reuptake inhibitors=all agonists of serotonin, norepinephrine, or both
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Up-regulation | show 🗑
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show | theory depressed ppl inherit diathesis-If exposed 2stress early systems become permanently sensitized>overreact 2 mild stressors 4 rest/life. Th based on observation->depressed ppl release more stress hormones. Maybe cortisol? Came from epigenetics
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Diathesis | show 🗑
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show | Depressed individuals synthesize more of this. This is evidence for the diathesis synthesis model of depression
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show | depressed individuals release more of this from their anterior pituitary. This is evidence for the diathesis synthesis model of depression
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show | depressed individuals release more of this from their adrenal cortex. This is evidence for the diathesis synthesis model of depression
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show | injections of this synthetic glucocorticoid does not reduce the release of glucocorticoids through negative feedback in many depressed patients, though they do in normal subject.->counterevidence for Diathesis stess model
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show | chronic fear persists in absence of direct threat
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show | anxiety disrupt normal function, Associated w/feelings/anxiety (fear worry despondency)&w/variety/psych stress rvns: tachycardia, hypertension (high BP), nausea,breathing difficulty,sleep disturbances,^ glucocorticoid levels. Experiences shape the dsorder
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show | rapid heartbeat associated w Anxiety Disorder
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show | high BP often associated with Anxiety disorder
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Types of Anxiety Disorder | show 🗑
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show | Generalized Anxiety Disorder, phobic anxiety disorder,panic disorder,OCD, PTSD
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show | stress responses +extreme feelings of anxiety that occur in the absence of any obvious precipitating stimulusPhobic anxiety disorders- similar to generalized anxiety disorders except that they are triggered by exposure to particular objects or situations
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show | rapid-onset attacks of extreme fear and severe symptoms of stress (e.g. choking, heart palpitations, shortness of breath); they are often components of generalized anxiety disorders and phobic disorders, but also exist as separate disorders
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show | characterized by frequently recurring, uncontrollable, anxiety-producing thoughts (obsessions) and impulses (compulsions)
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Posttraumatic Stress Disorder | show 🗑
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show | type of phobic anxiety disorder triggered by public places and open spaces
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Benzodiazepines | show 🗑
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show | type of Benzodiazepine (Librium) used to treat anxiety
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Diazepam | show 🗑
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Buspirone- | show 🗑
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show | anti-anxiety. Often effective against depression because of comorbidity
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show | tendency to occur in the same individual—comorbidity of anxiety disorders and depression make it hard to study both
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show | method of studying Anxiety where rats are places on a 4-armed plus-sign-shaped maze that is 50 cm above the floor. The measure of anxiety is the proportion of time the rats spend in the enclosed arms, rather than venturing onto exposed arms
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Defensive-burying test | show 🗑
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Risk-assessment test | show 🗑
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show | a disorder of tics,Some patients also exhibit signs of ADHD, OCD, or both. Onset in childhood or early adolesce. Tics helped by neuroleptics. Current hypoth is that results from excessive dopaminergic innervation of the striatum and associated cortex
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Tics | show 🗑
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Complex motor tics | show 🗑
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Complex verbal tics | show 🗑
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show | uttering obscenities
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Echolalia | show 🗑
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Palilalia | show 🗑
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Translational Research | show 🗑
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show | studies conducted on human subjects to assess the therapeutic efficacy of an untested drug or other treatment
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Active Placebos | show 🗑
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show | Drugs for which the market is too small for them to be profitable
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Translational bottleneck | show 🗑
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show | attaining sexual gratification from spying on people. Diagnosable in the DSM(But what about watching x-rated movies?)
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show | in Revolutionary US, people would be diagnosed with this if they questioned the colonies’ fight for independence. Recog in DSM
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show | form the basis of who has a problem and who doesn’t in DSM
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Hippocrates | show 🗑
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sensorium | show 🗑
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show | Egypt 1st;3 holes drilled in cranium. saw under skull w wire+remove triangular piece.
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trephine | show 🗑
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Springer | show 🗑
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Andersonville | show 🗑
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St. Mary’s of Bethlehem | show 🗑
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Pinel | show 🗑
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show | 2 prime movers for making mental healthcare humane
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George III of England | show 🗑
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show | cause seizures so severe -would induce seizure before syringe removed, opposing muscle contract @same time+ break bones +tear muscles from bone
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Electro convulsive schock (ECS) | show 🗑
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show | started by Freeman,take a small hammer &push down on eye. Metal piece cracks through skull and into brain to sever brain
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show | research on monkeys’ + frontal lobes. – Nobel prize 4 frontal lobotomies. Thought something in frontal lobe was screwing up the rest of the brain
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show | followed up on Moniz’ work & did lobotomies on people in a routine way- started doing Trans-orbital frontal leucotomies, 1stone using ice pick from home
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We still use psychosurgery for… | show 🗑
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show | part of the limbic system associated with OCD
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show | pain on your face that’s so severe that it causes you to lose consciousness, sometimes occurs 30 times a day,Usually commit suicide,blood vessel impinges on facial nerve,doesn’t respond to pain killers,Frontal lobotomy will make them indifferent to pain
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perceperation disorder | show 🗑
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show | gutteral laugh, uncontrollable laugh of those with frontal lobotomies.
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show | People with lobotomies have a perceperation disorder that you get from the actual treatment by the psychiatrist
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show | paranoid schizophrenia, stuporous catatonic schizophrenia, hebephrenic schizophrenia, simple/undifferentiated schizophrenia,
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Paranoia | show 🗑
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show | Most common subtype. Most important symptom for diagnosis is flight of ideas
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show | Same symptoms as schizophenia resulting from acute amphetamine intoxication
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show | the guilty mind
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The machinist | show 🗑
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show | Killed ppl at abortion clinic, schizophrenia, found guilty
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show | loss of interest in outcomes, change in eating habits, sleep disturbance (early waking,constant sleep, Social withdrawal
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K. Redfield Jameson | show 🗑
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show | can decrease the sensitivity of the postsynaptic membrane, so it needs more serotonin. Can be treated with SSRIs, which get the serotonin stock in the synapse instead of reuptake
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show | Used in patients that are so depressed that they cant be left alone. Creates a window for medicine
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show | Used to be called pre-senile dementia.Amyloid Plaques and Neurofibrillary tangles.
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Signs/Symptoms of Alzheimer's | show 🗑
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show | Microtubules in AD patients get tangled up so they can no longer carry neurotransmitters
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Amyloid Plaques | show 🗑
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show | AD brains have a ton of aluminum in it--turns out bc they cant adequately get rid of it
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show | AD might be one. produce motor deficits first. Can catch them. include Kuru, mad cow, Crutchfeld-Jacob syndrome etc. maybe genetic
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show | prions are inhaled and migrate to the olfactory bulb to olfactory receptor cells, where there is not an adequate blood-brain barrier to brevent entering brain. They deteriorate olfactory pathway in exact sequence as smell travels.
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show | prion disease found in tribe in Ornio, and other cannibalistic tribes, where males eat the brains of the elders when they die
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show | prion disese in England that makes your brain spongy
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Crutchfeld-Jacob syndrome | show 🗑
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show | self-replicating, virus-like protein without a cell membrane. cannot be killed by burning or typical forms of sterilization
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Cognitive behavioral therapy | show 🗑
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show | tend to be smaller in patients with tourettes
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show | Sometimes used as treatment for tourettes
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