Mechanism of action for major diuretics
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| show | Osmotic diuretic, ↑ tubular fluid osmolarity --> ↑ urine flow
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| Acetazolamide | show 🗑
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| Furosemide | show 🗑
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| show | Phenoxyacetic acid derivative. Same mechanism as furosemide. Used in pts with sulfa allergy.
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| show | Thiazide diuretic. Inhibits NaCl reabsorption in early distal tubule, reducing diluting capacity of nephron. ↓ Ca++ excretion.
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| show | Na-channel blocking class of K+-sparing diuretics. Work in cortical collecting duct. Block Na+ reabsorption and K+ and H+ secretion.
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| show | Competitive aldosterone receptor antagonist in cortical collecting duct. Reduces Na+ reabsorption and K+ and H+ secretion.
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| ↑ Urine NaCL | show 🗑
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| show | All diuretics except K+-sparing
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| ↑ Blood pH (alkalosis) | show 🗑
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| ↓ Blood pH (acidosis) | show 🗑
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| ↑ Urine Ca++ | show 🗑
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| show | Thiazides
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Created by:
golfspy
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